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Ischemia/hypoxia inhibits cardiomyocyte autophagy and promotes apoptosis via the Egr-1/Bim/Beclin-1 pathway

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Journal of Geriatric Cardiology 2020年第5期17卷 284-293页

作者： Bo SU xian-Tao WANG Yu-Han SUN Man-Yun long Jing zheng Wen-Hao WU Lang LI Department of Cardiology the First Affiliated Hospital of Guangxi Medical UniversityNanningChina

Background Myocardial injury caused by microvascular obstruction(MVO)is characterized by persistent ischemia/hypoxia(IH)of cardiomyocytes after *** and Egr-1 were closely associated with various cardiovascular diseases,including *** and Beclin-1 are the important genes for autophagy and *** aimed to explore whether the Egr-1/Bim/Beclin-1 pathway is involved in regulating autophagy and apoptosis in IH-exposed *** Neonatal rat cardiomyocytes exposed to the IH environment in vitro were transfected with lentivirus expressing Egr-1 or Egr-1 sh RNA,or further treated with 3-methyladenine(3-MA).The expressions of autophagy and apoptosis-associated genes were evaluated using RT-q PCR and Western blots *** vacuoles and autophagic flux were detected by transmission electron microscopy(TEM)and confocal microscope,*** injury was assessed by lactate dehydrogenase(LDH)leakage,and apoptosis was determined by flow *** IH exposure elevated Egr-1 and Bim expressions,and decreased Beclin-1 expression in rat ***-1 overexpression in IH-exposed cardiomyocytes significantly up-regulated the levels of Egr-1 and Bim,and down-regulated the level of ***-1 knockdown resulted in down-regulated expressions of Egr-1 and Bim,as well as up-regulated expression of *** addition,Egr-1 knockdown induced autophagy was suppressed by 3-MA *** and autophagic flux experiments also confirmed that Egr-1 inhibited autophagy progression in IH-exposed ***-1 suppression protected cardiomyocytes from IH-induced injury,as evidenced by the positive correlations between Egr-1 expression and LDH leakage or apoptosis index in IH-exposed *** IH-induced cardiomyocyte autophagy and apoptosis are regulated by the Egr-1/Bim/Beclin-1 pathway,which is a potential target for treating cardiomyocyte injury caused by MVO in the IH environment.

关键词： Autophagy Apoptosis Cardiomyocyte Egr-1 Ischemia/hypoxia

Radar high resolution range profile recognition via multi-SV method

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Journal of Systems Engineering and Electronics 2017年第5期28卷 879-889页

作者： long Li zheng Liu Tao Li National Laboratory of Radar Signal Processing Xidian University

For radar high resolution range profile (HRRP) recognition, three aspects are of great importance to improve the performance, i.e. discrimination for outlier, classification for inner and an accurate description for feature space. To tackle these issues, a novel target recognition method is designed, denoted by the multiple support vectors (multi-SV) method. With the proposed method, a special framework is constructed by a treble correlate support vector model to segment the feature space to two regions with the distribution of density, and then the description and classification hyperplane for each region are achieved. Based on the support vector framework, this method needs less memory and computation complexity to fit practical radar HRRP recognition. Finally, the experiment based on the measured data verifies the excellent performance of this method.

关键词： radar target recognition high resolution range profile support vector discrimination classification

Mineral resource analysis by parabolic fractals

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Mining Science and Technology 2009年第1期19卷 91-96页

作者： XIE Shu-yun YANG Yong-guo BAO zheng-yu KE xian-zhong LILT Xiao-long State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences Wuhan Hubei 430074 China Faculty of Earth Science China University of Geosciences Wuhan Hubei 430074 China Department of Geography York University Toronto ON M3J1P3 Canada School of Resources and Earth Sciences China University of Mining ＆ Technology Xuzhou Jiangsu 221116 China

Elemental concentration distributions in space have been analyzed using different approaches. These analyses are of great significance for the quantitative characterization of various kinds of distribution patterns. Fractal and multi-fractal methods have been extensively applied to this topic. Traditionally, approximately linear-fractal laws have been regarded as useful tools for characterizing the self-similarities of element concentrations. But, in nature, it is not always easy to find perfect linear fractal laws. In this paper the parabolic fractal model is used. First a two dimensional multiplicative multi-fractal cascade model is used to study the concentration patterns. The results show the parabolic fractal （PF） properties of the concentrations and the validity of non-linear fractal analysis. By dividing the studied area into four sub-areas it was possible to show that each part follows a non-linear parabolic fractal law and that the dispersion within each part varies. The ratio of the polynomial coefficients of the fitted parabolic curves can reflect, to some degree, the relative concentration and dispersal distribution patterns. This can provide new insight into the ore-forming potential in space. The parabofic fractal evaluations of ore-forming potential for the four suhareas are in good agreement with field investigation work and geochemical mapping results based on analysis of the original data.

