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Ring-Shaped Polyoxometalate Built by {Mn_(4)PW_(9)} and PO_(4) Units for Efficient Visible-Light-Driven Hydrogen Evolution

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CCS Chemistry 2021年第8期3卷 2095-2103页

作者： Hai-Lou Li Mo Zhang Chen Lian Zhong-Ling Lang Hongjin Lv guo-yu Yang MOE Key Laboratory of Cluster Science School of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 102488 MOE Key Laboratory of Polyoxometalate Science College of ChemistryNortheast Normal UniversityChangchunJilin 130024

A novel mixed-valence,ring-shaped multinuclear Mn-containing polyoxometalate,[H_(2)N(CH_(3))_(2)]_(15) NaH8-[Mn^(Ⅲ) 3MnIV(μ3-O)_(3)(OAc)PO4(B-α-PW_(9)O_(34))]_(4)·36H_(2)O(1)was made and systematically characterized using various spectroscopic and computational *** polyoxoanion can be described as a tetramer made of four[Mn^(Ⅲ) 3MnIV(μ3-O)3(OAc)(B-α-PW_(9)O_(34))]_(3)−({Mn^(Ⅲ) 3Mn^(IV)(PW_(9))})clusters and four PO_(4) linkers.

关键词： polyoxometalates polynuclear manganese clusters visible-light irradiation hydrogen evolution

PTEN-L promotes type I interferon responses and antiviral immunity

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Cellular & Molecular Immunology 2018年第1期15卷 48-57页

作者： yuanyuan Cao Hongyun Wang Liu Yang Zhen Zhang Chenlin Li Xu yuan Lang Bu Lang Chen yu Chen Chun-Mei Li Deyin guo Modern Virology Research Center College of Life SciencesWuhan UniversityWuhan430072China School of Basic Medical Sciences Wuhan UniversityWuhan430072China Laboratory for Medical Virology School of MedicineSun Yat-sen UniversityGuangzhou510080China

Phosphatase and tensin homolog deleted on chromosome ten(PTEN)is a well-known tumor suppressor that acts as a dual-specificity phosphatase and is frequently mutated in human *** previous work has demonstrated that PTEN also plays a vital role in type I interferon responses and antiviral innate ***,a translational variant of PTEN with a long N-terminal extension(PTEN-L)has been discovered that is secreted into the extracellular environment and enters recipient cells,where it exerts a phosphatase function antagonistic to PI3K/Akt signaling and *** this study,we demonstrate that PTEN-L promotes type I interferon responses and antiviral innate immunity during viral infection in a phosphatase activity-dependent *** with canonical PTEN,PTEN-L also exerts its antiviral function when it is applied exogenously in protein *** finding was confirmed in cell cultures and mouse infection ***,PTEN-L enhances the responses of both type I interferon and proinflammatory cytokines,thus suggesting that PTEN-L might possess additional functions compared with those of ***,the antiviral function of PTEN-L may open an avenue for the use of PTEN-L in antiviral therapy,particularly in patients with PTEN-deficient tumors.

关键词： antiviral responses innate immunity PTEN PTEN-L type I interferon

The RING Finger Protein Nt RCP1 Is Involved in the Floral Transition in Tobacco(Nicotiana tabacum)

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Journal of Genetics and Genomics 2015年第6期42卷 311-317页

作者： Hai-yun Wang Yi yu Yong-Duo Sun Li-Bo Han Xiao-Min Wu Jia-He Wu Gui-Xian Xia guo-Qin Liu State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural University State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of Sciences

The transition from the vegetative phase to the reproductive phase is a major developmental process in flowering *** underlying mechanism controlling this cellular process remains a research focus in the field of plant molecular *** the present work,we identified a gene encoding the C3H2C3-type RING finger protein Nt RCP1 from tobacco BY-2 *** analysis demonstrated that Nt RCP1 is a functional E3 ubiquitin *** tobacco plants,expression level of Nt RCP1 was higher in the reproductive shoot apices than in the vegetative *** RCP1-overexpressing plants underwent a more rapid transition from the vegetative to the reproductive phase and flowered markedly earlier than the wild-type *** analysis revealed that the shoot apical meristem of Nt RCP1-overexpressing plants initiated inflorescence primordia precociously compared to the wild-type plant due to accelerated cell *** of Nt RCP1 in BY-2 suspension cells promoted cell division,which was a consequence of the shortened G2 phase in the cell ***,our data suggest that Nt RCP1 may act as a regulator of the phase transition,possibly through its role in cell cycle regulation,during vegetative/reproductive development in tobacco plant.

