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Progression from ductal carcinoma in situ to invasive breast cancer:molecular features and clinical significance

Signal Transduction and Targeted Therapy 2024年第5期9卷 1841-1868页

作者： Jing Wang Baizhou Li Meng Luo Jia Huang kun Zhang Shu zheng Suzhan Zhang Jiaojiao Zhou The Key Laboratory of Cancer Prevention and Intervention China National Ministry of Educationthe Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Breast Surgery and Oncology the Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Zhejiang Provincial Clinical Research Center for Cancer HangzhouChina Department of Pathology the Fourth Affiliated HospitalZhejiang University School of MedicineYiwuChina Department of Plastic Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Cancer Center Zhejiang UniversityHangzhouChina

Ductal carcinoma in situ(DCIS)represents pre-invasive breast carcinoma.In untreated cases,25-60%DCIS progress to invasive ductal carcinoma(IDC).The challenge lies in distinguishing between non-progressive and progressive DCIS,often resulting in over-or under-treatment in many cases.With increasing screen-detected DCIS in these years,the nature of DCIS has aroused worldwide attention.A deeper understanding of the biological nature of DCIS and the molecular journey of the DCIS-IDC transition is crucial for more effective clinical management.Here,we reviewed the key signaling pathways in breast cancer that may contribute to DCIS initiation and progression.We also explored the molecular features of DCIS and IDC,shedding light on the progression of DCIS through both inherent changes within tumor cells and alterations in the tumor microenvironment.In addition,valuable research tools utilized in studying DCIS including preclinical models and newer advanced technologies such as single-cell sequencing,spatial transcriptomics and artificial intelligence,have been systematically summarized.Further,we thoroughly discussed the clinical advancements in DCIS and IDC,including prognostic biomarkers and clinical managements,with the aim of facilitating more personalized treatment strategies in the future.Research on DCIS has already yielded significant insights into breast carcinogenesis and will continue to pave the way for practical clinical applications.

关键词： clinical breast alterations

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Study on hydrodynamic diffusion law of the swelling particle slurry in karst pipeline

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Particuology 2024年第4期87卷 218-231页

作者： Bingchuan Cheng Haibo Li Guangming Pan Runhuai Deng Yu'an Gong Shujun Xu kun Zhou Zhuo zheng School of Civil Engineering Geotechnical and Structural Engineering Research CenterShandong UniversityJinan250061China The Fourth Prospecting of Shandong Coal Geology Bureau Weifang261000China China Railway 14th Bureau Group Corporation Limited Jinan250101China School of Trafic Engineering Shandong Jianzhu University.Fengming RoadLingang Development ZoneJinan250101China

The swelling particle grouting material has demonstrated remarkable plugging effectiveness in high-pressure and large-flow burst water within karst pipelines.Currently,current research on the rheolog-ical model,flow computation theory,and plugging mechanism of this material is lacking.The conven-tional grouting slurry diffusion process,using the liquid-liquid two-phase flow method,fails to accurately simulate high solubility slurry and particle swelling.To address these limitations,this study established a precise constitutive model to describe the swelling particle slurry diffusion process in dynamic water.Additionally,a coupling calculation method was proposed to analyze the spatiotemporal heterogeneity of viscosity during slurry diffusion by considering the migration of slurry and the changes in viscosity.To investigate the interaction between particle swelling and flow field changes,a Compu-tational Fluid Dynamics-Discrete Element Method(CFD-DEM)coupling model was developed for the diffusion of swelling particle slurry.It is demonstrated that slurry viscosity increases exponentially within the diffusion front as the particle swelling rate rises,and the drag force exhibits an intriguing behavior of initially increasing and then decreasing as the slurry flows through the pipeline.Further-more,the CFD-DEM coupling model proved to be more accurate in describing viscosity distribution and diffusion distance compared to the finite element solution.The primary objective of this paper is to reveal the plugging mechanism and provide theoretical support for the engineering application of the swelling particle grouting material.

