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Astrocyte transplantation for repairing the injured spinal cord

The Journal of Biomedical Research 2022年第5期36卷 312-320页

作者： xiaolong zheng Wei Wang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Key Laboratory of Neurological Diseases of Chinese Ministry of Education the School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China

Spinal cord injury(SCI)leads to permanent deficits in neural function without effective therapies,which places a substantial burden on families and society.Astrocytes,the major glia supporting the normal function of neurons in the spinal cord,become active and form glial scars after SCI,which has long been regarded as a barrier for axon regeneration.However,recent progress has indicated the beneficial role of astrocytes in spinal repair.During the past three decades,astrocyte transplantation for SCI treatment has gained increasing attention.In this review,we first summarize the progress of using rodent astrocytes as the primary step for spinal repair.Rodent astrocytes can survive well,migrate extensively,and mature in spinal injury;they can also inhibit host reactive glial scar formation,stimulate host axon regeneration,and promote motor,sensory,respiratory,and autonomic functional recovery.Then,we review the progress in spinal repair by using human astrocytes of various origins,including the fetal brain,fetal spinal cord,and pluripotent stem cells.Finally,we introduce some key questions that merit further research in the future,including rapid generation of large amounts of human astrocytes with high purity,identification of the right origins of astrocytes to maximize neural function improvement while minimizing side effects,testing human astrocyte transplantation in chronic SCI,and verification of the long-term efficacy and safety in large animal models.

关键词： spinal cord injury astrocyte transplantation regeneration

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Enhanced Formaldehyde Gas Sensor based on Au-loaded ZnSnO_(3) Microspheres Nanocomposites

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Journal of Wuhan University of Technology(Materials Science) 2022年第6期37卷 1061-1065页

作者：何星欣陈洁应智花 ZHENG Xiaolong zheng Peng College of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China

ZnSnO_(3) microspheres was compounded by hydrothermal method with sodium alginate(SA)as a crystal growth modifier,and the Au nanoparticles were decorated on the surface of ZnSnO_(3) microspheres by simple solution method and heat treatment process.The structure and morphology of the prepared samples were characterized by X-ray diffraction(XRD)and scanning electron microscopy(SEM).Under ultraviolet(UV)irradiation,the 0.2wt%Au/ZnSnO_(3)@4g/L SA sensor could detect HCHO and reached a good response of 18.8 at 20 ppm,which was three times higher than the ZnSnO_(3) in the absence of Au.This sensor also performed an outstanding linearity within 5-20 ppm HCHO and satisfied repeatability.Moreover,the possible mechanism of the influence of Au on gas sensitivity is also proposed.

关键词： ZnSnO_(3) Au HCHO gas sensor SA

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Dynamic defenses in cyber security:Techniques,methods and challenges Author links open overlay panel

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Digital Communications and Networks 2022年第4期8卷 422-435页

作者： Yu zheng zheng Li xiaolong Xu Qingzhan Zhao School of Computer and Software Nanjing University of Information Science and TechnologyNanjing210044JiangsuChina Key Laboratory for Novel Software Technology Nanjing UniversityNanjing210023JiangsuChina College of Information Science and Technology Shihezi University Geospatial Information Engineering Research CenterChina

Driven by the rapid development of the Internet of Things,cloud computing and other emerging technologies,the connotation of cyberspace is constantly expanding and becoming the fifth dimension of human activities.However,security problems in cyberspace are becoming serious,and traditional defense measures(e.g.,firewall,intrusion detection systems,and security audits)often fall into a passive situation of being prone to attacks and difficult to take effect when responding to new types of network attacks with a higher and higher degree of coordination and intelligence.By constructing and implementing the diverse strategy of dynamic transformation,the configuration characteristics of systems are constantly changing,and the probability of vulnerability exposure is increasing.Therefore,the difficulty and cost of attack are increasing,which provides new ideas for reversing the asymmetric situation of defense and attack in cyberspace.Nonetheless,few related works systematically introduce dynamic defense mechanisms for cyber security.The related concepts and development strategies of dynamic defense are rarely analyzed and summarized.To bridge this gap,we conduct a comprehensive and concrete survey of recent research efforts on dynamic defense in cyber security.Specifically,we firstly introduce basic concepts and define dynamic defense in cyber security.Next,we review the architectures,enabling techniques and methods for moving target defense and mimic defense.This is followed by taxonomically summarizing the implementation and evaluation of dynamic defense.Finally,we discuss some open challenges and opportunities for dynamic defense in cyber security.

