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Association between Serum Ferritin Levels and Metabolic-associated Fatty Liver Disease in Adults:a Cross-sectional Study Based on the NHANES

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Current Medical Science 2024年第3期44卷 494-502页

作者： Jiang-hui LI Xue-yao MA Yun yi Lu-rao LI Zhi-yong XU ying CHANG Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhan430071China Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases Wuhan430071China Endoscopy Center The People’s Hospital of YingshanHuanggang438799China

Objective Ferritin,initially acting as an iron-storage protein,was found to be associated with metabolic *** study was designed to investigate the association between serum ferritin and metabolic-associated fatty liver disease(MAFLD)using data from the National Health and Nutrition Examination Survey(NHANES)of the United State of *** A cross-sectional study was conducted,enrolling a total of 2145 participants from the NHANES in the 2017–2018 *** steatosis and liver fibrosis were assessed by ultrasound images and several non-invasive *** regression analysis was conducted to determine the associations between serum ferritin concentration and MAFLD and liver *** The analysis revealed that participants with higher serum ferritin levels(Q3 and Q4 groups)had a higher prevalence of MAFLD than those with the lowest serum ferritin levels[Q3 vs.Q1:OR=2.17(1.33,3.53),P<0.05 in fatty liver index(FLI);Q4 vs.Q1:OR=3.13(1.91,5.13),P<0.05 in FLI].Additionally,participants with the highest serum ferritin levels(Q4 group)displayed a higher prevalence of liver fibrosis[Q4 vs.Q1:OR=2.59(1.19,5.62),P<0.05 in liver stiffness measurement;OR=5.06(1.12,22.94),P<0.05 in fibrosis-4 index],with significantly increased risk observed in participants with concomitant diabetes[OR=7.45(1.55,35.72),P=0.012].Conclusion Our study revealed that elevated serum ferritin levels are associated with a higher prevalence of MAFLD and advanced liver fibrosis in *** serum ferritin levels combined with diabetes are important risk factors for liver fibrosis.

关键词： serum ferritin liver fibrosis metabolic-associated fatty liver disease National Health and Nutrition Examination Survey

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Azacitidine maintenance therapy for blastic plasmacytoid dendritic cell neoplasm allograft: A case report

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World Journal of Clinical Cases 2024年第1期12卷 136-141页

作者： Li-Li Tao hui-Ting Wen Zi-yi Wang Juan Cheng Li Zhao Department of Hematology The First Clinical Medical CollegeLanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Hematology The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Blastic plasmacytoid dendritic cell neoplasm(BPDCN)is a rare,highly invasive malignant *** is no universally accepted standard of care because of its rarity and the dearth of prospective *** is still challenging for some patients to achieve persistent clinical remission or cure,despite the success of allogeneic hematopoietic stem cell transplantation(allo-HSCT),indicating that there is still a significant recurrence *** report a case of prevention of BPDCN allograft recurrence by azacitidine maintenance therapy and review the relevant *** SUMMARY We report a 41-year-old man with BPDCN who was admitted to hospital due to skin sclerosis for>5 mo’*** was diagnosed by combined clinical assessment and laboratory *** diagnosis,the patients underwent induction consolidation chemotherapy to achieve the first complete remission,followed by bridging ***-transplantation,azacitidine(75 mg/m2 for 7 d)was administered as maintenance therapy,with repeat administration every 4–6 wk and appropriate extension of the chemotherapy *** 10 cycles,the patient has been disease free for 26 mo after *** assessments of bone marrow morphology,minimal residual disease,full donor chimerism,Epstein–Barr virus,and cytomegalovirus all yielded normal results with no abnormalities *** Azacitidine may be a safe and effective maintenance treatment for BPDCN following transplantation because there were no overt adverse events during the course of treatment.

