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High-altitude tree growth responses to climate change across the Hindu Kush Himalaya

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Journal of Plant Ecology 2021年第5期14卷 829-842页

作者： lili zheng Narayan Prasad Gaire Peili Shi Lhasa Plateau Ecosystem Research Station Key Laboratory of Ecosystem Network Observation and ModelingInstitute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100190China CAS Key Laboratory of Tropical Forest Ecology Xishuanghanna Tropical Botanical GardenChinese Academy of SciencesMenglunMenglaYunnan 666303China Central Department of Environmental Science Tribhuvan UniversityKirtipurKathniantluNepal

Aims Rapid warming at high altitudes may lead to a higher sensitivity in tree growth to *** key factors constraining tree radial growth and to what extent regional tree growth has suffered from climatic changes are *** Tree-ring width data were collected from 73 sites across the Hindu Kush Himalaya(HKH),including three dominant genera(Abies,Juniperus and Picea)at high altitudes over 3000 *** time warping was introduced to develop subregional chronologies by considering the synchrony of annual tree growth among different *** quantified the contribution of the climate variables,and analyzed the spatiotemporal variation of the growth–climate *** Findings The site chronologies were grouped into three clusters,corresponding to the three distinct bioclimatic zones,*** western HKH,central-eastern HKH and southeastern Tibetan Plateau(TP).Tree growth was positively correlated to winter and spring precipitation in the drier western HKH,and to winter temperature and spring precipitation in the humid southeastern *** growth was markedly constrained by the minimum temperature,especially in winter,with its importance increasing from the west toward the *** shown by moving correlation analysis,the signal of winter temperature in tree growth was weakened in the western and central-eastern HKH,while it was enhanced in the southeastern TP following rapid warming since the *** results highlight that continuous warming may cause forest recession due to warming-induced moisture deficit in the western HKH,but forest expansion in the southeastern TP.

关键词： tree ring high-altitude forests key climate factors tree growth-climate relationships growth trends climate sensitivity

促甲状腺激素不适当分泌综合征的临床特点与鉴别诊断

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中华内分泌代谢杂志 2024年第3期40卷 212-218页

作者：王莎莎李志臻赵艳艳张会娟栗夏莲秦贵军郑丽丽刘艳霞张梦阳郭丰郑州大学第一附属医院内分泌科郑州450052

目的通过全面的症状体征、生化、影像及动态试验分析,探讨垂体促甲状腺激素瘤(TSH瘤)和甲状腺激素抵抗综合征(RTH)的诊断和鉴别诊断。方法回顾性分析2016年7月至2022年9月于郑州大学第一附属医院就诊的14例血清学表现为游离三碘甲状腺... 详细信息

目的通过全面的症状体征、生化、影像及动态试验分析,探讨垂体促甲状腺激素瘤(TSH瘤)和甲状腺激素抵抗综合征(RTH)的诊断和鉴别诊断。方法回顾性分析2016年7月至2022年9月于郑州大学第一附属医院就诊的14例血清学表现为游离三碘甲状腺原氨酸和(或)游离甲状腺素水平升高而促甲状腺激素浓度不低于正常值患者的临床资料。结果TSH瘤7例、RTH 7例,平均确诊年龄分别为40.0岁和26.6岁。13例患者因甲状腺毒症或偶发心慌症状就诊,部分伴垂体占位效应或生长发育异常;1例患者因颈部增粗就诊。3例TSH瘤患者的血清性激素结合球蛋白升高。垂体磁共振成像显示,7例TSH瘤患者均为大腺瘤、1例RTH患者存在微腺瘤。13例患者行奥曲肽抑制试验均被抑制,但TSH瘤和RTH 24 h/2 h TSH抑制率存在明显差异,分别为46.6%~83.9%和4.6%~28.8%。6例RTH患者存在甲状腺激素受体β亚基突变。结论促甲状腺激素不适当分泌综合征临床较为罕见,主要包括TSH瘤和RTH,两者诊断及鉴别需结合家族史、症状体征、检查检验、动态试验及基因检测等综合研判,其中奥曲肽抑制试验24 h/2 h TSH抑制率可有效鉴别TSH瘤与RTH。

关键词：促甲状腺激素不适当分泌综合征促甲状腺激素瘤甲状腺激素抵抗综合征奥曲肽抑制试验

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校园反诈中心系统的设计与实现

中阿科技论坛（中英文） 2024年第9期 103-107页

作者：王谨平叶小惠郑丽丽章振培韩依宸宁德职业技术学院福建宁德355099

为了进一步增强学生对电信网络诈骗的防范意识,构建校园打击治理电信网络诈骗长效机制和校园安全新防线,预防电信网络诈骗案件的发生,学校教育工作者日益重视校园防诈反诈工作。文章在分析学生的反诈防范需求的基础上,设计开发了校园反... 详细信息

