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Non-negligible factors in low-pressure sprinkler irrigation:droplet impact angle and shear stress

Journal of Arid Land 2022年第11期14卷 1293-1316页

作者： HUI Xin zheng yudong MUHAMMAD Rizwan Shoukat TAN Haibin YAN Haijun College of Water Resources and Civil Engineering China Agricultural UniversityBeijing 100083China Engineering Research Center of Agricultural Water-Saving and Water Resources Ministry of EducationBeijing 100083China Semi-arid Agriculture Engineering&Technology Research Center of China Shijiazhuang 050051China

Droplet shear stress is considered as an important indicator that reflects soil erosion in sprinkler irrigation more accurately than kinetic energy,and the effect of droplet impact angle on the shear stress cannot be ignored.In this study,radial distribution of droplet impact angles,velocities,and shear stresses were investigated using a two-dimensional video disdrometer with three types of low-pressure sprinkler(Nelson D3000,R3000,and Komet KPT)under two operating pressures(103 and 138 kPa)and three nozzle diameters(3.97,5.95,and 7.94 mm).Furthermore,the relationships among these characteristical parameters of droplet were analyzed,and their influencing factors were comprehensively evaluated.For various types of sprinkler,operating pressures,and nozzle diameters,the smaller impact angles and larger velocities of droplets were found to occur closer to the sprinkler,resulting in relatively low droplet shear stresses.The increase in distance from the sprinkler caused the droplet impact angle to decrease and velocity to increase,which contributed to a significant increase in the shear stress that reached the peak value at the end of the jet.Therefore,the end of the jet was the most prone to soil erosion in the radial direction,and the soil erosion in sprinkler irrigation could not only be attributed to the droplet kinetic energy,but also needed to be combined with the analysis of its shear stress.Through comparing the radial distributions of average droplet shear stresses among the three types of sprinklers,D3000 exhibited the largest value(26.94-3313.51 N/m^(2)),followed by R3000(33.34-2650.80 N/m^(2)),and KPT(16.15-2485.69 N/m^(2)).From the perspective of minimizing the risk of soil erosion,KPT sprinkler was more suitable for low-pressure sprinkler irrigation than D3000 and R3000 sprinklers.In addition to selecting the appropriate sprinkler type to reduce the droplet shear stress,a suitable sprinkler spacing could also provide acceptable results,because the distance from the sprinkler exhibited a highly significan

关键词： center pivot irrigation system water droplet universal model soil erosion water-saving irrigation

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Cupric ion release and cytotoxicity for Yuangong Cu-IUDs and the release behavior of indomethacin for medicated 220 Cu-IUD

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Chinese Science Bulletin 2009年第18期54卷 3160-3166页

作者： CAO BianMei XI TingFei zheng yudong YANG LiFeng zheng Qi School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China National Institute for the Control of Pharmaceutical & Biological Products Beijing 100050 China Shenzhen Institute of Peking University Shenzhen 518057 China Wenzhou Medical College Wenzhou 325035 China

These years Yuangong copper-bearing intrauterine devices (Cu-IUDs) have been used because of less side effects in use. The corrosion of copper is essential to the success of contraception, and the release behavior of indomethacin from medicated Cu-IUD is related to its therapeutic effect. In this study, analytical methods were established to investigate the release behavior of cupric ion of three kinds of Yuangong Cu-IUDs and indomethacin of medicated Yuangong 220 Cu-IUD. Cu-IUDs were incubated in simulated uterine solution (SUS). The concentrations of cupric ion and indomethacin were analyzed by flame atomic absorption spectrometer (FAAS) for 60 days and UV/vis ?3310 spectrophotometer for 60 days, respectively. The morphology of copper after corrosion was characterized by SEM. In addition, we detected cytotoxicity by MTT of L929 mouse fibroblasts cells caused by extracts of the three Yuangong Cu-IUDs. The release behavior of cupric ion for three kinds of Yuangong Cu-IUDs was biphasic, which consisted of the initial burst release and then slow and constant release. In vitro release experiment confirmed a biphasic release of indomethacin from Yuangong 220. The copper wire of Yuangong Cu-IUDs showed uneven corrosion. The RGR value of Yuangong 365 Cu-IUD was smaller than that of medicated Yuangong 220 Cu-IUD and RGR value of medicated Yuangong 220 Cu-IUD was smaller than that of Yuangong 300 Cu-IUD. The cupric ion release and indomethacin release showed biphasic. Indomethacin increased the cupric ion release rate and might diminish the adverse effects caused by burst release of cupric ion. The toxicity grade of these three Yuangong Cu-IUDs was 4. We should canvass the adverse events of Cu-IUDs based on practical experiments, and try our best to reduce the toxicity of Cu-IUDs.

