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Alterations of tumor-related genes do not exactly match the histopathological grade in gastric adenocarcinomas

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World Journal of Gastroenterology 2010年第9期16卷 1129-1137页

作者： Guo-Yan Liu,Xiao-Hong Wu,Yi-Zhuo Lu,Chao Pan,Ping Yin,Hong-Feng Liao,Ji-Qin Su,Qing Ge,Qi Luo,Department of General Surgery,The Affiliated Zhongshan Hospital of Xiamen University,The Digestive Disease Research institute of Xiamen University,Xiamen 361004,fujian Province,china Guo-Yan Liu,Bin Xiong,Department of Oncology,The Affiliated Zhongnan Hospital of Wuhan University,Wuhan 430071,Hubei Province,china Kun-Hong Liu,Department of Data Mining,Software School of Xiamen University,Xiamen 361005,fujian Province,china Yong Zhang,Yu-Zhi Wang,The academy of Military Medical sciences,Beijing 100850,china Department of General Surgery The Affiliated Zhongshan Hospital of Xiamen University The Digestive Disease Research Institute of Xiamen University Xiamen 361004 Fujian Province China.

AIM:To investigate the diverse characteristics of different pathological gradings of gastric adenocarcinoma (GA) using tumor-related ***:GA tissues in different pathological gradings and normal tissues were subjected to tissue *** of 15 major tumor-related genes were detected by RNA in situ hybridization along with 3' terminal digoxin-labeled anti-sense single strandedoligonucleotide and locked nucleic acid modifying probe within the tissue *** data obtained were processed by support vector machines by four different feature selection methods to discover the respective critical gene/gene subsets contributing to the GA activities of different pathological ***:In comparison of poorly differentiated GA with normal tissues,tumor-related gene TP53 plays a key role,although other six tumor-related genes could also achieve the Area Under Curve (AUC) of the receiver operating characteristic independently by more than 80%.Comparing the well differentiated GA with normal tissues,we found that 11 tumor-related genes could independently obtain the AUC by more than 80%,but only the gene subsets,TP53,RB and PTEN,play a key *** the gene subsets,Bcl10,UVRAG,APC,Beclin1,NM23,PTEN and RB could distinguish between the poorly differentiated and well differentiated *** of a single gene could obtain a valid ***:Different from the traditional point of view,the well differentiated cancer tissues have more alterations of important tumor-related genes than the poorly differentiated cancer tissues.

关键词： Pathological grading Gastric adenocarcinoma Tumor-related gene Support vector machine RNA in situ hybridization

Synthesis and Crystal Structure of a New Praseodymium(Ⅲ)-Copper(Ⅱ)Polymeric Complex:〔Pr_(2)Cu_(3)(L_(1))_(6)〕_(n)(H_(2)L_(1)=NH{CH_(2)COOH}_(2))

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Chinese Journal of Structural Chemistry 1999年第1期18卷 6-10页

作者： MAO Jiang Gao \ SONG Ling\ Huang Jin Shun (State Key Laboratory of Structural Chemistry, fujian institute of Research on the Structure of Matter, the Chinese academy of sciences, fuzhou 350002)

A novel polymeric Pr 2Cu 3 complex of iminodiacetic acid (H 2L 1=NH{CH 2COOH} 2) Pr 2Cu 3(L 1) 6 n , 1, has been synthesized and structurally characterized. The title complex Pr 2Cu 3O 24 N 6C 24 H 30 ( M r =1258.97) crystallized in trigonal space group P3 c1 (No. 165) with a = 13.424(4), c=14.752(6); V=2303(1) 3; F(000)=1226; λ (Mo Kα )=35.2 cm -1 ; D c =1.820 g·cm -3 ; Z =2. The final R and R w are 0.072 and 0.081 respectively for 1412 reflections with I>3σ(I) . In crystal 1, the Pr 3+ ion is nine coordinated by 6 O atoms from three bidentate chelating carboxylate groups and 3 O atoms from three anti anti bridging carboxylic groups of six L 1 ligands; the Cu 2+ ion is six coordinated by 4 O and 2 N atoms from two pentadentate L 1 ligands. Each pair of Pr(Ⅲ) atoms is bridged by three L 1 ligands, each of which also chelates with one copper(Ⅱ) ion, thus forming a Pr 2Cu 3 cluster unit. Such cluster units are cross linked by flexible L 1 ligands into a three dimensional coordination framework.

关键词： crystal structure praseodymium(Ⅲ) copper(Ⅱ) complex iminodiacetic acid

Crotins, plant toxins from the seeds of Croton tigliun

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Crotins, plant toxins from the seeds of Croton tigliun

The 5th Congress of Toxicology in Developing Countries

作者： Ming-Huang Chen, Xiao-Ming ye, Zi-Ren Wang State Key Laboratory of Structural Chemistry, fujian institute of Research on the Structure of Matter, The Chinese academy of sciences, fuzhou, fujian 350002, china

Two plant toxins, crotin Ⅰand crotin Ⅱhave been isolated from the seeds of the Euphorbiacea Croton tiglium, which is a kind of Chinese medicinal herb named Ba Dou. The relative molecular masses estimated by SDS-PAGE were 40 and 15kDa and the isoetectric point estimated to be 8.0 and 6.7, respectively. The acute LD was evaluated at 72 h were 0.45 mg per mouse for crotin Ⅰand 2.23 mg

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Structural Effects on Defects and Growth in Crystals of Urea

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Chinese Journal of Structural Chemistry 1998年第1期17卷 47-51页

作者： ZHAO Qing-Lan HUANG Bing-Rong HUANG Yi-Sen SU Gen-Bo(fujian institute of Research on the Structure Of Matter,the Chinese academy Of Soiences, fuzhou 350002) fujian Inst. Res. Struct. of Matter Chinese Academy of Sciences Fuzhou 350002 China

The structural effects on the defective formation and the crystal mor-phology in the crystal of urea have been studied. The face development is discussedfrom the viewpoint of the molecular resonance structures and defects, and the form oflarge strained fields is also discussed from the existence of the structural channels alongthe c-axis.