为了进一步增强学生对电信网络诈骗的防范意识,构建校园打击治理电信网络诈骗长效机制和校园安全新防线,预防电信网络诈骗案件的发生,学校教育工作者日益重视校园防诈反诈工作。文章在分析学生的反诈防范需求的基础上,设计开发了校园反诈中心系统,并介绍了该系统的架构设计、模块设计和实现过程。应用表明:该系统能够根据各院校反诈工作需求进行定制化反诈宣传,提供反诈消息、反诈图片、反诈答题等功能模块和管理模块,让学生便捷、高效地学习反诈知识,从而引导学生增强防诈识骗能力,进而实现“无诈校园”的建设目标。

关键词： JavaWeb网站校园反诈反诈系统防诈识骗能力

精细管理应用于空勤科护理管理中的重要性分析

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智慧健康 2024年第1期10卷 186-189页

作者：范文曹丽平郑莉莉李蕾蕾付启梅东部战区空军医院江苏南京210001

在空勤科护理管理当中应用细节管理,将细节管理的重要性充分体现出来,加强细节管理在空勤科护理管理中的落实,对于促进护理质量的提高和预防差错事故、减少护患纠纷以及提高空勤人员护理满意度等具有重要意义。

关键词：精细管理空勤科护理管理

COPD患者不同卧位及膈肌功能状态对机械通气效果的影响

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护理学杂志 2024年第3期39卷 28-30,44页

作者：庄耀宁林彬钦陈一媛林德开林丹丹郑莉莉张云阮炼杰莆田学院附属医院呼吸与危重症医学科监护病房福建莆田351106

目的探讨慢性阻塞性肺疾病(COPD)患者有益于机械通气的最佳体位,为临床护理提供实证依据。方法方便抽取120例住院机械通气的COPD患者,采取床旁超声测量平卧位、30°、40°、60°4种卧位膈肌功能状态机械通气效果的参数。结果4种卧位膈... 详细信息

目的探讨慢性阻塞性肺疾病(COPD)患者有益于机械通气的最佳体位,为临床护理提供实证依据。方法方便抽取120例住院机械通气的COPD患者,采取床旁超声测量平卧位、30°、40°、60°4种卧位膈肌功能状态机械通气效果的参数。结果4种卧位膈肌活动度差异有统计学意义(均P<0.05),其中30~40°卧位膈肌活动度较佳;不同卧位机械通气中,卧位角度越小气道顺应性越好,吸气阻力越高,呼气阻力越低(均P<0.05);卧位角度越小,支持压力越低,通气效果更佳(均P<0.05)。结论COPD患者不同卧位膈肌功能状态及机械通气效果存在明显的趋势变化,一般情况下建议选取30~40°卧位行机械通气。

关键词：慢性阻塞性肺疾病膈肌机械通气卧位呼吸护理重症护理

In-depth analysis of the genome of Trypanosoma evansi, an etiologic agent of surra

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Science China(Life Sciences) 2019年第3期62卷 406-419页

作者： lili zheng Ning Jiang Xiaoyu Sang Naiwen Zhang Kai Zhang Hongyu Chen Na Yang Ying Feng Ran Chen Xun Suo Qijun Chen Key Laboratory of Zoonosis College of Animal Science and Veterinary Medicine Shenyang Agricultural University Department of Food Science Shenyang Agricultural University Department of Parasitology College of Veterinary Medicine Chinese Agricultural University

Trypanosoma evansi is the causative agent of the animal trypanosomiasis surra, a disease with serious economic burden worldwide. The availability of the genome of its closely related parasite Trypanosoma brucei allows us to compare their genetic and evolutionarily shared and distinct biological features. The complete genomic sequence of the T. evansi YNB strain was obtained using a combination of genomic and transcriptomic sequencing, de novo assembly, and bioinformatic analysis. The genome size of the T. evansi YNB strain was 35.2 Mb, showing 96.59% similarity in sequence and 88.97% in scaffold alignment with T. brucei. A total of 8,617 protein-coding genes, accounting for 31% of the genome, were predicted. Approximately 1,641 alternative splicing events of 820 genes were identified, with a majority mediated by intron retention, which represented a major difference in post-transcriptional regulation between T. evansi and T. brucei. Disparities in gene copy number of the variant surface glycoprotein, expression site-associated genes, microRNAs, and RNA-binding protein were clearly observed between the two parasites. The results revealed the genomic determinants of T. evansi, which encoded specific biological characteristics that distinguished them from other related trypanosome species.

关键词： Trypanosoma trypanosomiasis genome annotation function

The Emergence of Functional Ultrasound for Noninvasive Brain-Computer Interface

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Research 2024年第2期6卷 301-317页

作者： Hairong zheng lili Niu Weibao Qiu Dong Liang Xiaojing Long Guanglin Li Zhiyuan Liu Long Meng Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055China Shenzhen Institute of Advanced Integration Technology Chinese Academy of Sciences and The Chinese University of Hong KongShenzhen518055China

A noninvasive brain-computer interface is a central task in the comprehensive analysis and understanding of the brain and is an important challenge in international brain-science *** implanted brain-computer interfaces are cranial and invasive,which considerably limits their *** development of new noninvasive reading and writing technologies will advance substantial innovations and breakthroughs in the field of brain-computer ***,we review the theory and development of the ultrasound brain functional imaging and its ***,we introduce latest advancements in ultrasound brain modulation and its applications in rodents,primates,and human;its mechanism and closed-loop ultrasound neuromodulation based on electroencephalograph are also ***,high-frequency acoustic noninvasive brain-computer interface is prospected based on ultrasound super-resolution imaging and acoustic tweezers.

