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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen zhen wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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A mechanically robust egg white hydrogel scaffold with excellent biocompatibility by three-step green processing

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Science China(Technological Sciences) 2022年第7期65卷 1599-1612页

作者： wei zhen-zhen DONG Xuan ZHANG Yu-Qing School of Biology and Basic Medical Sciences Medical CollegeSoochow UniversitySuzhou 215123China College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

Egg white(EW) is one of the most common and high-quality nutritional proteins. A novel three-step green processing technology is constructed to process homogeneous EW into a mechanically robust EW hydrogel scaffold(EWHS) with excellent biocompatibility. The homogeneous EW is first treated with stream to form a hydrogel, then slowly dehydrated to form a fragile and almost transparent EW glass, and finally annealed into an EWHS. The EWHS is water-insoluble, wet soft and translucent and has a porous network structure, and its pore size distribution is between 0.1–1.0 μm. The tensile strength in wet state is as high as 5.0 MPa, the elongation at break is about 93%, and the swelling rate is about 85%. The order of the enzymatically residual rate of these EWHSs is pepsin > neutral protease > papain> trypsin > alkaline protease. Mouse L929 cells can adhere,proliferate, and grow well on the EWHSs. After EWHS was implanted in rats for three weeks, the levels of IL-6, TNF-α, and NF-κB inflammatory factors did not change significantly in comparison with the pseudo-operated and normal groups. This novel EW hydrogel biomaterial has potential applications in medical 3 D tissue engineering materials, such as tendons, soft tissues, and in vivo implants.

关键词： egg white hydrogel scaffolds dehydration heat treatment mechanical properties swelling rate

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Parametric Study on the Behavior of An Innovative Subsurface Tension Leg Platform in Ultra-Deep Water

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China Ocean Engineering 2017年第5期31卷 589-597页

作者： zhen Xing-wei HUANG Yi School of Naval Architecture and Ocean Engineering Dalian University of Technology

This study focuses on a new technology of Subsurface Tension Leg Platform （STLP）, which utilizes the shallow- water rated well completion equipment and technology for the development of large oil and gas fields in ultra-deep water （UDW）. Thus, the STLP concept offers attractive advantages over conventional field development concepts. STLP is basically a pre-installed Subsurface Sea-star Platform （SSP）, which supports rigid risers and shallow-water rated well completion equipment. The paper details the results of the parametric study on the behavior of STLP at a water depth of 3000 m. At first, a general description of the STLP configuration and working principle is introduced. Then, the numerical models for the global analysis of the STLP in waves and current are presented. After that, extensive parametric studies are carried out with regarding to SSP/tethers system analysis, global dynamic analysis and riser interference analysis. Critical points are addressed on the mooring pattern and riser arrangement under the influence of ocean current, to ensure that the requirements on SSP stability and riser interference are well satisfied. Finally, conclusions and discussions are made. The results indicate that STLP is a competitive well and riser solution in up to 3000 m water depth for offshore petroleum production.

关键词： subsurface tension leg platform parametric study global behavior ultra-deep water

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VERTICAL DISTRIBUTION OF LONGSHORE CURRENTS OVER PLANE AND BARRED BEACHES

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Journal of Hydrodynamics 2012年第5期24卷 718-728页

作者： ZHANG zhen-wei ZOU Zhi-li State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

Experiments were conducted to determine the vertical profile of the longshore currents over plane and barred beaches. The logarithmic law is applied to fit the data for the region below the wave trough and an adjusted logarithmic profile without the mass transport velocity is applied to the region above the wave trough. The results indicate that the logarithmic law fits the data well for both plane and barred beaches. The friction velocity and the relative roughness obtained by the data fitting are compared with relevant calculated results.

