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A preliminary study of imaging paclitaxel-induced tumor apoptosis with 99Tcm-His10-Annexin V

Chinese Medical Journal 2013年第15期126卷 2928-2933页

作者： zheng yu-min wang feng fang wei hua zi-chun wang zi-zheng meng qing-le yan jue Department of Nuclear Medicine China-Japan Friendship HospitalBeijing 100029 China Department of Nuclear Medicine Nanjing First Hospital affiliated to Nanjing Medical University Nanjing Jiangsu 210006 China Department of Nuclear Medicine Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences Beijing 100037China The State Key Laboratory of Pharmaceutical Biotechnology Nanjing University Nanjing Jiangsu 210093 China

Backgroud in tumors the process of apoptosis occurs over an interval of time after chemotherapy, it is important to determine the best time for detecting apoptosis by in vivo imaging. In this study, we evaluated the dynamics and feasibility of imaging non-small cell lung cancer （NSCLC） apoptosis induced by paclitaxel treatment using a 99Tcm-labeled Annexin V recombinant with ten consecutive histidines （Hislo-Annexin V） in a mouse model. Methods 99Tcm-His10-Annexin V was prepared by one step direct labeling; radio-chemical purity （RCP） and radio-stability was tested. The binding of 99Tcm-His10-Annexin V to apoptotic cells was validated in vitro using camptothecin-induced Jurkat cells. In vivo bio-distribution was determined in mice by dissection. The human H460 NSCLC tumor cell line （H460） tumor-bearing mice were treated with intravenous paclitaxel 24, 48 and 72 hours later. 99Tcm-His10-Annexin V was injected intravenously, and planar images were acquired at 2, 4 and 6 hours post-injection on a dual-head gamma camera fitted with a pinhole collimator. Tumor-to-normal tissue ratios （T/NT） were calculated by ROI analysis and they reflected specific binding of 99Tcm-His10-Annexin V. Mice were sacrificed after imaging. Caspase-3, as the apoptosis detector, was determined by flow cytometry, and DNA fragmentation was analyzed by the terminal deoxynucleotidytransferase mediated dUTP nick-end labeling （TUNEL） assay. Nonspecific accumulation of protein was estimated using bovine serum albumin （BSA）. The imaging data were correlated with TUNEL-positive nuclei and caspase-3 activity. Results 99Tcm-His10-Annexin V had a RCP 〉98% and high stability 2 hours after radio-labeling, and it could bind to apoptotic cells with high affinity. Bio-distribution of 99Tcm-His10-Annexin V showed predominant uptake in kidney, relatively low uptake in myocardium, liver and gastrointestinal tract, and rapid clearance from blood and kidney was observed. The TINT was significantly increased after pa

关键词： His10-Annexin V apoptosis non-small cell lung cancer

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Data release of the LAMOST pilot survey

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Research in Astronomy and Astrophysics 2012年第9期12卷 1243-1246页

作者： A-Li Luo Hao-Tong Zhang Yong-Heng Zhao Gang Zhao Xiang-Qun Cui Guo-Ping Li Yao-Quan Chu Jian-Rong Shi Gang wang Jian-Nan Zhang Zhong-Rui Bai Xiao-yan Chen feng-Fei wang yan-Xin Guo Jian-Jun Chen Bing Du Xiao Kong Ya-Juan lei Yin-Bi Li Yi-Han Song yue Wu yan-Xia Zhang Xin-Lin Zhou fang Zuo Peng Du Lin He Wen Hou Yi-Qiao Dong Jian Li Guang-wei Li Shuang Li Jing Song yuan Tian meng-Xin wang Yong-Hui Hou Zhi-Ying Huo Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu lei Jia fang-hua Jiang Xiang Jiang zi-Bo Jiang Ge Jin Ai-hua Li Qi Li Yin-Dun Mao zheng-Hong Tang qing-Sheng Tao Liang-Ping Tu Da-qing wang Dan wang Jian-Ping wang lei wang Shou-Guan wang Shu-qing wang Ya-Nan wang You wang yue-Fei wang ming-Zhi wei Xiang-Xiang Xue Xiao-zheng Xing Ling-Zhe Xu Xin-Qi Xu yan Xu De-hua yang Shi-Hai yang zheng-Qiu Yao Yong yu Hui yuan Chao Zhai En-Peng Zhang Jing Zhang Li-Ping Zhang weiZhang Yong Zhang Zhen-Chao Zhang ming Zhao fang Zhou Yong-Tian Zhu Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China lal @ lamost o rg Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Technologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects.