关键词：宫内节育器铜离子释放行为吲哚美辛细胞毒性避孕

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A self-crosslinking,double-functional group modified bacterial cellulose gel used for antibacterial and healing of infected wound

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Bioactive Materials 2022年第11期7卷 248-260页

作者： Yajie Xie Kun Qiao Lina Yue Tao Tang yudong zheng Shihui Zhu Huiyi Yang Ziyuan Fang School of Material Science and Engineering University of Science and Technology BeijingBeijingChina Hebei Key Laboratory of Hazardous Chemicals Safety and Control Technology School of Chemical and Environmental EngineeringNorth China Institute of Science and TechnologyLangfang065201HebeiChina Department of Burn Surgery The First Affiliated Hospital of Naval Medical UniversityShanghai200433China

Cellulose/chitosan composite,as a mature commercial antibacterial dressing,is an important type of wound repair material.However,how to achieve the perfect compound of two components and improve antibacterial activity is a major,lingering issue.In this study,a bifunctional group modified bacterial cellulose(DCBC)was prepared by carboxymethylation and selective oxidation.Further,the chitosan(CS)was compounded in the network of DCBC by self-crosslinking to form dialdehyde carboxymethyl bacterial cellulose/chitosan composites(S-DCBC/CS).The aldehyde group can react with amino of CS by Schiff base reaction.The carboxyl group of DCBC and the amorphous distribution of CS molecular chains increase the antimicrobial properties of com-posites.The bacteriostatic rate of composites could be higher than 95%.Bacteria can be attracted onto the surface of composites,what we call it“directional adhesion antibacterial effects”.In particular,a kind of large animal wound model,deep II degree infected scald of Bama miniature pig,was used to research the antimicrobial and healing properties of materials.The S-DCBC/CS can effectively inhibit bacterial proliferation of wound and kill the bacteria.The wound healing rate of S-DCBC/CS was up to 80%after three weeks.The composites show better antibacterial and promoting concrescence effects than traditional chitosan dressings.

关键词： Self-crosslinking Bacterial cellulose Cell migration Wound healing Antimicrobial properties

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养殖环境及贝源溶藻弧菌MLST分型及其毒力基因、耐药性分析

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渔业科学进展 2024年第1期45卷 211-223页

作者：郑玉东张翔姚梦丽谷莉黄博闻辛鲁生白昌明王崇明唐小千中国海洋大学水产动物病害与免疫学实验室山东青岛266003 中国水产科学研究院黄海水产研究所海洋渔业科学与食物产出过程功能实验室农业农村部海水养殖病害防治重点实验室青岛市海水养殖流行病学与生物安保重点实验室山东青岛266071

溶藻弧菌(Vibrio alginolyticus)是近年来贝类病害中最常见的细菌性病原之一,对贝类养殖产业的健康发展构成严重威胁。本研究旨在分析不同养殖环境水体和贝类组织中,溶藻弧菌的基因变异、毒力基因、耐药性及其分布规律。对12株溶藻弧菌... 详细信息

