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Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia

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Nano Research 2024年第7期17卷 6411-6419页

作者： Hao Chen Xianzhe Tang Yueye Huang Chen Chen Yuheng yang Chaojie Hao Wenqi Xie Tingjing Huang Xiaofeng Cheng Qingnan Xu Shicong Huang Zhi ye Xucong Lin Zhaowei Chen Zhitong Chen MOE Key Laboratory for Analytical Science of Food Safety and Biology and New Cornerstone Science LaboratoryCollege of ChemistryFuzhou UniversityFuzhou 350108China institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Advanced Therapeutic Center National Innovation Center for Advanced Medical DevicesShenzhen 518000China Department of Chemistry University College LondonLondon WC1H 0AJUK Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in fujian Province College of ChemistryFuzhou UniversityFuzhou 350108China Key Laboratory of Biomedical Imaging Science and System Chinese Academy of SciencesShenzhen 518055China

Androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs).Traditional therapeutic formulations,such as Minoxidil(MXD)tincture,have limitations in reshaping the perifollicular microenvironment and exhibit limited ***,we report a multi-synergistic therapeutic platform for high-performance hair regeneration *** platform combines microneedle(MN)patches loaded with MXD-encapsulated nanostructured lipid carriers(MXD-NLC-MNs)and cold atmospheric plasma(CAP).The MNs’mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells,promoting cell ***,in collaboration with MXD,the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor,leading to ***,the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAPgenerated nitric oxide(NO)to the sites of HF lesions,whereby the synergistic interaction between MXD and NO boosts perifollicular ***,the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine *** multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.

关键词： nanomedicine androgenetic alopecia microneedle cold atmospheric plasma drug delivery

Crystal Structure of Dodecaaminium Didecavanadate Dodecahydrate

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Chinese Journal of Structural Chemistry 1996年第1期15卷 40-43页

作者： Cheng Chang-Zhang Shao Shi-Bao Huang Xiao-Ying Lin Zhou-Bin(fujian institute of Research on the Structure of Matter ,Chinese academy in sciences, fuZhou, 350002 ) 中科院福建物质结构所福建福州

NH_4)_(12)(V_(10)O_(28))_2·(H_2O)_(12)M_r=2347. 44 , triclinic, P1, a=10. 155 (1), b=10. 286(3) , c=16. 732(9) A, a=96. 50(4), β=87.18(4),γ=108. 99 (1)°, V=1642(4) A ￣3, Z=1, D_c=2. 37 g/cm￣3, F(000)=1160,λ(MoKa)=0. 71069 A, μ=27. 43 cm￣(-1), T= 23℃,final R=0.040 and R_w=0. 058 for 4415 observatives reflections with I≥3σ(I).The title compound contains two (V_(10)O_(28))￣(-6) anions, twelve NH ions and twelve water *** decavanadate anion is an isolated group consisting of ten condensed VO_6 octahedra sharing edges. The anions and the water molecules as well as the cations and the water molecules are connected by the strong hydrogen bonds (the distances are in the range of 2. 758～2. 956 A ).the anions and the cations are connected by the strong hydrogen bonds (2. 720～2. 859A) and the electrostatic force.

关键词： crystal structure decavanadate anion aminium complex

Crystal Structure of [CH3CH（OH）COO]2Fe（H2O）2·H2O

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Chinese Journal of Structural Chemistry 1992年第1期11卷 44-46页

作者： Liu Ping Hong Mao-Chunfujian institute of Research on the Structure of Matter, Chinese academy of sciences, fuzhou, fujian 350002,Chian 中科院福建物质结构所福建福州

The title compound C6H16O9Fe, Mr = 288. 13, was synthesized and crystallized in monoclinic space group P21/c, a = 9. 409(4), b = 5. 812(4), c= 22. 122(7)(?) , β=90. 80(3)°. V = 1209. 6(?)3, Z = 4, Dc=1. 572g/cm3, F(000) = 592, μ = 12. 73cm-1, R = 0. 063, Rw= 0. 068 for 1191 observed reflections. The iron atom is surrounded by O(1 - 6) in a distorted octahedron.