关键词： techniques: spectroscopic survey — data reduction — data release

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-wei Liu Yi-Peng Jing Gang wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai yue Wu yan Cai Shu-yun Cao zi-huang Cao Jeffrey L.Carlin Hai-yuan Chen Jian-Jun Chen Kun-Xin Chen Li Chen Xue-lei Chen Xiao-yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-wei Fan lei feng Jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu yan-Xin Guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo lei Jia fang-hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong Xu Kong Ya-Juan lei Ai-hua Li Chang-hua Li Guang-wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li yan Li Yin-Bi Li Ye-Ping Li yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su zheng-Hong Tang qing-Sheng Tao yuan Tian Dan wang Da-Qi wang feng-Fei wang Guo-min wang Hai wang Hong-Chi wang Jian wang Jia-Ning wang Jian-Ling wang Jian-Ping wang Jun-Xian wang lei wang meng-Xin wang Shou-Guan wang Shu-qing wang Xia wang Ya-Nan wang You wang yue-Fei wang You-Fen wang Peng wei ming-Zhi wei Hong Wu Ke-Fei Wu Xue-Bing Wu yu-Zhong Wu Xiao-zheng Xing Ling-Zhe Xu Xin-Qi Xu yan Xu Tai-Sheng yan De-hua yang Hai-feng yang Hui-Qin yang ming yang zheng-Qiu Yao Yong yu Hui yuan Hai-Bo yuan Hai-Long yuan wei-min yuan Chao Zhai En-Peng Zhang hua-wei Zhang Jian-Nan Zhang Li-Pin Zhang wei Zhang Yong Zhang yan-Xia Zhang zheng-Chao Zhang ming Zhao fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)

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Military Medical Research 2020年第1期7卷 1-22页

作者： Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng fang Di huang Lu-Qi huang Qiao huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng yun-Bao Pan Zhen-yu Pan Xue-Qun Ren Hui-min Sun Ying wang yun-yun wang Hong Weng Chao-Jie wei Dong-fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao yu-feng yuan Tai-Sheng Ye Xiao-chun Zhang Ying-Wen Zhang Yin-Gao Zhang hua-min Zhang yan Zhao ming-Juan Zhao Hao zi Xian-Tao Zeng Yong-yan wang Xing-huan wang 无 Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Hospital Management Wuhan UniversityWuhan 430071China Department of Respiratory Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Pharmacy Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Evidence-Based Medicine and Knowledge Translation Henan UniversityKaifeng 475000China China Academy of Chinese Medical Sciences Beijing 100700China China Center for Evidence Based Traditional Chinese Medicine(CCEBTCM) Beijing 100700China Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Clinical Laboratory Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Infectious Diseases Zhongnan Hospital of Wuhan UniversityWuhan 430071China Division of Medical Affairs Zhongnan Hospital of Wuhan UniversityWuhan 430071China Division of Nursing Affairs Zhongnan Hospital of Wuhan UniversityWuhan 430071China Office of Nosocomial Infection Control Zhongnan Hospital of Wuhan UniversityWuhan 430071China Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Health Research Methods Evidenceand ImpactMcMaster UniversityHamiltonON L8S 4L8Canada Department of Traditional Chinese Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Global Health Institute Wuhan UniversityWuhan 430072China the Zhongnan Hospital of Wuhan University Novel Coronavirus Management and Research Team Evidence-Based Medicine Chapter of China International Exchange and Promotive Association for Medical and Health Care(CPAM)

In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named "2019 novel coronavirus(2019-nCoV)" by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV.

