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Stratigraphic framework and sedimentary evolution during the Cryogenian-Ediacaran transition in northeastern Sichuan Basin,South China

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Petroleum Science 2024年第2期21卷 823-835页

作者： Yi Zhang Hong-Wei Kuang Yong-Qing Liu Qiang Shi Dong-Ge Wang Ke-Ning Qi Yu-Chong Wang Da-Wei Qiao Xiao-Shuai Chen Li-Zhi Wu Meng Tian long Chen Yi Wei Liao-Yuan Song Jian Li Zi-Gang Wu Yun-Qian Liu Xuan-chun Liu An-Qing Chen Zhi-Wei Liao Institute of Geology Chinese Academy of Geological SciencesBeijing100037China State Key Laboratory of Coal Mine Disaster Dynamics and Control School of Resources and Safety EngineeringChongqing UniversityChongqing400044China No.205 Geological Team Chongqing Bureau of Geology and Minerals ExplorationChongqing401121China Chongqing Institute of Geological Survey Chongqing401122China Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu610059SichuanChina

The northeastern Sichuan area in the northern Yangtze margin has unique Ediacaran geological records,especially the Doushantuo Formation(DST),and become a hot research area in recent ***,the Cryogenian-Ediacaran(C-E)boundary has not been precisely identified,which restricts the in-depth study of geological information during this crucial transitional period and is unfavorable for a systematic and complete understanding of the Yangtze Block and even the global paleogeographic *** study conducted stratigraphy,sedimentology,and chronostratigraphy to establish the stratigraphic framework and sedimentary evolution of the C-E transition strata in northeastern *** results showed that the Ediacaran sediments,without the cap dolomite,unconformably overlaid the Cryogenian sediments in the studied *** Member II of the DST,characterized by 50-160 m of red-green sandstone(approximately equivalent to the original Chengkou“Guanyinya Formation”),directly overlaid the Cryogenian sediments and displayed a 623±2.3 Ma maximum depositional age from the detrital zircon U-Pb *** stratigraphic correlations indicate that the C-E transition strata in northeastern Sichuan had a consistent lithological association and sedimentary sequence characteristics but differed from the Three ***,the upper Nantuo massive glacial diamictites transition to the icebergs rafted lonestone-bearing mudstones at the top,then change upward to DST barrier coast *** proposed DST of the northeastern Sichuan Basin was divided into three lithostratigraphic members without the regional Member I cap dolomite:(i)Member II purple-red,gray-green sandstone strata,(ii)MemberⅢblack mudstone strata,and(iii)Member IV P-Mn bearing *** the C-E transition,the study area experienced(i)the global deglaciation stage in the terminal Marinoan glaciation and(ii)the filling-leveling up stage with clastic rocks in the early ***,the early Ediacaran

关键词： Marinoan glaciation Doushantuo formation Cap dolomite Deglacial and coastal deposits Detrital zircon U-Pb dating

2020年云南省城市居民对爱国卫生“7个专项行动”的知晓率和满意度分析

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医学动物防制 2022年第5期38卷 489-492页

作者：张昱冯琳郑春龙符锡涓田子颖黄国斐余军云南省疾病预防控制中心爱国卫生技术指导中心昆明650032 云南省卫生健康委爱国卫生运动委员会办公室国家统计局云南调查总队

目的了解云南省129个县(市区)居民对爱国卫生“7个专项行动”的知晓率和满意度,为下一步推进爱国卫生工作提供数据支撑和理论依据。方法采用多阶段抽样方法抽取居民进行入户问卷调查,利用χ^(2)检验和Kruskal-Wallis非参数检验进行数据... 详细信息

目的了解云南省129个县(市区)居民对爱国卫生“7个专项行动”的知晓率和满意度,为下一步推进爱国卫生工作提供数据支撑和理论依据。方法采用多阶段抽样方法抽取居民进行入户问卷调查,利用χ^(2)检验和Kruskal-Wallis非参数检验进行数据统计分析。结果有效问卷共计收回6449份,居民对爱国卫生“7个专项行动”知晓率为98.51%,性别(χ^(2)=5.32,P0.05)。居民整体满意度为88.71分,其中对“农贸市场全提升”的满意度最高(98.54分),对“公共厕所全达标”的满意度最低(86.99分),影响满意度的主要因素为“公共厕所全达标”行动(χ^(2)=10.07,P<0.05)和“清洁消毒全覆盖”行动(χ^(2)=38.57,P<0.05)。结论云南省居民对爱国卫生“7个专项行动”的知晓率和满意度总体情况较好,各部门和各行业要进一步落实公共厕所长效管护机制,并对公共场所日常消毒工作进行督导,提高居民对爱国卫生工作的满意度。