溶藻弧菌(Vibrio alginolyticus)是近年来贝类病害中最常见的细菌性病原之一,对贝类养殖产业的健康发展构成严重威胁。本研究旨在分析不同养殖环境水体和贝类组织中,溶藻弧菌的基因变异、毒力基因、耐药性及其分布规律。对12株溶藻弧菌分离株开展多位点序列分型(multilocus sequence typing,MLST)、毒力因子以及菌株耐药性分析,结果显示,12株溶藻弧菌的序列型(sequence typing,ST)分型互不相同,7株为Pub MLST数据库已经收录的ST型,5株因管家基因的等位基因位点变化而形成新的ST型,贝类养殖环境中的溶藻弧菌具有较高的遗传多样性。12株溶藻弧菌都携带tlh、fur和collagenase三种毒力基因,但均未检测到tdh、trh、toxR和tcpA毒力基因。溶藻弧菌携带毒力因子的种类和数量受地区分布等因素的影响。不同来源的溶藻弧菌均具有多重耐药特征,对青霉素和氨苄西林产生抗性。本研究表明,贝类养殖环境中的溶藻弧菌具有种群复杂、遗传多样性高的特点;不同来源菌株在毒力基因携带和耐药性方面存在较大差异。本研究通过探究不同区域内不同来源的溶藻弧菌遗传变异及耐药性差异,对贝源溶藻弧菌的有效防控提供一定理论参考。

关键词：溶藻弧菌 MLST 毒力基因耐药性分析

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A novel bioactive polyurethane with controlled degradation and L-Arg release used as strong adhesive tissue patch for hemostasis and promoting wound healing

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Bioactive Materials 2022年第11期7卷 471-487页

作者： Faxing Zou Yansen Wang yudong zheng Yajie Xie Hua Zhang Jishan Chen M.Irfan Hussain Haoye Meng Jiang Peng School of Material Science&Engineering University of Science and Technology BeijingBeijing10083China The First Affiliated Hospital of Chongqing Medical University China Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma&War InjuriesPLA Institute of OrthopedicsChinese PLA General HospitalBeijingChina

Effective strategy of hemostasis and promoting angiogenesis are becoming increasingly urgent in modern medicine due to millions of deaths caused by tissue damage and inflammation. The tissue adhesive has been favored as an optimistic and efficient path to stop bleeding, while, current adhesive presents limitations on wound care or potential degradation safety in clinical practice. Therefore, it is of great clinical significance to construct multifunctional wound adhesive to address the issues. Based on pro-angiogenic property of L-Arginine (L-Arg), in this study, the novel tissue adhesive (G-DLPUs) constructed by L-Arg-based degradable polyurethane (DLPU) and GelMA were prepared for wound care. After systematic characterization, we found that the G-DLPUs were endowed with excellent capability in shape-adaptive adhesion. Moreover, the L-Arg released and the generation of NO during degradation were verified which would enhance wound healing. Following the in vivo biocompatibility was verified, the hemostatic effect of the damaged organ was tested using a rat liver hemor-rhage model, from which reveals that the G-DLPUs can reduce liver bleeding by nearly 75% and no obvious inflammatory cells observed around the tissue. Moreover, the wound care effect was confirmed in a mouse full-thickness skin defect model, showing that the hydrogel adhesive significantly improves the thickness of newly formed dermis and enhance vascularization (CD31 staining). In summary, the G-DLPUs are promising candidate to act as multifunctional wound care adhesive for both damaged organ and trauma.

关键词： Tissue adhesive Pro-angiogenic Biodegradable safety Arginine-based polyurethane Hemostasis

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Influence of the extraction parameters on the cytotoxicity test results of Mg materials

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Progress in Natural Science:Materials International 2014年第5期24卷 507-515页

作者： Xiaoli Liu Tingfei Xi yudong zheng School of Materials Science and Technology University of Science and Technology Beijing Center for Biomedical Materials and Tissue Engineering Academy for Advanced Interdisciplinary Studies Peking University Shenzhen Key Laboratory of Human Tissue Regeneration and Repair Shenzhen Institute Peking University

