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Enhancing I0/I-Conversion Efficiency by Starch Confinement in Zinc-Iodine Battery

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Energy & Environmental Materials 2024年第1期7卷 118-124页

作者： Danyang Zhao Qiancheng zhu Qiancheng Zhou Wenming Zhang Ying Yu Shuo chen Zhifeng Ren Institute of Nanoscience and Nanotechnology College of Physical Science and Technology Central China Normal University National & Local Joint Engineering Laboratory of New Energy Photoelectric Devices College of Physics Science and Technology Hebei University department of physics and Tc SUH University of Houston

The redox couple of I0/I-in aqueous rechargeable iodine-zinc（I2.Zn）batteries is a promising energy storage resource since it is safe and costeffective,and provides steady output ***,the cycle life and efficiency of these batteries remain unsatisfactory due to the uncontrolled shuttling of polyiodide（I3-and I5-） and side reactions on the Zn anode.

关键词： aqueous battery conversion efficiency iodine–zinc battery starch confinement

Temporal Characteristics of Luminescencefrom Ultrashort-pulsed Infrared LaserStimulated Electron Trapping Materials

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Chinese Journal of Lasers 1997年第1期B6卷 86-90页

作者： RUAN Hao chen Shuchun GAN Fuxi(shanghai Institute of Optics & Fine Mechanics,Chinese Academy of Sciences, shanghai 2.1800)XU Jianhua ZHOU Guangpeng LU Xingze(Lases physics Laboratory,physics department,Fudan university,shanghai 2.0433,china) Fudan Univ Shanghai China

Temporal characteristics of luminescence from picosecond infrared laser stimulated electron trapping materials (ETM's) are demonstrated. The measurements show that the luminescent lifetimes of SrS(Eu,Sm) and SrS(Ce,Sm) are 41 ns and 46 ns, respectively. The results indicate that use of electron trapping materials in real-time optical information processing is possible.

关键词： electron trappig materials infrared stimulated luminescence temporal characteristics real-time information processing

Heme oxygenase 1 linked to inactivation of subchondral osteoclasts in osteoarthritis

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Journal of Zhejiang university-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 513-528页

作者： Miao CHU Guangdong chen Kai chen Pengfei {2. Zhen WANG Zhonglai QIAN Huaqiang TAO Yaozeng XU Dechun GENG department of Orthopedics the First Affiliated Hospital of Soochow UniversitySuzhou 215006China department of Orthopedics Yixing People’s HospitalYixing 214200China department of Orthopedics Hai’an People’s HospitalHai’an 226600China department of Orthopedics Suzhou Kowloon HospitalShanghai Jiao Tong University School of MedicineSuzhou 215028China

Osteoarthritis(OA)is a chronic progressive osteoarthropathy in the *** activation plays a crucial role in the occurrence of subchondral bone loss in early ***,the specific mechanism of osteoclast differentiation in OA remains *** our study,gene expression profiles related to OA disease progression and osteoclast activation were screened from the Gene Expression Omnibus(GEO)***2. and Funrich analysis tools were employed to find differentially expressed genes(DEGs).Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses demonstrated that chemical carcinogenesis,reactive oxygen species(ROS),and response to oxidative stress were mainly involved in osteoclast differentiation in OA subchondral ***,fourteen DEGs that are associated with oxidative stress were *** first ranked differential gene,heme oxygenase 1(HMOX1),was selected for further *** results showed that osteoclast activation in the pathogenesis of OA subchondral bone is accompanied by the downregulation of *** was revealed to inhibit osteoclastogenesis by targeting HMOX1 and upregulating the expression of antioxidant protein in ***,carnosol was found to alleviate the severity of OA by inhibiting the activation of subchondral osteoclasts in *** research indicated that the activation of osteoclasts due to subchondral bone redox dysplasia may serve as a significant pathway for the advancement of *** HMOX1 in subchondral osteoclasts may offer novel insights for the treatment of early OA.