关键词： breakthrough computer Computer

Noninvasive Assessment of Liver Fibrosis and Inflammation in Chronic Hepatitis B:A Dual-task Convolutional Neural Network(DtCNN)Model Based on Ultrasound Shear Wave Elastography

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1077-1085页

作者： Chengyan Wang lili zheng Yan Li Shujun Xia Jun Lv Xumei Hu Weiwei Zhan Fuhua Yan Ruokun Li Xinping Ren Human Phenome Institute Fudan UniversityShanghaiChina Ultrasound Department Ruijin Hospital Wuxi BranchShanghai Jiao Tong University School of MedicineWuxiJiangsuChina Department of Radiology Ruijin HospitalShang-hai Jiao Tong University School of MedicineShanghaiChina Ultrasound Department Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina School of Computer and Control Engineering Yantai UniversityYantaiShandongChina

Background and Aims:Liver stiffness(LS)measured by shear wave elastography(SWE)is often influenced by hepat-ic *** aim was to develop a dual-task convo-lutional neural network(DtCNN)model for the simultaneous staging of liver fibrosis and inflammation activity using ***:A total of 532 patients with chronic hepatitis B(CHB)were included to develop and validate the DtCNN *** additional 180 consecutive patients between De-cember 2019 and April 2021 were prospectively included for further *** patients underwent 2D-SWE examina-tion and serum biomarker assessment.A DtCNN model con-taining two pathways for the staging of fibrosis and inflam-mation was used to improve the classification of significant fibrosis(≥F2),advanced fibrosis(≥F3)as well as cirrhosis(F4).Results:Both fibrosis and inflammation affected LS measurements by *** proposed DtCNN performed the best among all the classification models for fibrosis stage[significant fibrosis AUC=0.89(95%CI:0.87-0.92),ad-vanced fibrosis AUC=0.87(95%CI:0.84-0.90),liver cirrho-sis AUC=0.85(95%CI:0.81-0.89)].The DtCNN-based pre-diction of inflammation activity achieved AUCs of 0.82(95%CI:0.78-0.86)for grade≥A1,0.88(95%CI:0.85-0.90)grade≥A2 and 0.78(95%CI:0.75-0.81)for grade≥A3,which were significantly higher than the AUCs of the single-task *** findings were observed in the prospec-tive ***:The proposed DtCNN improved di-agnostic performance compared with existing fibrosis staging models by including inflammation in the model,which sup-ports its potential clinical application.

关键词： Fibrosis Inflammation Shear wave elastography Chronic hepati-tis B Dual-task convolutional neural network.

Role of Epstein-Barr Virus Encoded Latent Membrane Protein 1 in the Carcinogenesis of Nasopharyngeal Carcinoma

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Cellular & Molecular Immunology 2007年第3期4卷 185-196页

作者： Hui zheng lili Li Duosha Hu Xiyun Deng Ya Cao Cancer Research Institute Xiangya School of Medicine Central South University Changsha Hunan China

Epstein-Barr virus （EBV）-encoded latent membrane protein 1 （LMPI） has been known to have oncogenic properties during latent infection in nasopharyngeal carcinoma （NPC）. Our studies focused on the role of LMP1 in NPC, and showed that LMP1 triggers the NF-κB, AP-1 and STAT signaling pathways. Strikingly, LMP1 was found to mediate the formation of a new heterodimer between c-Jun and JunB. Also, we have identified JAK/STAT and PI-PLC-PKC activation triggered by LMP1 through upregulating the expression of JAK3 and enhancing the phosphorylation of STATo The constitutive activation of these signaling cascades explains LMP1＇s ability to induce such a diverse array of morphological and phenotypic effects in cells and provides insight into how LMP1 may induce cell transformation, in which multihit targeted genes in the downstream play an essential role. All signaling cascades triggered by LMP1 ultimately lead to the disruption of the cell cycle： the acceleration of G1/S phase and the arrest of G2/M phase. We also found that LMP1 induced the expression of hTERT and promoted cell immortalization. Importantly, by intervening physical intracellular signal transduction pathways and disturbing the progression of the cell cycle, LMP1, an important oncoprotein encoded by EBV, is thought to be a key modulator in the pathogenesis of NPC. Interfering LMP1 signaling could be a promising strategy to target the malignant phenotype of NPC. Cellular ＆ Molecular Immunology.

关键词： latent membrane protein 1 nasopharyngeal carcinoma signal transduction