检索结果-南通市图书馆

Biomedical and Environmental Sciences 2006年第5期19卷 340-345页

作者： WEI HE zhen-yu ji CHENG-yu HUANG Department of Nutrition and Food Hygiene Huaxi School of Public Health Sichuan University Chengdu 610041 Sichuan China Henan Institute of Medical Sciences Zhengzhou 450052 Henan China

Objective To study the mechanism of lactose intolerance （LI） by cloning the mouse lactase cDNA and recombining a vector. Methods Total murine RNA was isolated from the small intestine of a 4-week-old BALB/c mouse （δ）. Crene-specific primers were designed and synthesized according to the cDNA sequences of lactase-phlorizin hydrolase （LPH） in human, rat, and rabbit. A coding sequence （CDS） fragment was obtained using RT-PCR, and inserted into a clone vector pNEB-193, then the cDNA was sequenced and analyzed using bioinformatics. Results The cDNA from the BALB/c mouse with 912 bp encoding 303 amino acid residues. Analysis of the deduced amino acid sequence using bioinforrnatics revealed that this cDNA shared extensive sequence homology with human LPH containing a conserved glycosyl hydrolase family 1 motif important for regulating lactase intolerance. Conclusion BALB/c mouse LPH cDNA （GenBank accession No： AY751548） provides a necessary foundation for study of the biological function and regulatory mechanism of the lactose intolerance in mice.

关键词： BALB/c mice LPH cDNA pNEB 193 Cloning Sequence

Dual protective role of HO-1 in transplanted liver grafts:A review of experimental and clinical studies

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第26期17卷 3101-3108页

作者： Chun-Feng Wang zhen-yu Wang ji-yu Li Department ofGeneral Surgery Xinhua Hospital School of Medicine ShanghaiJiao Tong University Shanghai 200092 China

Liver transplantation is considered as the most effective treatment for end-stage liver disease.However,serious complications still exist,particularly in two aspects:ischemia and subsequent reperfusion of the liver,causing postoperative hepatic dysfunction and even failure;and acute and chronic graft rejections,affecting the allograft survival.Heme oxygenase(HO),a stressresponse protein,is believed to exert a protective function on both the development of ischemia-reperfusion injury(IRI) and graft rejection.In this review of current researches on allograft protection,we focused on the HO-1.We conjecture that HO-1 may link these two main factors affecting the prognosis of liver transplantations.In this review,the following aspects were emphasized:the basic biological functions of HO-1,itsroles in IRI and allograft rejection,as well as methods to induce HO-1 and the prospects of a therapeutic application of HO-1 in liver transplantation.

关键词：肝移植保护作用审查缺血再灌注损伤临床实验血红素加氧酶排斥反应

Clinical analysis of secondary penile cancer:a case series at a tertiary referral center in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2024年第2期26卷 225-226页

作者： Xiao-yu Li Chun-Ru Xu Xing ji zhen-Peng Zhu zhen-Ke Guo Tian-yu Cai jian Lin Department of Urology Peking University First HospitalBeijing 100034China Institute of Urology Peking UniversityBeijing 100034China National Urological Cancer Center Beijing 100034China Beijing Key Laboratory of Urogenital Diseases(Male)Molecular Diagnosis and Treatment Center Beijing 100034China

Dear Editor,Secondary penile cancer is an extremely rare condition that refers to the metastasis of other malignancies to the penis.There are limited reports on secondary penile cancer in Asian populations,and perceptions about this disease are extremely scarce.We reviewed and analyzed the data of patients diagnosed with secondary penile cancer based on the pathological findings at Peking University First Hospital in Beijing,China,aiming to expand the clinical reference for this rare disease.

关键词： cancer rare finding

Spatial transcriptomics reveals that metabolic characteristics define the tumor immunosuppression microenvironment via iCAF transformation in oral squamous cell carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Oral Science 2024年第1期16卷 110-121页

作者： Zheqi Liu zhen Zhang yu Zhang Wenkai Zhou Xu Zhang Canbang Peng Tong ji Xin Zou Zhiyuan Zhang zhenhu Ren Department of Oral and Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghaiChina Department of Oral and Maxillofacial Surgery Zhongshan HospitalFudan UniversityShanghaiChina School and Hospital of Stomatology Kunming Medical UniversityKunmingChina Center for Tumor Diagnosis&Therapy Jinshan HospitalFudan UniversityShanghaiChina Department of Pathology Jinshan HospitalFudan UniversityShanghaiChina Hainan Western Central Hospital Academician Zhang Zhiyuan Team Innovation CenterDanzhouChina

