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Analysis of quality of life in patients after transgastric natural orifice transluminal endoscopic gallbladder-preserving surgery

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 318-325页

作者： Min-yu Zhang Sen-yuan zheng zheng-yu ru Zhi-Qiang Zhang Department of Gastroenterology The First Affiliated Hospital of Xinjiang Medical UniversityUrimuqi 830011Xinjiang Uygur Autonomous RegionChina

BACKGROUND At present,laparoscopic cholecystectomy(LC)is the main surgical treatment for ***,after gallbladder removal,there are many ***,it is hoped to remove stones while preserving the function of the gallbladder,and with the development of endoscopic technology,natural orifice transluminal endoscopic surgery came into *** To compare the quality of life,perioperative indicators,adverse events after LC and transgastric natural orifice transluminal endoscopic gallbladder-preserving surgery(EGPS)in patients with *** Patients who were admitted to The First Affiliated Hospital of Xinjiang Medical University from 2020 to 2022 were retrospectively *** adopted propen-sity score matching(1:1)to compare EGPS and LC *** A total of 662 cases were collected,of which 589 cases underwent LC,and 73 cases underwent *** score matching was performed,and 40 patients were included in each of the *** the EGPS group,except the gastr-ointestinal defecation(P=0.603),the total score,physical well-being,mental well-being,and gastrointestinal digestion were statistically significant compared with the preoperative score after surgery(P<0.05).In the LC group,except the mental well-being,the total score,physical well-being,gastrointestinal digestion,the gastrointestinal defecation was statistically significant compared with the preoperative score after surgery(P<0.05).When comparing between groups,gastrointestinal defecation had significantly difference(P=0.002)between the two groups,there was no statistically significant difference in the total postoperative score and the other three *** the surgery duration,hospital stay and cost,LC group were lower than EGPS *** recurrence factors of gallstones after EGPS were analyzed:and recurrence was not correlated with gender,age,body mass index,number of stones,and preoperative *** Whether EGPS or LC,it can improve the patient’s symp

关键词： Gallstones Natural orifice transluminal endoscopic surgery Gallbladder preservation Cholecystolithotomy Laparoscopic cholecystectomy Gastrointestinal quality of life index

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五年制高职创新创业教育“四阶梯递进”课程体系研究

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扬州职业大学学报 2024年第3期28卷 52-55页

作者：刘厚林郑如玉江苏联合职业技术学院江苏扬州225002

目前五年制高职创新创业教育课程体系存在系统性不足、教学生态亟待完善、教育实践亟待加强、教育理念亟待提升和课程实施主体合作机制不完善等问题。基于此,构建了通识教育—专创融合—双创实践—项目实战的“四阶梯递进”创新创业教... 详细信息

目前五年制高职创新创业教育课程体系存在系统性不足、教学生态亟待完善、教育实践亟待加强、教育理念亟待提升和课程实施主体合作机制不完善等问题。基于此,构建了通识教育—专创融合—双创实践—项目实战的“四阶梯递进”创新创业教育课程体系。并从强化课程设计、确保多课程渗透、注重跨专业融合、坚持德技并修、推动校企政合作等方面提出“四阶梯递进”创新创业教育课程的实施策略。

关键词：五年制高职创新创业教育四阶梯递进课程体系构建

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Isolation and identification of Fusarium oxysporum f. sp. cubense in Fujian Province, China

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Journal of Integrative Agriculture 2019年第8期18卷 1905-1913页

作者： WU Kai-li CHEN Wei-zhong YANG Shuai WEN Ya zheng yu-ru Wilfred Mabeche Anjago yuN Ying-zi WANG Zong-hua State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops College of Plant Protection Fujian Agriculture and Forestry University Fuzhou 350002 P.R.China Fujian Institute for Food and Drug Quality Control Fuzhou 350001 P.R.China Institute of Oceanography Minjiang University Fuzhou 350108 P.R.China

