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High formability Mg-Zn-Gd wire facilitates ACL reconstruction via its swift degradation to accelerate intra-tunnel endochondral ossification

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Journal of Magnesium and Alloys 2024年第1期12卷 295-315页

作者： Xuan He Ye Li Hongwei Miao Jiankun Xu Michael Tim-yun Ong Chenmin Wang lizhen zheng Jiali Wang Le Huang Haiyue Zu Zhi Yao Jie Mi Bingyang Dai Xu Li Patrick Shu-hang Yung Guangyin Yuan Ling Qin Musculoskeletal Research Laboratory of Department of Orthopaedics&Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory of Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongHong KongChina National Engineering Research Center of Light Alloy Net Forming School of Materials Science&EngineeringShanghai Jiao Tong UniversityShanghaiChina Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Orthopaedic Department Peking University Third HospitalBeijingChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong KongChina

After reconstructing the anterior cruciate ligament(ACL),unsatisfactory bone tendon interface healing may often induce tunnel enlargement at the early healing *** good biological features and high formability,Magnesium-Zinc-Gadolinium(ZG21)wires are developed to bunch the tendon graft for matching the bone tunnel during ***,tensile strength,degradation,and cytotoxicity of ZG21 wire are *** rabbit model is used for assessing the biological effects of ZG21 wire by Micro-CT,histology,and mechanical *** SEM/EDS,immunochemistry,and in vitro assessments are performed to investigate the underlying *** tests demonstrate the high formability of ZG21 wire as surgical ***-CT shows ZG21 wire degradation accelerates tunnel bone formation,and histologically with earlier and more fibrocartilage regeneration at the healing *** mechanical test shows higher ultimate load in the ZG21 *** SEM/EDS presents ZG21 wire degradation triggered calcium phosphate(Ca-P)*** results demonstrate upregulation of Wnt3a,BMP2,and VEGF at the early phase and TGFβ3 and Type II collagen at the late phase of *** vitro tests also confirmed the Ca-P in the metal extract could elevate the expression of Wnt3a,βcatenin,ocn and opn to stimulate *** vivo tests of clinical samples indicated suturing with ZG21 wire did not weaken the ultimate loading of human tendon *** conclusion,the ZG21 wire is feasible for tendon graft *** degradation products accelerated intra-tunnel endochondral ossification at the early healing stage and therefore enhanced bone-tendon interface healing in ACL reconstruction.

关键词： Magnesium wire ACL reconstruction Magnesium alloy Biomaterials Endochondral ossification

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综合护理干预在慢性阻塞性肺疾病合并冠心病中的效果

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中国医药指南 2024年第16期22卷 22-25页

作者：郑丽贞仙游县郊尾卫生院综合病区莆田351253

目的观察慢性阻塞性肺疾病(慢阻肺)合并冠心病采用综合护理干预的效果。方法选取2022年4月至2023年4月慢阻肺合并冠心病60例,按随机数字表法分组,两组各33例。对照组行常规护理,观察组行综合护理,对比心功能指标、肺功能指标、生活质... 详细信息

目的观察慢性阻塞性肺疾病(慢阻肺)合并冠心病采用综合护理干预的效果。方法选取2022年4月至2023年4月慢阻肺合并冠心病60例,按随机数字表法分组,两组各33例。对照组行常规护理,观察组行综合护理,对比心功能指标、肺功能指标、生活质量、自我效能、心理健康水平及遵医行为发生率。结果护理后,观察组左心室射血分数(LVEF)、左心室等容舒张时间(LIVRT)、左心室每搏量(LVSV)高于对照组(P<0.05);观察组第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、一秒率(FEV_(1)/FVC)高于对照组(P<0.05);观察组中国心血管病人生活质量评定问卷(CQQC)评分高于对照组(P<0.05);观察组自我效能感量表(GSES)评分高于对照组(P<0.05);观察组焦虑自评量表(SAS)、抑郁自评量表(SDS)评分低于对照组(P<0.05);观察组患者遵医行为发生率高于对照组(P<0.05)。结论对慢阻肺合并冠心病患者采用综合护理干预,有助于对患者心肺功能的调节,可逐渐缓解患者负性情绪,能够提升患者自我效能,逐渐改善生活质量,可在增加患者疾病认知情况基础上,促使患者遵医行为得到提升,应用价值较好。