关键词： defect structure growth urea crystal

SYNTHESIS AND STRUCTURE OF THE FIRST TUNGSTEN-IRON-SULfuR CUBANE-LIKE CLUSTER [WFe_3S_4(S_2CNC_4H_8)s]·2DMF CONTAINING DITHIOCARBAMATO LIGANDS

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Chinese Journal of Structural Chemistry 1989年第2期8卷 152-155页

作者：雷新建黄致盈等

The title compound (Mr =1236.54) crystallizes in monoclinic space group C2/c with a =12.553(4),b=20.121(6),c=19.659(2)A,β=102.96(2)°,V=4839.1A3, Z = 4 and DC -1.697g/cm3. The structure was solved by direct methods.A full matrix least-squares refinement for 2197 reflections with I>3σ(I) gave final R and Rw of 0.064 and 0.076,respectively. The [WFe3S4] core of the cluster can be considered to be a [WFe3] tetrahedron capped by a sulfur atom on each face to fora a distorted cubane. The 57Fe Mossbauer spectrum indicates that there are two types of Fe atoms of ratio 2:1 in the cluster.

关键词： monoclinic distorted refinement S2CNC4H8)s WFe3S4 FIRST sulfur reactant refined nitro

钙钛矿型晶体的倍频系数和离子位移、能带结构间的关系

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物理学进展 1993年第1期13卷 1-13页

作者：陈创天俞琳华中国科学院福建物质结构研究所福州350002

1974年作者提出了“非线性光学效应的离子基团理论”[1]:,并据此对钙钛矿型等体系的倍频系数作了理论计算,得到了很好的结果。本文进一步使用作者1981年建议的“晶体倍频系数的平均能带近似计算法”[2],从能带理论出发计算了钙钛矿型晶... 详细信息

1974年作者提出了“非线性光学效应的离子基团理论”[1]:,并据此对钙钛矿型等体系的倍频系数作了理论计算,得到了很好的结果。本文进一步使用作者1981年建议的“晶体倍频系数的平均能带近似计算法”[2],从能带理论出发计算了钙钛矿型晶体的倍频系数。计算结果表明:(1)由“平均能带近似法”仍可得到“钙钛矿型晶体倍频效应基团理论”[1]的几个基本论点,并给出后者的近似等级;(2)充分揭示了 SrTiO_3、KTaO_3晶体电场感应倍频系数X_(333)^(2ω)/X_(311)^(2ω)比值的变化与中心B离子的相对位移、能带结构、B-O键离子性之间的关系;(3)通过倍频系数和能带结构关系的研究,有可能把晶体倍频系数作为检验能带结构是否正确的一个新的数据;(4)由本文的计算公式,可以计算出在外电场作用下中心B离子相对于配位体氧原子的位移量△Z,并和外电场作用下的感应自发极化P_5的实验值相一致。

关键词：晶体钙钛矿型倍频系数能带结构

Non linear optical property of Rich d electron molecular system-Iridium cluster Ⅱ:the effect of ferrocene

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Non linear optical property of Rich d electron molecular sys...

中国化学会第五届全国结构化学学术会议

作者： fujun Li Kechen Wu State Key Laboratory of Structural Chemistry,fujian institute of Research on the Structure of Matter,Graduate School of the Chinese academy of sciences,Chinese academy of sciences,fujian,fuzhou,350002 china

＜正＞A series of ferrocene substituted carbonyl radium clusters have been calculated in the frame of TDDFT method focusing on their electronic structure and nonlinear optical *** can be denoted as follows:

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Geometry,electronic and optical properties of（PbS）n（n=1-16） clusters from density functional calculation

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Geometry,electronic and optical properties of（PbS）n（n=1-1...

中国化学会第五届全国结构化学学术会议

作者： Jiangang He Kechen Wu State Key Laboratory of Structural Chemistry,fujian institute of Research on the Structure of Matter,Graduate School of the Chinese academy of sciences,Chinese academy of sciences,fujian,fuzhou,350002 china

＜正＞In recent years,clusters have drawn considerable attention due to their peculiar electronic structure and physical properties which are different from their bulk counterparts and size-depended. As an important,d...

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One Bilayer Aluminoborate:Synthesis and Structure

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One Bilayer Aluminoborate:Synthesis and Structure

中国化学会第六届全国结构化学学术会议

作者： Lian-Zhi Wu,Lin-Cheng,Guo-Yu yang~* State Key Laboratory of Structural Chemistry,fujian institute of Research on the Structure of Matter,Chinese academy of sciences,fuzhou,fujian 350002,china.

A new bilayer aluminoborate(CHN)AlBO(OH)·2HO(1) was hydrothermally synthesized and the structure has been determined by single X-ray *** data for 1:a = 14.483(3) A,b = 29.039(6) A,c = 25.527(6) A,β= 99.972(4)°,V = 10574(4) *** alternate connectivity between the B-O clusters and the AlO tetrahedra through their vertices gives rise to a novel two-dimensional(2D)

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