关键词： Fe H2O CH3CH Crystal Structure of OH)COO

Instantaneous velocity determination and positioning using Doppler shift from a LEO constellation

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Satellite Navigation 2023年第1期4卷 28-40,I0002页

作者： Fei Guo Yan yang fujian Ma Yifan Zhu Hang Liu Xiaohong Zhang School of Geodesy and Geomatics Wuhan UniversityWuhan 430079China Hubei Luojia Laboratory Wuhan 430079China institute of Telecommunication and Navigation Satellites China Academy of Space TechnologyBeijingChina

To provide backup and supplementation for the Global Navigation Satellite System(GNSS),Doppler shift from Low Earth Orbit(LEO)satellites can be used as signals of opportunity to provide positioning,navigation,and timing *** this contribution,we frst investigate the model and performance of instantaneous velocity determination and positioning with LEO *** a LEO constellation with 288 satellites,we simulate Doppler shift observations at nine multi-GNSS experiment *** to the lower orbit,the performance of LEO velocity determination is much more sensitive to the initial receiver position error than that of *** results show that with the initial receiver position error increased from 0.1 to 10 m,the Root Mean Square Errors(RMSEs)increase from 0.73 to 2.65 cm/s,0.68 to 2.96 cm/s,and 1.67 to 4.15 cm/s in the east,north,and up directions,*** performances with GPS are compared with GPS+LEO,and it is found that LEO Doppler shift observations contribute to GPS velocity *** for LEO Doppler positioning,even if more than 30 visible LEO satellites are available,the position dilution of precision values can reach several *** that the error of LEO Doppler measurements is 0.01 m/s,the instantaneous Doppler positioning accuracy can achieve about a few meters,which is comparable to that of GNSS pseudorange positioning.A constant velocity model is adopted for state *** LEO Doppler positioning results show that an accuracy at centimeter to decimeter level can be achieved after solution *** a static simulated kinematic positioning test,the RMSEs range from a few decimeters to several meters in diferent regions by giving diferent *** a dynamic positioning test,the RMSEs are about 2–3 m in high latitude region.

关键词： Low earth orbit(LEO) GNSS Doppler shift Velocity determination Instantaneous Doppler positioning

A　QUANTUM　CHEMICAL　INVESTIGATION　OF　ACTIVITY　ORDER　OF　COORDINATION　CATALYSIS　OF　TRANSITION　METALS（Ⅲ）　……ACTIVATION　OF　MOLECULAR　OXYGEN

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Chinese Chemical Letters 1994年第5期5卷 381-382页

作者： Yuan Qing zheng (Departement of Chemistry, fujian Normal Uversity, fuzhou, 350007)Shou Zhi YU (Applied Physics institute, Henan academy of sciences, zhengzhou, 450003)

This paper tries to study the law of coordination activation of transition metals to molecular oxygen with quantum chemical methods in order to give some possible theoretical guidance to realization of the biological ...

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Bonding of the chain structure for novel boranes B_(3k+)H_(5k+p+3)^-

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Chinese Journal of Chemistry 1994年第4期12卷 289-294页

作者： ZHONG, Shi-Jun WANG, Yin-Gui ZHANG, Qian-ErState Key Laboratory of Structural Chemistry, fujian institute of Research on the Structure of Matter, Chinese academy of Science, fuzhou, fujian 350002, china.Department of Chemistry, and institute of Physical Chemistry, Xiamen University, Xiamen, fujian 361005, china

The molecular orbitals obtained from conventional quantum chemistry calculations, are expressed in terms of symmetrized valence bond functions of fragment, and a direct picture of chemical bonding can be drawn easily. This method is utilized, together with extended Huckel calculations, to interpret the bonding properties of a centipede-like chain structure for novel laser-producing boranes B3k+pH5k+p+3- which is constructed from the repeated unit B3H5 linked to each other by three B-H-B bonds.

关键词： Symmetrized valence bond function bridge bond novel boranes.