关键词： Cyber security Dynamic defense Moving target defense Mimic defense

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高屋建瓴,有企无止——访中铁咨询集团北京建筑规划设计有限公司董事长郑晓龙

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新建筑 2019年第3期 156-157页

作者：郑晓龙陈茹中铁工程设计咨询集团有限公司、中铁咨询集团北京建筑规划设计有限公司北京100055 新建筑杂志社武汉430074

中铁咨询集团北京建筑规划设计有限公司(下文称"中铁设计规划公司")是中铁工程设计咨询集团有限公司(下文称"集团")的控股子公司。集团大厦坐落于北京西站南面,站在大厦内就可以清晰看到西站全貌。特殊的地理位置亦昭示着其与铁路之间... 详细信息

中铁咨询集团北京建筑规划设计有限公司(下文称"中铁设计规划公司")是中铁工程设计咨询集团有限公司(下文称"集团")的控股子公司。集团大厦坐落于北京西站南面,站在大厦内就可以清晰看到西站全貌。特殊的地理位置亦昭示着其与铁路之间的特殊联系,集团在铁路标准设计、航测遥感、客运专线桥梁等方面一直保持领先的技术优势,并于2016年成立了院士专家工作站集团一直注重规划在整个设计链条中的战略地位,随着时代发展愈发重视,更将其提升至集团重点业务,并以自身之实力扶持公司成长。因此公司成立至今不过短短两载,但依托集团支持,开拓城乡市场、广纳四海英才、研发实用技术等举措,现已走上一条稳定发展的道路1月底本刊记者来到北京中铁设计大厦,专访了中铁设计规划公司郑晓龙董事长,郑先生将公司的源起、发展、前景娓娓道来,平实简洁的言语间透着对当下发展的坚信与似锦前程的期待。

关键词：郑晓龙董事长城市轨道交通规划设计

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Multivariable identification of membrane fouling based on compacted cascade neural network

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Chinese Journal of Chemical Engineering 2023年第1期53卷 37-45页

作者： Kun Ren zheng Jiao xiaolong Wu Honggui Han Faculty of Information Technology Beijing University of TechnologyBeijing 100124China Engineering Research Center of Digital Community Ministry of EducationBeijing 100124China Beijing Key Laboratory of Computational Intelligence and Intelligent System Beijing 100124China

The membrane fouling phenomenon,reflected with various fouling characterization in the membrane bioreactor(MBR)process,is so complicated to distinguish.This paper proposes a multivariable identification model(MIM)based on a compacted cascade neural network to identify membrane fouling accurately.Firstly,a multivariable model is proposed to calculate multiple indicators of membrane fouling using a cascade neural network,which could avoid the interference of the overlap inputs.Secondly,an unsupervised pretraining algorithm was developed with periodic information of membrane fouling to obtain the compact structure of MIM.Thirdly,a hierarchical learning algorithm was proposed to update the parameters of MIM for improving the identification accuracy online.Finally,the proposed model was tested in real plants to evaluate its efficiency and effectiveness.Experimental results have verified the benefits of the proposed method.

关键词： Membrane fouling Permeability Cascade neural networks Model Prediction

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Biological mechanisms and clinical efficacy of sulforaphane for mental disorders

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General Psychiatry 2022年第2期35卷 79-84页

作者： Wensi zheng xiaolong Li Tianhong Zhang Jijun Wang Shanghai Key Laboratory of Psychotic Disorders Shanghai Jiao Tong University School of Mental Health CenterShanghai MedicineShanghaiChina Shenzhen R&D Center Shenzhen Fushan BiotechShenzhenChina

Current clinical management of major mental disorders,such as autism spectrum disorder,depression and schizophrenia,is less than optimal.Recent scientific advances have indicated that deficits in oxidative and inflammation systems are lessthanoptimal.Recentscientific advances have indicated extensively involved in the pathogenesis of these disorders. These findings have led to expanded considerations for treatment.Sulforaphane(SFN)is a dietary phytochemical extracted from cruciferous vegetables.It is an effective activator of the transcription factor nuclear erythroid-2 like factor-2,which can upregulate multiple antioxidants and protect neurons against various oxidative damages.On the other hand,it can also significantly reduce inflammatory response to pathological states and decrease the damage caused by the immune response via the nuclear factor-kB pathway and other pathways.In this review,we introduce the biological mechanisms of SFN and the pilot evidence from its clinical trials of major mental disorders,hoping to promote an increase in psychiatric clinical studies of SFN.

