检索结果-南通市图书馆

Predictive Ability of Hypertriglyceridemic Waist,Hypertriglyceridemic Waist-to-Height Ratio,and Waist-to-Hip Ratio for Cardiometabolic Risk Factors Clustering Screening among Chinese Children and Adolescents

引用

Biomedical and Environmental Sciences 2024年第3期37卷 233-241页

作者： XIAO Tian Li YUAN Shu Qian GAO Jing Yu Julien SBaker YANG Yi De WANG Xi Jie zheng chan juan DONG Yan Hui ZOU Zhi Yong Key Laboratory of Molecular Epidemiology of Hunan Province School of MedicineHunan Normal UniversityChangsha 410081HunanChina The Institute of Interdisciplinary Studies Hunan Normal UniversityChangsha 410013HunanChina Chenzhou First People's Hospital Chenzhou 423000HunanChina Centre for Health and Exercise Science Research Hong Kong Baptist UniversityKowloon TongHong Kong 999077China Department of Sport Physical Education and HealthHong Kong Baptist UniversityKowloon TongHong Kong 999077China Vanke School of Public Health Tsinghua UniversityBeijing 100084China Institute of Child and Adolescent Health School of Public HealthPeking University Health Science CenterBeijing 100191China

Objective Hypertriglyceridemic waist(HW),hypertriglyceridemic waist-to-height ratio(HWHtR),and waist-to-hip ratio(WHR)have been shown to be indicators of cardiometabolic risk ***,it is not clear which indicator is more suitable for children and *** aimed to investigate the relationship between HW,HWHtR,WHR,and cardiovascular risk factors clustering to determine the best screening tools for cardiometabolic risk in children and *** This was a national cross-sectional *** and biochemical variables were assessed in approximately 70,000 participants aged 6–18 years from seven provinces in ***,physical activity,dietary intake,and family history of chronic diseases were obtained through ***,χ2 and logistic regression analysis was *** A significant sex difference was observed for HWHtR and WHR,but not for HW *** risk of cardiometabolic health risk factor clustering with HW phenotype or the HWHtR phenotype was significantly higher than that with the non-HW or non-HWHtR phenotypes among children and adolescents(HW:OR=12.22,95%CI:9.54-15.67;HWHtR:OR=9.70,95%CI:6.93-13.58).Compared with the HW and HWHtR phenotypes,the association between risk of cardiometabolic health risk factors(CHRF)clustering and high WHR was much weaker and not significant(WHR:OR=1.14,95%CI:0.97-1.34).Conclusion Compared with HWHtR and WHR,the HW phenotype is a more convenient indicator with higher applicability to screen children and adolescents for cardiovascular risk factors.

关键词： Hypertriglyceridemic waist Waist-to-hip ratio Children and adolescents China Hypertriglyceridemic waist-to-height ratio Cardiovascular risk factors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Prognostic Model Based on Colony Stimulating Factors-related Genes in Triple-negative Breast Cancer

引用

生物化学与生物物理进展 2024年第10期51卷 2741-2756页

作者： GUO Yu-Xuan WANG Zhi-Yu XIAO Pei-Yao zheng chan-juan FU Shu-Jun HE Guang-Chun LONG Jun WANG Jie DENG Xi-Yun WANG Yi-An Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province School of MedicineHunan Normal UniversityChangsha 410013China Engineering Research Center of Reproduction and Translational Medicine of Hunan Province Changsha 410013China Department of Pathology Institute of Oncology&Diagnostic Pathology CenterThe School of Basic Medical SciencesFujian Medical UniversityFuzhou 350122China Shenzhen Key Laboratory of Energy Electrocatalytic Materials Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Provincial Key Laboratory of New Energy Materials Service SafetyCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518055China

