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Size-dependent macrophage-targeting of mannose-modified rosiglitazone liposomes to alleviate inflammatory bowel disease

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Chinese Chemical Letters 2024年第1期35卷 385-391页

作者： Erjin Wang Run Han Mingyue Wu Yuan He Yaxin Cheng Jiahong lu ying zheng State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences(ICMS)University of MacaoMacao 999078China Department of Pharmacy Xuzhou Medical UniversityXuzhou 221004China Faculty of Health Sciences University of MacaoMacao 999078China Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research University of MacaoMacao 999078China

Inflammatory bowel disease (IBD) is a refractory chronic intestinal inflammatory disease caused by a malfunction of immune system. As the key immune cells in the intestine, macrophages play an important role in maintaining intestinal homeostasis and tissue repair of the IBD. Pharmacological modulation of macrophage function exhibits the promising therapeutic effect for IBD. In this study, mannose-modified liposomes (MAN-LPs) are prepared for macrophage targeting to improve therapeutic efficiency. Rosiglitazone (ROSI) as an agonist of peroxisome proliferators-activated receptor γ (PPAR-γ) is used as the model drug to fabricate different sized liposomes. The impacts of mannose modification and particle size for macrophage targeting are investigated in cells, zebrafish, and mouse models and the therapeutic effects of the MAN-LPs are evaluated on dextran sulfate sodium (DSS)-induced IBD mouse. Compared to unmodified liposome, MAN-LPs display higher uptake by RAW 264.7 cells and better co-localization with macrophage in zebrafish model. Furthermore, MAN-LPs could effectively accumulate in the inflammatory intestinal sites in IBD mouse model. Most importantly, the targeting ability of MAN-LPs is obviously enhanced with the increasing of particle size, whereas the largest MAN-LPs particles achieve the best anti-inflammatory effect in cells, and a higher therapeutic efficiency in IBD mouse model. Therefore, mannose-modified liposome is a promising strategy for macrophage-targeting in IBD treatment. Particle size of MAN-LPs will affect macrophage targeting ability, as well as the therapeutic effect in-vivo.

关键词： Macrophage targeting Liposome Mannose Particle size Inflammatory bowel disease

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New determination of the gravitational constant G

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National Science Review 2020年第12期7卷 1796-1797页

作者： zheng-Tian lu Hefei National Laboratory for Physical Sciences at the Microscale CAS Center for Excellence in Quantum Information and Quantum PhysicsUniversity of Science and Technology of China

A new and so far the most precise determination of the gravitational constant G has been made by Jun luo and colleagues at the Huazhong University of Science and Technology(HUST) [1].The combination of G with two other most fundamental physical constants,the speed of light c and Planck’s constant h,can together construct the natural units(*** units) of time,length and *** relationships inform us that,

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On Edge Singularity and Eigenvectors of Mixed Graphs

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Acta Mathematica Sinica,English Series 2008年第1期24卷 139-146页

作者： ying ying TAN Yi zheng FAN School of Mathematics and Computation Sciences Anhui UniversityHefei 230039 P. R. China Department of Mathematics and Physics Anhui Institute of Architecture and Industry Hefei 230022 Po R. China

Let G be a mixed glaph which is obtained from an undirected graph by orienting some of its edges. The eigenvalues and eigenvectors of G are, respectively, defined to be those of the Laplacian matrix L（G） of G. As L（G） is positive semidefinite, the singularity of L（G） is determined by its least eigenvalue λ1 （G）. This paper introduces a new parameter edge singularity εs（G） that reflects the singularity of L（G）, which is the minimum number of edges of G whose deletion yields that all the components of the resulting graph are singular. We give some inequalities between εs（G） and λ1 （G）（and other parameters） of G. In the case of εs（G） = 1, we obtain a property on the structure of the eigenvectors of G corresponding to λ1 （G）, which is similar to the property of Fiedler vectors of a simple graph given by Fiedler.

关键词： mixed graphs edge singularity Laplacian eigenvectors

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Evaluation of Cr Concentration Effect on Displacement Cascades in Fe-Cr Alloys with Piecewise Potential

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Acta Mechanica Solida Sinica 2020年第2期33卷 239-250页

作者： Xinhua Yang ying zheng Jie Li Department of Mechanics Huazhong University of Science and TechnologyWuhan 430074China Hubei Key Laboratory of Engineering Structural Analysis and Safety Assessment 1037 Luoyu RoadWuhan 430074China

A piecewise potential was constructed with combination of the concentration-dependent EAM(CD-EAM)potential and Ziegler-Biersack-Littmark(ZBL)potential,and the displacement cascades in random Fe-Cr binary alloys with a wide range of Cr concentration from 0 to 20%were simulated to evaluate the effect of Cr concentration on defect formation and evolution during the *** Cr concentration has little or no effect on the fraction of vacancy clusters,the number of surviving Frenkel pairs,or the self-interstitial and vacancy cluster sizes and a slight effect on the peak time and peak defect number,but a considerable effect on the Cr enrichment in the peak and surviving defects in the cascaded Fe-Cr *** the increase in Cr concentration,the Cr enrichment in the peak and surviving defects exhibits a *** higher enrichment degree in the surviving defects than in the peak defects shows more difficult recombination of Cr SIAs with vacancies.