关键词： 2019 novel coronavirus 2019-nCoV Respiratory disease Pneumonia Infectious diseases Rapid advice guideline Clinical practice guideline Evidence-based medicine

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The mini-GWAC optical follow-up of gravitational wave alerts – results from the O2 campaign and prospects for the upcoming O3 run

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Research in Astronomy and Astrophysics 2020年第1期20卷 107-123页

作者： Damien Turpin Chao Wu Xu-Hui Han Li-Ping Xin Sarah Antier Nicolas leroy Li Cao Hong-Bo Cai Bertrand Cordier Jin-Song Deng Wen-Long Dong Qi-Chen feng lei huang lei Jia Alain Klotz Cyril Lachaud hua-Li Li En-wei Liang Shun-fang Liu Xiao-meng Lu Xian-min meng yu-lei Qiu Hui-Juan wang Jing wang Shen wang Xiang-Gao wang Jian-yan wei Bo-Bing Wu yu-Jie Xiao Da-wei Xu yang Xu yuan-Gui yang Pin-Pin Zhang Ruo-Song Zhang Shuang-Nan Zhang Ya-Tong zhengandSi-Cheng Zou Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China LAL Univ.Paris-SudCNRS/IN2P3Universite Paris-SaclayF-91898 OrsayFrance APC Univ Paris DiderotCNRS/IN2P3CEA/lrfuObs de ParisSorbonne Paris CiteFrance CEA Saclay DRF/IRFU/Departement d’astrophysique91191 Gif-sur-YvetteFrance School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China Universite de Toulouse IRAP 14 Av.Edouard BelinF-31000 ToulouseFrance Institut de Recherche en Astrophysique et Planetologie(IRAP) UPS-OMPToulouseFrance Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physics and Electronic Information Huaibei Normal UniversityHuaibei 235000China

The second(O2)observational campaign of gravitational waves(GWs)organized by the LIGO/Virgo Collaborations has led to several breakthroughs such as the detection of GW signals from merger systems involving black holes or neutrons *** O2,14 GW alerts were sent to the astronomical community with sky regions mostly covering over hundreds of square *** them,six were finally confirmed as real astrophysical *** 2013,a new set of ground-based robotic telescopes called Ground-based Wide Angle Camera system(GWAC)project and its pathfinder mini-GWAC has been developed to contribute to the various challenges of multi-messenger and time domain *** GWAC system is built up in the framework of the ground-segment system of the SVOM mission that will be devoted to the study of the multi-wavelength transient sky in the next *** O2,only the mini-GWAC telescope network was fully *** to the wide field of view and fast automatic follow-up capabilities of the mini-GWAC telescopes,they were adept to efficiently cover the sky localization areas of GW event *** this paper,we present the mini-GWAC pipeline we have set up to respond to GW alerts and we report our optical follow-up observations of eight GW alerts detected during the O2 *** observations provided the largest coverage of the GW localization areas with a short latency made by any optical *** found tens of optical transient candidates in our images,but none of those could be securely associated with any confirmed black hole-black hole merger *** on this first experience and the near future technical improvements of our network system,we will be more competitive in detecting the optical counterparts from some GW events that will be identified during the upcoming O3 run,especially those emerging from binary neutron star mergers.

关键词： gravitational waves methods:data analysis methods:observational (stars:)gammaray burst:general