Objective Triple-negative breast cancer(TNBC)is the breast cancer subtype with the worst prognosis,and lacks effective therapeutic *** stimulating factors(CSFs)are cytokines that can regulate the production of blood cells and stimulate the growth and development of immune cells,playing an important role in the malignant progression of *** article aims to construct a novel prognostic model based on the expression of colony stimulating factors-related genes(CRGs),and analyze the sensitivity of TNBC patients to immunotherapy and drug *** We downloaded CRGs from public databases and screened for differentially expressed CRGs between normal and TNBC tissues in the TCGA-BRCA *** LASSO Cox regression analysis,we constructed a prognostic model and stratified TNBC patients into high-risk and low-risk groups based on the colony stimulating factors-related genes risk score(CRRS).We further analyzed the correlation between CRRS and patient prognosis,clinical features,tumor microenvironment(TME)in both high-risk and low-risk groups,and evaluated the relationship between CRRS and sensitivity to immunotherapy and drug *** We identified 842 differentially expressed CRGs in breast cancer tissues of TNBC patients and selected 13 CRGs for constructing the prognostic ***-Meier survival curves,time-dependent receiver operating characteristic curves,and other analyses confirmed that TNBC patients with high CRRS had shorter overall survival,and the predictive ability of CRRS prognostic model was further validated using the GEO *** combining clinical features confirmed that CRRS was an independent factor for the prognosis of TNBC ***,patients in the high-risk group had lower levels of immune infiltration in the TME and were sensitive to chemotherapeutic drugs such as 5-fluorouracil,ipatasertib,and *** We have developed a CRRS-based prognostic model composed of 13 differentially expre

关键词： triple-negative breast cancer colony stimulating factors prognostic model tumor microenvironment drug sensitivity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

时序营养概况问卷汉化版的信效度评价

引用

现代预防医学 2024年第12期51卷 2182-2187页

作者：龚悦陈明霞樊泽慧黄泽华肖田莉凡学龙郑婵娟阳益德湖南师范大学医学院湖南师范大学医学人文研究中心湖南师范大学新闻与传播学院

目的汉化时序营养概况问卷，并检验中文版问卷的信度和效度。方法按照Brislin翻译模式将英文版时序营养概况问卷翻译为中文，并进行文化调适。通过线下发放纸质问卷和线上收集电子问卷以评价问卷的信效度和可行性。结果本研究共收集... 详细信息

目的汉化时序营养概况问卷，并检验中文版问卷的信度和效度。方法按照Brislin翻译模式将英文版时序营养概况问卷翻译为中文，并进行文化调适。通过线下发放纸质问卷和线上收集电子问卷以评价问卷的信效度和可行性。结果本研究共收集了658份问卷，其中有效问卷共593份(问卷有效率为90.1%)。研究对象回答了中文版时序营养概况问卷、慕尼黑睡眠时型量表、匹兹堡睡眠质量指数量表和24 h膳食回顾。其中中文版时序营养概况问卷与匹兹堡睡眠质量指数量表和慕尼黑睡眠时型量表的相似条目(休息日/工作日的睡觉/觉醒时间)进行比对，其Pearson相关系数较高，中等至强相关，最高为第一阶段纸质问卷的休息日睡觉时间r=0.922(P<0.001)。将中文版时序营养概况问卷与24 h膳食回顾比较，有工作/休息日的睡觉、觉醒、首次膳食、中餐及末次膳食时间，除休息日午餐时间r为0.287(P=0.076),其余在0.441～0.659(P<0.05)之间。17个时序营养概况问卷条目的重测信度中共有7个条目的组内相关系数大于等于0.75。结论中文版时序营养概况问卷具有良好信效度，且能较好反映填写者膳食时间、睡觉时间真实情况，可用于评估人群的时序营养情况。

关键词：时序营养膳食窗口信度效度

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

独立学院公共计算机基础课程教学改革探索

引用

电脑知识与技术 2011年第6期7卷 3999-4000页

作者：郑婵娟华南师范大学增城学院计算机系广东广州5l1363

首先对独立学院公共计算机基础课程的现状和问题进行了分析，问题主要包括学生的计算机水平参差不齐、教学效率低、学生解决实际问题的能力差等。然后针对上述问题，提出了教学改革方案，包括开展分类分层次教学，改革教学方法，还要提... 详细信息

首先对独立学院公共计算机基础课程的现状和问题进行了分析，问题主要包括学生的计算机水平参差不齐、教学效率低、学生解决实际问题的能力差等。然后针对上述问题，提出了教学改革方案，包括开展分类分层次教学，改革教学方法，还要提升教师队伍的素质，提高学生的学习兴趣等等。

