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Defence Technology（防务技术） 2024年第7期37卷 1-13页

作者： Guangbo Xu Bingting Zha Hailu Yuan zhen zheng He Zhang Ministerial Key Laboratory of ZNDY Nanjing University of Science and TechnologyNanjing 210094China Science and Technology on Electromechanical Dynamic Control Laboratory Beijing 100081China Shanghai Radio Equipment Research Institute Shanghai 201109China

The phenomenon of a target echo peak overlapping with the backscattered echo peak significantly undermines the detection range and precision of underwater laser *** overcome this issue,we propose a four-quadrant dual-beam circumferential scanning laser fuze to distinguish various interference signals and provide more real-time data for the backscatter filtering *** enhances the algorithm loading capability of the *** order to address the problem of insufficient filtering capacity in existing linear backscatter filtering algorithms,we develop a nonlinear backscattering adaptive filter based on the spline adaptive filter least mean square(SAF-LMS)*** also designed an algorithm pause module to retain the original trend of the target echo peak,improving the time discrimination accuracy and anti-interference capability of the ***,experiments are conducted with varying signal-to-noise ratios of the original underwater target echo *** experimental results show that the average signal-to-noise ratio before and after filtering can be improved by more than31 d B,with an increase of up to 76%in extreme detection distance.

关键词： Laser fuze Underwater laser detection Backscatter adaptive filter Spline least mean square algorithm Nonlinear filtering algorithm

Enhancing blocking temperature using inverse hydrogen bonds for non-radical bridged dimeric Dy(Ⅲ)single-molecule magnets

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Science China Chemistry 2024年第10期67卷 3328-3338页

作者： Peng-Bo Jin Qian-Cheng Luo Ye-Ye Liu Yan-zhen zheng Frontier Institute of Science and Technology State Key Laboratory of Electrical Insulation and Power EquipmentMOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed MatterXi’an Key Laboratory of Electronic Devices and Material Chemistry and School of ChemistryXi’an Jiaotong UniversityXi’an 710054China

Single-molecule magnets(SMMs)are a kind of nanosized magnetic materials that are capable of storing massive bytes of *** coupling the spin centers in a proper manner is a usual approach to promote the working temperature(or blocking temperature)for *** delocalized radicals have been widely employed to accomplish this ***,we show a new manner by using weak but multiple B–H^(δ-)···Dy^(3+)inverse hydrogen bonding(IHB)interactions to control the magnetic couplings in a series of dimeric dysprosiacaborane *** approach leads to a record high T_(B)^(100s)of 10 K among non-radical bridged dimeric SMMs,which is mainly ascribed to strong ferromagnetic coupling(4.38 cm^(-1))and the proper alignment of the magnetic principle axes of the adjacent dysprosium(Ⅲ)*** verifying by theoretical calculations,these results demonstrate that IHB interactions can be used to construct strong axial ferromagnetic coupling and enhancing magnetic blocking temperature for SMMs.

关键词： single-molecule magnets carborane dysprosium ferromagnetic coupling inverse hydrogen bond

Strong Antiferromagnetic Exchange-Coupling Observed in Hydride-Bridged Dimeric Dysprosium(Ⅲ)Single-Molecule Magnet

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Chinese Journal of Chemistry 2024年第4期42卷 391-396页

作者： Qian-Cheng Luo Ke-Xin Yu Peng-Bo Jin Ye-Ye Liu Yuan-Qi Zhai Yan-zhen zheng Frontier Institute of Science and Technology State Key Laboratory of Electrical Insulation and Power EquipmentXi'an Key Laboratory of Electronic Devices and Materials ChemistrySchool of Chemistry and School of PhysicsXi'an Jiaotong University99 Yanxiang RoadXi'anShaanxi710054 China

