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World Journal of Gastroenterology 2025年第3期31卷 1-10页

作者： ming-Hua zheng Amedeo Lonardo Department of Hepatology MAFLD Research CenterThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Internal Medicine Azienda Ospedaliero-Universitaria of Modena(2023)Modena 41126Italy

Prognostication of compensated advanced chronic liver disease(cACLD)is of paramount importance for the physician-and-patient communication and for rational clinical *** paper published by Dallio et al reports on red cell distribution width(RDW)/platelet ratio(RPR)as a non-invasive biomarker in predicting decompensation of metabolic dysfunction-associated steatotic liver disease(MASLD)-related *** from other biomarkers and algorithms,RPR is inexpensive and widely available,based on parameters which are included in a complete blood *** is computed on the grounds of two different items,one of which,RDW,mirrors the host’s response to a variety of disease stimuli and is *** second parameter involved in RPR,platelet count,is more specific and has been used in the hepatological clinic to discriminate cirrhotic from non-cirrhotic chronic liver disease for *** disease is the primary cause of mortality among MASLD subjects,followed by extra-hepatic cancers and liver-related ***,MASLD biomarkers should be validated not only in terms of liver-related events but also in the prediction of major adverse cardiovascular events and cardiovascular mortality and extra-hepatic *** sized multi-ethnic confirmatory investigation is required to define the role and significance of RPR in the stratification of MASLD-cACLD.

关键词： Cirrhosis Liver fibrosis Natural course Prognostication Stratification

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茶叶企业品牌生态位影响因素及竞争策略分析

江西农业学报 2022年第9期34卷 207-212,224页

作者：郑明喆安康学院陕南生态经济研究中心陕西安康725000

为了找出影响区域品牌下茶叶企业品牌发展的因素,进一步提升区域品牌下茶叶企业品牌发展水平,笔者引入生态位相关理论,分析了区域品牌下茶叶企业品牌的发展问题。首先,基于生态位态势理论,分别分析了影响茶叶企业品牌“态”和“势”的因... 详细信息

为了找出影响区域品牌下茶叶企业品牌发展的因素,进一步提升区域品牌下茶叶企业品牌发展水平,笔者引入生态位相关理论,分析了区域品牌下茶叶企业品牌的发展问题。首先,基于生态位态势理论,分别分析了影响茶叶企业品牌“态”和“势”的因素,前者有地理标志区域品牌、企业规模、茶叶企业品牌覆盖面、产品品牌,后者有茶叶企业的技术研发能力、品牌忠诚度、企业管理水平、企业人才资源、可利用的外部资源。在此基础上,以陕西茶叶企业品牌为例,从生态宽度、生态位重叠度2个方面分析了茶叶企业品牌的生态位,并提出了茶叶企业应该选择差异化战略,避免恶性竞争;建立品牌联盟,扩大生态位空间;量力而为,注重战略规划;提高产品品质,建立品牌形象;转变观念,加强品牌保护等策略。

关键词：生态位品牌生态位茶叶企业区域品牌

农业供给侧结构性改革背景下茶叶区域公用品牌建设与维护策略研究

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湖北农业科学 2018年第14期57卷 122-125页

作者：郑明喆安康学院经济与管理学院陕西安康725000

基于农业供给侧结构性改革背景,运用系统基模分析法对影响茶叶区域公用品牌的因素进行了分析,发现茶叶区域共用品牌的发展存在4个成长上限基模、1个成长与投资不足基模,进而对发展与维护茶叶区域公用品牌提出相关建议。

关键词：农业供给侧结构性改革茶叶区域公用品牌系统基模

基于SWOT-CLPV模型的安康富硒茶区域品牌建设对策研究

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湖北农业科学 2021年第9期60卷 180-184页

作者：郑明喆安康学院经济与管理学院/陕南生态经济研究中心陕西安康725000

为了准确找出影响安康富硒茶区域品牌建设的因素,进而提升其发展水平,在充分分析安康富硒茶区域公用品牌建设优势、劣势以及外部环境中机会与威胁的基础上,运用SWOT-CLPV模型分析出杠杆作用、抑制作用、脆弱性和问题性4种竞争态势。最... 详细信息

为了准确找出影响安康富硒茶区域品牌建设的因素,进而提升其发展水平,在充分分析安康富硒茶区域公用品牌建设优势、劣势以及外部环境中机会与威胁的基础上,运用SWOT-CLPV模型分析出杠杆作用、抑制作用、脆弱性和问题性4种竞争态势。最后结合实际提出加快生态富硒资源开发、加强茶园标准化建设、壮大龙头企业、加强引才育才工作等对策。

关键词： SWOT-CLPV模型区域公用品牌安康富硒茶

Chordoid meningioma： a retrospective study of 17 cases at a single institution

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Chinese Medical Journal 2013年第4期126卷 789-791页