关键词：公共计算机基础课程独立学院教学改革分类分层次任务驱动

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

连续性肾脏替代疗法对多器官功能障碍综合征患者的疗效分析

引用

世界复合医学 2020年第4期6卷 35-37页

作者：郑婵娟隆安县人民医院内科广西南宁532799

目的探讨连续性肾脏替代疗法对多器官功能障碍综合征患者的疗效。方法选取该院2017年1月—2019年10月所收治的90例多器官功能障碍综合征患者,将入选患者随机分为研究组和对照组,每组45例患者,对照组患者采取常规治疗,研究组患者在对照... 详细信息

目的探讨连续性肾脏替代疗法对多器官功能障碍综合征患者的疗效。方法选取该院2017年1月—2019年10月所收治的90例多器官功能障碍综合征患者,将入选患者随机分为研究组和对照组,每组45例患者,对照组患者采取常规治疗,研究组患者在对照组基础上联合连续性肾脏替代疗法,对比疗效。结果研究组患者MAP(66.81±7.13)mmHg、CI(5.03±0.87)L/(min·m^2)、HR(84.81±9.32)次/min明显优于对照组(60.31±6.42)mmHg、(4.65±0.72)L/(min·m^2)、(95.41±10.54)次/min(t=4.540、2.260、5.050,P<0.05);研究组患者Scr(287.9±113.4)μmol/L、BUN(15.3±4.2)mmol/L、CRP(36.18±17.23)mg/L、Lac(1.03±0.35)mmol/L明显低于对照组(375.4±142.1)μmol/L、(20.8±6.2)mmol/L、(63.28±13.21)mg/L、(2.53±0.81)mmol/L(t=3.230、4.930、8.370、18.210,P<0.05);研究组患者治疗30 d后病死率33.3%明显对照组64.4%(χ^2=10.352,P<0.05)。结论多器官功能障碍综合征患者采取连续性肾脏替代疗法,有助于稳定机体血流动力学水平,调节血液生化指标,调节机体内环境,降低短期死亡率,适用于危重症患者,值得临床上深入研究。

关键词：连续性肾脏替代疗法多器官功能障碍综合征疗效

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

盐酸氨溴索注射液联合酚妥拉明注射液治疗小儿重症肺炎的疗效

引用

医学信息 2019年第16期32卷 136-137页

作者：郑婵娟佳木斯市中心医院儿科

目的观察盐酸氨溴索注射液联合酚妥拉明注射液治疗小儿重症肺炎的临床疗效。方法选取2017年2月～2018年2月在我院诊治的140例小儿重症肺炎患儿作为研究对象,随机分为对照组和观察组,各70例。对照组采用常规治疗,观察组在对照组基础上给... 详细信息

目的观察盐酸氨溴索注射液联合酚妥拉明注射液治疗小儿重症肺炎的临床疗效。方法选取2017年2月～2018年2月在我院诊治的140例小儿重症肺炎患儿作为研究对象,随机分为对照组和观察组,各70例。对照组采用常规治疗,观察组在对照组基础上给予盐酸氨溴索注射液联合酚妥拉明注射液治疗,对比两组临床治疗有效率、临床症状消失时间(发热、咳嗽、气促、湿啰音、心衰)及不良反应发生情况。结果观察组治疗总有效率为94.28%,高于对照组的78.57%,差异有统计学意义(P<0.05);观察组临床症状消失时间(发热、咳嗽、气促、湿啰音、心衰)均短于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为5.71%,低于对照组的28.57%,差异有统计学意义(P<0.05)。结论盐酸氨溴索注射液联合酚妥拉明注射液治疗小儿重症肺炎疗效确切,临床症状消退时间短,应用安全性高,可促进患儿的快速恢复。