关键词： Osteoclast Oxidative stress Osteoarthritis(OA) Heme oxygenase 1(HMOX1) Carnosol

Propofol attenuates oxidative stress-induced PC12.cell injury via p38 MAP kinase dependent pathway

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Acta Pharmacologica Sinica 2007年第8期28卷 1123-1128页

作者： Xing-jun WU~2.Yong-jun zheng~3 Yong-yao CUI~2.Liang zhu~2.Yang LU~(2.4) Hong-zhuan chen~(2.4) ~2.4} of Pharmacy shanghai Jiao Tong university School of Medicine,shanghai 2.002.,china ~3department of Anesthesiology,Renji Hospital,shanghai Jiao Tong university School of Medicine,shanghai 2.0001,china department of Pharmacy Shanghai Jiao Tong University School ofMedicineShanghai 200025China department of Anesthesiology Renji HospitalShanghai Jiao TongUniversity School of MedicineShanghai 200001China

Aim:To investigate the neuroprotective effect of propofol and its intracellularmechanism on neurons in ***:Cell viability was determined with 3-（4,5-dimethylthiazol-2.yl）-2.5-diphenyl tetrazolium bromide *** celldeath was determined by Hoechst 332.8 staining and a fluorescence-activatedcell *** caspase-3 activity was measured by fluorometric ***-activated protein（MAP）kinase phosphorylation was detected with ***:The pretreatment of rat pheochromocytoma cell line PC 12.withpropofol（1-10μmol/L）resulted in a significant recovery from hydrogen peroxide（H2.2.-induced cell death and the inhibition of H2.2.nduced caspase-3 activationand PC12.cell *** inhibited the H2.2.induced p38 MAP kinase,but not c-Jun N-terminal kinase or extracellular signal-regulated kinase 1 and ***:Propofol might attenuate H2.2.induced PC12.cell deaththrough the inhibition of signaling pathways mediated by the p38 MAP kinase.

关键词： propofol oxidative stress PC12.cells apoptosis p38 MAP kinase

Cr: LiNbO3 Planar Waveguide

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Chinese Journal of Lasers 1995年第4期B4卷 355-359页

作者： zhu Shengxiang JIANG Xuyang QIU Yuanwu(Pohl Institute,Tongji university, {2. 2.0092.WU Yongjian XU zhengquan(physics department, Jiaotong university,{2. 2.0052. Tongji Univ Shanghai China

Ｃｒ：ＬｉＮｂＯ３ＰｌａｎａｒＷａｖｅｇｕｉｄｅ￥ＺＨＵＳｈｅｎｇｘｉａｎｇ；ＪＩＡＮＧＸｕｙａｎｇ；ＱＩＵＹｕａｎｗｕ（ＰｏｈｌＩｎｓｔｉｔｕｔｅ，ＴｏｎｇｊｉＵｎｉｖｅｒｓｉｔｙ，ｓｈａｎｇｈａｉ２０００９２）Ｗ... 详细信息

Ｃｒ：ＬｉＮｂＯ３ＰｌａｎａｒＷａｖｅｇｕｉｄｅ￥ＺＨＵＳｈｅｎｇｘｉａｎｇ；ＪＩＡＮＧＸｕｙａｎｇ；ＱＩＵＹｕａｎｗｕ（ＰｏｈｌＩｎｓｔｉｔｕｔｅ，ＴｏｎｇｊｉＵｎｉｖｅｒｓｉｔｙ，ｓｈａｎｇｈａｉ２０００９２）ＷＵＹｏｎｇｊｉａｎ；ＸＵＺｈｅｎ?..

关键词： Cr:LiNbO3 optical waveguide proton exchange fluorescence spectra

Neoadjuvant camrelizumab(an anti-PD-1 antibody)plus chemotherapy or apatinib(a VEGFR-2.inhibitor)for initially unresectable stage II–III non-small-cell lung cancer:a multicentre,two-arm,phase 2.exploratory study