关键词： Karst pipeline Swelling particle grouting material Dynamic water diffusion Spatiotemporal variation of viscosity CFD-DEM coupling model

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Protein C deficiency with venous and arterial thromboembolic events

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World Journal of Clinical Cases 2024年第12期12卷 2000-2003页

作者： Nan Zhang Dong-kun Sun Xu Tian Xin-Yu zheng Tong Liu Department of Cardiology Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular DiseaseTianjin Institute of CardiologyThe Second Hospital of Tianjin Medical UniversityTianjin 300211China

Protein C(PC)is a key component of the vitamin K-dependent coagulation pathway.It exerts anticoagulant effects by inactivating factors V and VIII.Acquired or inherited PC deficiency results in a prothrombotic state,with presentations varying from asymptomatic to venous thromboembolism.However,there has been an increasing number of reports linking PC deficiency to arterial thromboembolic events,such as myocardial infarction and ischemic stroke.This editorial focuses on the association between PC deficiency and thromboembolism,which may provide some insights for treatment strategy and scientific research.

关键词： Protein C deficiency Venous thromboembolism Myocardial infarction Editorial Arterial thromboembolism

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Oscillation properties of eigenfunctions for Sturm-Liouville problems with interface conditions via Prufer transformation

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 191-200页

作者： LI Zhi-yu LI kun CAI Jin-ming QIN Jian-fang zheng Zhao-wen School of Mathematical Sciences Qufu Normal UniversityQufu 273165China College of Mathematics and Systems Science Guangdong Polytechnic Normal UniversityGuangzhou 510665China

A class of Sturm-Liouville problems with discontinuity is studied in this paper.The oscillation properties of eigenfunctions for Sturm-Liouville problems with interface conditions are obtained.The main method used in this paper is based on Prufer transformation,which is different from the classical ones.Moreover,we give two examples to verify our main results.

关键词： Sturm-Liouville problem interface condition oscillatory solution

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Comprehensive evaluation of rare case:From diagnosis to treatment of a sigmoid Schwannoma:A case report

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 244-250页

作者： Jing-Yi Li Xi-Zhuang Gao Jian Zhang Xiang-zheng Meng Yi-Xian Cao kun Zhao Clinical Medical College of Jining Medical University Jining Medical UniversityJining 272000Shandong ProvinceChina Department of Gastroenterology The First People's Hospital of JiningJining 272000Shandong ProvinceChina

BACKGROUND Schwannomas are uncommon tumors originating from Schwann cells,forming the neural sheath.They account for approximately 2%-6%of all mesenchymal tumors and are most commonly identified in peripheral nerve trunks,with rarity in the gastrointestinal tract.Among gastrointestinal locations,the stomach harbors the majority of nerve sheath tumors,while such occurrences in the sigmoid colon are exceptionally infrequent.CASE SUMMARY This study presented a clinical case involving a 60-year-old female patient who,during colonoscopy,was diagnosed with a submucosal lesion that was later identified as a nerve sheath tumor.The patient underwent surgical resection,and the diagnosis was confirmed through immunohistochemistry.This study highlighted an exceptionally uncommon occurrence of a nerve sheath tumor in the sigmoid colon,which was effectively managed within our department.Additionally,a comprehensive review of relevant studies was conducted.CONCLUSION The preoperative diagnosis of nerve sheath tumors poses challenges,as the definitive diagnosis still relies on pathology and immunohistochemistry.Although categorized as benign,these tumors have the potential to demonstrate malignant behavior.Consequently,the optimal treatment approach entails the complete surgical excision of the tumor,ensuring the absence of residual lesions at the margins.

关键词： Schwannoma Gastrointestinal stromal tumors Treatment Sigmoid colon Case report

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Technologies and studies of gas exchange in two-stroke aircraft piston engine:A review

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Chinese Journal of Aeronautics 2024年第1期37卷 24-50页

作者： Yu ZHOU Xueyu LI Shuiting DING Shuai ZHAO kun ZHU Longtao SHAO Farong DU Gerui WANG zheng XU Research Institute of Aero-Engine Beihang UniversityBeijing 100191China Aircraft/Engine Integrated System Safety Beijing Key Laboratory Beijing 100191China School of Transportation Science and Engineering Beihang UniversityBeijing 100191China Civil Aviation University of China Tianjin 300300China Aero Engine Academy of China Beijing 101304China School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beihang Hangzhou Innovation Institute Yuhang Hangzhou 310052China