Tumor progression is closely related to tumor tissue metabolism and reshaping of the microenvironment. Oral squamous cell carcinoma (OSCC), a representative hypoxic tumor, has a heterogeneous internal metabolic environment. To clarify the relationship between different metabolic regions and the tumor immune microenvironment (TME) in OSCC, Single cell (SC) and spatial transcriptomics (ST) sequencing of OSCC tissues were performed. The proportion of TME in the ST data was obtained through SPOTlight deconvolution using SC and GSE103322 data. The metabolic activity of each spot was calculated using scMetabolism,and k-means clustering was used to classify all spots into hyper-, normal-, or hypometabolic regions. CD4T cell infiltration and TGF-βexpression is higher in the hypermetabolic regions than in the others. Through CellPhoneDB and NicheNet cell-cell communication analysis, it was found that in the hypermetabolic region, fibroblasts can utilize the lactate produced by glycolysis of epithelial cells to transform into inflammatory cancer-associated fibroblasts (iCAFs), and the increased expression of HIF1A in iCAFs promotes the transcriptional expression of CXCL12. The secretion of CXCL12 recruits regulatory T cells (Tregs), leading to Treg infiltration and increased TGF-β secretion in the microenvironment and promotes the formation of a tumor immunosuppressive microenvironment. This study delineates the coordinate work axis of epithelial cells-iCAFs-Tregs in OSCC using SC, ST and TCGA bulk data, and highlights potential targets for therapy.

关键词： CXCL12 microenvironment squamous

Postoperative abdominal herpes zoster complicated by intestinal obstruction:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第6期12卷 1138-1143页

作者： zhen-yu Dong Rui-Xian Shi Xiao-Biao Song Ming-yue Du ji-Jun Wang Department of General Surgery Baotou Central HospitalBaotou 014040Inner Mongolia Autonomous RegionChina Department of General Surgery Baotou Medical CollegeBaotou 014040Inner Mongolia Autonomous RegionChina Department of Neurology Baotou Central HospitalBaotou 014040Inner Mongolia Autonomous RegionChina Department of Neurology Inner Mongolia Medical UniversityHohhot 010110Inner Mongolia Autonomous RegionChina

BACKGROUND Intestinal obstruction is a common occurrence in clinical practice.However,the occurrence of herpes zoster complicated by intestinal obstruction after abdominal surgery is exceedingly rare.In the diagnostic and treatment process,clinicians consider it crucial to identify the primary causes of its occurrence to ensure effective treatment and avoiding misdiagnosis.CASE SUMMARY Herein,we present the case of a 40-year-old female patient with intestinal obstruction who underwent laparoscopic appendectomy and developed herpes zoster after surgery.Combining the patient's clinical manifestations and relevant laboratory tests,it was suggested that the varicella zoster virus reactivated during the latent period after abdominal surgery,causing herpes zoster.Subsequently,the herpes virus invaded the visceral nerve fibers,causing gastrointestinal dysfunction and loss of intestinal peristalsis,which eventually led to intestinal obstruction.The patient was successfully treated through conservative treatment and antiviral therapy and subsequently discharged from the hospital.CONCLUSION Pseudo-intestinal obstruction secondary to herpes zoster infection is difficult to distinguish from mechanical intestinal obstruction owing to various causes.In cases of inexplicable intestinal obstructions,considering the possibility of a viral infection is essential to minimize misdiagnosis and missed diagnoses。

关键词： Herpes zoster Pseudo-intestinal obstruction Ogilvie syndrome Peripheral motor neuropathy Case report

Recent progress in self-propelled particles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2024年第1期36卷 61-77页

作者： zhen-yu Ouyang jian-zhong Lin Laboratory of Impact and Safety Engineering Ministry of EducationNingbo UniversityNingbo315201China Department of Mechanics State Key Laboratory of Fluid Power and Mechatronic SystemsZhejiang UniversityHangzhou310027China

Self-propelled particles are commonly found in a large number of planktonic organisms such as bacteria,fungi,and algae in nature,and researchers have taken a long interest in exploring their swimming mechanisms for more than a century.Especially in the past 20 years,with the development of computational fluid dynamics and flow display technology,as well as the need for the design of synthetic self-propelled particles and micro-swimming devices,self-propelled particles have become the forefront and hotspot of current research in the field of fluid mechanics.This paper first introduces the swimming characteristics of common self-propelled particles,leading to a classic“squirmer”type self-propelled particle model.On this basis,a systematic introduction and summary of the theoretical and numerical simulation research of“squirmer”will be conducted.Finally,the main challenges and opportunities faced by the current research will be summarized.

关键词： Self-propelled particles multiphase flow hydrodynamic interaction

First Passage Density of Brownian Motion with Two-sided Piecewise Linear Boundaries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2024年第6期40卷 1505-1520页

作者： zhen yu Mao Zai TIAN Center for Applied Statistics School of StatisticsRenmin University of ChinaBeijing 100872P.R.China School of Mathematics and Data Science Changji UniversityChangji 831100P.R.China

The first passage time has many applications in fields like finance,econometrics,statistics,and biology.However,explicit formulas for the first passage density have only been obtained for a few cases.This paper derives an explicit formula for the first passage density of Brownian motion with twosided piecewise continuous boundaries which may have some points of discontinuity.Approximations are used to obtain a simplified formula for estimating the first passage density.Moreover,the results are also generalized to the case of two-sided general nonlinear boundaries.Simulations can be easily carried out with Monte Carlo method and it is demonstrated for several typical two-sided boundaries that the proposed approximation method offers a highly accurate approximation of first passage density.