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The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-yun Zhao Shao-Lin Xiong Xiang-yang Wen Xin-Qiao Li Ce Cai Shuo Xiao Qi Luo Wen-Xi Peng Dong-Ya Guo zheng-hua An Ke Gong Jin-yuan Liao yan-Qiu Zhang yue huang Lu Li Xing Wen Fei Zhang Jing Duan Chen-wei wang Dong-Li Shi Peng Zhang Qi-Bin Yi Chao-yang Li yan-Bing Xu Xiao-hua Liang Ya-qing Liu Da-Li Zhang Xi-lei Sun Fan Zhang Gang Chen huan-yu wang Sheng yang Xiao-Jing Liu min Gao Mao-Shun Li Jin-Zhou wang Xing Zhou Yi Zhao wang-Chen Xue Chao zheng Jia-Cong Liu Xing-Bo Han Jin-Ling Qi Jia huang Ke-Ke Zhang Can Chen Xiong-Tao yang Dong-Jie Hou yu-Sa wang Rui Qiao Xiang Ma Xiao-Bo Li Ping wang Xin-Ying Song Li-ming Song Shi-Jie zheng Bing Li Hong-Mei Zhang yue Zhu wei Chen Jian-Jian He Zhen Zhang Jin Hou Hong-Jun wang yan-Chao Hao Xiang-yu wang Zong-yuan yang Zhi-Long Wen Zhi Chang yuan-yuan Du Rui Gao Xiao-Fei Lan yan-Guo Li Gang Li Xu-fang Li fang-Jun Lu Hong Lu Bin meng feng Shi Hui wang Hui-Zhen wang yu-Peng Xu Jia-wei yang Xue-Juan yang Shuang-Nan Zhang Chao-yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

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Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin Liu yue huang Guang-Cheng Xiao qing-Cui Bu Jin-Lu Qu Shu Zhang Shuang-Nan Zhang Shu-Mei Jia fang-Jun Lu Xiang Ma Lian Tao wei Zhang Li Chen Li-ming Song Ti-Pei Li yu-Peng Xu Xue-lei Cao Yong Chen Cong-Zhan Liu Ce Cai Zhi Chang Gang Chen Tian-Xiang Chen Yi-Bao Chen yu-Peng Chen wei Cui wei-wei Cui Jing-Kang Deng Yong-wei Dong yuan-yuan Du min-Xue Fu Guan-hua Gao He Gao min Gao ming-yu Ge yu-Dong Gu Ju Guan Cheng-Cheng Guo Da-wei Han Jia Huo Lu-hua Jiang wei-chun Jiang Jing Jin Yong-Jie Jin Ling-Da Kong Bing Li Cheng-Kui Li Gang Li Mao-Shun Li wei Li Xian Li Xiao-Bo Li Xu-fang Li yang-Guo Li zheng-wei Li Xiao-hua Liang Jing-yuan Liao Bai-Sheng Liu Guo-qing Liu Hong-wei Liu Xiao-Jing Liu Yi-Nong Liu Bo Lu Xue-feng Lu Qi Luo Tao Luo Bin meng Yi Nang Jian-Yin Nie Ge Ou Na Sai Ren-Cheng Shang Xin-Ying Song Liang Sun Ying Tan You-Li Tuo Chen wang Guo-feng wang Juan wang Ling-Jun wang Weng-Shuai wang yu-Sa wang Xiang-yang Wen Bai-yang Wu Bo-Bing Wu Mei Wu Shuo Xiao Shao-Lin Xiong He Xu Jia-wei yang Sheng yang yan-Ji yang Yi-Jung yang Qi-Bin Yi Qian-qing Yin yuan You Ai-Mei Zhang Cheng-Mo Zhang Fan Zhang Hong-Mei Zhang Juan Zhang Tong Zhang Wan-Chang Zhang Wen-Zhao Zhang Yi Zhang Yi-Fei Zhang Yong-Jie Zhang yuan-Hang Zhang yue Zhang Zhao Zhang Zhi Zhang zi-Liang Zhang Hai-Sheng Zhao Xiao-Fan Zhao Shi-Jie zheng Yao-Guang zheng Deng-Ke Zhou Jian-feng Zhou yu-Xuan Zhu Ren-Lin Zhuang yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

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Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants:a randomized phase 2 trial

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Signal Transduction and Targeted Therapy 2023年第2期8卷 672-682页