作者： Zhu Hong-da Chen Hong Xie Qing Gong Ye Mao Ying Zhong Ping Che Xiao-ming Jiang Chen-chuan Huang Feng-ping zheng Kang Li Shi-qi Gu Yu-xiang Bao Wei-ming Yang Bo-jie Wu Jin-song Wang Yin Xie Li-qian zheng ming-zhe Tang Hai-liang Wang Dai-jun Chen Xian-cheng Zhou Liang-fu Department of Neurosurgery Department of Neuropathology Huashan Hospital Fudan University Shanghai 200040 China

Chordoid meningioma （CM）, characterized by its resemblance to chordoma, was first described by Kepes et al＇ in 1988, and classified histologically as a WHO grade II neoplasm in the 2000 revision of the WHO grading system, featured by its aggressive clinical course, great risk of recurrence, and infrequent association with hematological conditions.2 This article describes the clinical course, radiological characteristics, postoperative treatment, and prognosis of 17 patients with CM who underwent surgical treatment at our hospital.

关键词： chordoid meningioma outcomes postoperative treatment

Histopathological classification and location of consecutively operated meningiomas at a single institution in China from 2001 to 2010

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Chinese Medical Journal 2013年第3期126卷 488-493页

作者： WANG Dai-jun XIE Qing GONG Ye MAO Ying WANG Yin CHENG Hai-xia ZHONG Ping CHE Xiao-ming JIANG Cheng-chuan HUANG Feng-ping zheng Kang LI Shi-qi GU Yu-xiang BAO Wei-min YANG Bo-jie WU Jing-song XIE Li-qian zheng ming-zhe TANG Hai-liang ZHU Hong-da CHEN Xian-cheng ZHOU Liang-fu Department of Neurosurgery Huashan Hospital Fudan UniversityShanghai 200040 China Department of Neuropathology Huashan Hospital Fudan University Shanghai 200040 China

Background Meningioma is one of the most common primary tumors of the central nervous system, but there are not many detailed studies on the sex, age, subtypes and locations of large series. This study was a retrospective analysis of the characteristics of meningioma cases consecutively operated on at a single institution in China from 2001 to 2010. Methods This study investigated the demographic background of 7084 meningioma cases, and the subtypes and locations of the tumors. Sex and age distributions were analyzed, and the pathological subtypes were classified according to the World Health Organization （WHO） classification. The location of the meningiomas was also categorized. Results The female：male ratio of the 7084 cases was 2.34：1. The mean age was 51.4 years （range, 11 months-86 years）. The mean age of cases of WHO grade I meningioma was significantly older than that of grade II or III meningiomas （P 〈0.001, Fisher＇s Least Significant Digit test）. There was a significantly higher female：male ratio in WHO grade I meningiomas than in grade II or grade III meningiomas （2.57, 1.03 and 0.76, respectively; P 〈0.001, X^2 test）. Meningothelial （n=2061） and fibrous meningiomas （n=3556） were the most common subtypes, comprising 79.3% of all meningiomas. All meningioma cases were classified into 23 locations in this study, with the cerebral convexity the most common site （38.33%, n=2722）. Cases with uncommon locations such as extra-cranial and sylvian fissure meningiomas were also present in this series. Conclusions Female predominance was found for benign meningiomas, while malignant subtypes showed male predominance. The mean age of patients with WHO grade Ⅰ meningiomas was older than that of patients with higher-grade tumors. Meningothelial and fibrous meningiomas were the most common subtypes. The cerebral convexity was the most common *** location.

关键词： age factors locations meningioma subtypes sex factors

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陕西省农村金融资源配置效率研究

江西农业学报 2023年第3期35卷 220-226页

作者：郑明喆南夏博安康学院陕南生态经济研究中心陕西安康725000

采用DEA-Malmquist指数分析法对陕西农村金融资源配置效率进行了实证分析,以期找出制约陕西农村金融资源配置效率提升的因素和陕西农业农村高质量发展的金融支持发力点。选用涉农贷款、农村居民收支差额和农业保险保费收入作为投入要素... 详细信息

采用DEA-Malmquist指数分析法对陕西农村金融资源配置效率进行了实证分析,以期找出制约陕西农村金融资源配置效率提升的因素和陕西农业农村高质量发展的金融支持发力点。选用涉农贷款、农村居民收支差额和农业保险保费收入作为投入要素,农村居民人均可支配收入和农林牧渔业总产值作为产出要素,对陕西农村金融资源配置效率进行了评价。结果表明:陕西省农村金融资源的规模收益递增,同时纯技术效率小于规模效率,农村金融资源配置的技术进步和全要素生产率波动较大,总体表现为陕西省农村金融资源配置效率低下,需增强农业保险有效需求;进一步创新农业保险品种;不断创新农业涉农信贷服务模式。

