检索结果-南通市图书馆

Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn–AhR–AQP4 signaling pathway

Signal Transduction and Targeted Therapy 2020年第1期5卷 2348-2360页

作者： Lisha Du Zikang Xing Bangbao Tao Tianqi Li Dan Yang Weirui Li yuanting zheng Chunxiang Kuang Qing Yang State Key Laboratory of Genetic Engineering School of Life SciencesFudan UniversitySonghu Road 2005Shanghai 200438China Department of Neurosurgery Xinhua HospitalShanghai Jiaotong UniversitySchool of MedicineKongjiang Road 1665Shanghai 200092China Department of Chemistry Tongji UniversitySiping Road 1239Shanghai 200092China Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityHandan Road 220Shanghai 200433China

Indoleamine 2,3-dioxygenase 1(IDO1),indoleamine 2,3-dioxygenase 2(IDO2),and tryptophan 2,3-dioxygenase(TDO)initiate the first step of the kynurenine pathway(KP),leading to the transformation of L-tryptophan(Trp)into L-kynurenine(Kyn)and other downstream *** is known as an endogenous ligand of the aryl hydrocarbon receptor(AhR).Activation of AhR through TDO-derived Kyn is a novel mechanism to support tumor growth in ***,the role of IDO1 and IDO2 in this mechanism is still ***,by using clinical samples,we found that the expression and activity of IDO1 and/or TDO(IDO1/TDO)rather than IDO2 were positively correlated with the pathologic grades of *** expression of IDO1/TDO rather than IDO2 was positively correlated with the Ki67 index and overall *** expression of IDO1/TDO was positively correlated with the expression of aquaporin 4(AQP4),implying the potential involvement of IDO1/TDO in glioma cell ***,we found that IDO1/TDO accounted for the release of Kyn,which activated AhR to promote cell motility via the Kyn–AhR–AQP4 signaling pathway in U87MG glioma ***103,an IDO1/TDO dual inhibitor,could block the IDO1/TDO–Kyn–AhR–AQP4 signaling pathway and exert anti-glioma effects in GL261 orthotopic glioma ***,our results showed that the IDO1/TDO–Kyn–AhR–AQP4 signaling pathway is a new mechanism underlying the malignancy of gliomas,and suggest that both IDO1 and TDO might be valuable therapeutic targets for gliomas.

关键词： IDO1 AQP4 glioma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recombinant expression of different mutant K-ras gene in pancreatic cancer Bxpc-3 cells and its effects on chemotherapy sensitivity

引用

Science China(Life Sciences) 2014年第11期57卷 1011-1017页

作者： SHAO TengFei zheng yuanting ZHAO Bei LI Tao CHENG KeGuang CAI WeiMin Department of Clinical Pharmacy School of Pharmacy Fudan University Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources Ministry of Education of China School of Chemistry& Chemical Engineering Guangxi Normal University

K-ras is a member of ras gene family which is involved in cell survival,proliferation and *** a mutation occurs in ras gene,the activation of Ras proteins may be prolonged to induce ***,the relationship between K-ras mutation and clinical outcomes in pancreatic cancer patients treated with chemotherapy agents is still under *** this study,we constructed five pAcGFP1-C3 plasmids for different types of K-ras gene(WT,G12V,G12R,G12D,and G13D)and stably transfected human pancreatic cancer Bxpc-3 cells with these *** wild type and mutant clones showed a comparable growth and expression of K-Ras-GFP fusion *** expression of some K-ras mutations resulted in a reduced sensitivity to gefitinib,5-FU,docetaxel and gemcitabine,while showed no effects on erlotinib or ***,compared with the wild type clone,K-Ras downstream signals(phospho-Akt and/or phospho-Erk)were increased in K-ras mutant ***,different types of K-ras mutation had non-identical K-Ras downstream signal activities and drug *** results are the first to reveal the relationship between different K-ras mutation and drug sensitivities of these anti-cancer drugs in pancreatic cancer cells in vitro.

关键词： cancer chemotherapeutic anti-cancer drug K-ras mutation plasmids pancreas

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Correction:Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn-AhR-AQP4 signaling pathway

引用

Signal Transduction and Targeted Therapy 2021年第12期6卷 3796-3797页

作者： Lisha Du Zikang Xing Bangbao Tao Tianqi Li Dan Yang Weirui Li yuanting zheng Chunxiang Kuang Qing Yang State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Songhu Road 2005 Shanghai 200438 China Institute of Science and Technology for Brain-Inspired Intelligence Fudan University Handan Road 220 Shanghai 200433 China Department of Neurosurgery Xinhua Hospital Shanghai Jiaotong University School of Medicine Kongjiang Road 1665 Shanghai 200092 China Department of Chemistry Tongji University Siping Road 1239 Shanghai 200092 China

In the process of collating the raw data,the authors noticed the inadvertent mistakes in Fig.4h&6g that need to be *** correct data are provided as *** key findings of the article are not affected by the *** apologize for the inadvertent *** authors mistakenly placed the wrong representative image showing the invasion ability of U87MG cells in the IFN-γ+1-MT *** correct version of Fig.4h is shown above.

