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外泌体在糖尿病治疗中的研究进展

分析试验室 2024年第2期43卷 229-237页

作者：郑文青李优鑫天津市现代药物传递及功能高效化重点实验室天津化学化工协同创新中心天津大学药物科学与技术学院天津300072

糖尿病(DMs)是威胁人类健康的严重代谢性疾病,其发病机制尚未明确,致病原因颇多。现已有多种糖尿病治疗方案,如注射外源胰岛素、植物源性天然产物、干细胞疗法等,但均存在难以改善胰岛β细胞、生物利用度差、免疫排斥等问题,因此亟待开... 详细信息

糖尿病(DMs)是威胁人类健康的严重代谢性疾病,其发病机制尚未明确,致病原因颇多。现已有多种糖尿病治疗方案,如注射外源胰岛素、植物源性天然产物、干细胞疗法等,但均存在难以改善胰岛β细胞、生物利用度差、免疫排斥等问题,因此亟待开发更加安全有效的治疗方案。外泌体(Exosomes)作为一种细胞分泌的囊泡,含有细胞内所有重要物质,且参与细胞间信息与物质传递,随着间充质干细胞等糖尿病有效治疗方案的逐步问世,同时包含多类同类物质的外泌体在糖尿病治疗中的潜力也逐步凸显,其可以通过多种途径同时降糖的作用被报道。本文综述了近十几年外泌体在Ⅰ型糖尿病(T1DM)与Ⅱ型糖尿病(T2DM)中的治疗方案,并介绍了其分子机制与具体治疗作用,以便为促进外泌体治疗策略在临床中的落实和应用提供参考。

关键词：外泌体糖尿病胰岛素抵抗胰岛β细胞受损胰岛移植免疫抑制

具有分段常数参数的Cohen-Grossberg神经网络的全局指数稳定

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湖北师范大学学报（自然科学版） 2024年第1期44卷 9-15页

作者：谢涛郑文晴湖北师范大学数学与统计学院湖北黄石435002

主要研究了具有分段常数参数的Cohen-Grossberg神经网络的全局指数稳定性,得到了保证平衡点的存在唯一性的充分条件,通过线性不等式方法,并构造适当的李雅普诺夫泛函,提出了系统的平衡点的全局指数稳定性的判据,最后给了一个数值例子验... 详细信息

主要研究了具有分段常数参数的Cohen-Grossberg神经网络的全局指数稳定性,得到了保证平衡点的存在唯一性的充分条件,通过线性不等式方法,并构造适当的李雅普诺夫泛函,提出了系统的平衡点的全局指数稳定性的判据,最后给了一个数值例子验证所得结果的有效性。

关键词： Cohen-Grossberg神经网络分段常数参数李雅普诺夫函数全局指数稳定性

Analytic solution of quasicrystal microsphere considering the thermoelectric effect and surface effect in the elastic matrix

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Applied Mathematics and Mechanics(English Edition) 2023年第8期44卷 1331-1350页

作者： Yunzhi HUANG wenqing zheng Xiuhua CHEN Miaolin FENG Department of Engineering Mechanics School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Marine Design and Research Institute of China Shanghai 200011China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China

The incorporation of the quasicrystalline phase into the metal matrix offers a wide range of potential applications in particle-reinforced metal-matrix *** analytic solution of the piezoelectric quasicrystal(QC)microsphere considering the thermoelectric effect and surface effect contained in the elastic matrix is presented in this *** governing equations for the QC microsphere in the matrix subject to the external electric loading are derived based on the nonlocal elastic theory,electro-elastic interface theory,and eigenvalue method.A comparison between the existing results and the finite-element simulation validates the present *** examples reveal the effects of temperature variation,nonlocal parameters,surface properties,elastic coefficients,and phason coefficients on the phonon,phason,and electric *** results indicate that the QC microsphere enhances the mechanical properties of the *** results are useful for the design and understanding of the characterization of QCs in micro-structures.