Recently more and more researchers query the predictability of cytotoxicity results of biomedical Mg alloys obtained according to ISO 10993 due to significant difference between in vitro and in vivo corrosion. This study aimed to observe the influence of different extraction parameters(time, volume/surface ratio and medium composition) on cytotoxicity results and illustrate whether more predictable results could be obtained by adjusting the extraction parameters. The results showed that longer extraction time and smaller extraction volume/surface ratio improve the sensitivity of screening Mg materials by making inferior Mg materials release relatively more ions to the extract; and more predictable results could not be obtained by the way of simply adding bovine serum albumin(BSA) into the extraction medium to the same level in vivo or simply using fetal bovine serum(FBS) directly as extraction medium, since BSA and FBS accelerated the corrosion of Mg materials during extraction and they affected the cells’ health states during the test. In order to get more predictable results, in our opinions, it is necessary to establish a database of primary cells’ hazards(metal ions, p H and H2gas) tolerance and a set of in vitro corrosion test with high similarity in vivo, which is very difficult to realize now however.

关键词： Mg alloys Cytotoxicity test Extraction parameters Corrosion Predictability

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功能化细菌纤维素纳米晶复合聚氨酯医用抗菌涂层的制备及性能研究

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纤维素科学与技术 2024年第1期32卷 28-38,I0001页

作者：杨惠仪张栗杨丁蒙贺玮谢亚杰乔堃郑裕东北京科技大学材料科学与工程学院北京100083 北京中杰瑞康科技有限公司北京100094

植入医疗器械的感染是临床治疗的难题之一,因此研究具有长效稳定抗菌效果的医用涂层对于医疗植入器械领域十分重要。本研究使用细菌纤维素膜片,通过粉碎―氧化法制备氧化改性细菌纤维素纳米晶体,并化学接枝阳离子化合物双胍制备获得新... 详细信息

植入医疗器械的感染是临床治疗的难题之一,因此研究具有长效稳定抗菌效果的医用涂层对于医疗植入器械领域十分重要。本研究使用细菌纤维素膜片,通过粉碎―氧化法制备氧化改性细菌纤维素纳米晶体,并化学接枝阳离子化合物双胍制备获得新型纳米抗菌材料NBC-BG,最后与聚氨酯(PU)进行复合制备了PU-NBC-BG医用抗菌涂层。通过多种材料表征手段,研究了不同比例添加下涂层的结构性能变化,同时通过抗菌实验证明了PU-NBC-BG涂层具有优良且稳定的抗菌性能以及抗生物膜效果,在医疗器械领域具有很好的前景。

关键词：细菌纤维素纳米晶双胍长效抗菌医用涂层

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Identification of Motor Nuclei in the Medulla Oblongata of Carp for Biological Control

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Journal of Bionic Engineering 2024年第2期21卷 842-851页

作者： Yang Zhao Yong Peng yudong Wen Lingjun Han Yanhong Yan Xueying Dong Hui Zhang zheng Zhao Xiaoyue Liu School of Electrical Engineering Yanshan UniversityQinhuangdao066004China School of Mechanical Engineering Yanshan UniversityQinhuangdao066004China Key Laboratory of National Defense of Mechanical Structure and Material Science Under Extreme Conditions Yanshan UniversityQinhuangdao066004China Institute of Marine Science and Engineering Yanshan UniversityQinhuangdao066004China Shijiazhuang University Shijiazhuang050035China