关键词： Blastic plasmacytoid dendritic cell neoplasm Azacitidine Allogeneic hematopoietic stem cell transplantation Maintenance therapy Case report

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精神分裂症患者自杀因素研究进展

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上海交通大学学报（医学版） 2020年第1期40卷 112-117页

作者：张建标吕钦谕徐健易正辉上海交通大学医学院附属精神卫生中心上海201108 江苏省南通市第四人民医院南通226005

自杀指自愿、主动结束自己生命的行为。精神分裂症是一种严重的精神疾病,该病患者自杀风险较高,对个人、家庭产生极大影响。精神分裂症患者自杀是其过早死亡的最主要原因。文章就精神分裂症患者自杀的相关危险因素、不同特征患者的自杀... 详细信息

自杀指自愿、主动结束自己生命的行为。精神分裂症是一种严重的精神疾病,该病患者自杀风险较高,对个人、家庭产生极大影响。精神分裂症患者自杀是其过早死亡的最主要原因。文章就精神分裂症患者自杀的相关危险因素、不同特征患者的自杀特点及干预措施等最新进展作一综述。

关键词：精神分裂症自杀干预措施

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组胺H3受体在精神分裂症阴性症状和认知功能中的研究进展

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复旦学报（医学版） 2021年第6期48卷 834-840页

作者：吕钦谕(综述) 陆佳晶易正辉(审校) 复旦大学附属华山医院精神医学科上海200040 上海交通大学医学院附属精神卫生中心普通精神科上海200030

精神分裂症是一种严重的神经精神障碍,阴性症状和认知功能是精神分裂症的核心症状,其发病机制与各种神经递质系统的失调有关。组胺H3受体及拮抗剂在中枢神经系统中发挥独特且关键的作用,可以作为重要的药物干预靶点。目前,H3受体拮抗剂... 详细信息

精神分裂症是一种严重的神经精神障碍,阴性症状和认知功能是精神分裂症的核心症状,其发病机制与各种神经递质系统的失调有关。组胺H3受体及拮抗剂在中枢神经系统中发挥独特且关键的作用,可以作为重要的药物干预靶点。目前,H3受体拮抗剂/反向激动剂对改善精神疾病的阴性症状和认知功能的结论不一致。因此,本文对组胺能H3受体及其拮抗剂在精神分裂症阴性症状和认知功能中的作用作一阐述,并对H3受体及其拮抗剂在精神分裂症阴性症状和认知功能治疗中的潜在用途进行展望。

关键词：精神分裂症组胺H3受体 H3拮抗剂/反向激动剂阴性症状认知功能

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Acute primary angle closure during the Omicron outbreak

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1337-1343页

作者： Dong Fang Wang-Ting Li Jia Liang Lu Chen Ning-Xin Dou hui-Yan zheng Can-Feng Huang Ting Xie yi-Jing Zhuang Peng-Feng Li Xing-Xing Mao Shao-Chong Zhang Shenzhen Eye Hospital Jinan UniversityShenzhen Key Laboratory of OphthalmologyShenzhen 518040Guangdong ProvinceChina

AIM:To investigate Omicron’s impact on clinical presentation of acute primary angle closure(APAC)in ***:A consecutive case series with historical controls was conducted at Shenzhen Eye Hospital,the largest specialized hospital in Shenzhen,*** records from a two-month period during the Omicron pandemic(December 1,2022,to January 31,2023)were compared with records from two control groups(12/2018–1/2019 and 12/2021–1/2022)before *** with APAC were included,and the prevalence of APAC and demographic characteristics in Omicron-infected and noninfected patients were ***:Seventy-one(23.43%)out of 303 patients were diagnosed with APAC in the pandemic cohort,which was 2.98 and 2.61 times higher than that in control cohorts(7.87%in 2019,8.96%in 2022,P<0.001).The pandemic cohort has significantly higher Omicron-infected rate(78.87%vs 0 vs 0;P<0.001),lower proportion of glaucoma history(16.90%vs 42.86%vs 41.67%,P=0.005),higher surgical rate(95.77%vs 83.33%vs 78.57%,P=0.024),higher total medical costs and larger pupil diameter(5.63±0.15 vs 4.68±0.15 vs 4.69±0.22 mm,P<0.01).In 83%Omicron-infected patients,ocular symptoms appeared within 3d after systemic symptoms *** multivariate analysis,Omicron infection(P<0.001)was the only independent predictor of pupil ***:In the Omicron epidemic in China,there is an increase of prevalence and severity of APAC,particularly focusing on the first 3d following infection.