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3015-3023页

作者： Haoran Xia Han Zhang zheng Ruan Huibiao Zhang Liangdong Sun Hezhong chen Yongxin Zhou Lele Zhang Dongliang Bian Xinsheng {2. Jing Zhang Fenghuan Sun Huansha Yu Nan Song Xiaogang Liu Yuming {2. Haiping Zhang Wenxin He Jian chen Jie Yang Guohan chen Shiliang Xie Dongfang Tang Xiaomiao Zhang Liang Duan Deping Zhao Qinchuan Li Peng Zhang Gening Jiang department of Thoracic Surgery Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina department of Thoracic Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina department of Thoracic Surgery Huadong Hospital Affiliated to Fudan UniversityShanghaiChina department of Thoracic Surgery Changhai HospitalNaval Medical UniversityShanghaiChina department of Thoracic-Cardiovascular Surgery Tongji HospitalTongji University School of MedicineShanghaiChina Central Laboratory Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Experimental Animal Center Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina department of Oncology Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina department of Thoracic Surgery Shanghai East HospitalTongji University School of MedicineShanghaiChina

This multicentre,two-arm,phase 2.study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in patients with initially unresectable stage II–III non-small-cell lung cancer(NSCLC).Eligible patients regardless of PD-L1 expression received neoadjuvant camrelizumab 2.0 mg and platinum-doublet chemotherapy every 3 weeks(arm A)or those with PD-L1-positive tumors received neoadjuvant camrelizumab and apatinib 2.0 mg once daily(arm B),for 2.4 cycles,followed by *** primary endpoint was major pathological response(MPR)*** patients in arm A and 2. in arm B were *** rates were 50.0%(15/30)in arm A and 42.9%(9/2.)in arm B,with all patients achieving R0 *** these patients,the MPR and pathological complete response rates were both 2..0%(95%CI 4.3–48.1)in arm A and were 55.6%(95%CI 2..2.86.3)and 11.1%(95%CI 0.3–48.2.in arm B,*** corresponding objective response rates were 33.3%(95%CI 11.8–61.6)and 55.6%(95%CI 2..2.86.3).With a median follow-up of 2..4 months(95%CI 19.0–2..0),the median event-free survival was not reached(NR;95%CI 13.6-NR)in arm A and 16.8 months(95%CI 8.6-NR)in arm *** 3 or above treatment-related adverse events occurred in eight(2..7%)patients in arm A and three(14.3%)in arm *** analysis showed baseline TYROBP expression was predictive of treatment response in arm *** camrelizumab plus chemotherapy or apatinib exhibits preliminary efficacy and manageable toxicity in patients with initially unresectable stage II–III NSCLC.

关键词： Surgery chemotherapy treatment

Software Method for the Extension of the STM/AFM Measuring Range

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Chinese Journal of Lasers 1999年第2期8卷 78-83页

作者： chen Jiabi LOU Xiaoxiao CAO Junqing zhuANG Songling ({2. of Instruments of university of shanghai for Science and Technology, shanghai 2.0093, china)WU Wei LIANG Zhongcheng ({2. of physics, Nanjing Normal university, Nanjing 2 上海理工大学仪表系上海 200093 上海理工大学仪表系上海南京师范大学物理系江苏南京

１ＩｎｔｒｏｄｕｃｔｉｏｎＳｃａｎｎｉｎｇｔｕｎｎｅｌｉｎｇｍｉｃｒｏｓｃｏｐｙ（ＳＴＭ）ａｎｄａｔｏｍｉｃｆｏｒｃｅｍｉｃｒｏｓｃｏｐｙ（ＡＦＭ）ａｒｅｉｎｓｔｒｕｍｅｎｔｓｗｉｔｈｕｌｔｒａｈｉｇｈｒｅｓｏｌｕ... 详细信息

１ＩｎｔｒｏｄｕｃｔｉｏｎＳｃａｎｎｉｎｇｔｕｎｎｅｌｉｎｇｍｉｃｒｏｓｃｏｐｙ（ＳＴＭ）ａｎｄａｔｏｍｉｃｆｏｒｃｅｍｉｃｒｏｓｃｏｐｙ（ＡＦＭ）ａｒｅｉｎｓｔｒｕｍｅｎｔｓｗｉｔｈｕｌｔｒａｈｉｇｈｒｅｓｏｌｕｔｉｏｎｉｎｖｅｎｔｅｄｉｎ１９８...

关键词： image matching affine transformation measuring range extension

CODIMENSION 3 BIFURCATIONS OFHOMOCLINIC ORBITS WITH ORBITFLIPS AND INCLINATION FLIPS

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Chinese Annals of Mathematics,Series B 2004年第4期25卷 555-566页

作者： SHUISHULIANG zhuDEMING CollegeofMathematicsandphysics ZhejiangNormalUniversityJinhua321004ZhejiangChina. departmentofMathematics EastChinaNormalUniversityShanghai200062China.