关键词：综合护理慢性阻塞性肺疾病冠心病生活质量心肺功能遵医行为

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陕西历史博物馆藏汉代“华仓”瓦当表面析出物的分析研究

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文物保护与考古科学 2024年第3期36卷 63-71页

作者：荆海燕郑丽珍白璐蔡淋陕西历史博物馆陕西西安710061 西安文理学院历史文化旅游学院陕西西安710065

陶质文物表面析出物中含有机酸盐的现象在国内鲜有报道。本研究采用离子色谱仪(IC)、扫描电子显微镜-能谱仪(SEM-EDS)、X射线衍射仪(XRD)、傅里叶变化显微红外光谱仪(FTIR)、超景深显微镜(DM)对一件馆藏汉代“华仓”瓦当表面析出物进行... 详细信息

陶质文物表面析出物中含有机酸盐的现象在国内鲜有报道。本研究采用离子色谱仪(IC)、扫描电子显微镜-能谱仪(SEM-EDS)、X射线衍射仪(XRD)、傅里叶变化显微红外光谱仪(FTIR)、超景深显微镜(DM)对一件馆藏汉代“华仓”瓦当表面析出物进行了表征和检测。结果表明,瓦当表面析出物主要由少量的二水硫酸钙和大量有机酸钙盐[Ca_(3)(CH_(3)COO)_(3)Cl(NO_(3))_(2)·6H_(2)O]组成,两种盐的形成与瓦当的制作过程、埋藏环境和灰尘有关,有机酸盐的形成还与馆藏环境中的乙酸有关。这种析出物不仅影响瓦当表面的真实文物信息,还会进一步腐蚀瓦当本体,建议从展柜中取出瓦当进行脱盐处理,存放在无酸的环境中。本检测分析为这件瓦当的保护修复方案的制定提供理论依据,也为类似文物样品的分析提供借鉴。

关键词：瓦当表面析出物有机酸分析检测技术

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One-step electrodeposition synthesis of bisphosphonate loaded magnesium implant:A strategy to modulate drug release for osteoporotic fracture healing

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Journal of Materials Science & Technology 2021年第19期78卷 92-99页

作者： Peng Wan Weidan Wang lizhen zheng Ling Qin Ke Yang School of Materials Science and Engineering Dongguan University of TechnologyDongguan523808China Li Ka Shing Institute of Health Sciences Department of Orthopaedics and TraumatologyThe Chinese University of Hong KongHong KongChina Department of Orthopaedics Affiliated Zhongshan Hospital of Dalian UniversityDalian116001China Institute of Metal Research Chinese Academy of SciencesShenyang110016China

Osteoporotic fracture with increase of aging population became an urgent orthopedic *** were widely recommended as effective clinical treatment *** of biodegradable Mg-based implants and merits of bisphosphonates was suggested for osteoporotic fracture *** the mild and sustained drug release,a novel one-step electrodeposition synthesis of drug loaded coating was proposed in this *** comparison to conventional soaking method,encapsulated zoledronate coating by one-step electrodeposition method could modulate drug release in first diffusion-controlled and later degradation-controlled *** in vitro cell response to zoledronate loaded coating showed enhanced proliferation and osteogenic differentiation of osteoblasts and no significant inhibition on osteoclasts,which could improve bone-forming and decrease bone resorption due to osteoporosis.