关键词： mistake correction invasion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Poor prognosis of stage I lung adenocarcinoma patients determined by elevated expression over pre/minimally invasive status of COL11A1 and THBS2 in the focal adhesion pathway

Poor prognosis of stage I lung adenocarcinoma patients deter...

引用

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： Jun Shang He Jiang Leming Shi yuanting zheng Fudan University

Patients with adenocarcinomas in situ(AIS) and minimally invasive(MIA) lung adenocarcinoma(LUAD) are curable by surgery,whereas 20% stage I patients die within five years *** hypothesize that poor-prognosis stage I patients may exhibit key molecular characteristics deviating from AIS/*** adhesion(FA) was identified as the only pathway significantly perturbed at both genomic and transcriptomic levels by comparing98 AIS/MIA and 99 ***,two FA genes(COL11A1 and THBS2) were found strongly upregulated from AIS/MIA to stage I while steadily expressed from normal to AIS/***,unsupervised clustering separated stage I patients into two molecularly and prognostically distinct subtypes(S1 and S2) based on COL11A1 and THBS2expressions(FA2).Subtype S1 resembled AIS/MIA,whereas S2 exhibited more somatic alterations and activated cancer-associated *** simple knowledge-driven model was validated with 12 external datasets,showing potential in identifying high-risk stage I patients for more intensive post-surgery treatment.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Differences of molecular events driving pathological and radiological progression of lung adenocarcinoma

Differences of molecular events driving pathological and rad...

引用

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： He Jiang Jun Shang Leming Shi yuanting zheng Fudan University

Introduction:Ground-glass opacity(GGO)-related lung adenocarcinoma(LUAD) has been detected increasingly in the clinic and its inert property and superior survival indicate unique biological ***,we do not know much about them in adenocarcinoma in situ(AIS),minimally invasive adenocarcinoma(MIA) and invasive lung adenocarcinoma(IAC),which hampers identification of key reasons of the inert property of GGO-related ***:Using whole-exome sequencing and RNA sequencing,taking into account both radiological and pathological classifications of the same 197 patients concomitantly,we systematically interrogate the genes driving the progression from GGO to solid nodule and potential reasons for the inertia of ***:Identifying the differences between GGO and solid nodule,we found that molecular commonalities of GGO-related IAC and AIS/MIA included lower TP53 mutation frequency and less active cell proliferation-related *** the differences in mGGO between AIS/MIA and IAC,we noticed that EGFR mutation frequency and CNV load were significantly higher in IAC than in AIS/*** T cell was also higher in IAC,while CD8+ T cell steadily decreased from AIS/MIA to ***,we also discovered molecular events that may drive the progression from GGO to solid nodule and AIS/MIA to IAC concomitantly,including TMB,APOBEC-related mutation,cell proliferation and matrix remodeling associated ***,we constructed a transcriptomic signature to quantify the development from GGO to solid nodule(G2S),which was an independent predictor of patients’ prognosis in 11 external LUAD ***:Our results provide deeper insights for the indolent nature of GGO.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Comparison of Plasma and Serum miRNA Profiles by Small RNA Sequencing

Comparison of Plasma and Serum miRNA Profiles by Small RNA S...

引用

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： Haiyan Wang Qingwang Chen Naixin Zhang Yaqing Liu Wanwan Hou Leming Shi yuanting zheng Fudan University

Background:Accumulated evidence has revealed that extracellular microRNAs(miRNAs) could be potential biomarkers for the diagnosis and therapy of various human ***-derived plasma and serum are the most commonly used samples for miRNA analysis of liquid ***,the question about plasma or serum which is preferable remains unclear and needs to be ***:We performed small RNA sequencing for paired plasma and serum samples which passed the quality control from 7 healthy individuals,3 replicates per *** we analyzed the number of detected miRNAs among all individuals and in each *** clustering analysis and Pearson correlation analysis were applied to assess the heterogeneity and similarity in miRNA expression profiles of plasma and ***,the coefficient of variation was calculated to evaluate the technical variability of miRNA ***,differentially expressed analysis was conducted to compare the difference in miRNA quantitation of plasma and serum,and KEGG and GO pathway enrichment analysis was carried out to reveal the significant pathway for differential miRNA ***:All 42 samples passed the quality control of small RNA sequencing and entered the subsequent *** the major extracellular RNA biotypes,miRNA accounted for the highest proportion in both plasma and serum,where the proportion of miRNA in plasma was slightly higher compared with serum(47.3% vs.42.9%).In plasma and serum,573 miRNAs and 522 miRNAs were detected,***,we found that miRNA expression between plasma and serum was highly correlated,with a correlation coefficient of 0.99(p<0.05).Lower biological and technical variability of miRNA expression was displayed in plasma than in ***,we identified three differentially expressed miRNAs (hsa-miR-1246,hsa-let-7i-3p,and hsa-miR-939-5p) with higher levels in serum than in plasma,which is mainly involved in organelle,ion binding,ce

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Prognostic Predictor and Immune Microenvironment Signatures of Aberrant Exon Skipping Events in Triple-Negative Breast Cancer

Prognostic Predictor and Immune Microenvironment Signatures ...

