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Efficacy and safety of Cimicifuga foetida extract on menopausal syndrome in Chinese women

Chinese Medical Journal 2013年第11期126卷 2034-2038页

作者： zheng ting-ping SUN Ai-jun XUE Wei WANG Ya-ping JIANG Ying ZHANG Ying LANG Jing-he Department of Obstetrics and Gynecology Peking Union MedicalCollege Hospital Chinese Academy of Medical Sciences & PekingUnion Medical College Beijing 100730 China

Background It is now recognized that Cimicifuga foetida extract is effective in alleviating menopausal symptoms. But the durations reported were usually short. This paper compares the clinical effects of different regimens of three-month course on climacteric symptoms in Chinese women, so as to evaluate the efficacy and safety of Cimicifuga foefida extract. Methods This was a prospective, randomized trial. Ninety-six early menopausal women were recruited and randomly assigned into 3 groups to take different kinds of medicine for 3 months; participants were given Cimicifuga foefida extract daily in group A （n=32）, given estradiol valerate and progesterone capsule cycle sequentially in group B （n=32）, and given estradiol valerate and medroxyprogesterone acetate cycle sequentially in group C （n=32）. The questionnaires of Kupperman menopause index, Menopause-Specific Quality of Life, and Hospital Anxiety and Depression Scale were finished before and after the treatment. The status of vaginal bleeding and breast tenderness was recorded every day. Results Eighty-nine participants （89/96, 92.7%） completed the treatment. Kupperman menopause index decreased after taking the medicine for 3 months in each group （with all P〈0.001）, but the score after the treatment was higher in group A than in the other 2 groups. Except for the score of sexual domain in group A （P=0.103）, the scores of all domains of the Menopause-Specific Quality of Life decreased significantly after the treatment in all groups （with all P〈-0.01）. Score of anxity decreased significantly in group A （P=0.0l 5） and B （P=0.003）. Incidence of breast tenderness was 12.9% （4/31） in groupA, 36.7% （11/30） in group B, and 14.3% （4/28） in group C. Incidence of vaginal bleeding was 6.5% （2/31）in group A, 26.7% （8/30） in group B, and 82.1% （23/28）in group C. Conclusions Cimicifuga foeticla extract is effective and safe in the treatment of menopausal syndrome. It is worth extending its use in the treatment of climacteric c

关键词： Cimicifuga foetida extract menopause Kupperman menopause index menopause-specific quality of life vaginal bleeding breast tenderness

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A Multi-center,Randomized,Controlled and Open Clinical Trial of Heyan Kuntai Capsule (和颜坤泰胶囊) and Hormone Therapy in Perimenopausal Women

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Chinese Journal of Integrative Medicine 2018年第7期24卷 487-493页

作者： SUN Ai-jun WANG Ya-ping GU Bei zheng ting-ping LIN Shou-qing BAI Wen-pei WEI Yang ZHANG Shao-fen ZHANG Ying Department of Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Obstetrics and Gynecology Beijing Shijitan Hospital Department of Gynecology Obstetrics and Gynecology Hospital of Fudan University

Objective： To evaluate the efficacy and safety of Heyan Kuntai Capsule（和颜坤泰胶囊, HYKT） and hormone therapy（HT） on perimenopausal syndromes（PMSs）. Methods： From 2005 to 2008, 390 women with PMSs were recruited from 4 clinic centers. The inclusion criteria included ages 40 to 60 years, estradiol（E2） below 30 ng/L, and follicle stimulating hormone（FSH） above 40 IU/L, etc. The patients were randomly assigned to HYKT group or HT group by random number table method, administrated HYKT or conjugated estrogen with/without medroxyprogesterone acetate tablets for 12 months. During treatment, the patients were interviewed quarterly, Kupperman Menopausal Index（KMI） scores, hot flush scores, insomnia scores, Menopause-Specific Quality of Life（MENQOL） scores and adverse effects were used for evaluating drug efficacy and safety respectively. The last interview was made at the end of 12-month treatment. Results： After treatment, KMI scores of HYKT group and HT group were both significantly decreased compared with baseline（P〈0.01） and there was no significant difference between groups（P〉0.05）, except that KMI of HYKT group was higher after 3-month treatment（P〈0.05）. After treatment, hot flush and insomnia scores were both improved significantly in two groups（P〈0.01）; and HT had a better performance than HYKT in improving hot flush（P〈0.05）. MENQOL were significantly improved in both groups after treatment（P〈0.01）; but there was no significant difference between two groups（P〉0.05）. The incidence of adverse event in the HYKT group was much lower than that in the HT group（P〈0.01）. Conclusions： HYKT could effectively relieve PMSs and improve patient quality of life without severe adverse reactions. Although HYKT exerted curative effects more slowly than hormone, it possessed better safety profile than hormone.

