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图书馆建设 2011年第3期 96-98,102页

作者：郑小红汕头市龙湖区图书馆广东汕头515041

新生代外来工渴望获取知识和技能培训,渴求充实的精神生活和健康心理。公共图书馆作为公益性文化机构,有责任破除自我封闭的服务倾向,依照柔性服务的要求和平等开放的原则,优化服务工具和手段,提高服务时效,提供多元化服务项目,延伸服... 详细信息

新生代外来工渴望获取知识和技能培训,渴求充实的精神生活和健康心理。公共图书馆作为公益性文化机构,有责任破除自我封闭的服务倾向,依照柔性服务的要求和平等开放的原则,优化服务工具和手段,提高服务时效,提供多元化服务项目,延伸服务范围,增强馆员的人性化服务意识和社会化服务意识,把握新生代外来工的心理需求和偏好,改善他们的文化生态环境,扩大图书馆的服务能力和社会影响力。

关键词：公共图书馆新生代外来工柔性服务

Transfer learning enhanced graph neural network for aldehyde oxidase metabolism prediction and its experimental application

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Acta Pharmaceutica Sinica B 2024年第2期14卷 623-634页

作者： Jiacheng Xiong Rongrong Cui Zhaojun Li Wei Zhang Runze Zhang Zunyun Fu xiaohong Liu zhenghao Li Kaixian Chen Mingyue zheng Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China College of Computer and Information Engineering Dezhou UniversityDezhou 253023China AI Department Suzhou Alphama Biotechnology Co.Ltd.Suzhou 215000China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and TechnologyShanghaiTech UniversityShanghai 200031China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Aldehyde oxidase(AOX)is a molybdoenzyme that is primarily expressed in the liver and is involved in the metabolism of drugs and other ***-mediated metabolism can result in unexpected outcomes,such as the production of toxic metabolites and high metabolic clearance,which can lead to the clinical failure of novel therapeutic *** models can assist medicinal chemists in rapidly evaluating the AOX metabolic risk of compounds during the early phases of drug discovery and provide valuable clues for manipulating AOX-mediated metabolism *** this study,we developed a novel graph neural network called AOMP for predicting AOX-mediated *** integrated the tasks of metabolic substrate/non-substrate classification and metabolic site prediction,while utilizing transfer learning from 13C nuclear magnetic resonance data to enhance its performance on both *** significantly outperformed the benchmark methods in both cross-validation and external *** AOMP,we systematically assessed the AOX-mediated metabolism of common fragments in kinase inhibitors and successfully identified four new scaffolds with AOX metabolism liability,which were validated through in vitro ***,for the convenience of the community,we established the first online service for AOX metabolism prediction based on AOMP,which is freely available at https://***.

关键词： Drugmetabolism Aldehyde oxidase Transferlearning Graph neural network Kinase inhibitor

Porous metal oxides in the role of electrochemical CO_(2) reduction reaction

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Journal of Energy Chemistry 2024年第1期88卷 373-398,I0009页

作者： Ziqi Zhang Jinyun Xu Yu Zhang Liping Zhao Ming Li Guoqiang Zhong Di Zhao Minjing Li Xudong Hu Wenju Zhu Chunming zheng xiaohong Sun School of Chemical Engineering and Technology Tianjin Key Laboratory of Green Chemical Technology and Process EngineeringState Key Laboratory of Separation Membrane and Membrane ProcessesTiangong UniversityTianjin 300387China School of Materials Science and Engineering Key Laboratory of Advanced Ceramics and Machining TechnologyMinistry of EducationTianjin UniversityTianjin 300072China

The global energy-related CO_(2) emissions have rapidly increased as the world economy heavily relied on fossil *** paper explores the pressing challenge of CO_(2) emissions and highlights the role of porous metal oxide materials in the electrocatalytic reduction of CO_(2)(CO_(2)RR).The focus is on the development of robust and selective catalysts,particularly metal and metal-oxide-based *** metal oxides offer high surface area,enhancing the accessibility to active sites and improving reaction *** tunability of these materials allows for tailored catalytic behavior,targeting optimized reaction mechanisms for CO_(2)*** work also discusses the various synthesis strategies and identifies key structural and compositional features,addressing challenges like high overpotential,poor selectivity,and low *** on these insights,we suggest avenues for future research on porous metal oxide materials for electrochemical CO_(2) reduction.

