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基于Web of Science的护士横向暴力研究热点及趋势可视化分析

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中国当代医药 2024年第14期31卷 96-101页

作者：张晓娟丁劲李子锋温萌甘肃卫生职业学院甘肃兰州730000 甘肃中医药大学附属医院护理部甘肃兰州730000 湖北省宜昌市中心人民医院护理部湖北宜昌443000

目的基于Web of Science数据库分析护士横向暴力研究热点及发展趋势。方法检索Web of Science核心合集数据库中护士横向暴力相关文献,检索时间为数据库建立至2022年12月31日17时,对文献特征进行探索,运用Histcite 1.0、VOSviewer 1.6.1... 详细信息

目的基于Web of Science数据库分析护士横向暴力研究热点及发展趋势。方法检索Web of Science核心合集数据库中护士横向暴力相关文献,检索时间为数据库建立至2022年12月31日17时,对文献特征进行探索,运用Histcite 1.0、VOSviewer 1.6.1、CiteSpace 5.5及SPSS 20.0软件进行文献计量学分析,并绘制知识图谱。结果本研究共检索出护理横向暴力相关文献71篇,发文量以美国最多,部分机构合作密切。第1篇关于职业护士横向暴力的研究发表于2003年,2015年与2016年是护理横向暴力文献发表数量最多的时期。研究热点主要集中在护理横向暴力的产生、负性影响及应对方式三个方面。结论近年来护理横向暴力发展缓慢,未来相关研究者们需加强对护理安全文化环境的促进、护理横向暴力的预防、护理教育的改革及护理横向暴力发生理论解释等方面的研究,确保护理服务业的健康持续发展。

关键词：护士横向暴力文献计量学 Histcite VOSviewer CiteSpace

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神经胶质瘤专病科研数据库建设与应用

中国数字医学 2022年第4期17卷 12-18页

作者：王若茗凡豪志张军霞张梓枫陈昌裕朱珉景慎旗南京医科大学生物医学工程与信息学院医学信息学系南京医科大学医学信息学与管理研究所南京211166 江苏省人民医院(南京医科大学第一附属医院)数据应用管理中心江苏省人民医院(南京医科大学第一附属医院)神经外科上海森亿医疗科技有限公司研究型医院事业部

目的:基于医院信息化平台部署神经胶质瘤专病科研数据库,提高科研数据采集效率和质量,推动神经胶质瘤科研工作。方法:参考国内外标准构建胶质瘤专病数据集,通过多层次术语抽取、归一化处理等技术实现多源异构数据集成。根据字段来源和... 详细信息

目的:基于医院信息化平台部署神经胶质瘤专病科研数据库,提高科研数据采集效率和质量,推动神经胶质瘤科研工作。方法:参考国内外标准构建胶质瘤专病数据集,通过多层次术语抽取、归一化处理等技术实现多源异构数据集成。根据字段来源和治理难度,采用多种技术进行多维度数据治理。采取“事前”数据管理和质量控制措施,保障临床研究阶段结果的科学性和可靠性。结果:神经胶质瘤专病库实现数据集成与治理、科研项目管理、患者管理、数据采集、数据检索分析等功能,提供高效、全量、实时的研究级数据支撑。结论:神经胶质瘤专病科研数据库有助于推动胶质瘤临床研究,促进学科发展,为开展真实世界研究、干预性多中心研究奠定了基础。

关键词：神经胶质瘤专病数据库胶质瘤专科电子病历数据集数据治理

miR-221/222 activate the Wnt/β-catenin signaling to promote triple-negative breast cancer

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Journal of Molecular Cell Biology 2018年第4期10卷 302-315页

作者： Sanhong Liu zifeng Wang Zukai Liu Shuo Shi Zhaoran zhang Jiawei zhang Haifan Lin Shanghai Institute of Advanced Immunochemical Studies ShanghaiTech University Shanghai China School of Life Science and Technology ShanghaiTech University Shanghai China The Yale Stem Cell Center and Department of Cell Biology Yale University School of Medicine New Haven CT USA