One dihydride-bridged dimeric Dy(Ⅲ)guanidinate complex,formulated as[{(Me_(3)Si)_(2)NC(NiPr)_(2)}_(2)Dy(μ-H)]_(2)(1Dy),was successfully isolated and the introduction of hydride bridges significantly reduces the intramolecular Dy(Ⅲ)…Dy(Ⅲ)distance to only 3.688(1)Å.To investigate the effect of such a short Dy(Ⅲ)…Dy(Ⅲ)distance on magnetism,we also prepared its dibromide-bridged analogue[{(Me_(3)Si)_(2)NC(NiPr)_(2)}_(2)Dy(μ-Br)]_(2)(2Dy),which has a much longer Dy(Ⅲ)…Dy(Ⅲ)distance of 4.605(4)Å.Surprisingly,2Dy demonstrates much larger effective energy barrier for magnetization reversal(U_(eff))and higher blocking temperature(T_(B)).The worse performance of 1Dy is attributed to the concerted effect of strong antiferromagnetic interactions between Dy(Ⅲ)ions(J_(total)=–2.683 cm^(–1))and the unparallel arrangement of magnetic principle axes of the Dy(Ⅲ)ions for 1Dy.

关键词： Single-molecule magnets Lanthanides Guanidinate ligand Hydride bridge Magnetic properties Ab initio calculations

Discovery of a potent and highly selective inhibitor of SIRT6 against pancreatic cancer metastasis in vivo

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1302-1316页

作者： Xinyuan Xu Qian Zhang Xufeng Wang Jing Jin Chengwei Wu Li Feng Xiuyan Yang Mingzhu Zhao Yingyi Chen Shaoyong Lu zhen zheng Xiaobing Lan Yi Wang Yan zheng Xuefeng Lu Qiufen Zhang Jian Zhang State Key Laboratory of Medical Genomics National Research Center for Translational Medicine at ShanghaiRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Medicinal Chemistry and BioinformaticsCenter Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of General Surgery Huashan HospitalCancer Metastasis InstituteFudan UniversityShanghai 200040China Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease School of Basic Medicine and Medical CenterUniversity of Science and Technology of ChinaHefei 230026China Department of Assisted Reproduction Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China College of Pharmacy Ningxia Medical UniversityYinchuan 750004China Department of Pancreatic Surgery Shanghai General HospitalShanghai Key Laboratory of Pancreatic DiseaseInstitute of Pancreatic DiseaseShanghai Jiao Tong University School of MedicineShanghai 200080China

Pancreatic cancer,one of the most aggressive malignancies,has no effective treatment due to the lack of targets and drugs related to tumour ***6 can promote the migration of pancreatic cancer and could be a potential target for antimetastasis of pancreatic ***,highly selective and potency SIRT6 inhibitor that can be used in vivo is yet to be ***,we developed a noveSIRT6 allosteric inhibitor,compound 11e,with maximal inhibitory potency and an IC_(50) value of 0.98±0.13μmol/***,compound 11e exhibited significant selectivity against other histone deacetylases(HADC1-11 and SIRT1-3)at concentrations up to 100μmol/*** allosteric site and the molecular mechanism of inhibition were extensively elucidated by cocrystal complex structure and dynamic structural ***,we confirmed the antimetastatic function of such inhibitors in four pancreatic cancer cell lines as well as in two mouse models of pancreatic cancer liver *** our knowledge,this is the first study to reveal the in vivo effects of SIRT6 inhibitors on liver metastatic pancreatic *** not only provides a promising lead compound for subsequent inhibitor developmentargeting SIRT6 but also provides a potential approach to address the challenge of metastasis in pancreatic cancer.

关键词： SIRT6 Inhibitor Allosteric Selectivity Cocrystal Pancreatic cancer metastasis

Molar ratio induced crystal transformation from coordination complex to coordination polymers

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Chinese Chemical Letters 2024年第4期35卷 539-543页

作者： Peng Meng Qian-Cheng Luo Aidan Brock Xiaodong Wang Mahboobeh Shahbazi Aaron Micallef John McMurtrie Dongchen Qi Yan-zhen zheng Jingsan Xu School of Chemistry and Physics&Centre for Materials Science Queensland University of TechnologyBrisbaneQLD 4000Australia Frontier Institute of Science and Technology Xi'an Jiaotong UniversityXi'an 710054China Central Analytical Research Facility Institute for Future EnvironmentsQueensland University of TechnologyBrisbaneQLD 4000Australia

Coordination complex of a copper cyanurate(Cu(Ⅱ)-CA) was transformed into coordination polymers upon the stimulus of extra Cu(Ⅱ) through “directed Ostwald ripening”. By increasing the molar ratio of Cu(Ⅱ) to CA, we obtained two coordination polymers with selective coordination sites: Cu(Ⅱ)-κ N(HCA)κ NCu(Ⅱ) and Cu(Ⅱ)-κ N(HCA)κ O-Cu(Ⅱ), which display disparate magnetic interactions.

