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Perioperative chemotherapy improves survival of patients with locally advanced diffuse gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2878-2892页

作者： Ze-Feng Li zheng Li Xiao-Jie Zhang Chong-Yuan Sun He Fei chun-Xia Du chun-Guang Guo Dong-Bing Zhao Department of Pancreatic and Gastric Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Whether patients with diffuse gastric cancer,which is insensitive to chemo-therapy,can benefit from neoadjuvant or adjuvant chemotherapy has long been *** To investigate whether perioperative chemotherapy can improve survival of patients with locally advanced diffuse gastric *** A total of 2684 patients with locally advanced diffuse gastric cancer from 18 population-based cancer registries in the United States were *** Compared with surgery alone,perioperative chemotherapy improved the prognosis of patients with locally advanced gastric *** stabilized inverse probability of treatment weighting(IPTW),the median overall survival(OS)times were 40.0 months and 13.0 months(P<0.001),*** IPTW,the median OS times were 33.0 months and 17.0 months(P<0.001),*** chemotherapy did not improve the prognosis of patients with locally advanced gastric cancer compared with adjuvant chemotherapy after *** IPTW,the median OS times were 38.0 months in the neoadjuvant chemotherapy group and 42.0 months in the adjuvant chemotherapy group(P=0.472).CONCLUSION Patients with diffuse gastric cancer can benefit from perioperative *** was no significant difference in survival between patients who received neoadjuvant chemotherapy and those who received adjuvant chemotherapy.

关键词： Gastric cancer Neoadjuvant chemotherapy Adjust chemotherapy Prognosis Survival

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植物生长调节剂对茭白孕茭的作用研究

植物生理学报 2018年第10期54卷 1605-1614页

作者：陈玥翁丽青郑春龙叶思诗黄正浩叶子弘崔海峰张雅芬中国计量大学生命科学学院浙江省生物计量及检验检疫技术重点实验室杭州310018 余姚市农业科学研究所浙江余姚315400 余姚市河姆渡镇现代农业公共服务中心浙江余姚315414

茭白(Zizania latifolia)是我国第二大水生蔬菜,具有很高的营养和药用价值,但其成熟季集中,价格优势不明显,因此提早孕茭已成为农民的迫切需求。研究表明茭白茎部菰黑粉菌(Ustilago esculenta)和植物内源激素含量是茭白孕茭的重要影响... 详细信息

茭白(Zizania latifolia)是我国第二大水生蔬菜,具有很高的营养和药用价值,但其成熟季集中,价格优势不明显,因此提早孕茭已成为农民的迫切需求。研究表明茭白茎部菰黑粉菌(Ustilago esculenta)和植物内源激素含量是茭白孕茭的重要影响因素。基于此,通过随机区组试验,首先将8种不同的植物生长调节剂及其复配组合作为备选孕茭调节剂,每种孕茭剂选择4个不同的喷施时间,采用随机抽样法对采收期的茭白进行生长指标测定,同时采用组织切片和荧光定量PCR方法测定茭白中菰黑粉菌的生长状态,在不影响孕茭产量的情况下筛选可能提早孕茭的组合及其喷施时间,并再次进行随机区组试验进一步确认。对比分析结果表明,在分蘖期喷施对碘苯氧乙酸能促进菰黑粉菌适量增殖,在保障茭白产量的同时提早孕茭时间,是理想的促孕茭时间调节剂。

关键词：茭白菰黑粉菌植物生长调节剂对碘苯氧乙酸

从“依赖养老”到“独立养老”:中国民众的养老意愿及其代际差异

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东南大学学报（哲学社会科学版） 2024年第1期26卷 104-112,152页

作者：龙书芹杨春华东南大学人文学院江苏南京210096 常州工学院人文学院江苏常州213032

根据江苏省道德发展智库开展的2022年全国调查数据分析研究发现,中国人的理想养老方式正经历从“依赖养老”到“独立养老”的转变且存在显著的代际差异,依靠子女的“依赖养老”比例随出生年代的推移而递减,而包含自我养老、机构养老和... 详细信息