关键词： waves coast logarithmic law surf zone

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Interfacial Structures Governed Plastic Deformation Behaviors in Metallic Multilayers

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Acta Metallurgica Sinica(English Letters) 2016年第2期29卷 199-204页

作者： Ming-zhen wei zhen-Hua Cao Xiang-Kang Meng Institute of Materials Engineering National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences Nanjing University Department of Physics School of Science Linyi University

In this work, we have investigated the mechanical properties of Cu/Ta, Ag/Cu and Ag/Nb multilayers with different heterogeneous interfaces. The results suggest that when individual layer thickness （h） is larger than 5-10 nm, the hardness/strength of three different multilayer systems has the similar length scale effect with decreasing layer thickness, while when h ≤ 5 nm, the three multilayer systems show remarkably different plastic deformation behaviors. The strength curves exhibit the variation trends of unchanging, softening and increasing corresponding to Cu/Ta, Ag/Cu and Ag/Nb multilayers, respectively. The microstructure analysis shows that three kinds of multilayers have totally different interfacial structures, which lead to the different strengthening or softening mechanisms.

关键词： Metallic multilayers Plastic deformation Interfacial structures Strengthening mechanism

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Breaking and mining-induced stress evolution of overlying strata in the working face of a steeply dipping coal seam

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International Journal of Coal Science & Technology 2021年第4期8卷 614-625页

作者： Xiaolou Chi Ke Yang zhen wei State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001AnhuiChina Institute of Energy Hefei Comprehensive National Science CenterHefei 230031AnhuiChina Key Laboratory of Mining Coal Safety and Construction Efficiency of Anhui Province and Ministry of Education Anhui University of Science and TechnologyHuainan 232001AnhuiChina

The breaking features and stress distribution of overlying strata in a steeply dipping coal seam(SDCS)differ significantly from those in a near-horizontal *** this study,the laws governing the evolution of vertical stress release and shear stress concentration in the overlying strata of coal seams with different dip angles are derived via numerical simulation,rock mechanics tests,acoustic emissions,and field ***,the stress-driven dynamic evolution of the overlying strata structure,in which a shear stress arch forms,is *** breaking the lower pari of the overlying strata,the shear stress transfers rapidly to the upper part of the working *** damaged zone of the overlying strata migrates upward along the dip direction of the working *** gangue in the lower part of the working face is compacted,leading to an increase in vertical *** the dip angle of the coal seam increases,the overlying strata fail suddenly under the action of shear ***,the behavioral response of the overlying strata driven by shear stresses in the longwall working face of an SDCS is identified and analyzed in *** present research findings reveal the laws governing the behavior of mine pressure in the working face of an SDCS,which in turn can be used to establish the respective on-site guidance.

关键词： Steeply dipping coal seam Migration of overlying strata Stress evolution Dynamic response

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Static output feedback stabilization for systems with time-varying delay based on a matrix transformation method

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Science China(Information Sciences) 2015年第1期58卷 188-200页

作者： LIU zhen wei ZHANG HuaGuang SUN QiuYe College of Information Science and Engineering Northeastern University State Key Laboratory of Synthetical Automation for Process Industries Northeastern University

This paper is concerned with the problem of static output feedback stabilization for linear systems with time-varying delay. A novel controller design is proposed based on a matrix transformation method with a new equation condition, which can solve the controller gain more easily and avoid complicated calculations of the non-linear matrix inequality. Then, the corresponding criteria can be obtained by combining the matrix transformation method and the ideas of non-uniformly dividing delay interval, which can guarantee the asymptotic stability of the closed-loop systems and calculate the satisfactory controller gain. Finally, two numerical examples are provided to verify the effectiveness of the proposed design scheme.

关键词： static output feedback matrix transformation method time-varying delay non-uniformly dividing delay interval equation condition

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Multi-stage Dynamic Post-disaster Recovery Strategy for Distribution Networks Considering Integrated Energy and Transportation Networks

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CSEE Journal of Power and Energy Systems 2021年第2期7卷 408-420页

作者： Xinyi Jiang Jian Chen Ming Chen zhen wei Key Laboratory of Power System Intelligent Dispatch and Control of Ministry of Education Shandong UniversityJinan 250061China State Grid Qingdao Power Supply Company Qingdao 266002China