作者： Nawal Al Kaabi yun Kai yang yu Liang Ke Xu Xue feng Zhang yun Kang yu Qin Jin Jun wei Hou Jing Zhang Tian yang Salah Hussein Mohamed Saif ElDein Ze hua lei Hao Zhang Shuai Shao Zhao ming Liu Ning Liu Xiang zheng Ji Guo Su Sen Sen yang Xiangfeng Cong Yao Tan Wenwen lei Xue Jun Gao Zhiwei Jiang Hui wang meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang mengjie yang Islam Eltantawy Peng Xiao Fu Jie Shen Jin Juan Wu zi Bo Han Li fang Du fang Tang Shi Chen Zhi Jing Ma Fan zheng Ya Nan Hou Xin yu Li Xin Li Zhao Nian wang Jin Liang Yin Xiao yan Mao Jin Zhang Liang Qu yun Tao Zhang Xiao ming yang Guizhen Wu Qi ming Li Sheikh Khalifa Medical City SEHAAbu DhabiUAE College of Medicine and Health Sciences Khalifa UniversityAbu DhabiUAE China National Biotec Group Company Limited BeijingChina The Sixth Laboratory National Vaccine and Serum Institute(NVSI)BeijingChina National Engineering Center for New Vaccine Research BeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention(China CDC)BeijingChina Clinical Medicine Office National Vaccine and Serum Institute(NVSI)BeijingChina Lanzhou Institute of Biological Products Company Limited LanzhouChina Beijing Key Tech Statistical Consulting Co. LtdBeijingChina Beijing Institute of Biological Products Company Limited BeijingChina Union 71 Abu DhabiUAE G42 Healthcare Abu DhabiUAE

An ongoing randomized,double-blind,controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate,named NVSI-06-09,as a booster dose in subjects aged 18 years and older from the United Arab Emirates(UAE),who had administered two or three doses of inactivated vaccine BBIBP-CorV at least 6 months prior to *** participants were randomly assigned with 1:1 to receive a booster dose of NVSI-06-09 or *** primary outcomes were immunogenicity and safety against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant,and the exploratory outcome was cross-immunogenicity against other circulating *** May 25 and 30,2022,516 adults received booster vaccination with 260 in NVSI-06-09 group and 256 in BBIBP-CorV *** results showed a similar safety profile between two booster groups,with low incidence of adverse reactions of grade 1 or *** immunogenicity,by day 14 post-booster,the fold rises in neutralizing antibody geometric mean titers(GMTs)from baseline elicited by NVSI-06-09 were remarkably higher than those by BBIBP-CorV against the prototype strain(19.67 vs 4.47-fold),Omicron BA.1.1(42.35 vs 3.78-fold),BA.2(25.09 vs 2.91-fold),BA.4(22.42 vs 2.69-fold),and BA.5 variants(27.06 vs 4.73-fold).Similarly,the neutralizing GMTs boosted by NVSI-06-09 against Beta and Delta variants were also 6.60-fold and 7.17-fold higher than those by *** findings indicated that a booster dose of NVSI-06-09 was well-tolerated and elicited broad-spectrum neutralizing responses against divergent SARS-CoV-2 variants,including Omicron and its sub-lineages.

关键词： phase neutral spectrum

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Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： Jun Liu Dan-Dan Li wei Dong yu-Qi Liu yang Wu Da-Xuan Tang Fu-chun Zhang meng Qiu Qi hua Jing-yu He Jun Li Bai Du Ting-Hai Du Lin-Lin Niu Xue-Jun Jiang Bo Cui Jiang-Bin Chen yang-Gan wang Hai-Rong wang Qin yu Jing He Yi-Lin Mao Xiao-fang Bin yue Deng yu-Dan Tian qing-hua Han Da-Jin Liu Li-Qin Duan ming-Jun Zhao Cui-Ying Zhang Hai-Ying Dai Ze-hua Li Ying Xiao You-Zhi Hu Xiao-yu huang Kun Xing Xin Jiang Chao-feng Liu Jing An feng-chun Li Tao Tao Jin-Fa Jiang Ying yang Yao-Rong Dong lei Zhang Guang Fu Ying Li Shu-wei huang Li-Ping Dou Lan-Jun Sun Ying-Qiang Zhao Jie Li yun Xia Jun Liu Fan Liu Wen-Jin He Ying Li Jian-Cong Tan yang Lin Ya-Bin Zhou Jian-Fei yang Guo-qing Ma Hui-Jun Chen He-Ping Liu Zong-Wu Liu Jian-Xiong Liu Xiao-Jia Luo Xiao-Hong Bin Ya-Nan yu Hai-Xia Dang Bing Li Fei Teng wang-min Qiao Xiao-Long Zhu Bing-wei Chen Qi-Guang Chen chun-Ti Shen Yong-yan wang yun-Dai Chen Zhong wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