Nutrient Value of Protein from Spores of Agaricus blazei Mutant Strain J3

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食用菌学报 2006年第4期 89-90页

作者： QIAN Ai-ping 1, WENG Bo-qi 2, WANG Yi-xiang 2, YAN Sun-an 1, JIANG Zhi-he 3 1Central Laboratory, fujian academy of agricultural sciences,fuzhou 350003, china 2agricultural Ecology institute,fujian academy of agricultural sciences,fuzhou 350013, china 3 The Development and Application Research Center of Edible fungi, fujian academy of agricultural sciences, fuzhou 350013, china

Protein from spores of Agaricus blazei,mutant strain J_ 3, was assessed in terms of six nutritive quality indices [Amino Acid Score （AAS）, Chemical Score （CS）,Essential Amino Acid Index （EAAI）,Biological Value （BV）, Nutritional Index （NI） and Amino Acid Ratio Coefficient Score （AARCS）]. The CS, AAS, EAAI, BV and NI values of protein from J_ 3 spores were 21.3%, 5.3%, 5.5%, 6.5% and 24.0% higher, respectively than for protein from J_ 1 spores.

关键词： Agaricus blazei mutant J_ 3 Nutrient value Spore

Structural comparison to the molybdenumsite of nitrogenase Synthesis and crystal structure of binuclear oxomolybdenum(V)complex with both omercaptophenolate and alkoxide ligands

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Chinese Journal of Chemistry 1993年第2期11卷 137-143页

作者： HU,Yong-Han KANG,Bei-Sheng CHEN,Xue-Tai HUANG,Liang-Ren WENG,Ling-Hong XU,Yong-Jin fujian institute of Research on the Structure of Matter and fuzhou Laboratory of Structural Chemistry,Chinese academy of sciences,fuzhou,fujian 350002 fujian institute of Research on the Structure of Matter and fuzhou Laboratory of Structural Chemistry Chinese Academy of Sciences Fuzhou Fujian 350002

Complex(n-Bu_4N)[Mo_2O_2(OMe)(mp)_3][1,mp=(o-OC_(?)H_4S)^(2-)]was synthesized by the reaction of MoOCl_3(THF)_2 and Na_2mp in EtOH and crystallized in monoclinic space group P2_(?)/n with crystal data:a=13.910(3),b=23.554(3),c=12.558(2)(?),β=105.20(2)°,Z=4,D_o=1.455g/ cm^3,final R=0.077 for 5325 reflections[I>3σ(I)].The two[Mo(O)mp]^+ moicties are bridged by one 1,2-bidentate ligand mp^(2-) with exceedingly small bite angle(69.0°)and bite distance (2.70(?))and by a methoxy *** structure can be interpreted as two distorted octahedra around the Mo atoms sharing a *** have been made to provide structural informa- tions for the syntheses of modelling compounds of FeMoco by comparing the Mo—O and Mo—S bond distances of o-mercaptophenolate ligated compounds to those of the molybdenum site of nitrogenase.

关键词： V)complex with both omercaptophenolate and alkoxide ligands Structural comparison to the molybdenumsite of nitrogenase Synthesis and crystal structure of binuclear oxomolybdenum

Effect of Selected Fermentation Conditions on the Anti-microbial Activity of Pleurotus tuber-regium Spent Culture Liquid

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食用菌学报 2006年第4期 78-80页

作者： CAI Hai-song, LIN Rong-bin, LIN Chen-qiang, zheng Yong-biao, LIN Xin-jian, CHEN Ji-chen*The Soil and Fertilizer institute, fujian academy of agricultural sciences, fuzhou, fujian 350013, china

The effect of different fermentation conditions on the anti-microbial activity of Pleurotus tuber-regium spent culture liquids was determined using Staphylococcus aureus (ATCC6538) as the indicator bacterium. Our data showed that the optimal submerged culture conditions were as follows: temperature, 30 ℃; initial pH of the culture medium, 7.0; culture volume, 80 mL/250 mL culture flask; shaker speed, 160 r/min; and culture period, 6 days.

关键词： Anti-microbial activity Fermentation Pleurotus tuber-regium