To improve the resilience of distribution networks(DNs),a multi-stage dynamic recovery strategy is proposed in this paper,which is designed for post-disaster DN considering an integrated energy system(IES)and transportation network(TN).First,the emergency response quickly increases the output of gas turbines(GTs)in the natural gas network(NGN),and responsively reconfigures the DN in microgrids,to maximize the amount of loads to be *** single-commodity flow model is adopted to construct spanning tree ***,in the second stage of energy storage recovery,mobile energy storage systems(MESSs)are deployed to cover the shortages of power demands,i.e.,to further restore the loads after evaluating the load recovery *** Floyd algorithm based dynamic traffic assignment(DTA)is selected to obtain the optimal path of the *** the third stage,the outputs of various post-disaster recovery measures are adjusted to achieve an economically optimized *** studies demonstrate the effectiveness of the proposed dynamic post-disaster recovery strategy.

关键词： Dynamic post-disaster recovery dynamic transportation network integrated energy system resilience distribution

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Research on the Optimization of a Drilling Rock Breaking Method Based on Fuzzy Cluster Analysis

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Fluid Dynamics & Materials Processing 2022年第3期18卷 751-760页

作者： Kun Du zhen wei Shengli Petroleum Engineering Co. Ltd.of SinopecDongying257100China

Improving drilling efficiency is the best way to reduce drilling costs and the choice of the drilling mode is instrumental in doing *** present,however,a standard approach for the optimization of these processes does not exists *** a comparative statistical analysis of the rock-breaking mechanisms and the characteristics of different drilling methods,this research proposes a set of cues to achieve this *** statistical data are classified by means of a fuzzy cluster analysis according to the anti-drilling characteristic parameters of *** results show that different drilling methods rely on their own rock breaking mechanisms and have distinct *** rotary table drilling method is the most commonly used drilling mode,however,it displays some limitations with regard to deep wells,ultra-deep wells and difficult *** combined drilling method has the advantages of both the rotary table drilling and the down-hole power drilling *** diamond compact(PDC)drill bits can lead to good results for medium hardness and weakly abrasive *** drilling for formations with high hardness and strong abrasiveness displays some limitations.

关键词： Drilling methods anti-drilling characteristic fussy clustering optimization method

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Sub-nanometer structured silicon-carbon composite nanolayers armoring on graphite for fast-charging and high-energy-density lithium-ion batteries

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Rare Metals 2023年第11期42卷 3692-3704页

作者： zhen-wei Li Mei-Sheng Han Jie Yu Songshan Lake Materials Laboratory Dongguan523808China Guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic Systems Shenzhen Engineering Lab for Supercapacitor MaterialsSchool of Material Science and EngineeringHarbin Institute of TechnologyShenzhenShenzhen 518055China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen518055China

Silicon/carbon composites are promising alternatives to current graphite anodes in commercial lithiumion batteries(LIBs)because of their high capacity and excellent ***,the unsatisfactory fastcharging capability and cycle stability of Si/C composites caused by slow charge transport capability and huge volume change under industrial electrode conditions severely hamper their ***,a novel Si/C anode was fabricated by homogeneously depositing amorphous C-Si nanolayers on graphite(C-Si@graphite).C-Si nanolayers with uniformly dispersed sub-nanometer Si particles in 3D carbon skeleton significantly boost electron and Li-ion transport and efficiently relieve Si's agglomeration and volume *** a result,the tailored C-Si@graphite electrodes show an excellent rate capacity(760.3 mAh·g^(-1)at 5.0C)and long cycle life of over 1000 cycles at 1.0C and800 cycles at 2.0C under industrial electrode *** addition,the assembled full cells(C-Si@graphite,anode;Li[Ni_(0.8)Co_(0.1)Mn_(0.1)]O_(2),cathode)present superior fastcharging capability(240.4 Wh·kg^(-1),charging for16.2 min,3.0C)and long cycle life(80.7%capacity retention after 500 cycles at 1.0C),demonstrating the massive potential of C-Si@graphite for practical application.

关键词： Si/C anode Sub-nanometer Si Fast-charging capability Lithium-ion batteries(LIBs)

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