Fusarium wilt, caused by Fusarium oxyporum f. sp. cubense(Foc), is the most serious disease affecting banana *** clarify the distribution of the Foc races in Fujian Province of China, 79 soil samples were collected from four regions of Zhangzhou City, the primary banana production area in Fujian. We isolated and identified 12 Foc strains based on internal transcribed spacer(ITS) sequence analysis, PCR amplification by using Foc-specific primers and pathogenicity *** analysis indicated that 11 isolates belong to Foc race 1, and 1 isolate belongs to the Foc tropical species race 4(TR4).Although TR4 has previously been reported to occur in primary banana-producing provinces, such as Hainan, Guangxi,and Guangdong of China, this is the first report of TR4 isolated from the soil in Fujian Province. Monitoring the presence of Foc, in particular, the TR4 strains in the soil, is the basic strategy to prevent and control Fusarium wilt.

关键词： Fusarium oxysporum f. sp. cubense(Foc) identification of physiological races pathogenicity test Fujian Fusarium wilt

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Applications of genetic code expansion technology in eukaryotes

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Protein & Cell 2024年第5期15卷 331-363页

作者： Qiao-ru Guo yu J.Cao State Key Laboratory of Chemical Oncogenomic Guangdong Provincial Key Laboratory of Chemical GenomicsPeking University Shenzhen Graduate SchoolShenzhen 518055China Institute of Chemical Biology Shenzhen Bay LaboratoryShenzhen 518132China

Unnatural amino acids(UAAs)have gained significant attention in protein engineering and drug development owing to their ability to introduce new chemical functionalities to *** eukaryotes,genetic code expansion(GCE)enables the incorporation of UAAs and facilitates posttranscriptional modification(PTM),which is not feasible in prokaryotic *** is also a powerful tool for cell or animal imaging,the monitoring of protein interactions in target cells,drug development,and switch ***,there is keen interest in utilizing GCE in eukaryotic *** review provides an overview of the application of GCE in eukaryotic systems and discusses current challenges that need to be addressed.

关键词： genetic code expansion unnatural amino acid eukaryotes basic research therapeutic applications

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Effect of Guanxin Danshen Dripping Pills on Coronary Heart Disease Comorbid with Depression or Anxiety: The ADECODE-Real World Study

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Chinese Journal of Integrative Medicine 2024年第5期30卷 443-448页

作者： WU Shi-hao SHI Wei-qi LI yu-hang LIU ru-hui HU Da-yi zheng Li-qiang MA Wen-lin Department of Geriatric Medicine Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Cardiology Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Cardiology Peking University People's HospitalBeijing 100044China School of Public Health Shanghai Jiao Tong UniversityShanghai 200030China

Objective: To evaluate the efficacy of Guanxin Danshen Dripping Pill(GXDSDP) in treating anxiety and depression in patients with coronary heart disease(CHD). Methods: A total of 1,428 patients diagnosed with CHD screened for anxiety, depression, and quality of life(QOL) at baseline received 0.4 g of GXDSDP treatment 3 times per day and returned for monthly reassessment. Patients were recruited after stable treatment for CHD and received assessment of General Anxiety Disorder-7(GAD-7), Patient Health Questionnaire-9(PHQ-9), and Seattle Angina Questionnaire(SAQ) for evaluating anxiety, depression, and *** were followed up 3 times, once every 4 weeks, during outpatient visits for 12 weeks. Results: At the third follow-up(F3), the anxiety symptom of 63.79%(673/1,055) of the patients improved to sub-clinical level, and the GAD-7 score improved significantly(8.11 vs. 3.87, P<0.01);57.52%(585/1,017) patients' depressive symptoms improved to sub-clinical level, with a significant improvement in PHQ-9 score(8.69 vs. 4.41, P<0.01) at F3. All aspects of QOL significantly improved at the end of treatment compared to those at baseline(all P<0.01) as assessed by SAQ: physical limitation(31.17 vs. 34.14), anginal stability(2.74 vs. 4.14), anginal frequency(8.16vs. 9.10), treatment satisfaction(13.43 vs. 16.29), and disease perception(8.69 vs. 11.02). Conclusions: A fixed dosage of GXDSDP may be a potential treatment option for CHD patients comorbid with anxiety or depression.(Registration No. ChiCTR2100051523)