The in-cylinder gas exchange process is crucial to the power performance of two-stroke aircraft piston engines,which is easily influenced by complex factors such as high-altitude performance variation and in-cylinder flow characteristics.This paper reviews the development history and characteristics of gas exchange types,as well as the current state of theory and the validation methods of gas exchange technology,while also discusses the trends of cutting-edge technologies in the field.This paper provides a theoretical foundation for the optimization and engineering design of gas exchange systems and,more importantly,points out that the innovation of gas exchange types,the modification of theoretical models,and the technology of variable airflow organization are the key future research directions in this field.

关键词： Aircraft piston engine Aircraft power systems Gas exchange High-altitude performance In-cylinder flow Two-stroke Unmanned Aerial Vehicles(UAVs)

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Facile preparation and efficient MnxCoy porous nanosheets for the sustainable catalytic process of soot

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Green Energy & Environment 2024年第3期9卷 516-528页

作者： Miaomiao Hu kun Zhou Tingyi Zhao zheng Li Xianhai Zeng Di Yu Xuehua Yu Mingqin Zhao Zhihui Shao Qixiang Xu Bing Cui Flavors and Fragrance Engineering&Technology Research Center of Henan Province College of Tobacco ScienceHenan Agricultural UniversityZhengzhou450002China School of Ecology and Environment Zhengzhou UniversityZhengzhou450001China College of Energy Xiamen UniversityXiamen361102China College of Chemistry and Chemical Engineering Shenyang Normal UniversityShenyang110034China

The pursuit of high-performance is worth considerable effort in catalysis for energy efficiency and environmental sustainability. To develop redox catalysts with superior performance for soot combustion, a series of Mn_(x)Co_(y) oxides were synthesized using MgO template substitution.This method greatly improves the preparation and catalytic efficiency and is more in line with the current theme of green catalysts and sustainable development. The resulting Mn_(1)Co_(2.3) has a strong activation capability of gaseous oxygen due to a high concentration of Co^(3+) and Mn^(3+). The Mn doping enhanced the intrinsic activity by prompting oxygen vacancy formation and gaseous oxygen adsorption. The nanosheet morphology with abundant mesoporous significantly increased the solid–solid contact efficiency and improved the adsorption capability of gaseous reactants. The novel design of Mn_(1)Co_(2.3)oxide enhanced its catalytic performance through a synergistic effect of Mn doping and the porous nanosheet morphology, showing significant potential for the preparation of high-performance soot combustion catalysts.

关键词： Soot combustion Intrinsic activity Contact efficiency Mn doping DFT

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Polarization engineering in porous organic polymers for charge separation efficiency and its applications in photocatalytic aerobic oxidations

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Science China Chemistry 2024年第3期67卷 1000-1007页

作者： kun Wu Pei-Wen Cheng Xin-Yi Liu Ji zheng Xiao-Wei Zhu Mo Xie Puxin Weng Weigang Lu Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinan UniversityGuangzhou 510632China Guangdong Rare Earth Photofunctional Materials Engineering Technology Research Center School of Chemistry and EnvironmentJiaying UniversityMeizhou 514015China

Photocatalytic aerobic oxidation reactions are largely governed by the efficiency of charge separation and subsequent reactive oxygen species(ROS) generation. Herein, we report a polarization engineering strategy to promote the charge separation and ROS generation efficiency by substituting the benzene unit with furan/thiophene in porous organic polymers(POPs). Benefiting from the extent of local polarization, the thiophene-containing POP(JNU-218) exhibits the best photocatalytic performance in aerobic oxidation reactions, with a yield much higher than those for the furan-containing POP(JNU-217) and the benzenecontaining POP(JNU-216). Experimental studies and theoretical calculations reveal that the increase of local polarization can indeed reduce the exciton binding energy, and therefore facilitate the separation of electron-hole pairs. This work demonstrates a viable strategy to tune charge separation and ROS generation efficiency by modulating the dipole moments of the building blocks in porous polymeric organic semiconductors.