根据江苏省道德发展智库开展的2022年全国调查数据分析研究发现,中国人的理想养老方式正经历从“依赖养老”到“独立养老”的转变且存在显著的代际差异,依靠子女的“依赖养老”比例随出生年代的推移而递减,而包含自我养老、机构养老和新型养老的“独立养老”比例则随着出生年代的推移而递增。从影响因素看,家庭养老资源和个人资源对“依赖-独立”养老模式有显著影响,且这种影响存在明显的代际差异。首先,子女状况对人们养老意愿的影响锐减,子女数量对大多数人的养老意愿都没有显著影响,且有无儿子仅仅对“50后、60后”和“70后”群体的养老意愿有显著影响,子女是否为独生子女更是仅仅在“50后、60后”群体中显著,说明传统的养儿防老观念已经发生悄然改变。其次,家庭经济资源不再是“依赖养老”的底气,反而逐渐转变成了“独立养老”的动力,对于“50后、60后”“90后、00后”群体而言,家庭经济资源越好的个体反而越愿意选择“独立养老”。第三,个人的经济状况越好或受教育程度越高的人越愿意选择“独立养老”。因此,家庭养老资源、个人资源对人们养老意愿产生作用的方式及其代际差异,奠定了未来中国社会化养老的心理基础。

关键词：养老意愿 “依赖养老” “独立养老” 代际差异

High density dislocations enhance creep ageing response and mechanical properties in 2195 alloy sheet

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Journal of Central South University 2024年第7期31卷 2194-2209页

作者： WEI Shuo MA Pei-pei CHEN long-hui YANG Jian-shi ZHAN Li-hua LIU chun-hui Light Alloy Research Institute Central South UniversityChangsha 410083China State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South UniversityChangsha 410083China School of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China Advancd Research Center Central South UniversityChangsha 410083China Light Alloy Research

The creep strain of conventionally treated 2195 alloy is very low,increasing the difficulty of manufacturing Al-Cu-Li alloy sheet parts by creep age ***,finding a solution to improve the creep formability of Al-Cu-Li alloy is vital.A thorough comparison of the effects of cryo-deformation and ambient temperature large pre-deformation(LPD)on the creep ageing response in the 2195 alloy sheet at 160℃with different stresses has been *** evolution of dislocations and precipitates during creep ageing of LPD alloys are revealed by X-ray diffraction and transmission electron ***-quality 2195 alloy sheet largely pre-deformed by 80%without edge-cracking is obtained by cryo-rolling at liquid nitrogen temperature,while severe edge-cracking occurs during room temperature *** creep formability and strength of the 2195 alloy are both enhanced by introducing pre-existing dislocations with a density over 1.4×10^(15)m^(−2).At 160℃and 150 MPa,creep strain and creep-aged strength generally increases by 4−6 times and 30−50 MPa in the LPD sample,respectively,compared to conventional T3 alloy *** elongation of creep-aged LPD sample is low but remains relevant for *** high-density dislocations,though existing in the form of dislocation tangles,promote the formation of refined T1 precipitates with a uniform dispersion.

关键词： creep ageing Al-Cu-Li alloy high dislocation density cryogenic rolling dislocation strengthening

A newly proposed heatstroke-induced coagulopathy score in patients with heat illness: A multicenter retrospective study in China

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Chinese Journal of Traumatology 2024年第2期27卷 83-90页

作者： Qing-Wei Lin Lin-Cui Zhong long-Ping He Qing-Bo Zeng Wei Zhang Qing Song Jing-chun Song Department of Critical Care Medicine The 908th Hospital of Chinese PLA Logistic Support ForcesNanchang360104Jiangsu ProvinceChina Department of Emergency Medicine The 900th Hospital of Chinese PLA Logistic Support ForcesFuzhou350000China Department of Critical Care Medicine Hainan Hospital of Chinese PLA General HospitalSanya572013Hainan ProvinceChina