关键词： RING finger protein Floral transition Cell division cycle Tobacco

Refined mapping of loss of heterozygosity on 1q31.1-32.1 in sporadic colorectal carcinoma

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World Journal of Gastroenterology 2008年第10期14卷 1582-1587页

作者： Chong-Zhi Zhou guo-Qiang Qiu Jun-wei Fan Xiao-Liang Wang Hua-Mei Tang Li Huang yu-Hao Sun Zhi-Hai Peng Department of General Surgery.Shanghai Jiaoiong University Affiliated First People's Hospital Shanghai 200080 China Department of Pathology Shanghai Jiaotong University Affiliated First People's Hospital Shanghai 200080 China

AIM: To explore precise deleted regions and screen the candidate tumor suppressor genes related to sporadic colorectal carcinoma. METHODS: Six markers on 1q31.1-32.1 were chosen. These polymorphic microsatellite markers in 83 colorectal cancer patients tumor and normal DNA were analyzed via PCR. PCR products were electrophoresed on an ABI 377 DNA sequencer. Genescan 3.1 and Genotype 2.1 software were used for Loss of heterozygosity (LOH) scanning and analysis. Comparison between LOH frequency and clinicopathological factors was performed by χ2 test. RESULTS: 1q31.1-32.1 exhibited higher LOH frequency in colorectal carcinoma. The average LOH frequency of 1q31.1-32.1 was 23.0%, with the highest frequency of 36.7% (18/49) at D1S2622, and the lowest of 16.4% (11/67) at D1S412, respectively. A minimal region of frequent deletion was located within a 2 cM genomic segment at D1S413-D1S2622 (1q31.3-32.1). There was no significant association between LOH of each marker on 1q31.1-32.1 and the clinicopathological data (patient sex, age, tumor size, growth pattern or Dukes stage), which indicated that on 1q31.1-32.1, LOH was a common phenomenon in all kinds of sporadic colorectal carcinoma. CONCLUSION: Through our refined deletion mapping,the critical and precise deleted region was located within 2 cM chromosomal segment encompassing 2 loci (D1S413, D1S2622). No significant association was found between LOH and clinicopathologic features in 1q31.1-32.1.

关键词： Sporadic colorectal carcinoma Loss of heterozygosity Tumor suppressor genes 1q31.1-32.1

SYNTHESIS　AND　PROPERTIES　OF　THERMOTROPIC　LIQUID　CRYSTALLINE　COPOLYESTERS　CONTAINING　BIS（4－HYDROXYPHENYL）METHANONE（Ⅵ）

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Chinese Chemical Letters 1995年第11期6卷 339-342页

作者： De Wen DONG Ping HAN Zhen guo CHI yu Shan NI(Changchun Institute of Applied Chemistry, Academia Sinica, Changchun,130022) Acad Sinica Changchun Inst Appl Chem Changchun 130022 Peoples R China

A series of thermotropic liquid crystalline copolyesters were synthesized by thermal polycondensation of p-hydroxybenzoic acid, terephthalic acid, bis (4-hydroxyphenyl )methanone and diols. The resulting copolyesters ... 详细信息

关键词： BIS AND CONTAINING

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A novel NF1 frame-shift mutation c.703＿704delTA in a Chinese pedigree with neurofibromatosis type 1

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International Journal of Ophthalmology(English edition) 2018年第9期11卷 1562-1565页

作者： Jun Chen Bo guo Min Ren Hong Lin Xin Zhang Si-Yi Chen Xiao-Tian yu Zhu-Ping Xu Department of Ophthalmology West China HospitalSichuan University Department of Oncology West China HospitalSichuan University

We analyzed the clinical features and NF1 gene mutation in a Chinese pedigree of neurofibromatosis type 1（NF1）. Three members of this family were NF1 patients presenting with different clinical phenotypes and the others were asymptomatic. Exons of NF1 were amplified by polymerase chain reaction, sequenced, compared with a reference database. One novel NF1 frame-shift mutation c.703_704delTA, which resulted in a premature stop signal at codon 720 and the synthesis of truncated, was revealed. This mutation segregated with the NF1 members is likely responsible for the pathogenesis of NF1 in the family.