The homoclinic bifurcations in four dimensional vector fields are investigated by setting up a local coordinates near the homoclinic orbit. This homoclinic orbit is nonprincipal in the meanings that its positive semi-orbit takes orbit flip and its unstable foliation takes inclination flip. The existence, nonexistence, uniqueness and coexistence of the 1-homoclinic orbit and the 1-periodic orbit are studied. The existence of the twofold periodic orbit and three-fold periodic orbit are also obtained.

关键词： Bifurcation Homoclinic orbit Orbit flip Inclination flip Periodic orbit

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Cynaroside regulates the AMPK/SIRT3/Nrf2.pathway to inhibit doxorubicin-induced cardiomyocyte pyroptosis

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Journal of Zhejiang university-Science B(Biomedicine & Biotechnology) 2024年第9期25卷 756-772页

作者： Hai ZOU Mengyu ZHANG Xue YANG Huafeng SHOU zhenglin chen Quanfeng {2. Ting LUO Xiaozhou MOU Xiaoyi chen department of Critical Care Medicine Fudan University Shanghai Cancer CenterShanghai200032China department of Oncology Shanghai Medical CollegeFudan UniversityShanghai200032China Xianghu Laboratory Hangzhou311231China Clinical Research Institute Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang ProvinceZhejiang Provincial People’s Hospital(Affiliated People’s Hospital)Hangzhou Medical CollegeHangzhou310014China Center for Reproductive Medicine Department of GynecologyZhejiang Provincial People’s Hospital(Affiliated People’s Hospital)Hangzhou Medical CollegeHangzhou310014China Graduate School of Zhejiang Chinese Medical university Hangzhou310053China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Laboratory(Hangzhou)for Risk Assessment of Agricultural Products of Ministry of AgricultureInstitute of Agro-product Safety and NutritionZhejiang Academy of Agricultural SciencesHangzhou310021China General Surgery Cancer CenterDepartment of Hepatobiliary&Pancreatic Surgery and Minimally Invasive SurgeryZhejiang Provincial People’s Hospital(Affiliated People’s Hospital)Hangzhou Medical CollegeHangzhou310014China

Doxorubicin(DOX)is a commonly administered chemotherapy drug for treating hematological malignancies and solid tumors;however,its clinical application is limited by significant ***(Cyn)is a flavonoid glycoside distributed in honeysuckle,with confirmed potential biological functions in regulating inflammation,pyroptosis,and oxidative ***,the effects of Cyn were evaluated in a DOX-induced cardiotoxicity(DIC)mouse model,which was established by intraperitoneal injections of DOX(5 mg/kg)once a week for three *** mice in the treatment group received dexrazoxane,MCC950,and Cyn every two *** biochemistry,histopathology,immunohistochemistry,reverse transcription-quantitative polymerase chain reaction(RT-qPCR),and western blotting were conducted to investigate the cardioprotective effects and potential mechanisms of Cyn *** results demonstrated the significant benefits of Cyn treatment in mitigating DIC;it could effectively alleviate oxidative stress to a certain extent,maintain the equilibrium of cell apoptosis,and enhance the cardiac function of *** effects were realized via regulating the transcription levels of pyroptosis-related genes,such as nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3),caspase-1,and gasdermin D(GSDMD).Mechanistically,for DOX-induced myocardial injury,Cyn could significantly modulate the expression of pivotal genes,including adenosine monophosphate-activated protein kinase(AMPK),peroxisome proliferator-activated receptorγcoactivator-1α(PGC-1α),sirtuin 3(SIRT3),and nuclear factor erythroid 2.related factor 2.Nrf2..We attribute it to the mediation of AMPK/SIRT3/Nrf2.pathway,which plays a central role in preventing DOX-induced cardiomyocyte *** conclusion,the present study confirms the therapeutic potential of Cyn in DIC by regulating the AMPK/SIRT3/Nrf2.pathway.

关键词： Cynaroside Doxorubicin Pyroptosis Cardiotoxicity Oxidative stress