关键词：公共卫生爱国卫生运动知晓率满意度年龄因素性别因素

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新技术方法在新药研发中的应用

中国新药杂志 2024年第14期33卷 1458-1465页

作者：王春明牛张明张龙德睿智药(苏州)新药研发有限公司苏州215100 杭州德睿智药科技有限公司杭州310000

新药研发是一个漫长且复杂的过程,需要高投入并伴有高风险和较低的成功率,因此提高新药研发效率,以最快的速度获得高质量的药物分子是所有新药研发企业梦寐以求的结果。为了克服传统二维细胞和动物实验模型简单、与人相关性差、低预测性... 详细信息

新药研发是一个漫长且复杂的过程,需要高投入并伴有高风险和较低的成功率,因此提高新药研发效率,以最快的速度获得高质量的药物分子是所有新药研发企业梦寐以求的结果。为了克服传统二维细胞和动物实验模型简单、与人相关性差、低预测性和/或高成本的弊端,开发和使用人体相关性更好、预测性更高、耗时更少、花费更低、动物福利更好的新技术方法已经迫在眉睫。高通量组学、类器官、器官芯片、模型引导的药物开发、人工智能等新型的技术和方法经过几十年的发展已经越来越成熟,并已经在新药研发领域展现出潜在的应用价值和应用前景。本文将对上述5种新技术方法在新药研发中的应用进行综述,使读者能够对这些新技术方法有一定的了解,以促进这些新技术方法在新药研发中的应用。

关键词：新药研发新技术方法组学类器官器官芯片模型引导的药物开发人工智能

Accuracy of FreeStyle Libre flash glucose monitoring in patients with type 2 diabetes who migrated from highlands to plains

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World Journal of Diabetes 2024年第6期15卷 1254-1262页

作者： Zeng-Mei Sun Yuan-Ze Du Su-Yuan Wang Shu-Yao Sun Yan Ye Xue-Ping Sun Ming-Xia Li Hua He Wun-chun long Cheng-Hui Zhang Xuan-Yu Yao Wu-Yi Fan Ling Wang Yun-Hong Wu Department of Endocrinology and Metabolism Hospital of the People's Government of the Tibet Autonomous Region in ChengduChengdu 614000Sichuan ProvinceChina Department of Nursing Hospital of Chengdu Office of the People's Government of Tibet Autonomous RegionChengdu 610041Sichuan ProvinceChina Department of Endocrinology Hospital of Chengdu Office of the People's Government of Tibet Autonomous RegionChengdu 610041Sichuan ProvinceChina

BACKGROUND The FreeStyle Libre flash glucose monitoring(FGM)system entered the Chinese market in 2017 to complement the self-monitoring of blood *** to its increased usage in clinics,the number of studies investigating its accuracy has ***,its accuracy has not been investigated in highland populations in *** To evaluate measurements recorded using the FreeStyle Libre FGM system compared with capillary blood glucose measured using the enzyme electrode method in patients with type 2 diabetes(T2D)who had migrated within 3 mo from highlands to *** Overall,68 patients with T2D,selected from those who had recently migrated from highlands to plains(within 3 mo),were hospitalized at the Department of Endocrinology from August to October 2017 and underwent continuous glucose monitoring(CGM)with the FreeStyle Libre FGM system for 14 *** the study period,fingertip capillary blood glucose was measured daily using the enzyme electrode method(Super GL,China),and blood glucose levels were read from the scanning probe during fasting and 2 h after all three ***,the time interval between reading the data from the scanning probe and collecting fingertip capillary blood was controlled to<5 *** accuracy of the FGM system was evaluated according to the CGM ***,the factors influencing the mean absolute relative difference(MARD)of this system were analyzed by a multiple linear regression *** Pearson’s correlation analysis showed that the fingertip and scanned glucose levels were positively correlated(R=0.86,P=0.00).The aggregated MARD of scanned glucose was 14.28±13.40%.Parker's error analysis showed that 99.30%of the data pairs were located in areas A and *** to the probe wear time of the FreeStyle Libre FGM system,MARD_(1 d) and MARD_(2-14 d) were 16.55%and 14.35%,respectively(t=1.23,P=0.22).Multiple stepwise regression analysis showed that MARD did not correlate with blood glucose when

关键词： Type 2 diabetes Flash glucose monitoring Accuracy Continuous glucose monitor High altitude

Cationic surface polarization centers on ionic carbon nitride for efficient solar-driven H_(2)O_(2) production and pollutant abatement

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Chinese Chemical Letters 2024年第10期35卷 383-388页

作者： Zhenyu Hu Zhenchun Yang Shiqi Zeng Kun Wang Lina Li chun Hu Yubao Zhao MOE Key Laboratory for Water Quality and Conservation of the Pearl River Delta Institute of Environmental Research at Greater BayGuangzhou UniversityGuangzhou510006China