关键词： quasicrystal(QC)microsphere thermoelectric effect surface effect

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面向制造和装配的箱体类零件设计开发

中国高新科技 2024年第10期 13-15页

作者：郑文清竭尽超上汽通用五菱汽车股份有限公司广西柳州545000

箱体类零件作为产品的主体结构,将直接影响产品性能、寿命、体验、成本等核心竞争力。在竞争日趋激烈的现代制造业,优秀的设计决定了产品的上限。文章针对箱体类零件的设计面向制造和装配,将制造风险的规避、贯彻先进柔性制造、降低产... 详细信息

箱体类零件作为产品的主体结构,将直接影响产品性能、寿命、体验、成本等核心竞争力。在竞争日趋激烈的现代制造业,优秀的设计决定了产品的上限。文章针对箱体类零件的设计面向制造和装配,将制造风险的规避、贯彻先进柔性制造、降低产品成本等可操作性强的设计理念进行综合分析与应用,在有限的设计周期内最大化产品力。

关键词：设计面向制造设计面向装配箱体类零件产品设计清洁度柔性制造

Deep Learning Based 2D Human Pose Estimation:A Survey

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Tsinghua Science and Technology 2019年第6期24卷 663-676页

作者： Qi Dang Jianqin Yin Bin Wang wenqing zheng School Beijing University of Posts and TelecommunicationsBeijing 100876China State Key Lab.of Intelligent Technology and Systems Tsinghua UniversityBeijing 100084China School of Information and Communication Engineering Beijing University of Posts and Telecommunications Beijing 100876China

Human pose estimation has received significant attention recently due to its various applications in the real world. As the performance of the state-of-the-art human pose estimation methods can be improved by deep learning, this paper presents a comprehensive survey of deep learning based human pose estimation methods and analyzes the methodologies employed. We summarize and discuss recent works with a methodologybased taxonomy. Single-person and multi-person pipelines are first reviewed separately. Then, the deep learning techniques applied in these pipelines are compared and analyzed. The datasets and metrics used in this task are also discussed and compared. The aim of this survey is to make every step in the estimation pipelines interpretable and to provide readers a readily comprehensible explanation. Moreover, the unsolved problems and challenges for future research are discussed.

关键词： human pose estimation deep learning computer vision

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大型薄膜型LNG船疲劳强度分析

舰船科学技术 2024年第15期46卷 9-15页

作者：张玉奎郑文青高明星陈倩陈莹俞佳妮中国船舶及海洋工程设计研究院上海200011

以某17.5×10^(4)m^(3)LNG船的结构设计为例,采用谱分析法对全船典型结构进行疲劳强度分析。针对LNG船的满载和压载2种常用航行载况,分别建立全船有限元模型和水动力模型。利用三维水动力软件计算在多个浪向、波浪频率的规则波上的波浪... 详细信息

以某17.5×10^(4)m^(3)LNG船的结构设计为例,采用谱分析法对全船典型结构进行疲劳强度分析。针对LNG船的满载和压载2种常用航行载况,分别建立全船有限元模型和水动力模型。利用三维水动力软件计算在多个浪向、波浪频率的规则波上的波浪载荷,进一步求得结构的应力传递函数。根据Miner线性累计损伤理论,选用北大西洋波浪散布图和适当的S-N曲线,计算结构的疲劳损伤。除了计算波浪诱导的高周疲劳损伤,还通过简化算法计算装货/卸货诱导的低周疲劳损伤。评估结果表明,部分结构可以通过适当增加结构尺寸和优化结构型式以满足NA40年的设计要求,但也有少量位置需要打磨。基于实船的设计过程,通过和船东、船级社紧密沟通,对建造需求和规范条文有较深入的理解,对大型LNG船设计有较高的参考价值。

关键词： LNG船薄膜型疲劳强度谱分析法简化算法

Fe-doped NiCo_(2)O_(4)hollow hierarchical sphere as an efficient electrocatalyst for oxygen evolution reaction

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Frontiers of Materials Science 2021年第4期15卷 577-588页

作者： wenqing zheng Han SUN Xinping LI Shu ZHANG Zhuoxun YIN Wei CHEN Yang ZHOU College of Chemistry and Chemical Engineering Qiqihar UniversityQiqihar 161006China Heilongjiang Provincial Key Laboratory of Catalytic Synthesis for Fine Chemicals Qiqihar 161006China College of Science Qiqihar UniversityQiqihar 161006China