关键词： CO_(2)reduction Carbon dioxide Transformation Porous metal oxides Electrocatalysis

经典名方桂枝芍药知母汤沿革演变与方证信息分析

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中国实验方剂学杂志 2023年第17期29卷 174-184页

作者：郑安平郑晓红南京中医药大学中医药文献研究所南京210023

经典名方桂枝芍药知母汤作为2018年《古代经典名方目录(第一批)》中的第15首,出自东汉张仲景《金匮要略》,由桂枝、麻黄、附子、知母、芍药、白术、防风、生姜、甘草9味药组成,功用祛风除湿、散寒除痹、佐以滋阴清热,主治风寒湿侵淫兼... 详细信息

经典名方桂枝芍药知母汤作为2018年《古代经典名方目录(第一批)》中的第15首,出自东汉张仲景《金匮要略》,由桂枝、麻黄、附子、知母、芍药、白术、防风、生姜、甘草9味药组成,功用祛风除湿、散寒除痹、佐以滋阴清热,主治风寒湿侵淫兼见化热伤阴之历节、痹证、鹤膝风等病证。在“传承精华,古为今用”的号召下,立足于古今文献考证分析,厘清此方历史沿革以及组成、方义、炮制、剂量、煎服法、主治等方证关键信息。再进行现代文献统计分析时,发现临床应用桂枝芍药知母汤治疗病症广泛,主要用于风湿性疾病的风湿及类风湿性关节炎、痛风及痛风性关节炎、银屑病性关节炎等以及骨科疾病的膝骨性关节炎、强直性脊柱炎、坐骨神经痛、膝关节腔积液等疾病,亦可用于内分泌系统、妇科、呼吸系统、循环系统等其他系统疾病,病机总责风寒湿或兼热邪袭人,体现了中医异病同治的思想。采用文献统计学方法分析研究桂枝芍药知母汤的古今文献,探明其沿革演变规律及方证关键信息,以为经典名方桂枝芍药知母汤的成药研发及后续深入研究提供理论依据。

关键词：金匮要略经典名方桂枝芍药知母汤沿革演变方证信息

Influence of ground effect on flow field structure and aerodynamic noise of high-speed trains

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第2期25卷 147-160页

作者： Xiaoming TAN Linli GONG xiaohong ZHANG Zhigang YANG Key Laboratory of Intelligent Manufacturing and Service Performance Optimization of Laser and Grinding in Mechanical Industry Hunan Institute of Science and TechnologyYueyang414000China Key Laboratory of Traffic Safety on Track(Central South University) Ministry of EducationSchool of Traffic&Transportation EngineeringCentral South UniversityChangsha410075China

The simulation of the ground effect has always been a technical difficulty in wind tunnel tests of high-speed *** this paper,large eddy simulation and the curl acoustic integral equation were used to simulate the flow-acoustic field results of high-speed trains under four ground simulation systems(GSSs):“moving ground+rotating wheel”,“stationary ground+rotating wheel”,“moving ground+stationary wheel”,and“stationary ground+stationary wheel”.By comparing the fluid-acoustic field results of the four GSSs,the influence laws of different GSSs on the flow field structure,aero-acoustic source,and far-field radiation noise characteristics were investigated,providing guidance for the acoustic wind tunnel testing of high-speed *** calculation results of the aerodynamic noise of a 350 km/h high-speed train show that the moving ground and rotating wheel affect mainly the aero-acoustic performance under the train *** influence of the rotating wheel on the equivalent sound source power of the whole vehicle was not more than 5%,but that of the moving ground slip was more than 15%.The average influence of the rotating wheel on the sound pressure level radiated by the whole vehicle was 0.3 dBA,while that of the moving ground was 1.8 dBA.

关键词： High-speed train Aero-acoustics Flow field structure Large eddy simulation Moving ground condition Rotating wheel

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《黄帝内经》五运六气气化理论与天人合一

中医杂志 2019年第12期60卷 1008-1014页

作者：郑晓红南京中医药大学中医文化研究中心

认为气是天人合一的物质基础,气化是天人合一的理论依据。从五运六气,天人相应,六气属性,标本中气从化,神机气立,根结之穴,药物性味,五脏六腑,经络腧穴,脏气法时,气动于中、象形于外,体质与患病的倾向性等方面阐述了五运六气气化理论是... 详细信息

认为气是天人合一的物质基础,气化是天人合一的理论依据。从五运六气,天人相应,六气属性,标本中气从化,神机气立,根结之穴,药物性味,五脏六腑,经络腧穴,脏气法时,气动于中、象形于外,体质与患病的倾向性等方面阐述了五运六气气化理论是中医学天人合一思想的理论基础和主要载体。认为气化论是运气学说所阐述的核心,影响和促进了伤寒六经气化学说的产生和发展。

关键词：天人合一五运六气气化

Design and Control of an Autonomous Bat-like Perching UAV

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Journal of Bionic Engineering 2024年第3期21卷 1253-1264页

作者： Long Bai Wei Wang xiaohong Chen Yuanxi Sun State Key Laboratory of Mechanical Transmission Chongqing UniversityChongqing400044China