引用

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： Qingwang Chen Zehui Cao Ruolan Zhang Erfei Shang Qiaochu Chen Leming Shi yuanting zheng Fudan University

Background:Exon skipping(ES) is defined as the procedure of mature RNA processing where a selected exon is excluded from the *** one essential type of alternative splicing(AS) event,aberrant ES plays an important role in the pathogenesis of cancer and the formation of the tumor ***,characterization of aberrant ES profiles in the malignancy and prognosis of triple-negative breast cancer(TNBC) is little known and urgently ***:We quantified the percent spliced in(PSI) values for ES events in 360 tumor tissues and88 adjacent-normal tissues from the Fudan University Shanghai Cancer Center(FUSCC)TNBC ***,we performed differential comparative analysis to obtain cancer-associated ES events(CAES).Unsupervised cluster analysis was performed to analyze the characteristics of immune infiltration in the ***,univariate Cox and stepwise multivariate Cox regression analyses were conducted to find the prognosis associated with CAES and the best prognostic CAES ***,pathway enrichment and gene set enrichment analysis(GSEA) was further employed to reveal the significant pathways for prognosis-related CAES ***:A total of 277 CAES were identified(|delta PSI tumor-normal| > 0.10,FDR<0.05),including 101 up-regulated and 176 down-regulated in tumor *** of 241parent genes revealed 84 GO pathways with statistical significance(FDR<0.05),with the top pathways related to cell adhesion molecule binding,cell leading edge,*** clustering analysis with CAES identified three clusters with different immune microenvironment components,immune score,and stromal score in TNBC(P<0.05).Univariate and multivariate Cox regression analyses identified six CAES associated with better prognoses(P<0.05).Results of GSEA showed the CAES signature might confer a strong tumor metabolism phenotype in the high-risk group with elevated activities in folate biosynthesis and phospholipase D pathways

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Investigation of the physical,chemical properties and Absorption Mechanisms of S-propargyl-cysteine,an Amino Acid Derivate from Garlic

Investigation of the physical,chemical properties and Absorp...

引用

第十二次全国临床药理学学术会议

作者： Guo Ma,Lin Zhang,Hongrui Liu,yuanting zheng,Qing Zhu,Peng Zhang,Jinlian Zhang, Jiayuan Lin,Yizhun Zhu,Weimin Cai

Objective To characterize the major physical,chemical properties and absorption mechanisms of S-propargyl-cysteine(SPRC) in gastrointestinal tract. Methods The equilibrium solubility of SPRC in different aqueous solutions and organic solvents were determined by saturation *** dissociation constants(pKa) in acid and basic region were determined using the potential titration *** true partition coefficient(logP) in n-octanol/water and apparent distribution coefficient(logD) in different pH PBS buffer were determined by shake-flask *** of SPRC was observed by incubating SPRC with the gastrointestinal *** absorption mechanisms of SPRC were studied via rat in situ gastrointestinal perfusion *** absorption influence factors,including administration doses,absorption segments,pH environment,potential transporters and bile excretion,were observed in this *** RP-HPLC methods were developed to determine the concentrations of SPRC in the gastrointestinal perfusates,bile and other solutions.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

微时代高职院校学生国防教育策略探析

引用

辽宁省交通高等专科学校学报 2022年第1期24卷 64-67页

作者：王烁生郑苑婷揭阳职业技术学院广东揭阳522000

新媒体是微时代催生的新媒介,对高职院校国防教育带来了机遇与挑战。本文对微时代背景下高职院校学生国防教育工作所面临的机遇与挑战作出分析与论述,并从师资队伍建设、师生媒介素养提升、国防教育内容丰富以及国防教育途径创新四个方... 详细信息

新媒体是微时代催生的新媒介,对高职院校国防教育带来了机遇与挑战。本文对微时代背景下高职院校学生国防教育工作所面临的机遇与挑战作出分析与论述,并从师资队伍建设、师生媒介素养提升、国防教育内容丰富以及国防教育途径创新四个方面,对微时代环境下的高职院校学生国防教育策略进行研究与探讨。

关键词：微时代高职院校国防教育新媒体

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于八景文化的潮汕站南站房景观浮雕设计研究

引用

陶瓷 2022年第7期 17-21页

作者：陈沛捷郑苑婷揭阳职业技术学院广东揭阳522000

潮州八景构建并传承了可行、可望、可游、可居的山水意象,在潮汕地区家喻户晓。将八景文化融入到潮汕站南站房景观浮雕设计中,能够有效提升高铁站房的文化属性。笔者以清代四条屏《潮州古城图》为蓝本,通过提炼、征引、转化等设计策略... 详细信息

潮州八景构建并传承了可行、可望、可游、可居的山水意象,在潮汕地区家喻户晓。将八景文化融入到潮汕站南站房景观浮雕设计中,能够有效提升高铁站房的文化属性。笔者以清代四条屏《潮州古城图》为蓝本,通过提炼、征引、转化等设计策略的应用,合理建构出城市的意象,在公共空间中实现了潮汕地域文化元素的传承与创新。

关键词：潮州八景潮汕站景观浮雕设计应用

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：