关键词： Molar ratio dependent crystal transformation Copper cyanurate Ostwald ripening Molecular magnetism One-dimensional chain

不确定性与中国思想的开端:《周易》思想新释

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社会科学 2024年第5期 39-52页

作者：郑震南京大学社会学院

不确定性已成为困扰现代人的核心问题之一,而以理智主义为主导的现代西方主流话语面对这一问题的挑战却步履维艰。因此,从中国传统思想中寻找因应不确定性的不同思路不仅是一种与西方主流现代话语对话的方式,也是现代中国社会存在与发... 详细信息

不确定性已成为困扰现代人的核心问题之一,而以理智主义为主导的现代西方主流话语面对这一问题的挑战却步履维艰。因此,从中国传统思想中寻找因应不确定性的不同思路不仅是一种与西方主流现代话语对话的方式,也是现代中国社会存在与发展的内在需求。以时空性的事件为叙事主体,并采用一种方法论意义上关系主义和经验主义的《周易》,为我们回应不确定性问题提供了一个很好的机会。它以其流动于确定和不确定之间的灵活变通的思路,为我们揭示了一种在变化不定的宇宙中安身立命的生存之道,而这一思想对以儒家和道家为代表的中国传统思想文化产生了深远的影响。

关键词：不确定性时空性事件关系《周易》

调节型文化与调节型社会——对中国古代社会等级关系的一种思考

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广东社会科学 2024年第4期 214-224,287页

作者：郑震南京大学社会学院南京210046

儒家思想致力于在情感和秩序之间找到一个合理的结合点,以此来实现一种理想化的社会秩序。这一思想与一定程度兼顾不同社会等级群体的情感诉求的主导性的调节型文化有着内在关联,正是基于对这一文化类型的判断,我们将中国古代社会称为... 详细信息

儒家思想致力于在情感和秩序之间找到一个合理的结合点,以此来实现一种理想化的社会秩序。这一思想与一定程度兼顾不同社会等级群体的情感诉求的主导性的调节型文化有着内在关联,正是基于对这一文化类型的判断,我们将中国古代社会称为一种调节型的社会。然而这个通过调节型机制而一定程度缓和了内部张力的中央集权的国家,也正因此而陷入难以走出自身局限的困境之中,最终难逃一种政治的平庸。

关键词：调节型文化调节型社会儒家思想社会等级地位格局

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北朝后期碑刻文字存古现象研究

语言研究 2024年第2期44卷 87-93页

作者：刘征郑振峰河北经贸大学新闻与文化传播学院石家庄050061 河北师范大学文学院石家庄050024

北朝后期的文字具有存古的特点,文章首先探讨存古现象在北朝后期的起始与发展,国别及地域差异等基本概况;其次探讨在楷书通行的时代刻意杂糅篆隶笔法的书写面貌;再次探讨碑刻中所掺杂的古文字的形体与结构,详述形变原因、路径与结果,剖... 详细信息

北朝后期的文字具有存古的特点,文章首先探讨存古现象在北朝后期的起始与发展,国别及地域差异等基本概况;其次探讨在楷书通行的时代刻意杂糅篆隶笔法的书写面貌;再次探讨碑刻中所掺杂的古文字的形体与结构,详述形变原因、路径与结果,剖析其时代性,总结北朝后期古文字古俗并存的时代特点;最后探讨文字存古类碑刻所揭示的文化现象。

关键词：北朝碑刻隶书古文字

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藁本内酯对脂多糖诱导的急性肺损伤小鼠肺组织损伤的影响

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中国临床药理学杂志 2024年第11期40卷 1588-1592页

作者：郑振羽佘晖福州市第二医院呼吸与危重症医学科福建福州350007

目的研究藁本内酯调控干扰素基因刺激蛋白(STING)/TANK结合激酶1(TBK1)/核因子-κB(NF-κB)信号对脂多糖(LPS)诱导的急性肺损伤小鼠模型肺组织损伤的影响。方法将小鼠分成对照组、模型组(LPS肺损伤小鼠模型)、实验低剂量组(LPS肺损伤小... 详细信息