关键词： Guanxin Danshen Dripping Pill coronary heart disease depression anxiety quality of life Chinese medicine

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High-risk factors for delirium in severely ill patients and the application of emotional nursing combined with pain nursing

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World Journal of Psychiatry 2024年第7期14卷 1027-1033页

作者： Hong-ru Li yu Guo Emergency Intensive Care Unit The Fourth Affiliated Hospital of Soochow University(Suzhou Dushu Lake Hospital)Suzhou 215000Jiangsu ProvinceChina

BACKGROUND Delirium is a neuropsychiatric syndrome characterized by acute disturbances of consciousness with rapid onset,rapid progression,obvious fluctuations,and preventable,reversible,and other *** with delirium in the intensive care unit(ICU)are often missed or misdiagnosed and do not receive adequate *** To analyze the risk factors for delirium in ICU patients and explore the applica-tion of emotional nursing with pain nursing in the management of *** General data of 301 critically ill patients were retrospectively collected,including histories(cardiovascular and cerebrovascular diseases,hypertension,smoking,alcoholism,and diabetes),age,sex,diagnosis,whether surgery was performed,and patient origin(emergency/clinic).Additionally,the duration of sedation,Richmond Agitation Sedation Scale score,combined emotional and pain care,ven-tilator use duration,vasoactive drug use,drainage tube retention,ICU stay du-ration,C-reactive protein,procalcitonin,white blood cell count,body tempe-rature,Acute Physiology and Chronic Health Evaluation II(APACHE II)score,and Sequential Organ Failure Assessment score were recorded within 24 h after ICU *** were assessed for delirium according to confusion assessment method for the ICU,and univariate and multivariate logistic regre-ssion analyses were performed to identify the risk factors for delirium in the *** Univariate logistic regression analysis was performed on the 24 potential risk factors associated with delirium in ICU *** results showed that 16 risk factors were closely related to delirium,including combined emotional and pain care,history of diabetes,and patient *** logistic regression analysis revealed that no combined emotional and pain care,history of diabetes,emergency source,surgery,long stay in the ICU,smoking history,and high APACHE II score were independent risk factors for de-lirium in ICU *** Patients

关键词： Critical illness Delirium Risk factor Intensive care unit Emotional nursing Pain nursing

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Status and trends of carbon emissions research at the county level in China

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Advances in Climate Change Research 2024年第2期15卷 338-352页

作者： Ang-Zu CAI ru GUO yu-Hao ZHANG Jiang WU College of Environmental Science and Engineering Institute of Environmental Planning and ManagementTongji UniversityShanghai 200092China Institute of Carbon Neutrality Tongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China College of Architecture and Urban Planning Tongji UniversityShanghai 200092China Megacity Elaborated Urban Governance Institute Tongji UniversityShanghai 200092China

This study provides a comprehensive overview of the challenges to achieving carbon neutrality at the county level in China and offers targeted recommendations,laying the groundwork for future specialized research in this area.A total of 283 relevant studies(2004-2023)were analyzed to assess county-level carbon emissions through three phases:bibliometric analysis,frontier analysis,and future *** findings reveal that publication trends were largely influenced by domestic and foreign *** cluster discerns ten primary themes,ranging from conceptual frameworks to research *** frontier analysis of the literature highlights the leading research areas,which include carbon neutrality pathway,driving factors,spatiotemporal variation of carbon emissions,the co-effects of pollutants and carbon reduction,and carbon emissions in China's rural *** from the results of bibliometric and frontier analyses,this study elucidates the recommendations for achieving carbon neutrality at the county level from three perspectives:effective regional policy guidance,emphasis on ecological conservation,and the deployment of advanced carbon reduction and sequestration *** study enriches the body of knowledge on carbon emissions at the county level and holds significant implications for China's comprehensive push towards achieving its carbon neutrality objectives.