关键词： Bisphosphonate Magnesium Coating Electrodeposition Osteoporosis

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馆藏汉代瓦当表面可溶盐的化学组成分析

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分析科学学报 2024年第2期40卷 244-248页

作者：荆海燕马芬郑丽珍白璐付文斌陕西历史博物馆陕西西安710061 西北大学化学与材料科学学院陕西西安710127 西安文理学院历史文化旅游学院陕西西安710065

采用离子色谱仪(IC),扫描电子显微镜-能谱仪(SEM-EDS),X射线衍射仪(XRD)和傅里叶变化显微红外光谱仪(FTIR)等现代分析仪器,对陕西历史博物馆馆藏的汉代瓦当表面可溶盐进行了鉴定,并分析了相关的化学组成。结果表明,瓦当表面可溶盐含有石... 详细信息

采用离子色谱仪(IC),扫描电子显微镜-能谱仪(SEM-EDS),X射线衍射仪(XRD)和傅里叶变化显微红外光谱仪(FTIR)等现代分析仪器,对陕西历史博物馆馆藏的汉代瓦当表面可溶盐进行了鉴定,并分析了相关的化学组成。结果表明,瓦当表面可溶盐含有石膏(Ca SO_(4)·2H_(2)O)和有机酸钙盐[Ca_(3)(CH_(3)COO)_(3)Cl(NO_(3))_(2)·6H_(2)O]等成分。

关键词：瓦当可溶盐扫描电子显微镜-能谱 X射线衍射离子色谱

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Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy

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Nano-Micro Letters 2021年第10期13卷 29-76页

作者： Xu Li Bingyang Dai Jiaxin Guo lizhen zheng Quanyi Guo Jiang Peng Jiankun Xu Ling Qin Musculoskeletal Research Laboratory Department of Orthopedics and TraumatologyThe Chinese University of Hong KongSha TinHong KongSARPeople’s Republic of China Joint Laboratory of Chinese Academic of Science and Hong Kong for Biomaterials The Chinese University of Hong KongSha TinHong KongSARPeople’s Republic of China Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma and War Injuries PLAInstitute of OrthopedicsChinese PLA General HospitalBeijingPeople’s Republic of China Innovative Orthopedic Biomaterial and Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongSha TinHong KongSARPeople’s Republic of China

Osteoarthritis is the most prevalent chronic and debilitating joint disease,resulting in huge medical and socioeconomic ***-articular administration of agents is clinically used for pain ***,the effectiveness is inapparent caused by the rapid clearance of *** overcome this issue,nanoparticles as delivery systems hold considerable promise for local control of the pharmacokinetics of therapeutic *** the therapeutic programs are inseparable from pathological progress of osteoarthritis,an ideal delivery system should allow the release of therapeutic agents upon specific features of *** this review,we firstly introduce the pathological features of osteoarthritis and the design concept for accurate localization within cartilage for sustained drug ***,we review the interactions of nanoparticles with cartilage microenvironment and the rational ***,we highlight advances in the therapeutic schemes according to the pathology ***,armed with an updated understanding of the pathological mechanisms,we place an emphasis on the development of“smart”bioresponsive and multiple modality nanoparticles on the near horizon to interact with the pathological *** anticipate that the exploration of nanoparticles by balancing the efficacy,safety,and complexity will lay down a solid foundation tangible for clinical translation.

关键词： Nanoparticle Drug delivery Osteoarthritis Articular cartilage Nanomedicine

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Effects of fruit bagging on the physiochemical changes of grapefruit(Citrus paradisi)

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Food Quality and Safety 2022年第4期6卷 651-663页

作者： Anze Jiang lizhen zheng Dengliang Wang Chen Kang Jue Wu Peilin Fang Jinping Cao Chongde Sun Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology Zhejiang UniversityHangzhouChina Shandong(Linyi)Institute of Modern Agriculture Zhejiang UniversityLinyiChina Characteristic Agricultural Industry Development Center of Kecheng District QuzhouChina Quzhou Academy of Agricultural Sciences QuzhouChina

