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基于题后反思平台提升学生数学解题能力

当代教研论丛 2018年第8期5卷 68-69页

作者：郑志明福建省福安市第八中学福建福安355000

构建题后反思平台,对于学生而言,在提高他们数学解题的思维能力方面有很大的帮助。题后反思,可以帮助学生在解题后通过学生或者老师,对问题有一个全面的思考和了解,并且形成一个好的思维能力。作为教师,我们可以建立一个题后反思平台,... 详细信息

构建题后反思平台,对于学生而言,在提高他们数学解题的思维能力方面有很大的帮助。题后反思,可以帮助学生在解题后通过学生或者老师,对问题有一个全面的思考和了解,并且形成一个好的思维能力。作为教师,我们可以建立一个题后反思平台,从而促进学生形成这种习惯,然后提高解题的能力。

关键词：教学方式高中数学题型反思平台

A review of deep learningg methods for ligand based drug virtual screening

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Fundamental Research 2024年第4期4卷 715-737页

作者： Hongjie Wu Junkai Liu Runhua Zhang Yaoyao Lu Guozeng Cui zhiming Cui Yijie Ding School of Electronic and Information Engineering Suzhou University of Science and TechnologySuzhou 215009China Yangtze Delta Region Institute(Quzhou) University of Electronic Science and Technology of ChinaQuzhou 32400China

Drug discovery is costly and time consuming,and modern drug discovery endeavors are progressively reliant on computational methodologies,aiming to mitigate temporal and financial expenditures associated with the *** particular,the time required for vaccine and drug discovery is prolonged during emergency situations such as the coronavirus 2019 ***,the performance of deep learning methods in drug virtual screening has been particularly *** has become a concern for researchers how to summarize the existing deep learning in drug virtual screening,select different models for different drug screening problems,exploit the advantages of deep learning models,and further improve the capability of deep learning in drug virtual *** review first introduces the basic concepts of drug virtual screening,common datasets,and data representation ***,large numbers of common deep learning methods for drug virtual screening are compared and *** addition,a dataset of different sizes is constructed independently to evaluate the performance of each deep learning model for the difficult problem of large-scale ligand virtual ***,the existing challenges and future directions in the field of virtual screening are presented.

关键词： Virtual screening Deeplearning Drug discovery Drug-targetinteraction Drug-target affinity

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生物反应器的研究及其相关问题思考

安徽化工 2005年第1期31卷 54-57页

作者：郑之明中国科学院等离子体物理研究所离子束生物工程重点实验室合肥230031

分析了生物反应器工程的研究现状,探讨了研究中存在的一些问题并提出了解决这些问题的研究思路。

关键词：生物反应器生物化学工程生物技术微生物基因工程

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浅谈表面电阻测试仪

科学之友 2012年第4期 21-22页

作者：郑芝明博罗县质量技术监督检测所

表面电阻测试仪同时具有测量表面电阻和接地电阻的功能,主要用于测量静电消耗和绝缘表面的传导性能,可重复测量,操作简单。

关键词：表面电阻测试仪校准方法

Stability and variability of molecular subtypes: comparative analysis of primary and metastatic triple-negative breast cancer

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Cancer Biology & Medicine 2024年第9期21卷 784-798页

作者： Xiuzhi Zhu Xiaohan Ying Yin Liu Yunyi Wang Li Chen zhiming Shao Xi Jin Yizhou Jiang Zhonghua Wang Key Laboratory of Breast Cancer in Shanghai Shanghai Institute of Infectious Disease and Biosecurity Department of Oncology Shanghai Medical College Fudan University Department of Breast Surgery Fudan University Shanghai Cancer Center

