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A modeling study of aerosol effects on cloud radiative property and precipitation

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Chinese Science Bulletin 2010年第15期55卷 1554-1559页

作者： FANG Wen zheng guoguang WANG Wei-Chyung Chinese Academy of Meteorological Sciences Beijing 100081 China Atmospheric Sciences Research Center State University of New York Albany NY 12203 USA

A two-moment (mass and number) warm cloud scheme together with ground and aircraft measurements over Beijing is used in a regional model to study the effects of aerosols on cloud radiative property and *** a prescribed tri-modal lognormal aerosol size distribution,the aerosol numbers are calculated from prognostic aerosol masses,for which advection,diffusion,and cloud drop activation/deactivation are ***,the accumulation mode of a tri-lognormal aerosol size distribution is fitted to the aircraft measured values for a cold front case passed through northern China during June 25-26,*** the simulations,the warm cloud scheme simulates explicitly the cloud drops and subsequently affects the radiative heating and cooling,and *** with different initial conditions for being fitted with aircraft measurements,continental and maritime aerosol numbers were *** is found that more aerosols result in more but smaller cloud drops and more cloud water,leading to an increase in *** effects on rains are complex:smaller cloud drops have less efficient coagulation for raindrop to form (autoconversion),leading to fewer raindrop numbers and less rainwater;while more cloud water enhances the accretion for raindrop ***,for the whole cloud system,the impact of increasing aerosols inhibits precipitation.

关键词：辐射效应气溶胶降水财产 Northern 对数正态分布建模地面测量

Receptor role of membrane bound macrophage colony-stimulating factor

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Chinese Science Bulletin 1998年第12期43卷 1034-1037页

作者： Wu Kefu He Zhihong zheng guoguang Rao Qing Wang Xin Chinese Acad Med Sci Inst Hematol Natl Lab Expt Hematol Tianjin 300020 Peoples R China Peking Union Med Coll Tianjin 300020 Peoples R China

According to the definition of cytokine, the direction of signaling should be from cytokine to receptor. The counter receptor was presented. Membrane bound macrophage colony-stimulating factor (m-M-CSF) and its receptor (M-CSF-R) were shown in human leukemic cell line J6-1 as autojuxtacrine mechanism. Soluble M-CSF receptor (sM-CSF-R), which was isolated from J6-1 cells membrane, was added into J6-1 cell culture. It was observed inhibition of J6-1 cell proliferation, decreasing of mitosis index and ratio of multinuclear cells, enlargement of cell diameter and volume, down regulation of numerous surface antigens. Dramatic change of intracellular pH was shown between several min to 20 min after treatment of sM-CSF-R. It suggested that some information was transmitted via m-M-CSF from sM-CSF-R. This counter signaling was not influenced by saccharification of m-M-CSF.

关键词： cytokine macrophage colony-stimulating factor receptor juxtacrine.

The effects of legumain in THP1 leukemia cells

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BIOCELL 2021年第1期45卷 149-156页

作者： DONGYUE ZHANG LINA WANG HAO WANG XIAOQIAN LV QIAN REN guoguang zheng State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology&Blood Disease HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin300020China

Legumain is a C13 family cysteine *** plays diverse roles under both physiological and pathological *** high-level expression of legumain is detected in solid *** promotes the proliferation and migration of tumor ***,the effect of legumain in blood diseases has not been *** this report,we studied the effect of legumain on leukemia cells by overexpressing it in THP1 *** results demonstrated that legumain promoted cell proliferation,whereas it had little effect on cell ***,legumain promoted the migration of THP1 *** was worth noting that legumain decreased the stemness of THP1 *** evidence showed that legumain decreased the expression of Oct4,Sox2,Myc in THP1 *** study reveals the multifaced effects of legumain in leukemia cells and broadens the knowledge of legumain in malignancies.

关键词： Legumain Leukemia Proliferation Migration Stemness

Internalization and half-life of membrane-bound macrophage colony-stimulating factor

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Chinese Science Bulletin 2000年第18期45卷 1697-1703页

作者： TANG Shengsong LIU Hanzhi CHEN Guibin RAO Qing GENG Yiqi zheng guoguang zheng Dexian WU Kefu State Key Laboratory of Experimental Hematology Institute of HematologyChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China

The binding of recombinant human macrophage colony-stimulating factor (M-CSF) soluble receptor (rh-M-CSF-sR) to membrane-bound macrophage colony stimulating factor (m-M-CSF) and the internalization and recycling of rh-M-CSF-sR/m-M-CSF complexes mediated by m-M-CSF were studied with a model of J6-1 cell line. The results indicated that m-M-CSF bound rh-M-CSF-sR with high affinity (Kd= 1.78×10 12 mol/L) and mediated a temperature- and energy-dependent internalization of rh-M-CSF-sR, and that internalized rh-M-CSF-sR could return to the cell surface in an m-M-CSF-bound state, suggesting that m-M-CSF may have a capability to mediate the internalization and recycling of rh-M-CSF-sR/m-M-CSF complexes. In addition, the half-lives of cell-associated M-CSF and its receptor of stimulated normal human cord blood mononuclear cells (CBMCs) and 4 leukemic cell lines were measured by indirect immunoflu-orescence and flow cytometry. The results showed that the half-lives of the various kinds of M-CSF isoforms and

关键词： macrophage colony-stimulating factor endocytosis half-life.