Perching allows small Unmanned Aerial Vehicles(UAVs)to maintain their altitude while significantly extending their flight duration and reducing ***,current research on flying habitats is poorly adapted to unstructured environments,and lacks autonomous capabilities,requiring ideal experimental environments and remote control by *** solve these problems,in this paper,we propose a bat-like UAV perching mechanism by investigating the bat upside-down perching method,which realizes double self-locking in the perching state using the ratchet and four-link dead point *** on this perching mechanism,this study proposes a control strategy for UAVs to track targets and accomplish flight perching autonomously by combining a binocular camera,single-point LiDAR,and pressure *** perching experiments were conducted for crossbar-type objects *** experimental results show that a multirotor UAV equipped with the perching mechanism and sensors can reliably achieve autonomous flight perching and re-flying off the target *** power consumption is reduced to 2.9%of the hovering state when perched on the target object.

关键词： Bio-inspired design Perching mechanism UAV Autonomous flight

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《伤寒论》三阴三阳与《黄帝内经》气化理论

中华中医药杂志 2023年第11期38卷 5167-5174页

作者：郑晓红南京中医药大学南京210023

《黄帝内经》对中华文明的贡献,主要表现在天人合一、道法自然的思想以及对周期性气化规律、生命规律的认识。三阴三阳表明的是气有多少,与人体的气化功能相联系;五行之治表明的是形有盛衰、太过不及,与人体的形质脏腑相联系。天地五行... 详细信息

《黄帝内经》对中华文明的贡献,主要表现在天人合一、道法自然的思想以及对周期性气化规律、生命规律的认识。三阴三阳表明的是气有多少,与人体的气化功能相联系;五行之治表明的是形有盛衰、太过不及,与人体的形质脏腑相联系。天地五行之气分别入通五藏,各以气命其藏,其作用定位在脏腑,故名“脏腑辨证”;天地三阴三阳六气分别入通六经,各以气命其经,其作用定位在六经,故名“六经辨证”。《黄帝内经》中主要有两大经络系统:天人(六经向上)循行系统,是天人感应气立循环系统,延伸包涵了十一经、十二经上行经络系统;人身(十二经贯注)循行系统,是人身气血阴阳内循环神机系统。天地与人身三阴三阳,具有气候病候的相关性、规律性。人天同虚,同气相感。如早期干预、提前纠偏补虚,可有效防止杂症重症。天地三阴三阳作用六经发病,此即《伤寒论》的外感证、表证;人身非直接外感而自身三阴三阳亦可为病,此即《伤寒论》的里证、杂证。六经辨证的实质是辨六气病机。针药的作用:一是调节人天关系,降低人对外部的敏感性、易感性;二是调节人体气血阴阳与形神能量。三阴三阳辨证贯穿着八纲而联系于经络脏腑,六经钤百病。《黄帝内经》气化理论是三阴三阳辨证的学术根基与发展源泉,深化对天地、生命气化的认识,就能通辨症外之症、证外之证,立处法外之法、方外之方。

关键词：《黄帝内经》《伤寒论》三阴三阳气化理论

Fault-tolerant identity-based encryption from SM9

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Science China(Information Sciences) 2024年第2期67卷 104-117页

作者： xiaohong LIU Xinyi HUANG Zhaohui CHENG Wei WU Fujian Provincial Key Laboratory of Network Security and Cryptology College of Computer and Cyber SecurityFujian Normal University Artificial Intelligence Thrust Information HubThe Hong Kong University of Science and Technology (Guangzhou) Olym Information Security Technology Ltd. Center for Applied Mathematics of Fujian Province School of Mathematics and StatisticsFujian Normal University

This paper initiates the formal study of attribute-based encryption within the framework of SM9,the Chinese National Cryptography Standard for Identity-Based Cryptography, by presenting two new faulttolerant identity-based encryption(FIBE) schemes. Our first scheme uses the same private-key/ciphertext structure as the original SM9 algorithm and operates in a small attribute universe. As a result, it can be effectively and smoothly integrated into the information systems using SM9. In the random oracle model,we prove that our scheme is ciphertext-indistinguishable against fuzzy selective-identity and chosen-plaintext attacks under the(k + 3)-DBDHI assumption. Our second design is a large universe FIBE scheme based on SM9 that is ciphertext-indistinguishable against chosen-plaintext attacks in the random oracle model under the(f, g)-GDDHE assumption. Finally, we compare the communication and computing costs of our schemes to those of other classical ones. The comparison shows that our schemes have comparable performance as others. We believe that our findings will accelerate the applications of SM9 in modern information systems such as cloud computing and blockchain.

关键词： attribute-based encryption identity-based encryption fault-tolerant SM9