关键词：农村金融涉农信贷农业保险农民收入 DEA-Malmquist指数分析法

Preoperative surgical planning for intracranial meningioma resection by virtual reality

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Chinese Medical Journal 2012年第11期125卷 2057-2061页

作者： TANG Hai-liang SUN Hua-ping GONG Ye MAO Ying WU Jing-song ZHANG Xiao-luo XIE Qing XIE Li-qian zheng ming-zhe WANG Dai-jun ZHU Hong-da TANG Wei-jun FENG Xiao-yuan CHEN Xian-cheng ZHOU Liang-fu Department of Neurosurgery Huashan Hospital Shanghai 200040 China Department of Radiology Huashan Hospital Shanghai 200040 China

Background The Dextroscope system by Volume Interactions （Singapore） had been applied to minimally invasive neurosurgery in many units. This system enables the neurosurgeon to interact intuitively with the three-dimensional graphics in a direct manner resembling the way one communicates with the real objects. In the paper, we explored its values in pre-operation surgical planning for intracranial meningiomas resection. Methods Brain computed tomography （CT）, magnetic resonance imaging （MRI）, and magnetic resonance venography （MRV） were performed on 10 patients with parasagittal and falcine meningiomas located on central groove area; brain CT, MRI and magnetic resonance angiography （MIRA） were performed on 10 patients with anterior skull base meningiomas and 10 patients with sphenoid ridge meningiomas. All these data were transferred to Dextroscope virtual reality system, and reconstructed. Then meningiomas, skull base, brain tissue, drainage vein and cerebral arteries were displayed within the system, and their anatomic relationships were evaluated. Also, the simulation operations were performed. Results For parasagittal and falcine meningiomas, the relationships of tumor with drainage vein and superior sagittal sinus were clearly displayed in the Dextroscope system. For anterior skull base and sphenoid ridge meningiomas, the relationships of tumor with bilateral internal carotid arteries, anterior cerebral arteries, middle cerebral arteries and skull base were vividly displayed within the virtual reality system. Surgical planning and simulation operation of all cases were performed as well. The real operations of all patients were conducted according to the simulation with well outcomes. Conclusions According to the virtual reality planning, neurosurgeons could get more anatomic information about meningioma and its surrounding structures, especially important vessels, and choose the best approach for tumor resection, which would lead to better prognosis for patient

关键词： virtual reality, Dextroscope system, intracranial meningioma surgical planning

Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina Quan Ling Wang Jing Ren Chenguang zheng Jiajia Yang Dong ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

Notch信号通路基因在人脑动静脉畸形和周围脑组织中的差异表达

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中国临床神经科学 2012年第6期20卷 625-631页

作者：郑名哲陈衔城汤海亮谢清宫晔复旦大学附属华山医院神经外科 200040

目的:应用基因芯片研究人脑动静脉畸形(BAVM)的畸形团及周围脑组织的Notch信号通路相关基因的差异表达。方法:收集有出血史的5例BAVM标本,在畸形团、周围脑组织分别取材,进行Notch信号通路基因芯片杂交,得到基因芯片上各基因点数值型信... 详细信息

目的:应用基因芯片研究人脑动静脉畸形(BAVM)的畸形团及周围脑组织的Notch信号通路相关基因的差异表达。方法:收集有出血史的5例BAVM标本,在畸形团、周围脑组织分别取材,进行Notch信号通路基因芯片杂交,得到基因芯片上各基因点数值型信号强度,计算其均数和标准差。计算畸形团芯片及周围脑组织芯片上各基因点的比值。取比值>1.5或<0.67的因子,归纳总结出表达水平有明显差异的基因。以realtime PCR方法对其中任意选取的2个基因进行验证。结果:在113个Notch信号通路基因中,共筛选出27个明显变化的基因,其中,上调4个,下调23个。较为重要的基因包括Notch信号通路配体DLL1、DLL3,受体及配体裂解关键基因ADAM10、ADAM17,Notch信号通路靶基因HES5,Notch相关的Sonic Hedgehog通路基因GLI1、Wnt信号通路基因FZD1、原癌基因LMO2。realtime PCR验证DLL1和HES5两个基因,其检测结果与芯片结果基本相符。部分Notch信号通路关键基因在两个部位表达无差异。结论:多个Notch信号通路基因在BAVM畸形团及周围脑组织存在差异表达,提示BAVM的发生发展与Notch信号通路有关。周围脑组织中,Notch信号通路亦可能存在异常。差异表达的基因可作为BAVM进一步研究的切入点。

关键词：脑动静脉畸形脑组织 Notch信号通路基因芯片