关键词： neurofibromatosis type 1 NF1 gene frameshift mutation

Liquid chromatography coupled with time-of-flight and ion trap mass spectrometry for qualitative analysis of herbal medicines

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Journal of Pharmaceutical Analysis 2011年第4期1卷 235-245页

作者： Xiao-Fei Chen Hai-Tang Wu Guang-guo Tan Zhen-yu Zhu Yi-Feng Chai Department of Pharmaceutical Analysis School of Pharmacy Second Military Medical University Shanghai 200433 China Shanghai Key Laboratory for Pharmaceutical Metabolite Research Shanghai 200433 China

With the expansion of herbal medicine （HM） market, the issue on how to apply up-to- date analytical tools on qualitative analysis of HMs to assure their quality, safety and efficacy has been arousing great attention. Due to its inherent characteristics of accurate mass measurements and multiple stages analysis, the integrated strategy of liquid chromatography （LC） coupled with time-of-flight mass spectrometry （TOF-MS） and ion trap mass spectrometry （IT-MS） is well-suited to be performed as qualitative analysis tool in this field. The purpose of this review is to provide an overview on the potential of this integrated strategy, including the review of general features of LC-IT-MS and LC-TOF-MS, the advantages of their combination, the common procedures for structure elucidation, the potential of LC-hybrid-IT-TOF/MS and also the summary and discussion of the applications of the integrated strategy for HM qualitative analysis （2006-2011）. The advantages and future developments of LC coupled with IT and TOF-MS are highlighted.

关键词： High-performanceliquid chromatography(HPLC) Time-of-flight massspectrometry(TOF-MS) Ion trap massspectrometry (IT-MS) Herbal medicine (HM)

Experimental and numerical investigation of a Hall thruster with a chamfered channel wall

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Chinese Physics B 2018年第10期27卷 484-494页

作者： Hong Li guo-Jun Xia Wei Mao Jin-Wen Liu Yong-Jie Ding Da-Ren yu Xiao-Gang Wang Plasma Propulsion Laboratory Harbin Institute of Technology Harbin 150001 China Beijing Institute of Control Engineering Beijing 100190 China Department of Physics Harbin Institute of Technology Harbin 150001 China

A discharge channel with a chamfered wall not only has application in the design of modern Hall thrusters, but also exists where the channel wall is eroded, and so is a common status for these units. In this paper, the laws and mechanisms that govern the effect of the chamfered wall on the performance of a Hall thruster are investigated. By applying both experimental measurement and particle-in-cell simulation, it is determined that there is a moderate chamfer angle that can further improve the optimal performance obtained with a straight channel. This is because the chamfering of the wall near the channel exit can enhance ion acceleration and effectively reduce ion recombination on the wall, which is favorable to the promotion of the thrust and efficiency. However, the chamfer angle should not be too large; otherwise, both the density of the propellant gas and the distribution of the plasma potential in the channel are influenced, which is undesirable for efficient propellant utilization and beam concentration. Therefore, it is suggested that the chamfer shape of the channel wall is an important factor that must be carefully considered in the design of Hall thrusters.

关键词： Hall thruster chamfered wall discharge performance physical mechanism

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地缘地理学学科构建探析

世界地理研究 2009年第3期18卷 146-153页

作者：于国政樊华东北师范大学城市与环境科学学院长春130024

随着世界一体化、全球化及多极化的趋势加强,国际社会对地缘关系与地缘化等问题的关注愈发明显。地缘的思想已经引入政治、经济等各个领域,但是从地理学角度对地缘问题作出总体、全面的把握尚属罕见。在国内外对地缘关系问题的研究已具... 详细信息

随着世界一体化、全球化及多极化的趋势加强,国际社会对地缘关系与地缘化等问题的关注愈发明显。地缘的思想已经引入政治、经济等各个领域,但是从地理学角度对地缘问题作出总体、全面的把握尚属罕见。在国内外对地缘关系问题的研究已具规模的前提下,笔者在近年对地缘学的探讨与研究的基础上,首次从地理学思想出发,提出构建研究地缘相关问题的新学科——地缘地理学。地缘地理学的构建不仅在理论上有其现实意义,而且有其重大实践价值,这一新学科对于地理学及其相关分支学科的发展将产生深远影响。本文对地缘地理学做出了初步的界定,并探讨了研究对象、研究内容、研究领域及学科框架体系等相关问题。

关键词：地缘地理学地缘区位地缘区地缘化