关键词： perimenopausal syndromes Heyan Kuntai Capsule hormone therapy Kupperman Menopausal Index Menopause-Specific Quality of Life Chinese medicine

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How to determine the dosage of oral progesterone among patients with menstrual disorders？

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Chinese Medical Journal 2012年第11期125卷 1970-1974页

作者： zheng ting-ping SUN Ai-jun WANG Ya-ping XUE Wei JIANG Ying ZHANG Ying CHEN Rong JIN Li-na LANG Jing-he Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China School of Medicine Shandong University Jinan Shandong 250012 China

Background Few studies have given suggestions on appropriate individual progesterone dosage in patients with progesterone deficiency. This study was designed to provide a reference for the clinical use of oral progesterone by exploring the relationship among Body Mass Index （BMI）, dosage of progesterone, and serum progesterone concentration. Many gynecology and obstetrics doctors are unfamiliar with progesterone treatment. Our study is intended to help determine the dosage of oral progesterone. Methods This was a block randomized, open-label, prospective clinical trial. Eighty women undergoing cessation of menses were recruited, given oral progesterone therapy for 10 consecutive days. They were randomly assigned to four groups （four different doses of progesterone, n=20）： group A 100 rag/d, group B 200 rag/d, group C 300 mg/d, and group D 400 mg/d. Results Seventy-four patients （92.5%, 74/80） completed the study. It was observed that administration of progesterone significantly increased serum progesterone concentration in the four groups （all P 〈0.001）. And there is a positive correlation between the increase and dosage （rp=0.613, P 〈0.001）. A further linear regression analysis found the major regression equation： when 18.5 kg/m^2 -≤BMI 〈24 kg/m^2, Y=8.4820×10^0.003x （R^2=0.425, P 〈0.001）; Y was the increase of serum progesterone concentration in nmol/L, and X was the dosage of oral progesterone in mg/d. Conclusions Serum progesterone levels went up linearly as the dosage increased. The higher the patient＇s BMI, the higher dosage would be needed to achieve the same serum progesterone for different patients can be roughly calculated progesterone concentration. The appropriate dosage of ora in light of the results of this study.

关键词： optimal dosage ofprogesterone body mass index, progesterone deficiency

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Insulin Resistance in Polycystic Ovary Syndrome Improved by Chinese Medicine Dingkun Pill(定坤丹):A Randomized Controlled Clinical Trial

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Chinese Journal of Integrative Medicine 2019年第4期25卷 246-251页

作者： DENG Yan XUE Wei WANG Yan-fang LIU Xiao-hui ZHU Shi-yang MA Xiao ZUO Hong-ling JIANG Jian-fa zheng ting-ping SUN Ai-jun Department of Obstetrics and Gynecology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical Sciences Technology Center for Protein Sciences School of Life SciencesTsinghua University Department of Obstetrics and Gynecology The Second Hospital of Hebei Medical University Department of Obstetrics and Gynecology Third Xiangya HospitalCentral South University Department of Obstetrics and Gynecology Beijing Chaoyang Hospital Affiliated of Capital Medical University

Objective: To assess the ef?cacy and safety of the Chinese medicine Dingkun Pill(定坤丹,DKP) on insulin resistance in women with polycystic ovary syndrome(PCOS).Methods: A total of 117 women with PCOS were randomly assigned to Group A(38 women),Group B(40 women),or Group C(39 women) in a randomization sequence with SAS software and a 1:1:1 allocation ratio using random block sizes of 6,and were given 7 g of oral DKP daily(Group A),1 tablet of Diane-35 orally daily(Group B),or 7 g of oral DKP daily plus 1 tablet of Diane-35 orally daily(Group C).Patients took all drugs cyclically for 21 consecutive days,followed by 7 drug-free *** treatment course for the 3 groups was continued for 3 consecutive *** glucose tolerance tests(OGTT)were performed before treatment and again after 2 and 3 months of therapy,respectively,and homeostasis model assessment for insulin resistance(HOMA-IR) and quantitative insulin sensitivity check index(QUICKI) were ***: Of 117 women with PCOS,110 completed the entire course of therapy: 35 in Group A,36 in Group B,and 39 in Group *** treatment,all three groups showed signi?cant decreases in fasting glucose: at1 h glucose decreased signi?cantly in Group A(by 0.5±1.4 mmol/L,P=0.028) and Group C(by 0.5±1.2 mmol/L,P=0.045); while showing a tendency to increase in Group B(by 0.4±1.9 mmol/L,P=0.238).HOMA-IR decreased signi?cantly in Group C [by 0.5(–2.2 to 0.5) m IU mmol/L2,P=0.034].QUICKI was signi?cantly increased in Groups A and C(by 0.009±0.02,P=0.033 and by 0.009±0.027,P=0.049,respectively),while no change was observed in Group ***-measure ANOVA showed that the absolute changes in all parameters(except for glucose at1 h),including glucose and insulin levels at all time-points during OGTT and in HbA1 c,HOMA-IR,and QUICKI,were not signi?cantly different among the 3 groups after treatment(P>0.05).Conclusion: DKP or DKP combined with Diane-35 produce a slight improvement in insulin sensitivity compared with Diane-3