关键词： parabolic fractal multiplicative multifractal cascade modeling ore-forming potential geochemical mapping

Test analysis of detection of damage to a complicated spatial model structure

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Acta Mechanica Sinica 2011年第3期27卷 399-405页

作者： long-He Xu Zhong-xian Li Jia-Ru Qian School of Civil Engineering Beijing Jiaotong University 100044 Beijing China School of Civil Engineering Tianjin University 300072 Tianjin China Department of Civil Engineering Tsinghua University 100084 Beijing China

A two-stage damage detection approach is proposed and experimentally demonstrated on a complicated spatial model structure with a limited number of measurements. In the experiment,five known damage patterns,including 3 brace damage cases and 2 joint damage cases,were simulated by removing braces and weakening beam鈥揷olumn connections in the structure. The limited acceleration response data generated by hammer impact were used for system identification,and modal parameters were extracted by using the eigensystem realization algorithm. In the first stage,the possible damaged locations are determined by using the damage index and the characteristics of the analytical model itself,and the extent of damage for those substructures identified at stage I is estimated in the second stage by using a second-order eigen-sensitivity approximation method. The main contribution of this paper is to test the two-stage method by using the real dynamic data of a complicated spatial model structure with limited sensors. The analysis results indicate that the two-stage approach is ableto detect the location of both damage cases,only the severity of brace damage cases can be assessed,and the reasonable analytical model is critical for successful damage detection.

关键词： Damage detection. Complicated structure. Two-stage approach - Eigen-sensitivity analysis. Joint dam- age

Resilient and Safe Platooning Control of Connected Automated Vehicles Against Intermittent Denial-of-Service Attacks

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IEEE/CAA Journal of Automatica Sinica 2023年第5期10卷 1234-1251页

作者： Xiaohua Ge Qing-long Han Qing Wu xian-Ming Zhang the School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia the School of Engineering and Technology Central Queensland UniversityRockhampton QLD 4701Australia

Connected automated vehicles(CAVs)serve as a promising enabler for future intelligent transportation systems because of their capabilities in improving traffic efficiency and driving safety,and reducing fuel consumption and vehicle emissions.A fundamental issue in CAVs is platooning control that empowers a convoy of CAVs to be cooperatively maneuvered with desired longitudinal spacings and identical velocities on *** paper addresses the issue of resilient and safe platooning control of CAVs subject to intermittent denial-of-service(DoS)attacks that disrupt vehicle-to-vehicle ***,a heterogeneous and uncertain vehicle longitudinal dynamic model is presented to accommodate a variety of uncertainties,including diverse vehicle masses and engine inertial delays,unknown and nonlinear resistance forces,and a dynamic platoon ***,a resilient and safe distributed longitudinal platooning control law is constructed with an aim to preserve simultaneous individual vehicle stability,attack resilience,platoon safety and ***,a numerically efficient offline design algorithm for determining the desired platoon control law is developed,under which the platoon resilience against DoS attacks can be maximized but the anticipated stability,safety and scalability requirements remain ***,extensive numerical experiments are provided to substantiate the efficacy of the proposed platooning method.

关键词： Connected automated vehicles(CAVs) cooperative adaptive cruise control denial-of-service(DoS)attacks resilient control vehicle platooning vehicle-to-vehicle communication

Communication Resource-Efficient Vehicle Platooning Control With Various Spacing Policies

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 362-376页

作者： Xiaohua Ge Qing-long Han xian-Ming Zhang Derui Ding IEEE School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia

Platooning represents one of the key features that connected automated vehicles may possess as it allows multiple automated vehicles to be maneuvered cooperatively with small headways on roads. However, a critical challenge in accomplishing automated vehicle platoons is to deal with the effects of intermittent and sporadic vehicle-to-vehicle data transmissions caused by limited wireless communication resources. This paper addresses the co-design problem of dynamic event-triggered communication scheduling and cooperative adaptive cruise control for a convoy of automated vehicles with diverse spacing policies. The central aim is to achieve automated vehicle platooning under various gap references with desired platoon stability and spacing performance requirements, while simultaneously improving communication efficiency. Toward this aim, a dynamic event-triggered scheduling mechanism is developed such that the intervehicle data transmissions are scheduled dynamically and efficiently over time. Then, a tractable co-design criterion on the existence of both the admissible event-driven cooperative adaptive cruise control law and the desired scheduling mechanism is derived. Finally, comparative simulation results are presented to substantiate the effectiveness and merits of the obtained results.