Observed Climate Changes and Their Causes

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China Today 2010年第11期59卷 14-17页

作者： zheng guoguang Administrator of the China Meteorological Administration

CLIMATE change is a major global challenge facing the world today. It relates to the survival of the human beings and the development of all countries,

关键词：气候变化原因观测全球气候变暖经济发展不确定性

Macrophages in leukemia microenvironment

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Blood Science 2019年第1期1卷 29-33页

作者： Lina Wang guoguang zheng State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjinChina

Macrophages,the important component of tissue microenvironment,play important roles in both physiological and pathological processes,including tumor and ***-associated macrophages are involved in tumor proliferation,angiogenesis,invasion,metastasis,and chemotherapy *** leukemia,macrophages are educated by leukemia microenvironment to obtain specific activated phenotype and participate in leukemia *** studies have shown that accumulation of macrophages in leukemia patients or mouse model is correlated with poor ***,increasing attentions have been paid to study the characteristics of them and to develop novel therapeutic strategies targeting macrophages against *** this article,we summarize recent development of macrophages in leukemia microenvironment.

关键词： Heterogeneity Leukemia microenvironment Leukemia-associated macrophages(LAMs) Macrophages Targeting therapy

Paris Climate Change Conference: A Fresh Start of International Climate Governance in the New Era

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Chinese Journal of Urban and Environmental Studies 2016年第1期4卷 46-54页

作者： zheng guoguang CHAO Qingchen ZHANG Yongxiang China Meteorological Administration National Climate Center

After tough negotiations, the Paris Agreement finally reached at the Climate Change Conference in Paris. When taking the background into consideration, though the process is tortuous and arduous, the desirability of the Agreement needs no affirmation. Global warming is unequivocal,posing a serious risk to global economic, social sustainable development and natural as well as ecological environment. Scientific evidence shows that human activity is the main cause of current global warming. Tackling climate change should be the path leading the whole society to shift towards low-carbon, green, and circular development, in order to achieve the sustainable development of the international community. World leaders gathered in Paris to discuss actions against climate change and helped establish an international climate governance system after 2020. As governments and the international community are gradually reaching a consensus on the issue of addressing climate change, positive political will and the awareness of win–win cooperation are growing strong. The adoption of the Paris Agreement indicates a new phase of international climate governance, encouraging the parties to participate with more inclusive and practical ways.

关键词： Climate agreement international system green development Paris climate change conference

RESISTIVITY ANOMALY IN THE HIGH-TEMPERATURE SUPERCONDUCTOR Bi-Sr-Ca-Cu-O

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Chinese Physics Letters 1988年第12期5卷 564-566页

作者： YUAN Songliu WANG Wei zheng guoguang RAN Qize GUAN Weiyan zheng Jiaqi Institute of Physics and Surface Physics LaboratoryAcademia SinicaBeijing On leave from Department of Physics Chinese University of Science and TechnologyHefei

An anomalous resistance drop was observed near 190K in the R-T measurement on a sample in Bi-Sr-Ca-Cu-O system and the transition completed at *** keeping the sample at room temperature for 10h,the temperature dependence of the resistance changed from semiconducting to metallic behavior,while the ending of the transition remained at *** might be an evidence of the existence of a metastable superconducting phase in Bi-Sr-Ca-Cu-O system with Tc as high as 190K.

关键词： resistance system metastable

The convergence of hematology and immunology(November 13-15;Tianjin, China)

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Blood Science 2020年第2期2卷 41-43页

作者： guoguang zheng Lai Guan Ng Tao Cheng State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China Singapore Immunology Network(SIgN) A∗STAR(Agency for ScienceTechnology and Research)Biopolis138648 Singapore

The Convergence of Hematology and Immunology(CHI),which was sponsored by State Key Laboratory of Experimental Hematology,Institute of Hematology and Blood Diseases Hospital,Chinese Academy of Medical Sciences(CAMS),was held in Tianjin,***-chaired by Tao Cheng of Institute of Hematology and Blood Diseases Hospital at CAMS(Tianjin,China),Lai Guan NG,and Florent Ginhoux of Singapore Immunology Network(Singapore),the two-day meeting invited 34 scientists from China,the United States,Singapore,Israel,Sweden,Switzerland,Japan,Italy,and Australia to present and share their latest views on the topics in hematology and immunology.

关键词： Blood Immunology CAMS