Objective: Triple-negative breast cancer(TNBC) is a heterogeneous and aggressive cancer. Although our previous study classified primary TNBC into four subtypes, comprehensive longitudinal investigations are ***: We assembled a large-scale, real-world cohort comprised of 880 TNBC patients [465 early-stage TNBC(e TNBC) and 415 metastatic TNBC(m TNBC) patients] who were treated at Fudan University Shanghai Cancer Center. The longitudinal dynamics of TNBC subtypes during disease progression were elucidated in this patient cohort. Comprehensive analysis was performed to compare primary and metastatic lesions within specific TNBC ***: The recurrence and metastasis rates within 3 years after initial diagnosis in the e TNBC cohort were 10.1%(47/465). The median overall survival(OS) in the m TNBC cohort was 27.2 months [95% confidence interval(CI), 24.4±30.2 months], which indicated a poor prognosis. The prognostic significance of the original molecular subtypes in both e TNBC and m TNBC patients was confirmed. Consistent molecular subtypes were maintained in 77.5% of the patients throughout disease progression with the mesenchymal-like(MES) subtype demonstrating a tendency for subtype transition and brain metastasis. Additionally, a precision treatment strategy based on the metastatic MES subtype of target lesions resulted in improved progression-free survival in the FUTURE ***: Our longitudinal study comprehensively revealed the clinical characteristics and survival of patients with the original TNBC subtypes and validated the consistency of most molecular subtypes throughout disease progression. However, we emphasize the major importance of repeat pathologic confirmation of the MES subtype.

关键词： Triple-negative breast cancer metastasis molecular subtype overall survival primary tumor

Direct ink writing of multifunctional gratings with gel-like MXene/norepinephrine ink for dynamic electromagnetic interference shielding and patterned Joule heating

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Nano Research 2024年第3期17卷 1585-1594页

作者： Pei-Zhu Jiang zhiming Deng Peng Min Lvxuan Ye Cheng-Zhang Qi Hao-Yu Zhao Ji Liu Hao-Bin Zhang Zhong-Zhen Yu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China School of Chemistry CRANN and AMBERTrinity College DublinDublin D02PN40Ireland

Intelligent electromagnetic interference(EMI)shielding modulators with a wide tuning range and cyclic stability are urgently needed but their fabrication remains challenging.A gel-like MXene/norepinephrine ink is developed and multifunctional MXene gratings with wide EMI shielding effectiveness(SE)tuning range,superior reversibility,and high mechanical flexibility are constructed by direct ink writing approach for dynamic EMI shielding and patterned Joule heating *** modulable MXene/norepinephrine grating with a high conductivity of 3510 S·cm-1 can conveniently realize the seamless modulation of the EMI SE by adjusting the angle between the MXene grating filaments and the electric field of the incident electromagnetic waves,offering highly reversible switching between shielding“On”(28.0 dB)and“Off”(0.5 dB)***,due to the optimized integration of the MXene ink and the rationally designed pattern,a superior specific EMI SE of 95,688.2 dB·cm^(2)·g^(-1) is achieved in the“On”***,the MXene/norepinephrine ink can be used to fabricate many complex patterned gratings with superior stability,instant responsibility,and superb mechanical flexibility,exhibiting a unique patterned Joule heating *** writing of multifunctional gratings paves a means for developing intelligent EMI shielding materials,wearable electronic devices,and advanced thermal management materials.

关键词： MXene ink direct ink writing electromagnetic interference shielding multifunctional gratings Joule heating

Solvent-Free Manufacturing of Lithium-Ion Battery Electrodes via Cold Plasma

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Energy & Environmental Materials 2024年第1期7卷 28-33页

作者： zhiming Liang Tianyi Li Holden Chi Joseph Ziegelbauer Kai Sun Ming Wang Wei Zhang Tuo Liu Yang-Tse Cheng Zonghai Chen Xiaohong Gayden Chunmei Ban Paul M.Rady Department of Mechanical Engineering University of Colorado BoulderBoulder CO 80309USA Advanced Photon Source Argonne National LaboratoryLemont IL 60439USA Intecells Inc. Southfield MI 48084USA Department of Materials Science and Engineering Michigan Center for Materials CharacterizationUniversity of MichiganAnn Arbor MI 48109USA Department of Chemical and Materials Engineering University of KentuckyLexington KY 40506USA Department of Chemistry University of KentuckyLexington KY 40506USA Chemical Sciences and Engineering Division Argonne National LaboratoryLemont IL 60439USA