关键词： Fe-Cr alloy Cr concentration Molecular dynamics Displacement cascades

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Remarkably reducing carbon loss and H2 consumption on Ni–Ga intermetallic compounds in deoxygenation of methyl esters to hydrocarbons

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Journal of Energy Chemistry 2020年第2期29卷 194-208页

作者： Ning Zhao ying zheng Jixiang Chen Tianjin Key Laboratory of Applied Catalysis Science and Technology Department of Catalysis Science and EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China

Ni–Ga alloy(Ni/Ga atomic ratio of 8),Ni3Ga and Ni5Ga3 intermetallic compounds(IMCs)catalysts were prepared from Ni–Mg-Al-Ga layered double hydroxides(LDHs)for the deoxygenation of methyl esters to *** the alloy and IMCs,the presence of Ga reduced the surface Ni atom density,and the charge transfer from Ga to Ni increased the electron density of *** the deoxygenation of methyl laurate,the Ni catalyst gave a complete hydrogenolysis of methyl laurate to CH4at 330°C and 3.0 MPa,while the presence of Ga promoted the HDO pathway and suppressed C–C bond hydrogenolysis and *** Ni5Ga3 catalyst exhibited the best desired *** at 400°C,it gave the yield of C11 and C12 hydrocarbons of ~99%,and the selectivity to CH4(SCH4) was only 2.4%.In the deoxygenation of methyl octanoate and methyl palmitate,the Ni5Ga3 catalyst also gave the yield of hydrocarbons above95%.Reactivity evaluation and methyl propionate-TPD and TPSR results indicate that the C–OCH3 bond instead of the O–CH3 one was cleaved on both Ni and bimetallic Ni–Ga *** is highlighted that methanol,derived from the C–OCH3 bond hydrogenolysis,mainly decomposed to CO and H2 on IMCs,while it was converted to methane on metallic Ni and *** is of great significance that H2 could be yielded from the methyl ester *** short,the utilization of Ni–Ga IMCs can effectively reduce carbon loss and H2 consumption,all of which are ascribed to the geometric and electronic effects of Ga.

关键词： Ni–Ga intermetallic compounds Methyl ester Decarbonylation/decarboxylation Hydrodeoxygenation C–C bond hydrogenolysis Methanation

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The Concurrent Record-breaking Rainfall over Northwest India and North China in September 2021

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Advances in Atmospheric Sciences 2023年第4期40卷 653-662页

作者： ying NA Riyu lu Beijing Municipal Climate Center Beijing 100089China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of the Chinese Academy of SciencesBeijing 100049China

Extremely heavy rainfall occurred over both Northwest India and North China in September *** precipitation anomalies were 4.1 and 6.2 times interannual standard deviation over the two regions,respectively,and broke the record since the observational data were available,i.e.,1901 for India and 1951 for *** this month,the Asian uppertropospheric westerly jet was greatly displaced poleward over West Asia,and correspondingly,an anomalous cyclone appeared over *** anomalous cyclone transported abundant water vapor into Northwest India,leading to the heavy rainfall *** addition,the Silk Road pattern,a teleconnection pattern of upper-level meridional wind over the Eurasian continent and fueled by the heavy rainfall in Northwest India,contributed to the heavy rainfall in North *** study emphasizes the roles of atmospheric teleconnection patterns in concurrent rainfall extremes in the two regions far away from each other,and the occurrence of rainfall extremes during the post-or pre-monsoon period in the northern margins of monsoon regions.

关键词： extreme precipitation Northwest India North China westerly jet Silk Road pattern

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A Lower Bound for the Algebraic Connectivity of a Graph in Terms of the Domination Number

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Acta Mathematicae Applicatae Sinica 2018年第4期34卷 752-760页

作者： Yi-zheng FAN ying-ying TAN School of Mathematical Sciences Anhui University Hefei 230601 P. R. China School of Mathematics and Physics Anhui Jianzhu University Hefei 230601 China

We investigate how the algebraic connectivity of a graph changes by relocating a connected branch from one vertex to another vertex, and then minimize the algebraic connectivity among all connected graphs of order n with fixed domination number γ≤（n＋2）/3, and finally present a lower bound for the algebraic connectivity in terms of the domination number. We also characterize the minimum algebraic connectivity of graphs with domination number half their order.