关键词： SFN mechanisms expanded

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Radar fast long-time coherent integration via TR-SKT and robust sparse FRFT

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Journal of Systems Engineering and Electronics 2023年第5期34卷 1116-1129页

作者： CHEN xiaolong GUAN Jian zheng Jibin ZHANG Yue YU Xiaohan Naval Aviation University Yantai 264001China National Laboratory of Radar Signal Processing Xidian UniversityXi’an 710071China School of Electronic and Communication Engineering Sun Yat-Sen UniversityGuangzhou 510000China Unit 91977 of the PLA Beijing 100036China

Long-time coherent integration(LTCI)is an effective way for radar maneuvering target detection,but it faces the problem of a large number of search parameters and large amount of calculation.Realizing the simultaneous compensation of the range and Doppler migrations in complex clutter back-ground,and at the same time improving the calculation efficiency has become an urgent problem to be solved.The sparse transformation theory is introduced to LTCI in this paper,and a non-parametric searching sparse LTCI(SLTCI)based maneuvering target detection method is proposed.This method performs time reversal(TR)and second-order Keystone transform(SKT)in the range frequency&slow-time data to complete high-order range walk compensation,and achieves the coherent integra-tion of maneuvering target across range and Doppler units via the robust sparse fractional Fourier transform(RSFRFT).It can compensate for the nonlinear range migration caused by high-order motion.S-band and X-band radar data measured in sea clutter background are used to verify the detection performance of the proposed method,which can achieve better detection performance of maneuvering targets with less computational burden compared with several popular integration methods.

关键词： radar maneuvering target detection sea clutter long-time coherent integration(LTCI) sparse transformation time reversal(TR) second-order Keystone transform(SKT)

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One-Pot Three-Component Synthesis of 2-Methyl-3-aminobenzofurans Using Calcium Carbide as a Concise Solid Alkyne Source

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Chinese Journal of Chemistry 2021年第11期39卷 2990-2994页

作者： xiaolong Ma Zhiqiang Wang Zhenrong Liu zheng Li College of Chemistry and Chemical Engineering Northwest Normal UniversityLanzhouGansu730070 China

A one-pot three-component method for the synthesis of 2-methyl-3-aminobenzofurans using calcium carbide as a concise solid alkyne source,and salicylaldehydes and secondary amines as starting materials is described.This protocol has salient feature of the use of inexpensive,abundant and easy-to-handle alkyne source,avoiding the use of inflammable and explosive acetylene gas as an original alkyne source.In addition,step economy,satisfactory yield,and simple work-up procedure are also advantages of this route.

关键词： Cyclization Multicomponent reactions Synthetic methods Calcium carbide Alkyne source Benzofuran

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Platform governance in the era of AI and the digital economy

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Frontiers of Engineering Management 2023年第1期10卷 177-182页

作者： xiaolong zheng Gang ZHOU Daniel Dajun ZENG The State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence Chinese Academy of SciencesBeijing 100190China

1 Introduction Companies that supply online services such as Twitter,Weibo,and Taobao are known as platform companies(Gorwa,2019).Many top companies offer their services through platforms and use Internet technology to facilitate economic transactions,transmit information,connect people,and make predictions(Fenwick et al.,2019).Such platforms cover all areas of society,including politics(Gillespie,2017),labor relations,cultural production(Scholz,2016;van Doorn,2017),and consumption(Nieborg and Poell,2018).The rapid development of Internet technology has increased the influence of network platforms.Such platforms have changed the rules of global business operations and influenced the global political landscape.Following some high-profile negative events,calls for strengthening the regulation of online platforms and holding them accountable have been growing(Suzor,2019).

关键词： companies services operations

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Insight into macroscale superlubricity of polyol aqueous solution induced by protic ionic liquid

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Friction 2022年第12期10卷 2000-2017页

作者： Zhiwen zheng xiaolong LIU Hongxiang YU Haijie CHEN Dapeng FENG Dan QIAO State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Currently,macroscale liquid superlubricity remains limited to low applied loads and typical ceramic friction pairs.In this study,a robust macroscale superlubricity with a coefficient of friction(COF)of approximately 0.006 is realized at the bearing steel interface induced by protic ionic liquids(ILs)in propylene glycol aqueous solution,and the lubrication system exhibits excellent anti-corrosion properties.Results show that superlubricity can be achieved by employing ILs with longer alkyl chains over a wide load(700 r/min)range.By systematically investigating factors affecting superlubricity,including the IL structure,ionization degree,test conditions,polyol,water-to-alcohol ratio,and lubrication state,the superlubricity mechanism is discussed.Notably,a thicker and denser stern layer can be formed using ILs with longer alkyl chains,which participates in the tribochemical reaction with the metal substrate to form a tribofilm during rubbing.The hydrogen bond network layer formed by the hydrogen ion and polycol aqueous solution can withstand high applied loads.Water can be used to reduce the shear stress of polyols,and enable superlubricity to be achieved under high-speed rotations.Moreover,an inevitable running-in period serves as a dispersing contact stress and dynamically forms a lubricating film,where the lubrication state locates mixed lubrication and then transforms into boundary lubrication as the roughness of the contact surface increases.This study is expected to significantly promote the development and application of superlubricity in the engineering field.

关键词： macroscale superlubricity ionic liquids(ILs) steel interface corrosion tribochemical reaction

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