Brain-controlled technology is the key technology in biological control,and the corresponding relationship between animal brain nuclei and motor behavior is the core.The purpose of this study was to explore the motor nuclei of the medulla oblongata in carp.The carps were subjected to electrical stimulation and chemical stimulation experiments,respectively,in the water-free state,and the effective chemical stimulation sites were injected with the pontamine sky blue solution.The brain tissue sections were obtained by paraffin tissue section technology and the neutral red staining method.By comparing the positions of the brain nuclei shown in earlier studies,the motor nerve nuclei in the medulla oblongata were identified.The brain electrode was implanted into the motor nucleus of the medulla oblongata,and the underwater control experiment and behavioral tests were carried out with different electrical stimulation parameters.The results showed that the abducens nucleus(NVI)was the motor nucleus that controls the ipsilateral steering,and the facial nucleus(NVII)was the motor nucleus that controls the forward movement.By adjusting the stimulation voltage and the stimulation pulse number,the carp can be stably controlled to achieve a left–right steering motion of 30°–180°and a forward motion of more than 80 cm/s.This study indicated that the quantitative control of the steering and forward behavior of the carp can be achieved by electrical stimulation of the NVI and NVII,which provided a certain experimental basis for the accurate control of the carp robot.

关键词： Biological control Carp Medulla oblongata motor nucleus Electrical stimulation technique Chemical stimulation technique

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Trajectory tracking guidance of interceptor via prescribed performance integral sliding mode with neural network disturbance observer

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Defence Technology（防务技术） 2024年第2期32卷 412-429页

作者： Wenxue Chen yudong Hu Changsheng Gao Ruoming An School of Astronautics Harbin Institute of TechnologyHarbin 150001China

This paper investigates interception missiles’trajectory tracking guidance problem under wind field and external disturbances in the boost phase.Indeed,the velocity control in such trajectory tracking guidance systems of missiles is challenging.As our contribution,the velocity control channel is designed to deal with the intractable velocity problem and improve tracking accuracy.The global prescribed performance function,which guarantees the tracking error within the set range and the global convergence of the tracking guidance system,is first proposed based on the traditional PPF.Then,a tracking guidance strategy is derived using the integral sliding mode control techniques to make the sliding manifold and tracking errors converge to zero and avoid singularities.Meanwhile,an improved switching control law is introduced into the designed tracking guidance algorithm to deal with the chattering problem.A back propagation neural network(BPNN)extended state observer(BPNNESO)is employed in the inner loop to identify disturbances.The obtained results indicate that the proposed tracking guidance approach achieves the trajectory tracking guidance objective without and with disturbances and outperforms the existing tracking guidance schemes with the lowest tracking errors,convergence times,and overshoots.

关键词： BP network neural Integral sliding mode control(ISMC) Missile defense Prescribed performance function(PPF) State observer Tracking guidance system

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Regulatory science for hernia mesh: Current status and future perspectives

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Bioactive Materials 2021年第2期6卷 420-432页

作者： Wenbo Liu Yajie Xie yudong zheng Wei He Kun Qiao Haoye Meng School of Material Science and Engineering University of Science and Technology Beijing30 Xueyuan RoadHaidian DistrictBeijingChina Center for Medical Device Evaluation National Medical Products AdministrationIntellectual Property Publishing House MansionQixiang RoadHaidian DistrictBeijingChina

Regulatory science for medical devices aims to develop new tools,standards and approaches to assess the safety,effectiveness,quality and performance of medical devices.In the field of biomaterials,hernia mesh is a class of implants that have been successfully translated to clinical applications.With a focus on hernia mesh and its regulatory science system,this paper collected and reviewed information on hernia mesh products and biomaterials in both Chinese and American markets.The current development of regulatory science for hernia mesh,including its regulations,standards,guidance documents and classification,and the scientific evaluation of its safety and effectiveness was first reported.Then the research prospect of regulatory science for hernia mesh was discussed.New methods for the preclinical animal study and new tools for the evaluation of the safety and effectiveness of hernia mesh,such as computational modeling,big data platform and evidence-based research,were assessed.By taking the regulatory science of hernia mesh as a case study,this review provided a research basis for developing a regulatory science system of implantable medical devices,furthering the systematic evaluation of the safety and effectiveness of medical devices for better regulatory decision-making.This was the first article reviewing the regulatory science of hernia mesh and biomaterial-based implants.It also proposed and explained the concepts of evidence-based regulatory science and technical review for the first time.

关键词： Regulatory science Safety and effectiveness Hernia mesh Regeneration Remolding

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