关键词： Omicron acute primary angle closure ocular symptoms

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RuCo alloy nanoparticles embedded within N-doped porous two-dimensional carbon nanosheets:a high-performance hydrogen evolution reaction catalyst

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Tungsten 2024年第1期6卷 114-123页

作者： Jin-hui Wang Shao-Wei Yang Fu-Bin Ma yi-Ke Zhao Shi-Nuo Zhao zheng-Yu Xiong Dong Cai Hai-Dong Shen Kai Zhu Qiu-Yu Zhang Yue-Ling Cao Tian-Shuai Wang He-Peng Zhang Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China Xi’an Key Laboratory of Functional Organic Porous Materials School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710129China School of Power and Energy Northwestern Polytechnical UniversityXi’an 710129China Chongqing Science and Technology Innovation Center of Northwestern Polytechnical University Chongqing 401135China

Developing cost-effective electrocatalysts with high activity and stability especially at high current density is of great significance for the large-scale commercial application of electrochemical water splitting to hydrogen production but still remains ***,we report an effective confinement pyrolysis strategy to fabricate embedded ruthenium-cobalt nanoclusters supported on N-doped porous two-dimensional carbon nanosheets(RuCo@CN).Markedly,the embedded structure can effectively prevent the migration,agglomeration,and leaching of nanoparticles,thus endowing the RuCo@CN catalyst with high *** be exact,high stability with up to 650 h can be achieved at high current density(-500 and-1000 mA·cm^(-2)).Besides,the RuCo@CN catalysts also exhibit highly reactive with low overpotentials of only 11mV at-10 mA·cm^(-2).Density functional theory calculations reveal that the introduction of cobalt reduces the decomposition barrier of H_(2)O for RuCo@CN alloy,thus promoting hydrogen evolution reaction.

关键词： Hydrogen evolution reaction Confinement pyrolysis strategy Mosaic structure Stability

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Spatially resolved transcriptomic profiling of placental development in dairy cow

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Zoological Research 2024年第3期45卷 586-600页

作者： Guang-hui Tan Shi-Jie Liu Ming-Le Dou De-Feng Zhao Ao Zhang Heng-Kuan Li Fu-Nong Luo Tao Shi Hao-Ping Wang Jing-Yuan Lei Yong Zhang Yu Jiang yi zheng Fei Wang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Animal Biotechnology of the Ministry of Agriculture Northwest A&F UniversityYanglingShaanxi 712100China College of Information Engineering Northwest A&F UniversityYanglingShaanxi 712100China

The placenta plays a crucial role in successful mammalian *** animals possess a semi-invasive placenta characterized by a highly vascularized structure formed by maternal endometrial caruncles and fetal placental cotyledons,essential for full-term fetal *** cow placenta harbors at least two trophoblast cell populations:uninucleate(UNC)and binucleate(BNC)***,the limited capacity to elucidate the transcriptomic dynamics of the placental natural environment has resulted in a poor understanding of both the molecular and cellular interactions between trophoblast cells and niches,and the molecular mechanisms governing trophoblast differentiation and *** fill this knowledge gap,we employed Stereo-seq to map spatial gene expression patterns at near single-cell resolution in the cow placenta at 90 and 130 days of gestation,attaining high-resolution,spatially resolved gene expression *** on clustering and cell marker gene expression analyses,key transcription factors,including YBX1 and NPAS2,were shown to regulate the heterogeneity of trophoblast cell *** communication and trajectory analysis provided a framework for understanding cell-cell interactions and the differentiation of trophoblasts into BNCs in the placental *** analysis of cell trajectories identified a set of genes involved in regulation of trophoblast ***,spatial modules and co-variant genes that help shape specific tissue structures were ***,these findings provide foundational insights into important biological pathways critical to the placental development and function in cows.

关键词： Spatial transcriptomics Dairy cow Placenta Gestation

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Receptor tyrosine kinase-like orphan receptor 1:A novel antitumor target in gastrointestinal cancers

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World Journal of Clinical Oncology 2024年第5期15卷 603-613页

作者： zheng-Long Wu ying Wang Xiao-Yuan Jia yi-Gang Wang hui Wang Xinyuan Institute of Medicine and Biotechnology College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou 310018Zhejiang ProvinceChina Department of Oncology Zhejiang Xiaoshan HospitalHangzhou 311201Zhejiang ProvinceChina

Receptor tyrosine kinase-like orphan receptor 1(ROR1)is a member of the type I receptor tyrosine kinase ***1 is pivotal in embryonic development and cancer,and serves as a biomarker and therapeutic *** has soluble and membrane-bound subtypes,with the latter highly expressed in ***1 is conserved throughout evolution and may play a role in the development of gastrointestinal cancer through multiple signaling pathways and molecular *** suggest that overexpression of ROR1 may increase tumor invasiveness and ***,ROR1 may regulate the cell cycle,stem cell characteristics,and interact with other signaling pathways to affect cancer *** review explores the structure,expression and role of ROR1 in the development of gastrointestinal *** discusses current antitumor strategies,outlining challenges and prospects for treatment.