Purpose:In patients with heatstroke, disseminated intravascular coagulation (DIC) is associated with greater risk of in-hospital mortality. However, time-consuming assays or a complex diagnostic system may delay immediate treatment. Therefore, the present study proposes a new heatstroke-induced coagulopathy (HIC) score in patients with heat illness as an early warning indicator for ***:This retrospective study enrolled patients with heat illness in 24 Chinese hospitals from March 2021 to May 2022. Patients under 18 years old, with a congenital clotting disorder or liver disease, or using anticoagulants were excluded. Data were collected on demographic characteristics, routine blood tests, conventional coagulation assays and biochemical indexes. The risk factors related to coagulation function in heatstroke were identified by regression analysis, and used to construct a scoring system for HIC. The data of patients who met the diagnostic criteria for HIC and International Society on Thrombosis and Haemostasis defined-DIC were analyzed. All statistical analyses were performed using SPSS ***:The final analysis included 302 patients with heat illness, of whom 131 (43.4%) suffered from heatstroke, including 7 death (5.3%). Core temperature (OR = 1.681, 95% CI 1.291 - 2.189, p < 0.001), prothrombin time (OR = 1.427, 95% CI 1.175 - 1.733, p < 0.001) and D-dimer (OR = 1.242, 95% CI 1.049 - 1.471, p = 0.012) were independent risk factors for heatstroke, and therefore used to construct an HIC scoring system because of their close relation with abnormal coagulation. A total score ≥ 3 indicated HIC, and HIC scores correlated with the score for International Society of Thrombosis and Hemostasis-DIC (r = 0.8848, p < 0.001). The incidence of HIC (27.5%) was higher than that of DIC (11.2%) in all of 131 heatstroke patients. Meanwhile, the mortality rate of HIC (19.4%) was lower than that of DIC (46.7%). When HIC developed into DIC, parameters of coagulation dysfunct

关键词： Heat illness Heatstroke Coagulation disorders Diagnosis Disseminated intravascular coagulation

Time-dependent model for two-phase flow in ultra-high water-cut reservoirs: Time-varying permeability and relative permeability

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Petroleum Science 2024年第4期21卷 2536-2553页

作者： Shao-chun Wang Na Zhang Zhi-Hao Tang Xue-Fei Zou Qian Sun Wei Liu College of Energy Resources Chengdu University of Technology College of Petroleum Engineering Shandong Institute of Petroleum and Chemical Technology

For the ultra-high water-cut reservoirs, after long-term water injection exploitation, the physical properties of the reservoir change and the heterogeneity of the reservoir becomes increasingly severe, which further aggravates the spatial difference of the flow field. In this study, the displacement experiments were employed to investigate the variations in core permeability, porosity, and relative permeability after a large amount of water injection. A relative permeability endpoint model was proposed by utilizing the alternating conditional expectation(ACE) transformation to describe the variation in relative permeability based on the experimental data. Based on the time dependent models for permeability and relative permeability, the traditional oil-water two-phase model was improved and discretized using the mimetic finite difference method(MFD). The two cases were launched to confirm the validation of the proposed model. The impact of time-varying physical features on reservoir production performance was studied in a real water flooding reservoir. The experimental results indicate that the overall relative permeability curve shifts to the right as water injection increases. This shift corresponds to a transition towards a more hydrophilic wettability and a decrease in residual oil saturation. The endpoint model demonstrates excellent accuracy and can be applied to time-varying simulations of reservoir physics. The impact of variations in permeability and relative permeability on the reservoir production performance yields two distinct outcomes. The time-varying permeability of the reservoir results in intensified water channeling and poor development effects. On the other hand, the time-varying relative permeability enhances the oil phase seepage capacity, facilitating oil displacement. The comprehensive time-varying behavior is the result of the combined influence of these two parameters, which closely resemble the actual conditions observed in oil field expl

关键词： Mimetic finite difference Water flooding reservoir Time-varying physical properties Numerical simulation