关键词： Carbon emissions Emission reduction County Carbon neutrality Sustainability

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Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio:Markers predicting immune-checkpoint inhibitor efficacy and immune-related adverse events

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 577-582页

作者： Qiu-yu Jiang ru-Yi Xue Department of Gastroenterology and Hepatology Zhongshan HospitalShanghai Institute of Liver DiseaseFudan UniversityShanghai 200032China Department of Gastroenterology and Hepatology Shanghai Baoshan District Wusong Central Hospital(Zhongshan Hospital Wusong BranchFudan University)Shanghai 200940China

We conducted a comprehensive review of existing prediction models pertaining to the efficacy of immune-checkpoint inhibitor(ICI)and the occurrence of immune-related adverse events(irAEs).The predictive potential of neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)in determining ICI effectiveness has been extensively investigated,while limited research has been conducted on predicting ***,the combined model incor-porating NLR and PLR,either with each other or in conjunction with additional markers such as carcinoembryonic antigen,exhibits superior predictive capabilities compared to individual markers *** and PLR are promising markers for clinical *** models ought to incorporate established efficacious models and newly identified ones,thereby constituting a multifactor composite ***,efforts should be made to explore effective clinical application approaches that enhance the predictive accuracy and efficiency.

关键词： Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Immunecheckpoint inhibitor Immune-related adverse event

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DAIS: a method for identifying spatial domains based on density clustering of spatial omics data

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Journal of Genetics and Genomics 2024年第8期51卷 884-887页

作者： Qichao yu ru Tian Xin Jin Liang Wu College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China BGI Research ShenzhenGuangdong 518083China BGI ResearchChongqing 401329China BGI Research ShenzhenGuangdong 518083China BGI Research Chongqing 401329China

In multicellular organisms,the spatial arrangement of cells profoundly influences the biological functions of tissues,underscoring the importance of identifying spatial domains in *** advancements in spatial omics,particularly spatial transcriptomics(ST)(Bressan et al.,2023),have enhanced our understanding of tissue spatial organization(Zhang et al.,2022;Tian et al.,2023).

关键词： arrangement identifying domains

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Role of angiotensin receptor-neprilysin inhibitor in diabetic complications

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World Journal of Diabetes 2024年第5期15卷 867-875页

作者： Ying Liu Cun-yu Lu Yi zheng yu-Min Zhang Ling-Ling Qian Ku-Lin Li Gary Tse ru-Xing Wang Tong Liu Department of Cardiology Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular DiseaseTianjin Institute of CardiologySecond Hospital of Tianjin Medical UniversityTianjin 300211China Department of Cardiology Xuzhou No.1 Peoples HospitalXuzhou 221005Jiangsu ProvinceChina Department of Cardiology Wuxi 9^(th)People’s Hospital Affiliated to Soochow UniversityWuxi 214062Jiangsu ProvinceChina Department of Cardiology Wuxi People’s Hospital Affiliated to Nanjing Medical UniversityWuxi 214023Jiangsu ProvinceChina School of Nursing and Health Studies Metropolitan UniversityHong Kong 999077China Kent and Medway Medical School Kent CT27NTCanterburyUnited Kingdom

Diabetes mellitus is a prevalent disorder with multi-system manifestations,causing a significant burden in terms of disability and deaths ***-tensin receptor-neprilysin inhibitor(ARNI)belongs to a class of medications for treating heart failure,with the benefits of reducing hospitalization rates and *** review mainly focuses on the clinical and basic investigations related to ARNI and diabetic complications,discussing possible physiological and molecular mechanisms,with insights for future applications.

关键词： Angiotensin receptor-neprilysin inhibitor Diabetic mellitus Complication

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