关键词：盐酸氨溴索酚妥拉明小儿重症肺炎

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

儿童青少年血清IGF-1及IGFBP-3的正常参考值研究

引用

医学信息 2019年第18期32卷 178-180页

作者：郑婵娟佳木斯市中心医院儿科

目的探讨儿童青少年血清胰岛素生长因子-1(IGF-1)及胰岛素因子结合蛋白-3(IGFBP-3)的正常参考值。方法选取2018年1月～2019年1月在我院体检的312例健康的儿童、青少年为研究对象,分别测定其IGF-1、IGFBP-3水平,并分析IGF-1、IGFBP-3与... 详细信息

目的探讨儿童青少年血清胰岛素生长因子-1(IGF-1)及胰岛素因子结合蛋白-3(IGFBP-3)的正常参考值。方法选取2018年1月～2019年1月在我院体检的312例健康的儿童、青少年为研究对象,分别测定其IGF-1、IGFBP-3水平,并分析IGF-1、IGFBP-3与年龄、性别、发育阶段的关系。结果男孩血清IGF-1峰值为13岁,女孩为11岁;男孩血清IGFBP-3峰值为14岁,女孩为11岁;高峰值出现后,IGF-1、IGFBP-3水平随年龄增长缓慢下降或维持高峰值;同年龄比较男孩血清IGF-1水平高于女孩、IGFBP-3水平低于女孩,差异有统计学意义(P<0.05);年龄、发育阶段与血清IGF-1值呈正相关(r=0.241,P<0.01),IGFBP-3与年龄呈正相关(r=0.323,P<0.01)。结论建立儿童青少年IGF-1、IGFBP-3水平正常参考值,可与监测其生长、临床症状以及生长激素治疗后随访具有重要的参考价值。

关键词：儿童青少年血清胰岛素生长因子-1 胰岛素因子结合蛋白-3

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Comprehensive Bile Acid Profiling of ABCB4-mutated Patients and the Prognostic Role of Taurine-conjugated􀀖􀄮􀀏􀀙􀄮􀀏􀀚􀄮􀀏􀀔􀀕􀄮􀀐􀀷􀁈􀁗􀁕􀁄􀁋􀁜􀁇􀁕􀁒􀁛􀁜􀁏􀁄􀁗􀁈􀁇􀀃􀀥􀁌􀁏􀁈􀀃􀀤􀁆􀁌􀁇􀀃􀁌􀁑􀀃􀀦􀁋􀁒􀁏􀁈􀁖􀁗􀁄􀁖􀁌􀁖

引用

Journal of Clinical and Translational Hepatology 2024年第2期12卷 151-161页

作者： Teng Liu Ren-Xue Wang Jun Han Zhong-Die Li Jonathan ASheps Li-juan zheng Xiao-Xiao Xu Victor Ling Jian-She Wang Department of Pediatrics Shanghai Medical CollegeFudan UniversityThe Center for Pediatric Liver DiseasesChildren’s Hospital of Fudan UniversityShanghaiChina BC Cancer Agency VancouverBritish Columbia V5Z 1L3Canada University of Victoria-Genome BC Proteomics Center University of VictoriaVictoriaBritish Columbia V8Z 7X8Canada Shanghai Key Laboratory of Birth Defect ShanghaiChina

Background and Aims:We asked if comprehensive bile acid profiling could provide insights into the physiopathology of ABCB4-mutated patients and evaluated the prognostic value of taurine-conjugated tetrahydroxylated bile acid(tauro-THBA)in ***:Serum bile acid profiles were evaluated in 13 ABCB4-mutated patients with 65 healthy controls by ultra-high-performance liquid chromatography/multiple-reaction monitoring-mass spectrometry(UPLC/MRM-MS).The concentration of tauro-THBA was compared between ABCB4-mutated patients with different *** areas under the curve(AUCs)of tauro-THBA were compared between ABCB11-mutated patients with native liver survival and those who died or underwent liver transplantation before 3 years of age by receiver operating characteristic curve(ROC),with another patient cohort for further ***:The overall hydrophobicity indices of bile acids in ABCB4-mutated patients(12.99±3.25 m)were significantly lower than those of healthy controls(14.02±1.74 m,p<0.000).That was due to markedly increased bile acid modifications including conjugation,sulfation,and *** in the tauro-THBA concentration in ABCB4-mutated patients with different prognoses were not *** analysis indicated that levels of tauro-THBA of<60 nM yielded an AUC of 0.900 with a sensitivity of 80%and specificity of 87.5%for ABCB11-mutated patients with different prognoses(p=0.0192).Of the 15 patients with good prognosis,14 were classified correctly and four of the five patients with a poor prognosis were classified correctly(14:15 vs.1:5,p=0.005)with tauro-THBA as a ***:Tauro-THBA concentration may be a biomarker for predicting the clinical outcome in low gammaglutamyl transferase intrahepatic cholestasis patients.