目的研究藁本内酯调控干扰素基因刺激蛋白(STING)/TANK结合激酶1(TBK1)/核因子-κB(NF-κB)信号对脂多糖(LPS)诱导的急性肺损伤小鼠模型肺组织损伤的影响。方法将小鼠分成对照组、模型组(LPS肺损伤小鼠模型)、实验低剂量组(LPS肺损伤小鼠模型,20 mg·kg^(-1)藁本内酯)、实验中剂量组(LPS肺损伤小鼠模型,60 mg·kg^(-1)藁本内酯)、实验高剂量组(LPS肺损伤小鼠模型,100 mg·kg^(-1)的藁本内酯)、DMXAA组(LPS肺损伤小鼠模型,100 mg·kg^(-1)的藁本内酯、STING信号激动药DMXAA)。用蛋白质印迹法检测STING、p-TBK1、TBK1、p-p65、p65蛋白的表达水平,用二喹啉甲酸(BCA)法检测肺泡灌洗液总蛋白,用瑞士吉姆萨染色计数肺泡灌洗液中炎性细胞数目,用酶联免疫吸附测定法检测肿瘤坏死因子-α(TNF-α)含量,用硫代巴比妥酸法检测肺组织中丙二醛(MDA)含量。结果对照组、模型组和实验低、中、高剂量组及DMXAA组的STING蛋白相对表达水平分别为0.13±0.03、0.46±0.02、0.36±0.04、0.27±0.02、0.20±0.03和0.38±0.04,p-TBK1/TBK1蛋白比值分别为0.15±0.02、0.56±0.02、0.43±0.01、0.31±0.01、0.20±0.02和0.30±0.02,p-p65/p65蛋白比值分别为0.24±0.01、0.66±0.03、0.41±0.02、0.32±0.04、0.22±0.02和0.42±0.03,肺泡灌洗液中总蛋白含量分别为(173.79±15.44)、(304.21±19.29)、(243.59±17.60)、(212.51±18.24)、(187.11±11.59)和(241.69±30.12)μg·mL^(-1),巨噬细胞数目分别为(0.11±0.02)×10^(8)、(0.94±0.09)×10^(8)、(0.72±0.08)×10^(8)、(0.57±0.04)×10^(8)、(0.41±0.04)×10^(8)和(0.71±0.08)×10^(8)cell·mL^(-1),模型组的上述指标与对照组相比,实验低、中、高剂量组的上述指标与模型组相比,DMXAA组的上述指标与实验高剂量组相比,在统计学上差异均有统计学意义(均P<0.05)。结论藁本内酯抑制STING/TBK1/NF-κB信号减轻LPS诱导的急性肺损伤小鼠模型肺组织损伤。

关键词：藁本内酯急性肺损伤干扰素基因刺激蛋白/TANK结合激酶1/核因子-κB信号炎症氧化损伤

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性别视角下的人口与发展

山东女子学院学报 2024年第3期 1-9页

作者：郑真真中国社会科学院人口与劳动经济研究所北京100710

具有里程碑意义的《国际人口与发展会议行动纲领》,强调生殖健康及权利、妇女赋权和性别平等是人口与发展的基础,推动性别平等成为人口与发展议题的重要组成部分。回顾中国人口研究领域的女性/性别与发展研究,多年来积累了丰富的成果,... 详细信息

具有里程碑意义的《国际人口与发展会议行动纲领》,强调生殖健康及权利、妇女赋权和性别平等是人口与发展的基础,推动性别平等成为人口与发展议题的重要组成部分。回顾中国人口研究领域的女性/性别与发展研究,多年来积累了丰富的成果,但也存在问题和局限。30年来全球人口形势发生了重要变化,在21世纪面临新的挑战。推动人口与发展议题中的性别主流化,尤其注重家庭和生育、生殖健康、城镇化与人口流动方面具有性别视角的研究,将有助于在应对新挑战的同时,促进性别平等和发展。

关键词：人口与发展性别平等女性人口