Slurry casting has been used to fabricate lithium-ion battery electrodes for decades,which involves toxic and expensive organic solvents followed by high-cost vacuum drying and electrode *** work presents a new manufacturing method using a nonthermal plasma to create inter-particle binding without using any polymeric binding materials,enabling solvent-free manufacturing electrodes with any electrochemistry of *** cold-plasma-coating technique enables fabricating electrodes with thickness(>200 pm),high mass loading(>30 mg cm^(-2)),high peel strength,and the ability to print lithium-ion batteries in an arbitrary *** crosscutting,chemistry agnostic,platform technology would increase energy density,eliminate the use of solvents,vacuum drying,and calendering processes during production,and reduce manufacturing cost for current and future cell ***,lithium iron phosphate and lithium cobalt oxide were used as examples to demonstrate the efficacy of the cold-plasma-coating *** is found that the mechanical peel strength of cold-plasma-coating-manufactured lithium iron phosphate is over an order of magnitude higher than that of slurry-casted lithium iron phosphate *** cells assembled with a graphite anode and the cold-plasma-coating-lithium iron phosphate cathode offer highly reversible cycling performance with a capacity retention of 81.6%over 500 *** the highly conductive cathode material lithium cobalt oxide,an areal capacity of 4.2 mAh cm^(-2)at 0.2 C is *** anticipate that this new,highly scalable manufacturing technique will redefine global lithium-ion battery manufacturing providing significantly reduced plant footprints and material costs.

关键词： cold plasma deposition lithium-ion battery solvent-free manufacturing

高效液相色谱-电喷雾质谱法分离和鉴别枯草芽孢杆菌产生的脂肽类化合物

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色谱 2008年第3期26卷 343-347页

作者：陈华王丽袁成凌郑之明余增亮中国科学院离子束生物工程学重点实验室安徽合肥230031

枯草芽孢杆菌JA因产生多种脂肽类化合物而具有广阔的开发前景。JA发酵液经过离心、酸沉淀、甲醇抽提等步骤得到脂肽类化合物的粗提物。将粗提物溶于流动相,采用反相高效液相色谱分离,对收集的洗脱峰组分进行电喷雾质谱(ESI-MS)分析。根... 详细信息

枯草芽孢杆菌JA因产生多种脂肽类化合物而具有广阔的开发前景。JA发酵液经过离心、酸沉淀、甲醇抽提等步骤得到脂肽类化合物的粗提物。将粗提物溶于流动相,采用反相高效液相色谱分离,对收集的洗脱峰组分进行电喷雾质谱(ESI-MS)分析。根据质荷比推断JA菌株产生的脂肽类化合物属于3个家族,分别为surfactin,iturin和fengycin,是枯草芽孢杆菌合成的重要生物表面活性素。对一级质谱中的主成分进行串联质谱分析,进一步确定了3种脂肽类化合物的分子结构。实验证明ESI-MS是一种鉴定脂肽类化合物及其同系物的可靠方法。

关键词：高效液相色谱-电喷雾质谱法枯草芽孢杆菌脂肽类化合物

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路基非饱和土抗剪强度的吸力效应

土木建筑与环境工程 2012年第4期34卷 1-5,18页

作者：刘东燕郑志明侯龙赵宝云伍川生重庆大学土木工程学院重庆400045 重庆市公路局重庆401147 美国科罗拉多矿业大学戈尔登80401

从宏观的吸力控制型直剪试验和微观的土体颗粒结构2方面入手,对路基非饱和土抗剪强度的吸力效应进行了研究。在不同吸力和不同法向应力条件下完成4组剪切试验,并选取2种不同含水量的同类型土样进行结构扫描。研究结果表明,与粘性土不同... 详细信息

从宏观的吸力控制型直剪试验和微观的土体颗粒结构2方面入手,对路基非饱和土抗剪强度的吸力效应进行了研究。在不同吸力和不同法向应力条件下完成4组剪切试验,并选取2种不同含水量的同类型土样进行结构扫描。研究结果表明,与粘性土不同的是,当粉质砂土含水量逐渐降低时,土体基质吸力对土体抗剪强度的贡献效果并不是一直增加的,而是存在一个峰值。这种现象主要是由于土体微观结构以及所含水分的存在形式所造成的。另外,土体所处的应力环境也会对土体强度的吸力贡献情况造成影响。

关键词：路基非饱和土宏微观方法吸力效应气-液交界面弯月形水膜