Triple-negative breast cancer （TNBC）, characterized by the lack of expression of the estrogen receptor, the progesterone receptor, and the human epidermal growth factor receptor 2, is an aggressive form of cancer that conveys unpredictable and poor prognosis due to limited treatment options and lack of effective targeted therapies. Wnt/β-catenin signaling is hyperactivated in TNBC, which promotes the progression of TNBC. However, the molecular mechanism of Wnt/β-catenin activation in TNBC remains unknown. Here, we report the drastic overexpression of miR-221/222 in all of four TNBC cell lines and TNBC primary tumor samples from patients. Furthermore, we demonstrate by both ex vivo and xenograft experiments that inhibiting miR-221/222 expression in a TNBC cell line （MDA-MB-231） suppresses its proliferation, viability, epithelial-to-mesenchymal transition, and migration; whereas expressing miR-221/222 in a non-TNBC line （MCF7） promotes all of the above cancer properties. miR-221/222 achieve so by directly repressing multiple negative regulators of the Wnt/β-catenin signaling pathway, including WIF1, SFRP2, DKK2, and AXIN2, to activate the pathway. Notably, the level of miR-221/222 expression is inversely correlated whereas that of WIF1, DKK2, SFRP2, and AXIN2 expression is positively correlated with the patient survival. Last, we show that anti-miR-221/222 significantly increases apoptotic cells with tamoxifen/Wnt3a treatment but not with cyclophosphamide/Wnt3a treatment. These results demonstrate that miR-221/222 activate the Wnt/β-catenin signaling to promote the aggressiveness and TNBC properties of breast cancers, and thus reveal a new prospect for TNBC treatment.

关键词： miR-221/222 Wnt/β-catenin triple-negative breast cancer

孟鲁司特钠联合布地奈德治疗小儿过敏性鼻炎的效果分析

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中国社区医师 2024年第18期40卷 41-43页

作者：周子锋张润庆谭奕民开平市妇幼保健院广东开平529300

目的:观察过敏性鼻炎患儿应用孟鲁司特钠联合布地奈德治疗的效果,并分析其对炎性因子水平、免疫功能的影响。方法:选取2022年6月—2023年6月开平市妇幼保健院收治的过敏性鼻炎患儿100例作为研究对象,按照随机数字表法分为单药组与联合组... 详细信息

目的:观察过敏性鼻炎患儿应用孟鲁司特钠联合布地奈德治疗的效果,并分析其对炎性因子水平、免疫功能的影响。方法:选取2022年6月—2023年6月开平市妇幼保健院收治的过敏性鼻炎患儿100例作为研究对象,按照随机数字表法分为单药组与联合组,各50例。单药组给予吸入用布地奈德混悬液雾化吸入治疗,联合组在单药组基础上给予孟鲁司特钠咀嚼片口服治疗。比较两组治疗效果。结果:联合组流鼻涕、打喷嚏、鼻塞、鼻痒症状消失时间早于单药组,差异有统计学意义(P0.05)。结论:孟鲁司特钠联合布地奈德治疗小儿过敏性鼻炎的效果显著,可缓解患儿临床症状,改善炎性反应及免疫功能,且安全性较高。

关键词：过敏性鼻炎儿童孟鲁司特钠布地奈德

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集装箱储能系统散热及抗震性研究

储能科学与技术 2013年第6期2卷 642-648页

作者：张子峰王林陈东红王骁雄朱东梅李丽娜深圳比亚迪电力科学研究院广东深圳518118

集装箱式储能系统将储能系统的所有部件全部集中在一个或多个标准集装箱内,具有占地少、便于安装、可移动等优点,作为一种新形式的储能系统,其在电网中的应用越来越多。本文作者阐述了某公司电力科学研究院对集装箱式储能系统的研究,主... 详细信息

集装箱式储能系统将储能系统的所有部件全部集中在一个或多个标准集装箱内,具有占地少、便于安装、可移动等优点,作为一种新形式的储能系统,其在电网中的应用越来越多。本文作者阐述了某公司电力科学研究院对集装箱式储能系统的研究,主要包括散热系统设计及抗震性设计,并分别利用Icepak软件及CAE软件进行了热仿真及有限元分析,结果证明了系统散热与抗震设计的有效性。