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The DIRECT consortium and the REST-meta-MDD project:towards neuroimaging biomarkers of major depressive disorder

引用

Psychoradiology 2022年第1期2卷 32-42页

作者： Xiao Chen Bin Lu Hui-Xian Li Xue-Ying Li yu-wei wang Francisco Xavier Castellanos Li-Ping Cao Ning-Xuan Chen wei Chen yu-Qi Cheng Shi-Xian Cui Zhao-yu Deng Yi-Ru fang Qi-Yong Gong Wen-Bin Guo zheng-Jia-Yi Hu Li Kuang Bao-Juan Li le Li Tao Li Tao Lian Yi-Fan Liao yan-Song Liu Zhe-Ning Liu Jian-Ping Lu qing-hua Luo hua-qing meng Dai-Hui Peng Jiang Qiu yue-Di Shen Tian-Mei Si yan-qing Tang Chuan-yue wang Fei wang hua-Ning wang Kai wang Xiang wang Ying wang zi-Han wang Xiao-Ping Wu chun-ming Xie Guang-Rong Xie Peng Xie Xiu-feng Xu Hong yang Jian yang Shu-Qiao Yao Yong-Qiang yu Yong-Gui yuan Ke-Rang Zhang wei Zhang Zhi-Jun Zhang Jun-Juan Zhu Xi-Nian Zuo Jing-Ping Zhao yu-feng Zang the DIRECT consortium Chao-Gan yan CAS Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijing 100101China International Big-Data Center for Depression Research Chinese Academy of SciencesBeijing 100101China Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Graduate University of Chinese Academy of SciencesBeijing 101408China Department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew YorkNY 10016USA Nathan Kline Institute for Psychiatric Research OrangeburgNew YorkNY 10962USA 9Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370China Capital Normal University Beijing 100089China Department of Psychiatry Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020ZhejiangChina Department of Psychiatry First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan UniversityChengduSichuan 610044China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengduSichuan 610052China Department of Psychiatry and National Clinical Research Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011HunanChina Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Xijing Hospital of Air Force Military Medical University Xi’anShaanxi 710032China Center for Cognitive Science of Language Beijing Language and Culture UniversityBeijing 100083China Affiliated Mental Health Center&Hangzhou Seventh People’s Hospital Zhejiang University School of

Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder(MDD),repro-ducible findings are lacking,probably reflecting mostly small sample sizes and heterogeneity in analytic *** address these issues,the Depression Imaging REsearch ConsorTium(DIRECT)was *** REST-meta-MDD project,pooling 2428 functional brain images processed with a standardized pipeline across all participating sites,has been the first effort from *** this review,we present an overview of the moti-vations,rationale,and principal findings of the studies so far from the REST-meta-MDD *** from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network,in whole-brain topological properties,in dynamic features,and in functional *** well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven *** these fruitful explorations,DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations.A state-of-the-art,surface-based preprocessing pipeline has also been introduced to improve *** images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diag-nosis *** addition,large-scale longitudinal studies targeting brain network alterations following antidepressant treatment,aggregation of diffusion tensor images,and the development of functional magnetic resonance imaging-guided neuromodulation approaches are *** these endeavours,we hope to accelerate the translation of functional neuroimaging findings to clinical use,such as evaluating longitudinal effects of antidepressant medications and developing individualized

关键词： major depressive disorder DIRECT R-fMRI database neuroimaging

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