关键词： Receptor tyrosine kinase-like orphan receptor 1 Gastrointestinal cancers Therapeutic target Molecular mechanisms Antitumor strategies

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精神分裂症患者的情感体验和表达（英文）

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上海精神医学 2017年第5期29卷 268-276页

作者： Min-yi CHU Xu LI Qin-yu LV zheng-hui yi Eric F. C. CHEUNG Raymond C. K. CHAN Translational Neuropsychology and Applied Cognitive Neuroscience Laboratory Shanghai Mental Health Centre Shanghai Jiao Tong University School of Medicine Shanghai China Neuropsychology and Applied Cognitive Neuroscience Laboratory CAS Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Beijing China School of Psychology Central China Normal University Hubei China Shanghai Mental Health Centre Shanghai Jiao Tong University School of Medicine Shanghai China Castle Peak Hospital Hong Kong Special Administration Region China Department of Psychology University of Chinese Academy of Sciences Beijing China

背景:精神分裂症存在情感体验和表达障碍。然而,大多数以往研究往往只局限于情感体验(尤其是快感缺乏)或只针对表达。较少有同时研究精神分裂症患者情感体验和表达。目的 :本研究旨在考察精神分裂症患者的快感体验和情感表达。尤其是,... 详细信息

背景:精神分裂症存在情感体验和表达障碍。然而,大多数以往研究往往只局限于情感体验(尤其是快感缺乏)或只针对表达。较少有同时研究精神分裂症患者情感体验和表达。目的 :本研究旨在考察精神分裂症患者的快感体验和情感表达。尤其是,特别关注精神分裂症患者的情感障碍(包括快感体验和表达)和阴性症状之间的关系。方法 :150例患者完成了愉快情绪体验量表(Temporal Experience of Pleasure Scale)和情感表达量表(Emotional Expressivity Scale)的评估。结果 :精神分裂症患者表现出快感缺乏,但情感表达的能力完整。以阴性症状为主的精神分裂症患者在期待性愉快体验,尤其是抽象性期待愉快体验上的缺损更为明显结论:研究结果表明,精神分裂症患者存在出快感缺乏,但他们表达情感的能力似乎完好无损。快感缺乏尤以阴性症状为主的精神分裂症患者更为突出。

关键词：情感体验情感表达精神分裂症

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神经网络自适应PI控制器在有源滤波器中的应用

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电力系统保护与控制 2011年第16期39卷 74-79页

作者：冯亚琼王昕周荔丹郑益慧上海交通大学电工与电子技术中心上海200240 上海交通大学电气系上海200240

针对有源电力滤波器的电流跟踪控制问题,设计一种神经网络自适应PI控制器。该控制器将神经网络技术和PI控制器设计方法相结合,控制器采用PI控制器结构,具有结构简单、计算时间短、易于实现等优点。同时利用神经网络技术,使其输出作为最... 详细信息

针对有源电力滤波器的电流跟踪控制问题,设计一种神经网络自适应PI控制器。该控制器将神经网络技术和PI控制器设计方法相结合,控制器采用PI控制器结构,具有结构简单、计算时间短、易于实现等优点。同时利用神经网络技术,使其输出作为最优控制规律下的PI控制器的参数值,并根据误差大小对控制器参数进行在线实时自适应整定,从而满足大工况、全工作条件和最优性的要求。仿真实验表明,神经网络自适应PI控制器较一般的PI控制器有更快的响应速度和更高的补偿精度,而且经过神经网络自适应PI控制器作用后,其电网电流的谐波畸变率和电流跟踪误差均降低到PI控制器的55%左右。

关键词：有源电力滤波器电流跟踪控制神经网络自适应 PI控制器

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