关键词： Bile acids MDR3 BSEP PFIC Liquid chromatography-mass spectrometry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

试论工程测量技术专业学生可持续发展能力的培养

引用

北京测绘 2015年第6期29卷 143-146页

作者：郑婵娟李涛赣南师范学院江西应用技术职业学院江西赣州341000

高等职业教育已成为我国教育界的一大热点问题,工程测量技术专业作为江西应有技术职业学院的重点建设专业之一,其毕业生的可持续发展能力关乎着自身能否适应未来变化的同时,也影响着专业对学生培养方式的改革和发展。本文提出了五个具... 详细信息

高等职业教育已成为我国教育界的一大热点问题,工程测量技术专业作为江西应有技术职业学院的重点建设专业之一,其毕业生的可持续发展能力关乎着自身能否适应未来变化的同时,也影响着专业对学生培养方式的改革和发展。本文提出了五个具体措施来提高工程测量技术专业学生可持续发展的能力。

关键词：高职教育工程测量技术专业可持续发展能力

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

First-line penpulimab(an anti-PD1 antibody)and anlotinib(an angiogenesis inhibitor)with nab-paclitaxel/gemcitabine(PAAG)in metastatic pancreatic cancer:a prospective,multicentre,biomolecular exploratory,phase II trial

引用

Signal Transduction and Targeted Therapy 2024年第7期9卷 2960-2969页

作者： Huizi Sha Fan Tong Jiayao Ni Yi Sun Yahui Zhu Liang Qi Xiaoqin Li Wei Li Yan Yang Qing Gu Xing Zhang Xiaoxuan Wang chan Zhu Dongsheng Chen Baorui Liu juan Du The Comprehensive Cancer Center Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing University&Clinical Cancer Institute of Nanjing UniversityNanjingChina The Comprehensive Cancer Center Nanjing Drum Tower HospitalClinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingChina Department of Oncology The Affiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Oncology The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjingChina National Institute of Healthcare Data Science at Nanjing University NanjingChina State Key Laboratory of Neurology and Oncology Drug Development Jiangsu Simcere Diagnostics Co.Ltd.Nanjing Simcere Medical Laboratory Science Co.Ltd.NanjingChina

Metastatic pancreatic cancer(mPC)has a dismal ***,we conducted a prospective,multicentre,single-arm,phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combination with nab-paclitaxel/gemcitabine(PAAG)in patients with first-line mPC(NCT05493995).The primary endpoints included the objective response rate(ORR)and disease control rate(DCR),while secondary endpoints encompassed progression-free survival(PFS),overall survival(OS),and *** 66 patients analysed for efficacy,the best response,indicated by the ORR,was recorded at 50.0%(33/66)(95%CI,37.4–62.6%),with 33 patients achieving partial response(PR).Notably,the DCR was 95.5%(63/66,95%CI,87.3–99.1%).The median PFS(mPFS)and OS(mOS)were 8.8(95%CI,8.1–11.6),and 13.7(95%CI,12.4 to not reached)months,*** 3/4 treatment-related adverse events(TRAEs)were reported in 39.4%of patients(26/66).In prespecified exploratory analysis,patients with altered SWI/SNF complex had a poorer ***,low serum CA724 level,high T-cell recruitment,low Th17 cell recruitment,and high NK CD56dim cell scores at baseline were potential predicative biomarkers for more favourable *** conclusion,PAAG as a first-line therapy demonstrated tolerability with promising clinical efficacy for *** biomolecular findings identified in this study possess the potential to guide the precise clinical application of the triple-combo regimen.

关键词： CA724 prospective centre

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：