关键词： porous organic polymer local polarization photocatalytic aerobic oxidation charge separation reactive oxygen species exciton binding energy

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Changes in posterior corneal elevation after small incision lenticule extraction for different myopic diopters

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 491-498页

作者： Xiao-Tong Sun Yang Zhang Xiao-kun Mei Nan-Nan zheng Ling-Zhi Niu Xiao-Li Qu Ai-Ping Song Jian Zhuo Department of Ophthalmology the First Affiliated Hospital of Shandong First Medical UniversityShandong Provincial Qianfoshan HospitalJinan 250014Shandong ProvinceChina

●AIM:To study the changes and effect factors of posterior corneal surface after small incision lenticule extraction(SMILE)with different myopic diopters.●METHODS:Ninety eyes of 90 patients who underwent SMILE were included in this retrospective study.Patients were allocated into three groups based on the preoperative spherical equivalent(SE):low myopia(SE≥-3.00 D),moderate myopia(-3.00 D>SE>-6.00 D)and high myopia(SE≤-6.00 D).Posterior corneal surfaces were measured by a Scheimpflug camera preoperatively and different postoperative times(1wk,1,3,6mo,and 1y).Posterior mean elevation(PME)at 25 predetermined points of 3 concentric circles(2-,4-,and 6-mm diameter)above the best fit sphere was analyzed.●RESULTS:All surgeries were completed uneventfully and no ectasia was found through the observation.The difference of myopia group was significant at the 2-mm ring at 1 and 3mo postoperatively(1mo:P=0.017;3mo:P=0.018).The effect of time onΔPME was statistically significant(2-mm ring:P=0.001;4-mm ring:P<0.001;6-mm ring:P<0.001).The effect of different corneal locations onΔPME was significant except 1wk postoperatively(1mo:P=0.000;3mo:P=0.000;6mo:P=0.001;1y:P=0.001).Posterior corneal stability was linearly correlated with SE,central corneal thickness,ablation depth,residual bed thickness,percent ablation depth and percent stromal bed thickness.●CONCLUSION:The posterior corneal surface changes dynamically after SMILE.No protrusion is observed on the posterior corneal surface in patients with different degrees of myopia within one year after surgery.SMILE has good stability,accuracy,safety and predictability.

关键词： myopia posterior corneal elevation corneal ectasia small incision lenticule extraction

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Efficient removal of U(VI) from wastewater by a sponge-like 3D porous architecture with hybrid electrospun nanofibers

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Water Science and Engineering 2024年第2期17卷 150-156页

作者： Lin Hu Lin Chen Xian-kun Wu Rui Luo Rong-guan Lv zheng-hao Fei Feng Yang School of Chemistry and Environmental Engineering Yancheng Teachers UniversityYancheng 224051China Jiangsu Province Engineering Research Center of Agriculural Breeding Pollution Control and Resource Yancheng 224051China Jiangsu Nanda Huaxing Science and Technology of Environmental Protection Co.Ltd. Yancheng 224001China

Removal of uranium(VI)from nuclear wastewater is urgent due to the global nuclear energy exploitation.This study synthesized novel sponge-like 3D porous materials for enhanced uranium adsorption by combining electrospinning and fibrous freeze-shaping techniques.The materials possessed an organic-inorganic hybrid architecture based on the electrospun fibers of polyacrylonitrile(PAN)and SiO_(2).As a sup-porting material,the surface of fibrous SiO_(2) could be further functionalized by cyano groups via(3-cyanopropyl)triethoxysilane.All the cyano groups were turned into amidoxime(AO)groups to obtain a amidoxime-functionalized sponge(PAO/SiO_(2)-AO)through the subsequent ami-doximation process.The proposed sponge exhibited enhanced uranium adsorption performance with a high removal capacity of 367.12 mg/g,a large adsorption coefficient of 4.0×10^(4)mL/g,and a high removal efficiency of 97.59%.The UO_(2)^(2+)adsorption kinetics perfectly conformed to the pseudo-second-order reaction.The sorbent also exhibited an excellent selectivity for UO_(2)^(2+) with other interfering metal ions.2023 Hohai University.Production and hosting by Elsevier B.V.

关键词： Uranium removal Sponge Amidoximation Organic-inorganic hybrid structure Electrospinning

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