关键词： Diane-35 Dingkun Pill Chinese medicine polycystic ovary syndrome oral glucose tolerance tests insulin resistance

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吴城鄱阳湖自然保护区鱼体重金属的富集及安全性评价

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水生生物学报 2017年第4期41卷 878-883页

作者：涂宗财庞娟娟郑婷婷唐平平王辉张露沙小梅陈雪岚江西师范大学生命科学学院功能有机小分子教育部重点实验室南昌330022 南昌大学食品科学与技术国家重点实验室南昌330047

为研究吴城鄱阳湖自然保护区鱼类重金属的污染情况,以鄱阳湖吴城6种常见淡水鱼(鲤、鳙、鲢、草鱼、青鱼、鳊)为研究对象,分别研究鱼心脏、肝脏、鳃丝和肌肉等部位中铜、锌、铅、镉4种重金属的富集情况,并采用目标危险系数(THQ)评价其健... 详细信息

为研究吴城鄱阳湖自然保护区鱼类重金属的污染情况,以鄱阳湖吴城6种常见淡水鱼(鲤、鳙、鲢、草鱼、青鱼、鳊)为研究对象,分别研究鱼心脏、肝脏、鳃丝和肌肉等部位中铜、锌、铅、镉4种重金属的富集情况,并采用目标危险系数(THQ)评价其健康风险。结果显示,重金属元素在鱼体不同器官中的富集程度不同,Cd在肝脏中的含量最高,Cu在肝脏和心脏中的含量最高,Pb在肝脏中的富集含量最低,Zn在各器官的总体含量要高于其他3种元素。4种重金属在鱼肌肉中的含量均符合国内外标准。目标危险系数(THQ)分析结果表明,Pb导致的健康风险最高,Cd最低,单一重金属THQ值和复合重金属TTHQ值均小于1,说明吴城鄱阳湖自然保护区鱼类重金属的污染程度较低,不会对消费者健康产生潜在危害。

关键词：吴城鄱阳湖自然保护区淡水鱼重金属富集安全性评价

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Magnitude and uniformity improvement of the received optical power for an indoor VLC system jointly assisted by angle-diversity transceivers and STAR-IRS

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Optoelectronics Letters 2025年

作者： YANG ting WANG ping HE Huimeng XIONG Yingfei SUN Yanzhe LIU Qi School of Telecommunications Engineering， Xidian University

To improve the quality of the illumination distribution， one novel indoor visible light communication (VLC) system， which is jointly assisted by the angle-diversity transceivers and simultaneous transmission and reflection-intelligent reflecting surface (STAR-IRS)， has been proposed in this work. A Harris Hawks optimizer algorithm (HHOA)-based two-stage alternating iteration algorithm (TSAIA) scheme is presented to jointly optimize the magnitude and uniformity of the received optical power. Besides， to demonstrate the superiority of the proposed strategy， several benchmark schemes are simulated and compared. Results showed that compared to other optimization strategies， the TSAIA scheme is more capable of balancing the average value and variance of the received optical power when the maximal ratio combining (MRC) strategy is adopted at the receiver. Moreover， as the number of the STAR-IRS elements increases， the optical power variance of the system optimized by TSAIA scheme would become smaller while the average optical power would get larger. This study will benefit the design of received optical power distribution for indoor VLC systems.

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生物电Fenton系统对餐饮含油废水处理研究

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工业水处理 2017年第10期37卷 78-81页

作者：韩英杰杜英才张吉强陈婷郑平滨州学院资源环境系山东滨州256603 浙江大学环境工程系浙江杭州310058 山东省核与辐射安全监测中心山东济南250117

利用生物电Fenton系统对某高校食堂的餐饮含油废水进行处理,探讨了系统对餐饮含油废水的处理性能,考察了温度、阴极液初始pH和阴极曝气量等因素对系统性能的影响,并进行了工艺条件优化。结果表明,系统运行的最佳工艺条件:温度35℃,阴极... 详细信息

利用生物电Fenton系统对某高校食堂的餐饮含油废水进行处理,探讨了系统对餐饮含油废水的处理性能,考察了温度、阴极液初始pH和阴极曝气量等因素对系统性能的影响,并进行了工艺条件优化。结果表明,系统运行的最佳工艺条件:温度35℃,阴极液初始pH=3,阴极曝气量0.2 L/min。在最佳工艺条件下,阳极COD去除率、阴极油去除率和输出电压分别达到91.1%、95.3%和431.9 m V。