关键词： graph algebraic connectivity domination number

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Prediction of the local and total thermal insulations of a bedding system based on the 3D virtual simulation technology

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Building Simulation 2023年第8期16卷 1467-1480页

作者： Qing zheng Hongbo Wang ying Ke School of Textile Science and Engineering Jiangnan UniversityWuxi 214122China School of Design Jiangnan UniversityWuxi 214122China

The thermal insulation of a bedding system is one of the most critical factors affecting sleeping thermal *** study reported a mathematical model to evaluate both local and total thermal insulations of a bedding *** determine the geometric parameters in the model,the geometric model of the bedding system was developed using a 3D virtual simulation *** reliability was validated by comparing it with the 3D scanning *** predicted local and total thermal insulations of bedding systems were compared with those measured by the thermal manikin obtained in a previous *** bedding systems included six down quilts with different filling weights and involved three body *** results showed that the predicted thermal insulation values agreed well with the experimental *** predicted local and total thermal insulations were with acceptable accuracy,whose errors were within 20%and 10%,***,the research discussed the effects of two main parameters(i.e.,the proportions and partial thermal resistances of heat transfer parts)on bedding thermal insulations and provided practical suggestions for regulating bedding thermal *** study has important implications for evaluating the thermal comfort of the bedding system and contributes to improving the sleeping environment.

关键词： thermal insulation prediction model bedding system heat transfer virtual simulation

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The Contribution of United States Aircraft Reconnaissance Data to the China Meteorological Administration Tropical Cyclone Intensity Data:An Evaluation of Homogeneity

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Advances in Atmospheric Sciences 2024年第4期41卷 639-654页

作者： Ming ying Xiaoqin lu Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China

This paper investigates the homogeneity of United States aircraft reconnaissance data and the impact of these data on the homogeneity of the tropical cyclone(TC)best track data for the seasons 1949-1987 generated by the China Meteorological Administration(CMA).The evaluation of the reconnaissance data shows that the minimum central sea level pressure(MCP)data are relatively homogeneous,whereas the maximum sustained wind(MSW)data show both overestimations and spurious abrupt *** comparisons suggest that both the reconnaissance MCP and MSW were well incorporated into the CMA TC best track *** no spurious abrupt changes were evident in the reconnaissance-related best track MCP data,two spurious changepoints were identified in the remainder of the best-track MCP ***,the influence of the reconnaissance MSWs seems to extend to the best track MSWs unrelated to reconnaissance,which might reflect the optimistic confidence in making higher estimates due to the overestimated extreme wind“observations”.In addition,the overestimation of either the reconnaissance MSWs or the best track MSWs was greater during the early decades compared to later decades,which reflects the important influence of reconnaissance data on the CMA TC best track *** wind-pressure relationship(WPR)used in the CMA TC best track dataset is also evaluated and is found to overestimate the MSW,which may lead to inhomogeneity within the dataset between the aircraft reconnaissance era and the satellite era.

关键词： tropical cyclone intensity homogeneity best track aircraft reconnaissance

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Microscale spherical TiO_(2)powder prepared by hydrolysis of TiCl_(4)solution:Synthesis and kinetics

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Particuology 2024年第1期84卷 60-71页

作者： Peiyi Yan ying Zhang Shili zheng School of Rare Earths University of Science and Technology of ChinaHefei230026China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341119China Key Laboratory of Green Process and Engineering National Engineering Research Center of Green Recycling for Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing100190China State Key Laboratory of Vanadium and Titanium Resources Comprehensive Utilization Panzhihua617000China

Hydrolysis of TiCl_(4)solution is capable of preparing microscale TiO_(2)*** research studied the synthesis of microscale spherical TiO_(2)powders and the hydrolysis *** effects of the flow field generated by different agitators and baffles in the crystallizer,the initial free acid concentration,the initial equivalent TiO_(2)concentration,and the temperature on the hydrolysis progress and powder morphology were systematically *** results show that the flow field in a crystallizer can significantly affect the morphology and particle size of the powders,and the axial flow can improve the sphericity of the *** increased free HCl and equivalent TiO_(2)concentrations in the pregnant solution inhibit the forward hydrolysis reaction,prolong the time to reach equilibrium,and reduce the *** appropriate temperature matching the compositions of the pregnant solution is crucial for the powder morphology and *** with sizes ranging from around 5 um-40μm can be tuned under controlled flow field,solution compositions,and temperature *** addition,the Cheng and Wunderlich modified Avrami equation was used for the crystallization kinetic *** effects of the free HCl concentration,equivalent TiO_(2)concentration,and hydrolysis temperature are reflected in the reaction rate constant and active nuclei reduction *** the free HCl and equivalent TiO_(2)concentrations will reduce the reaction rate constant and accelerate the deactivation of the active nuclei,thus increasing the final powder size,while increasing the temperature will lead to the opposite results.

关键词： TiCl_(4) Hydrolysis Microscale TiO_(2) Spherical Kinetics

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