Solar-driven H_(2)O_(2)production and emerging organic pollutants(EOPs)elimination are of great significance from the perspective of environmental *** efficiency of the photocatalytic reaction system is the key challenge to be *** this work,the strategy of constructing surface ionic local polarization centers to enhance the exciton dissociation of the polymeric photocatalytic is *** bipyridinium cation(TMAP)is complexed on a K^(+)-incorporated carbon nitride(CNK)framework,and the combination of local polarization centers both on the surface(bipyridinium cation)and bulk(K+cation)contributes to a superior photocatalytic H_(2)O_(2)production performance,affording a remarkable H_(2)O_(2)generation rate of 46.8μmol h^(-1)mg^(-1)and a high apparent quantum yield(AQY)value of 77.5%under irradiation of 405 nm *** substantiated experimentally by steady state/transient spectroscopy techniques,the surface local polarization centers increase the population of the long-lived trapped electrons,and thereby promote the interfacial charge transfer process for chemical conversion *** strategy is potentially applicable to the design of a wide range of efficient solar-to-chemical conversion systems.

关键词： Local polarization Oxygen reductionreaction Hydrogen peroxide production Pollutantdegradation Polymeric carbon nitride

Effect of Jianpi Shengxue Tablet on Iron Metabolism and Nutritional Status in Patients with Renal Anemia:A Prospective,Randomized,Open,Parallel Controlled and Multicenter Clinical Study

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Current Medical Science 2024年第3期44卷 603-610页

作者： Juan YANG Meng-yuan LIANG Yu LI Hao ZHANG Wei LI Jing LV Li-ping DONG Jing-song JIN Cheng YANG Qing-hong ZHANG Li long Rong ZOU Yi GAO Dan SONG chun-qin PAN Ying YAO Xiao-lin ZHAN Xiao-hui WANG Department of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Nephrology The First People’s Hospital of GuiyangGuiyang550000China Department of Nephrology The Third Xiangya HospitalCentral South UniversityChangsha410000China Department of Nephrology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China Department of Nephrology Wuhan No. 4 HospitalWuhan430033China Department of Nephrology Hubei Provincial Hospital of Traditional Chinese MedicineWuhan430060China Department of Nephrology Central Theater General Hospital of PLAWuhan430064China Department of Nephrology Taihe HospitalShiyan442000China Department of Nephrology Third People’s Hospital of Hubei ProvinceWuhan430033China Department of Nephrology Hubei Province Integrated Traditional Chinese and Western Medicine Hospital of Hubei provinceWuhan430024China Department of Nephrology Xi’an No.3 HospitalAffiliated Hospital of Northwest UniversityXi’an710000China Department of Nephrology Shenzhen Guangming District People’s HospitalShenzhen518000China Department of Nephrology Xiantao First People’s HospitalXiantao433000China Department of Nutrition Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Nephrology Huangshi Central HospitalHuangshi435000China Department of Nephrology The Fifth Hospital of WuhanWuhan430050China

Objective This study aimed to analyze the clinical efficacy of the Jianpi Shengxue tablet for treating renal *** A total of 200 patients with renal anemia from December 2020 to December 2022 were enrolled and randomly divided into two *** in the control group were treated with polysaccharide-iron complex,and those in the experimental group were administered Jianpi Shengxue *** 8 weeks of continuous treatment,the therapeutic outcomes regarding anemia were compared between the two *** After treatment,the red blood cell(RBC)count,hematocrit(HCT),reticulocyte percentage(RET),ferritin(SF),serum iron(SI),transferrin saturation(TSAT),and serum albumin(ALB)all increased(P<0.01),and the clinical symptom score and total iron binding capacity decreased(P<0.01)in the experimental ***,the improvements in RBC,HCT,RET,SF,SI,TAST,ALB,and clinical symptoms(fatigue,anorexia,dull skin complexion,numbness of hands and feet)in the experimental group were significantly greater than those in the control group(P<0.05).The total effective rate for treating renal anemia was significantly higher in the experimental group than in the control group(P<0.01).Conclusion The Jianpi Shengxue tablet demonstrates efficacy in treating renal anemia,leading to significant improvements in the laboratory examination results and clinical symptoms of patients with renal anemia.