关键词：集装箱式储能系统散热抗震

Boosting the Ni-Zn interplay via O/N dual coordination for high-efficiency CO_(2) electroreduction

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Carbon Energy 2023年第4期5卷 68-80页

作者： Ying zhang Hailei Jiang Anuj Kumar Hongchuan zhang Zongge Li Tongxin Xu Yuan Pan Yaqun Wang Zhiming Liu Guoxin zhang zifeng Yan State Key Laboratory of Heavy Oil Processing College of Chemistry and Chemical EngineeringChina University of Petroleum(East China)QingdaoShandongChina Department of Chemistry Institute of Humanities and Applied ScienceGLA UniversityMathuraIndia College of Chemistry and Chemical Engineering Liaocheng UniversityLiaochengShandongChina Al‐Ion Battery Research Center College of Energy Storage TechnologyShandong University of Science and TechnologyQingdaoShandongChina Shandong Engineering Laboratory for Preparation and Application of High‐performance Carbon‐Materials College of Electromechanical EngineeringQingdao University of Science and TechnologyQingdaoShandongChina

Design of supportive atomic sites with a controllably adjusted coordinating environment is essential to advancing the reduction of CO_(2) to value-added fuels and chemicals and to achieving carbon ***,atomic Ni(Zn)sites that are uniquely coordinated with ternary Zn(Ni)/N/O ligands were successfully decorated on formamide-derived porous carbon nanomaterials,possibly forming an atomic structure of Ni(N_(2)O_(1))-Zn(N_(2)O_(1)),as studied by combining X-ray photoelectron spectroscopy and X-ray absorption *** the mediation of additional O coordination,the Ni-Zn dual site induces significantly decreased desorption of molecular *** NiZn-NC decorated with rich Ni(N_(2)O_(1))-Zn(N_(2)O_(1))sites remarkably gained>97%CO Faraday efficiency over a wide potential range of -0.8 to -1.1 V(relative to reversible hydrogen electrode).Density functional theory computations suggest that the N/O dual coordination effectively modulates the electronic structure of the Ni-Zn duplex and optimizes the adsorption and conversion properties of CO_(2) and subsequent *** from the conventional pathway of using Ni as the active site in the Ni-Zn duplex,it is found that the Ni-neighboring Zn sites in the Ni(N_(2)O_(1))-Zn(N_(2)O_(1))coordination showed much lower energy barriers of the CO_(2) protonation step and the subsequent dehydroxylation step.

关键词： atomic dispersion carbon materials CO_(2)reduction formamide metal-nitrogen-carbon

Single-atom Zn for boosting supercapacitor performance

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Nano Research 2022年第3期15卷 1715-1724页

作者： Zongge Li Danni Wang Huifang Li Mang Ma Ying zhang zifeng Yan Stefano Agnoli Guoxin zhang Xiaoming Sun State Key Laboratory of Heavy Oil Processing China University of Petroleum(East China)Qingdao 266580China Al-ion Battery Research Center Department of Electrical Engineering and AutomationShandong University of Science and TechnologyQingdao 266590China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Department of Chemical Sciences University of PadovaVia Marzolo 1Padova I-35131Italy College of Electromechanical Engineering Shandong Engineering Laboratory for Preparation and Application of High-performance CarbonMaterialsQingdao University of Science&TechnologyQingdao 266061China

Single-atom metal-incorporated carbon nanomaterials(CMs)have shown great potential towards broad catalytic *** this work,we show that N-doped porous CMs embedded with redox-able Zn atoms exhibit superior capacitive *** Zn(~2.72 at.%)/N(~12.51 at.%)doping were realized by incorporating Zn2+and benzamide into the condensation and carbonization of formamide and subsequent annealing at 900℃.The Zn and N species are mutually benefited during the formation of ZnN4 *** as-obtained Zn1NC material affords a very large capacitance of 621 F·g^(−1)(at 0.1 A·g^(−1)),superior rate capability(~65%retention at 100 A·g^(−1)),and excellent cycling stability(0.00044%per cycle at 10 A·g^(−1)).These merits are attributed to the high Zn/N loading,atomic Zn-boosted pseudocapacitive behavior,large specific surface area(~1,085 m^(2)·g^(−1)),and rich pore hierarchy,thus ensuring both large pseudo-capacitance(e.g.,~37.9%at 10 mV·s^(−1))and double-layer *** of establishing a new type of high Zn/N-loading carbon materials,our work uncovers the capacitive roles of atomically dispersed metals in CMs.