We prepared porous Fe-doped nickel cobaltate(Fe-NiCo_(2)O_(4))hollow hierarchical nanospheres through a facile self-templated synthetic *** to the porous hollow structure and composition,the Fe-NiCo_(2)O_(4)presented vastly superior electrocatalytic activity for the oxygen evolution reaction(OER),compared with NiCo_(2)O_(4)and the majority of other OER *** an aim of stimulating a current density of 10 mA$cm-2,the Fe-NiCo_(2)O_(4)catalyst needs an overpotential of 210 mV,which is on a par with the general properties of commercial *** addition,the Fe-NiCo_(2)O_(4)catalyst performed stably in long-term *** excellent activity and long-term stability showed that such catalysts have great promise for widespread application in the field of water splitting.

关键词： ion exchange hierarchical nanostructure electronic structure transfer oxygen evolution reaction water splitting

Needs and challenges of optical atmospheric monitoring on the background of carbon neutrality in China

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 49-62页

作者： wenqing Liu Chengzhi Xing Anhui Institute of Optics and Fine Mechanics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 23001China

The achievement of the targets of coordinated control of PM2.5 and O3 and the carbon peaking and carbon neutrality depend on the development of pollution and greenhouse gas monitoring *** monitoring technology,based on its technical characteristics of high scalability,high sensitivity and wide-targets detection,has obvious advantages in pollution/greenhouse gases monitoring and has become an important direction in the development of environmental monitoring *** present,a system of environmental optical monitoring technology with differential optical absorption spectroscopy(DOAS),cavity ring-down spectroscopy(CRDS),light detection and ranging(LIDAR),laser heterodyne spectroscopy(LHS),tunable diode laser absorption spectroscopy(TDLAS),fourier transform infrared spectroscopy(FTIR)and fluorescence assay by gas expansion(FAGE)as the main body has been ***,with the promotion of“reduction of pollution and carbon emissions”strategy,there have been significant changes in the sources of pollution/greenhouse gases,emission components and emission concentrations,which have put forward new and higher requirements for the development of monitoring *** the future,we should pay more attention to the development of new optical monitoring techniques and the construction of stereoscopic monitoring system,the interdisciplinarity(among mathematics,physics,chemistry and biology,etc.),and the monitoring of greenhouse gases and research on atmospheric chemistry.

关键词： Pollution Greenhouse gas Optical atmospheric monitoring Needs and challenges

Optimal Nonlinear Robust Sliding Mode Control of an Excitation System Based on Mixed Linear H_(2)/H_(∞) Matrix Inequalities

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Protection and Control of Modern Power Systems 2024年第4期9卷 1-22页

作者： Yidong Zou Yunhe Wang Jinbao Chen wenqing Hu Yang zheng Wenhao Sun Zhihuai Xiao the School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China

In this paper,an optimal nonlinear robust sliding mode control(ONRSMC)based on mixed H_(2)/H_(∞)linear matrix inequalities(LMIs)is designed for the excitation system in a“one machine-infinite bus system”(OMIBS)to enhance system ***,the direct feedback linearization method is used to establish a mathematical model of the OMIBS incorporating *** is then designed for this model,employing the mixed H_(2)/H_(∞)*** chaos mapping-based adaptive salp swarm algorithm(CASSA)is introduced to fully optimize the parameters of the sliding mode control,ensuring optimal performance under a specified *** demonstrates rapid convergence and reduced like-lihood of falling into local optima during ***,ONRSMC is obtained through inverse transformation,exhibiting the advantages of simple structure,high reliability,and independence from the accuracy of system *** simulation scenarios are employed to validate the effectiveness and robustness of ONRSMC,including mechanical power variation,generator three-phase short circuit,transmission line short circuit,and generator parameter *** results indicate that ONRSMC achieves optimal dynamic performance in various operating conditions,facilitating the stable operation of power systems following faults.

关键词： Excitation sliding mode linear matrix inequality salp swarm algorithm