关键词： Boundary non-crossing probability first density passage density two-sided piecewise continuous boundaries Brownian motion

Direct ink writing of multifunctional gratings with gel-like MXene/norepinephrine ink for dynamic electromagnetic interference shielding and patterned Joule heating

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第3期17卷 1585-1594页

作者： Pei-Zhu jiang Zhiming Deng Peng Min Lvxuan Ye Cheng-Zhang Qi Hao-yu Zhao ji Liu Hao-Bin Zhang Zhong-zhen yu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China School of Chemistry CRANN and AMBERTrinity College DublinDublin D02PN40Ireland

Intelligent electromagnetic interference(EMI)shielding modulators with a wide tuning range and cyclic stability are urgently needed but their fabrication remains challenging.A gel-like MXene/norepinephrine ink is developed and multifunctional MXene gratings with wide EMI shielding effectiveness(SE)tuning range,superior reversibility,and high mechanical flexibility are constructed by direct ink writing approach for dynamic EMI shielding and patterned Joule heating applications.The modulable MXene/norepinephrine grating with a high conductivity of 3510 S·cm-1 can conveniently realize the seamless modulation of the EMI SE by adjusting the angle between the MXene grating filaments and the electric field of the incident electromagnetic waves,offering highly reversible switching between shielding“On”(28.0 dB)and“Off”(0.5 dB)states.Notably,due to the optimized integration of the MXene ink and the rationally designed pattern,a superior specific EMI SE of 95,688.2 dB·cm^(2)·g^(-1) is achieved in the“On”state.Furthermore,the MXene/norepinephrine ink can be used to fabricate many complex patterned gratings with superior stability,instant responsibility,and superb mechanical flexibility,exhibiting a unique patterned Joule heating behavior.Direct writing of multifunctional gratings paves a means for developing intelligent EMI shielding materials,wearable electronic devices,and advanced thermal management materials.

关键词： MXene ink direct ink writing electromagnetic interference shielding multifunctional gratings Joule heating

Musculoskeletal ultrasound to evaluate the efficacy of acupuncture: a review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2024年第3期44卷 629-632页

作者： WANG Dingyue yu Yana WANG Yiyuan ZHANG zhen Department of Ultrasound the First Affiliated Hospital of China Medical University

Acupuncture is a typical example of Traditional Chinese Medicine and has been used in China for hundreds of years to treat a wide range of illnesses. However, in the clinic, issues and deficiencies were primarily seen in four areas: loss of accuracy in the operation process; difficulty understanding the depth of acupuncture; difficulty using reinforcing and reducing techniques; and lack of a clear dynamic effect of acupuncture points following acupuncture. Musculoskeletal ultrasonography may quantitatively evaluate the acupuncture location and display the distribution of small nerves near and within the fascia of the acupuncture point in real time. The subjects were asked how they felt about receiving Qi when the needle body reached different depths and different tissues. The Qi obtained from an acupuncture point and the connective tissue of the fascia can be further understood by combining the physiological response of the acupuncture point with the anatomical structure,which offers a new method for defining the nature of the acupuncture point and standardizing the acupuncture point.

关键词： acupuncture De Qi dynamic effect musculoskeletal ultrasound visualization

The breaking of spin symmetry in the single-particle resonances in deformed nuclei

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第3期35卷 237-245页

作者： zhen-yu zheng Shou-Wan Chen Quan Liu School of Physics and Optoelectronic Engineering Anhui UniversityHefei 230601China

The exploration of spin symmetry (SS) in nuclear physics has been instrumental in identifying atomic nucleus structures.In this study,we solve the Dirac equation from the relativistic mean field (RMF) in complex momentum representation.We investigated SS and its breaking in single-particle resonant states within deformed nuclei,with a focus on the illustrative nucleus168Er.This was the initial discovery of a resonant spin doublet in a deformed nucleus,with the expectation of the SS approaching the continuum threshold.With increasing single-particle energy,the splitting of the resonant spin doublets widened significantly.This escalating splitting implies diminishing adherence to the SS,indicating a departure from the expected behavior as the energy levels increase.We also analyzed the width of the resonant states,showing that lower orbital angular momentum resonances possess shorter decay times and that SS is preserved within broad resonant doublets,as opposed to narrow resonant doublets.Comparing the radial density of the upper components for the bound-state and resonant-state doublets,it becomes evident that while SS is well-preserved in the bound states,it deteriorates in the resonant states.The impact of nuclear deformation (β_(2)) on SS was examined,demonstrating that an increase in β_(2) resulted in higher energy and width splitting in the resonant spin doublets,which is attributed to increased component mixing.Furthermore,the sensitivity of spin doublets to various potential parameters such as surface diffuseness (a),radius (R),and depth (Σ0) is discussed,emphasizing the role of these parameters in SS.This study provides valuable insights into the behavior of spin doublets in deformed nuclei and their interplay with the nuclear structure,thereby advancing our understanding of SS in the resonance state.

关键词： Spin symmetry Resonant states Deformed nuclei Complex-momentum representation