Fruit bagging is a commonly used cultivation measure to protect citrus fruit from insects and adverse *** present study aimed to comprehensively investigate the effects of bagging on the physiochemical characteristics of *** grapefruit were bagged at approximately 110–120 d after anthesis with a one-layer kraft paper bag with black coating inside(SL),a double-layer kraft paper bag with one black paper as the inner layer(DL),and a three-layer kraft paper bag with two black papers as inner layers(TL),*** performance liquid chromatography-high resolution mass spectrometry(UPLC-HRMS)technique was used to identify a total of 19 flavonoids,2 phenylpropanoids,9 coumarins,and 5 *** using UPLC,50 carotenoids were *** chromatography–mass spectrometry was used to identify 3 soluble sugars,3 organic acids,and 11 amino *** the quantitated components in the peel(albedo and flavedo),the chlorophylls and the carotenoids components(such as luteoxanthin,violaxanthin,9-cis-violaxanthin,xanthophyll,zeaxanthin andβ-carotene)were significantly downregulated by bagging,causing the surface color of bagged fruit to turn yellow earlier but paler than that of the unbagged control,particularly in the three-layer kraft bag *** the peel,the color and the carotenoid content of the juice sacs were less *** physiochem-ical compounds other than pigments,including soluble sugars,organic acids,amino acids,flavonoids,coumarins and limonoids,were minimally affected by bagging *** results indicated that bagging at approximately 110–120 d after anthesis exerted influence mainly on peel color,but less on sugars,acids,amino acids,flavonoids,limonoids and coumarins of grapefruit.

关键词： grapefruit fruit bagging physiochemical characteristics fruit quality

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高产直立型芸豆新品种冀张芸2号的选育与应用研究

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贵州农业科学 2024年第2期52卷 1-6页

作者：赵芳李姝彤郑丽珍高运青尚启兵徐东旭关翔宇张家口市农业科学院河北张家口075000 阳原县职业技术教育中心河北阳原075000

【目的】选育优质高产常规芸豆品种,满足市场对优质高产芸豆品种的需求。【方法】张家口市农业科学院以美国优异资源芸豆15-3-9为母本,坝上红芸豆为父本,进行杂交配制组合,后代采用系谱法成功选育出优质高产芸豆新品种冀张芸2号(2021年... 详细信息

【目的】选育优质高产常规芸豆品种,满足市场对优质高产芸豆品种的需求。【方法】张家口市农业科学院以美国优异资源芸豆15-3-9为母本,坝上红芸豆为父本,进行杂交配制组合,后代采用系谱法成功选育出优质高产芸豆新品种冀张芸2号(2021年进行成果评价,评价号:张科开评字[2021]第63号)。【结果】冀张芸2号在2016—2017年张家口市区域试验中,2年平均产量2049.31 kg/hm^(2),比对照品种(英国红)增产10.55%;生产鉴定试验的平均产量为1903.83 kg/hm2,比对照品种(英国红)增产11.21%。冀张芸2号干籽粒粗蛋白含量28.64%,粗脂肪含量1.21%,粗淀粉含量43.58%。【结论】冀张芸2号属于高蛋白芸豆品种,优质高产、粒大颗匀、商品性好、抗旱耐瘠、抗病性强、广适性好,适宜冀北及山西、内蒙等类似生态区种植。

关键词：芸豆冀张芸2号选育高蛋白杂交组配系谱法产量

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Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits

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Bioactive Materials 2021年第11期6卷 4176-4185页

作者： Dick Ho Kiu Chow Jiali Wang Peng Wan lizhen zheng Michael Tim Yun Ong Le Huang Wenxue Tong Lili Tan Ke Yang Ling Qin Musculoskeletal Research Laboratory Department of Orthopaedics&TraumatologyThe Chinese University of Hong KongHong Kong SARChina Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongShatinHong Kong SARChina Institute of Metal Research Chinese Academy of SciencesShenyangChina School of Materials Science and Engineering Dongguan University of TechnologyDongguanChina