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以隔离变压器作负载的变频器功率考核技术

企业技术开发 2019年第5期38卷 18-21,26页

作者：余志涛郑春龙徐莉杰中车株洲电力机车研究所有限公司

文章针对常规负载的优缺点,从保证测试质量、提升测试效率、降低作业门槛、节约设备和人力资源投入成本、节能减排等方向出发,为业界提出一套较为合理有效的变频器功率考核试验系统及其方法。同时,结合笔者多年从事变频器测试技术工作... 详细信息

文章针对常规负载的优缺点,从保证测试质量、提升测试效率、降低作业门槛、节约设备和人力资源投入成本、节能减排等方向出发,为业界提出一套较为合理有效的变频器功率考核试验系统及其方法。同时,结合笔者多年从事变频器测试技术工作积累的经验进行验证和分析,为合理选择变频器功率考核试验方法和测试系统,提供一套优选的参考和指导。

关键词：变频技术功率考核质量成本

Effect of bariatric surgery on metabolism in diabetes and obesity comorbidity:Insight from recent research

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World Journal of Diabetes 2024年第4期15卷 586-590页

作者： Hui-Hong Tang Dong Wang Cheng-chun Tang Department of Cardiology Zhongda HospitalSoutheast UniversityNanjing 210009Jiangsu ProvinceChina School of Medicine Southeast UniversityNanjing 210009Jiangsu ProvinceChina

Obesity is a prevalent cause of diabetes mellitus(DM)and is a serious danger to human *** 2 DM(T2DM)mostly occurs along with *** obesity-induced DM is caused by an excessive long-term diet and surplus *** surgery can improve the symptoms of T2DM in some obese *** different types of bariatric surgery may have different *** are some models built by researchers to discuss the surgical procedures’effects on me-tabolism in diabetes animal models and diabetes *** is high time to conclude all this effects and recommend procedures that can better improve metabolism.

关键词： Bariatric surgery Obesity Diabetes Animal models Diabetes patients

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混合基础隔震体系优化设计及性能

振动工程学报 2024年第1期37卷 137-147页

作者：李春祥龙秋雨曹黎媛上海大学力学与工程科学学院土木工程系上海200444

为解决基础隔震结构中隔震层位移需求过大的问题,提出了一种基础隔震结构(Base Isolated Structure,BIS)+串并联调谐质量阻尼器惯容器(Tuned Tandem Mass Damper-Inerter, TTMDI)的混合隔震体系。采用Bouc-Wen滞回模型模拟隔震层的非线... 详细信息

为解决基础隔震结构中隔震层位移需求过大的问题,提出了一种基础隔震结构(Base Isolated Structure,BIS)+串并联调谐质量阻尼器惯容器(Tuned Tandem Mass Damper-Inerter, TTMDI)的混合隔震体系。采用Bouc-Wen滞回模型模拟隔震层的非线性力-变形行为,基于随机等效线性化和模式搜索优化算法并考虑地震动模型,在频域内建立了BIS+TTMDI体系的优化设计框架。分别从鲁棒性、有效性、刚度和阻尼系数、冲程及对地震频率敏感性方面对BIS+TTMDI体系的性能进行评估,并与BIS+调谐质量阻尼器(Tuned Mass Damper, TMD)、串并联调谐质量阻尼器(TunedTandemMassDamper,TTMD)和调谐质量阻尼器惯容器(TunedMass Damper-Inerter, TMDI)进行比较。通过对近场地震动下某七层混合基础隔震结构(包括BIS+TTMDI和BIS+TMDI体系)的动力弹塑性分析,评价了其减/隔震性能。结果表明:BIS+TTMDI体系具有最好的减/隔震性能和强鲁棒性;而且在BIS+TTMDI体系中TTMDI的总阻尼需求不到BIS+TMDI体系中TMDI的一半,因而更为经济实用。

关键词：混合基础隔震结构振动控制优化设计等效线性化动力弹塑性分析

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