关键词： Automated vehicles constant time headway spacing constant spacing cooperative adaptive cruise control event-triggered communication vehicle platooning

A Scalable Adaptive Approach to Multi-Vehicle Formation Control with Obstacle Avoidance

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IEEE/CAA Journal of Automatica Sinica 2022年第6期9卷 990-1004页

作者： Xiaohua Ge Qing-long Han Jun Wang xian-Ming Zhang IEEE School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourneVIC 3122Australia Department of Computer Science and School of Data Science City University of Hong KongChina

This paper deals with the problem of distributed formation tracking control and obstacle avoidance of multivehicle systems(MVSs)in complex obstacle-laden *** MVS under consideration consists of a leader vehicle with an unknown control input and a group of follower vehicles,connected via a directed interaction topology,subject to simultaneous unknown heterogeneous nonlinearities and external *** central aim is to achieve effective and collisionfree formation tracking control for the nonlinear and uncertain MVS with obstacles encountered in formation maneuvering,while not demanding global information of the interaction *** this goal,a radial basis function neural network is used to model the unknown nonlinearity of vehicle dynamics in each vehicle and repulsive potentials are employed for obstacle ***,a scalable distributed adaptive formation tracking control protocol with a built-in obstacle avoidance mechanism is *** is proved that,with the proposed protocol,the resulting formation tracking errors are uniformly ultimately bounded and obstacle collision avoidance is *** simulation results are elaborated to substantiate the effectiveness and the promising collision avoidance performance of the proposed scalable adaptive formation control approach.

关键词： Adaptive control collision avoidance distributed formation control multi-vehicle systems neural networks obstacle avoidance repulsive potential

MnCeOx/diatomite catalyst for persulfate activation to degrade organic pollutants

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Journal of Environmental Sciences 2020年第3期32卷 206-217页

作者： Lijun Niu Guang xian Zeqing long Guangming Zhang Ningyu Zhou School of Environment and Natural Resource Renmin University of ChinaBeijing 100872China Department of Military Installations Army Lorange Gistics University of PLAChongqing 401311China

Persulfate(PS)-based oxidation technologies are attracting increasing attentions in water treatment due to their high efficiency and *** this study,a novel diatomite supported MnCeOx composite(MnCeOx/diatomite) was prepared and characterized for activation of PS to degrade organic *** indicated that diatomite not only dispersed MnCeOx and increased the specific surface area of catalyst,but also improved the low-valence metal site(Mn^2+and Ce^3+) and reactive oxygen species site(-OH) of MnCeOx,thus enhancing the activities of ***/diatomite/PS showed high efficiency for multiple dyes and pharmaceutical *** rate(k) of MnCeOx/diatomite(kMnCeOx/diatomite) was three times higher than the sum of constant rate of MnCeOx(kMnCeOx)and constant rate of diatomite(kdiatomite).In addition,MnCeOx/diatomite showed wide pH application(5-9).Cl^- and NO3^2- had no effect while SO4^2- and humid acid had slightly negative effects on MnCeOx/diatomite/PS ***,MnCeOx/diatomite showed good reusability and *** analyses indicated that electron transfer of Mn and Ce attributed to the activation of PS and oxygen to produce free ***4·^-,·OH and O2·^-on the surface of catalyst were the main active free radicals to attack pollutants.

关键词： MnCeOx/diatomite Persulfate Dyes and pharmaceutical pollutants Hydroxyl functional group

Morphology control in high-efficiency all-polymer solar cells

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InfoMat 2022年第4期4卷 48-70页

作者： Kangkang Zhou Kaihu xian long Ye School of Materials Science and Engineering Tianjin Key Laboratory of Molecular Optoelectronic SciencesTianjin UniversityTianjinChina State Key Laboratory of Applied Optics Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchunChina

All-polymer solar cells(All-PSCs)have attracted tremendous research interest in the recent decade due to the great potentials in stretchable electronic applications in terms of long-term stability and mechanical *** by the molecular design of novel polymer acceptors and morphology optimization,the power conversion efficiency(PCE)of All-PSCs has developed rapidly and now exceeded 17%.This review outlines the promising strategies for high-performance All-PSCs from the aspect of morphology control with the motivation to rationally guide the *** this review,we briefly discuss the thermodynamic mixing principles of all-polymer blends and the effects of the molecular structure of conjugated polymers on thin-film morphology in *** crucial role of molecular miscibility in influencing morphological features and performance metrics was *** also expound on the effective methods of controlling film morphology through properly tuning the aggregation behavior of *** particular,insightful studies on the commonly used naphthalene diimide-based acceptor polymers and the newly emerging polymerized nonfullerene small molecule acceptors(ITIC-series,Y6-series,etc)are discussed in ***,we present an outlook on the major challenges and the new opportunities of All-PSCs for efficiency breakthroughs targeting 20%.

关键词： aggregated structure all-polymer solar cells morphology tuning photovoltaic polymers polymer acceptor