Displaced fractures of patella often require open reduction surgery and internal fixation to restore the extensor continuity and articular *** fixation with biodegradable magnesium(Mg)pins enhanced fracture *** hypothesized that fixation with Mg pins and their degradation over time would enhance healing of patellar fracture radiologically,mechanically,and *** patellar fracture surgery was performed on thirty-two 18-weeks old female New Zealand White *** fracture was fixed with a pin made of stainless steel or pure Mg,and a figure-of-eight stainless steel band *** were harvested at week 8 or 12,and assessed with microCT,tensile testing,microindentation,and *** analysis showed that Mg group showed 12%higher in the ratio of bone volume to tissue volume at week 8,and 38.4%higher of bone volume at week *** testing showed that the failure load and stiffness of Mg group were 66.9%and 104%higher than the control group at week 8,*** week 12,Mg group was 60.8%higher in ultimate strength than the control *** showed that,compared to the Control group,Mg group showed 49.9%higher Vickers hardness and 31%higher elastic modulus at week 8 and 12,*** week 12,the new bone of Mg group remodelled to laminar bone,but those of the control group remained woven *** of transverse patellar fracture with Mg pins and its degradation enhanced new bone formation and mechanical properties of the repaired patella compared to the Control group.

关键词： Patellar fracture Tension band wire Biodegradable implant Osteogenesis Microindentation

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Combination of magnesium ions and vitamin C alleviates synovitis and osteophyte formation in osteoarthritis of mice

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Bioactive Materials 2021年第5期6卷 1341-1352页

作者： Hao Yao Jiankun Xu Jiali Wang Yifeng Zhang Nianye zheng Jiang Yue Jie Mi lizhen zheng Bingyang Dai Wenhan Huang Shuhang Yung Peijie Hu Yechun Ruan Qingyun Xue Kiwai Ho Ling Qin Musculoskeletal Research Laboratory Department of Orthopaedics&TraumatologyFaculty of MedicineThe Chinese University of Hong KongHong KongChina Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory Li Ka Shing Institute of HealthThe Chinese University of Hong KongHong KongChina Joint Laboratory of Chinese Academic of Science and Hong Kong for Biomaterials The Chinese University of Hong KongHong KongChina School of Biomedical Engineering Sun Yat-sen UniversityGuangzhouPR China School of Life Science and Technology Shanghai Tech UniversityShanghaiPR China Department of Biomedical Engineering Polytechnic University of Hong KongHong KongChina Department of Orthopedics Beijing HospitalNo.5th Clinical Medical CollageHealth Science CenterPeking UniversityBeijingPR China

Introduction:We previously demonstrated that magnesium ions(Mg^(2+))was a novel therapeutic alternative for osteoarthritis(OA)through promoting the hypoxia inducible factor-1α(HIF-1α)-mediated cartilage matrix ***,oxidative stress can inhibit the expression of HIF-1α,amplify the inflammation that potentially impairs the therapeutic efficacy of Mg^(2+) in ***(VC),a potent antioxidant,may enhance the efficacy of Mg^(2+) in OA *** study aims to investigate the efficacy of combination of Mg^(2+)and VC on alleviating joint destruction and pain in *** and methods:Anterior cruciate ligament transection with partial medial meniscectomy induced mice OA model were randomly received intra-articular injection of either saline,MgCl2(0.5 mol/L),VC(3 mg/ml)or MgCl2(0.5 mol/L)plus VC(3 mg/ml)at week 2 post-operation,twice weekly,for 2 *** pain and pathological changes were assessed by gait analysis,histology,western blotting and ***:Mg^(2+) and VC showed additive effects to significantly alleviate the joint destruction and *** efficacy of this combined therapy could sustain for 3 months after the last *** demonstrated that VC enhanced the promotive effect of Mg^(2+) on HIF-1αexpression in ***,combination of Mg^(2+) and VC markedly promoted the M2 polarization of macrophages in ***,combination of Mg^(2+) and VC inhibited osteophyte formation and expressions of pain-related ***:Intra-articular administration of Mg^(2+)and VC additively alleviates joint destruction and pain in *** current formulation may be a cost-effective alternative treatment for OA.

关键词： Osteoarthritis Magnesium Vitamin C Cartilage Inflammation Osteophyte

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