关键词：生物电Fenton 餐饮含油废水废水处理

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32例XO/XY性腺发育不全临床特点分析

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中国医学科学院学报 2016年第4期38卷 411-414页

作者：蒋建发田秦杰薛薇邓燕郑婷萍孙爱军中国医学科学院北京协和医学院北京协和医院妇产科北京100730

目的探讨XO/XY性腺发育不全的临床特点,以提高其临床认识及诊治。方法回顾性分析2008年1月至2015年5月北京协和医院收治的XO/XY性腺发育不全患者的临床资料。结果 32例患者社会性别均为女性,年龄6～33岁,主要以无自主月经或身材矮小就... 详细信息

目的探讨XO/XY性腺发育不全的临床特点,以提高其临床认识及诊治。方法回顾性分析2008年1月至2015年5月北京协和医院收治的XO/XY性腺发育不全患者的临床资料。结果 32例患者社会性别均为女性,年龄6～33岁,主要以无自主月经或身材矮小就诊。平均身高（144.54±13.90）cm,多伴有特纳综合征典型体征。患者中27例（84.38%）乳房发育未达Ⅲ级、28例（87.5%）腋毛稀疏或无、26例（81.25%）阴毛稀疏或无、18例（56.25%）外阴发育幼稚、5例（15.63%）阴蒂增大。卵泡刺激素平均为（78.56±35.62）m IU/ml,黄体生成素为（20.23±11.35）m IU/ml,雌二醇为（9.94±8.21）pg/ml,睾酮为（0.24±0.18）ng/ml。所有患者均行性腺切除术,病理提示性腺分化形式多样,其中4例发生肿瘤。结论 XO/XY性腺发育不全主要表现为原发闭经或身材矮小,第二性征发育差,促性腺激素水平升高,性腺有恶变风险。

关键词：性腺发育不全 45,X/46,XY 临床特点

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出口型菜薹新品种超杂13号的选育

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中国蔬菜 2011年第4期 88-90页

作者：高灿红周凯徐福乐沈吉昌郑廷平福建超大现代种业有限公司福建福州350003 福建超大现代农业科技研究所福建福州350003

超杂13号是以核不育系GMS0807为母本,以自交系9909为父本配制而成的菜薹一代杂种,该品种生长势强、株型直立紧凑;株高约30.3cm,开展度23.2cm,菜薹紧实匀称、油绿有光泽;主薹高20～26cm,横径1.2～1.8cm,单株质量40～60g;中熟,播种至初收3... 详细信息

超杂13号是以核不育系GMS0807为母本,以自交系9909为父本配制而成的菜薹一代杂种,该品种生长势强、株型直立紧凑;株高约30.3cm,开展度23.2cm,菜薹紧实匀称、油绿有光泽;主薹高20～26cm,横径1.2～1.8cm,单株质量40～60g;中熟,播种至初收35～38d(天),延续采收5～7d(天);抽薹整齐,齐花,味甜,纤维少,品质优,适宜市销和出口;抗逆性强;产量800kg·(667m2)-1左右。适宜于华南地区种植。

关键词：菜薹超杂13号一代杂种

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Metastable seed-crystals: epitaxial growth of branched-array organic heterostructure nanowires

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Science China Chemistry 2025年

作者： Jin Feng Zhen-Yu Geng ting-Yao Song Ying-Xin Ma Chuan-Zeng Wang Wei Zhang Hong-Tao Lin Jin Zhou Shu-ping Zhuo Shu-Hai Chen Xue-Dong Wang School of Chemistry and Chemical Engineering Shandong University of Technology Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & DevicesSoochow University College of Chemistry and Chemical Engineering Hunan Normal University

Tunable light–matter interactions are exhibited by organic low-dimensional crystals, making these crystals a promising platform for organic photonics. However, the precise synthesis of organic low-dimensional crystals remains challenging due to the stochastic nature of molecular nucleation processes. Herein, the directed nucleation process is driven by the introduction of metastable seed-crystals as the trunk, which ultimately leads to branched-array organic heterostructures. The successful formation of organic heterostructures with high-density branched arrays is attributed to the highest attachment energy (Eatt（023）=-104.25 kcal mol-1) of the exposed （023） crystal plane during the seed-crystal growth route. Significantly, these as-prepared heterostructures inherently have an ultralow lattice mismatch ratio η of 0.7%between trunk and branch, which contributes to the multi-channel photon transportation. Therefore, this work provides valuable insights into a versatile synthetic strategy for accessing low-dimensional heterostructures for integrated optoelectronics.

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