关键词： Jianpi Shengxue tablet renal anemia randomized open parallel control multicenter clinical study

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我国畜牧业风险研究进展及未来展望

中国农业资源与区划 2024年第7期45卷 247-260页

作者：赵曦然杨春龙雪芬中国农业科学院农业经济与发展研究所

[目的]通过系统梳理畜牧业风险相关研究进展，分析现有研究可能存在的不足，在此基础上提出该领域未来研究展望，以期丰富我国畜牧业风险领域的研究。[方法]文章采用文献分析法和总结归纳法，从畜牧业风险的定义及类型、评估、管理策略... 详细信息

[目的]通过系统梳理畜牧业风险相关研究进展，分析现有研究可能存在的不足，在此基础上提出该领域未来研究展望，以期丰富我国畜牧业风险领域的研究。[方法]文章采用文献分析法和总结归纳法，从畜牧业风险的定义及类型、评估、管理策略等三方面对该领域相关研究进行综述。[结果]（1）畜牧业风险在定义要点和风险类型划分上和农业风险存在共性，研究侧重养殖风险、养殖户面临风险类型，缺乏对畜牧业风险的严格定义和对畜牧产业链多环节、多主体风险的系统识别和认知。（2）畜牧业风险评估主要从风险类型（自然风险、市场风险、疫病风险）视角展开，评估对象不够全面系统，不同视角的评估各有侧重，缺乏畜牧业风险综合评估，评估方法研究也有待探索。（3）畜牧业风险管理宏观主体（政府）和微观主体（养殖户）采取了多种策略，但已有研究未能及时追踪风险管理工具和策略有效性变化情况，缺乏对新型风险管理工具的效果的研究，不同管理工具和策略的相关性研究也不足。[结论]该文认为未来可以丰富畜牧业风险理论研究，识别比较不同特征下的畜牧业风险差异；充实畜牧业风险评估内容，开展综合风险评估，弥补不同畜种风险和单种风险评估的不足；优化畜牧业风险评估方法，构建综合风险评估体系，创新不同类型风险评估的具体方法，发展定量评估；评估并跟踪畜牧业风险管理策略实施效果，完善风险管理工具和策略的相关性研究四方面开展深入研究。

关键词：畜牧业风险风险评估研究综述展望

我国省域卫生资源与医疗压力的时空分异格局和脱钩关系演化

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中国卫生政策研究 2024年第2期17卷 23-31页

作者：索云龙付谦冯占春华中科技大学同济医学院医药卫生管理学院湖北武汉430030

目的:明晰省域卫生资源与医疗压力时空特征与变动趋势,为我国卫生健康事业高质量发展提供建议。方法:基于2010—2020年全国31个省份面板数据,构建省域卫生资源与医疗压力综合评价体系,采用全局熵值法与探索性空间分析揭示两者时空分异... 详细信息

目的:明晰省域卫生资源与医疗压力时空特征与变动趋势,为我国卫生健康事业高质量发展提供建议。方法:基于2010—2020年全国31个省份面板数据,构建省域卫生资源与医疗压力综合评价体系,采用全局熵值法与探索性空间分析揭示两者时空分异与关联格局,并引入Tapio脱钩指数阐释其演化特征与趋势。结果:观测期内,我国绝大多数省份卫生资源和医疗压力稳中略升,二者具备空间正相关与聚集性特征,并同经济发展与人口需求关系密切;全国主流脱钩状态由负脱钩向正脱钩转变,递进脱钩态势明显,区域卫生发展持续向好。结论与建议:各省份需结合本省卫生事业发展现状,注重要素与结构的时空耦合,以优化卫生资源配置结构与增强卫生体系韧性为抓手发挥区域卫生体系的比较优势。

关键词：卫生资源医疗压力时空分异脱钩指数

Mesenchymal stem cells: A promising therapeutic avenue for nonalcoholic fatty liver disease

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World Journal of Stem Cells 2024年第8期16卷 780-783页

作者： chun-Han Cheng Wen-Rui Hao Tzu-Hurng Cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305Taiwan Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328Taiwan

Non-alcoholic fatty liver disease(NAFLD)is a pressing global health concern that is associated with metabolic syndrome and *** the basis of the insights provided by Jiang et al,this editorial presents an exploration of the potential of mesenchymal stem cells(MSCs)for NAFLD *** have numerous desirable characteristics,including immunomodulation,anti-inflammatory pro-perties,and tissue regeneration promotion,rendering them attractive candidates for NAFLD *** preclinical and early clinical studies have high-lighted the efficacy of MSCs in improving liver function and reducing disease severity in NAFLD ***,MSC heterogeneity,long-term safety concerns,and unoptimized therapeutic protocols remain substantial *** these challenges through standardized protocols and rigorous clinical trials is essential to the safe and successful application of MSCs in NAFLD *** research into MSC mechanisms and therapeutic optimization is required to improve treatments for NAFLD and related liver diseases.

关键词： Mesenchymal stem cells Non-alcoholic fatty liver disease Therapeutic potential Liver fibrosis Regenerative medicine Stem cell therapy Inflammation Clinical trials