关键词： atomic dispersion zinc doping nitrogen doping carbon nanomaterial supercapacitor

Hierarchical peony-like FeCo-NC with conductive network and highly active sites as efficient electrocatalyst for rechargeable Zn-air battery

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Nano Research 2020年第4期13卷 1090-1099页

作者： Yiyan Wang Anuj Kumar Mang Ma Yin Jia Yu Wang Ying zhang Guoxin zhang Xiaoming Sun zifeng Yan State Key Laboratory of Heavy Oil Processing China University of Petroleum(East China)Qingdao 266580China Department of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China Department of Chemistry Institute of Humanities and applied ScienceGLA UniversityMathura-281406India

Carbon materials featuring hierarchical pores and atomically dispersed metal sites are promising catalysts for energy storage and conversion ***,we developed a facile strategy to construct functional carbon materials with a fluffy peony-like structure and dense binary FeCo-Nx active sites(termed as f-FeCo-CNT).By regulating the metal content in precursors,a three-dimensional(3D)interconnected conductive carbon nanotubes network was in-situ formed throughout the atomically dispersed FeCo-NC matrix during *** advantage of rich pore hierarchy and co-existence of highly active FeCo-Nx sites and beneficial FeCo alloy nanoparticles,the f-FeCo-CNT material exhibited excellent bifunctional performance towards oxygen reduction reaction/oxygen evolution reactions(ORR/OER)with respect to the atomically dispersed FeCo-NC(SA-f-FeCo-NC)and commercial Pt/C+Ru02 mixture,surpassing the SA-f-FeCo-NC with a 20 mV higher ORR half-wave potential and a 100 mV lower OER overpotential(at 10.0 mA/cm^2).Remarkably,the f-FeCo-CNT-assembled Zn-air battery(ZAB)possessed a maximum specific power of 195.8 mW/cm^2,excellent rate capability,and very good cycling stability at large current density of 20.0 mA/cm^*** work provides a facile and feasible synthetic strategy of constructing low-cost cathode materials with excellent comprehensive ZAB performance.

关键词： atom ically dispersed catalyst hierarchical structure carbon nanotube oxygen electrocatalyst rechargeable zinc-air battery

Mechanism of forming an ink-bottle-like pore structure based on SBA-15 by a novel MOCVD technique

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Chinese Science Bulletin 2010年第4期55卷 446-451页

作者： zhang Ying FRANK Leung-YUK Lam YAN zifeng HU XiJun School of Chemistry & Chemical Engineering China University of Petroleum Dongying 257061 China Department of Chemical Engineering Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China

Metallorganic chemical vapor deposition is used as a novel simple pore tailoring method to fine-tune the pore opening size of SBA-15 materials without significant loss in pore volume and surface area. By using acetylene as carbon source and copper (II) acetylacetonate as precursor, the poremouth of SBA-15 is effectively reduced from 5.78 nm to 3.67 nm while maintaining the pore body at 5.78 nm. The effect of four pore modification factors-the ratio of acetylene/nitrogen, the feeding time of carbon precursor, the ratio of SBA-C/Cu(acac)2 and the cycles of MOCVD on the final pore structure of the SBA-15/carbon/copper composite is studied. The morphology and microstructure of the resulting product SBA-C-Cu are characterized by XRD patterns, TEM images and EDS analysis. The XRD and TEM reveal that the SBA-C-Cu composite is highly hexagonally ordered and has similar particle morphology as the original SBA-15.

关键词：金属有机化学气相沉积化学气相沉积技术 SBA 分子筛孔结构铜复合材料化学气相沉积法透射电子显微镜