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成人Xp11.2易位/TFE3基因融合相关性肾细胞癌^(18)F-FDG PET/CT显像1例

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中华核医学与分子影像杂志 2024年第1期44卷 41-42页

作者：胡中岛尚华张雪梅郭小瑞郝潞平李红梅河北医科大学第二医院核医学科石家庄050061

患者男, 23岁, 右部腰痛5 d, 自觉乏力, 无肉眼血尿等症状, 腹部未见包块, 于外院行增强CT检查发现右肾恶性占位, 双侧腹膜后多发肿大淋巴结, 为求进一步诊治就诊本院。入院常规检验无明显异常, 未见镜下血尿, 后行18F-FDG(南京江原安... 详细信息

患者男, 23岁, 右部腰痛5 d, 自觉乏力, 无肉眼血尿等症状, 腹部未见包块, 于外院行增强CT检查发现右肾恶性占位, 双侧腹膜后多发肿大淋巴结, 为求进一步诊治就诊本院。入院常规检验无明显异常, 未见镜下血尿, 后行18F-FDG(南京江原安迪科正电子研究发展有限公司提供)PET/CT(荷兰Philips Vereos)显像。静脉注射266.4 MBq18F-FDG后60 min行PET/CT显像(图1), 结果示:右肾中上部团块状混杂密度影, 边界欠清, 较大横截面积约5.1 cm×4.5 cm, 上下径约8.3 cm, 伴代谢不均匀升高, SUVmax 6.9, 考虑恶性病变;右侧膈肌后方(第1腰椎水平)、腹主动脉及下腔静脉周围多发大小不等淋巴结, 部分融合成团, 较大者位于下腔静脉后方平第1腰椎下方, 大小约3.4 cm×3.0 cm×4.9 cm, CT值约19 HU, 以上淋巴结部分肿大, 部分伴坏死, 呈代谢不均匀升高, SUVmax 6.3~12.5, 考虑转移。

关键词： PET/CT显像肿大淋巴结肾细胞癌镜下血尿恶性病变安迪侧腹膜常规检验

The Kangding earthquake swarm of November, 2014

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Earthquake Science 2015年第3期28卷 197-207页

作者： Wen Yang Jia Cheng Jie Liu xuemei zhang China Earthquake Networks Center Institute of Geology China Earthquake Administrator

There was an earthquake swarm of two major events of MS6.3 and MS5.8 on the Xianshuihe fault in November, 2014. The two major earthquakes are both strike-slip events with aftershock zone along NW *** have analyzed the characteristics of this earthquake sequence. The b value and the h value show the significant variations in different periods before and after the MS5.8earthquake. Based on the data of historical earthquakes, we also illustrated the moderate-strong seismic activity on the Xianshuihe fault. The Kangding earthquake swarm manifests the seismic activity on Xianshuihe fault may be in the late seismic active period. The occurrence of the Kangding earthquake may be an adjustment of the strong earthquakes on the Xianshuihe fault. The Coulomb failure stress changes caused by the historical earthquakes were also given in this article. The results indicate that the earthquake swarm was encouraged by the historical earthquakes since1893, especially by the MS7.5 Kangding earthquake in1955. The Coulomb failure stress changes also shows the subsequent MS5.8 earthquake was triggered by the MS6.3earthquake.

关键词： Kangding earthquake swarm of 2014 Xianshuihe fault Seismic activity Coulomb failure stress change

Triterpenoids from Uncaria rhynchophylla and Their PTP1B Inhibitory Activity

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Phyton-International Journal of Experimental Botany 2022年第8期91卷 1809-1816页

作者： Shuaibin Luo xuemei zhang Kang He Juan Zou Chang-An Geng Guizhou University of Traditional Chinese Medicine Guiyang550025China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesYunnan Key Laboratory of Natural Medicinal ChemistryKunming650201China

Uncaria rhynchophylla(Gouteng)is a famous traditional Chinese medicine used for psychiatric and hypotensive purposes in *** this study,the ethyl acetate(EtOAc)part of *** was revealed with protein tyrosine phosphatase 1B(PTP1B)inhibitory *** investigation on the EtOAc part yielded one new triterpenoid,3β-formyloxy-6β,19α-dihydroxyurs-12-en-28-oic acid(1)and four known ones,3β,6β,19α-trihydroxyurs-12-en-28-oic acid(2),2-oxopomolic acid(3),3β,19α-dihydroxy-6-oxo-olean-12-en-28-oic acid(4)and sumaresinolic acid(5).The structure of compound 1 was determined by extensive HRESIMS,IR,1D and 2D NMR spectroscopic *** ursane-type triterpenoids(2 and 3)showed selective inhibition on PTP1B with IC50 values of 48.2 and 178.7μ*** enzyme kinetic study suggested that compounds 2 and 3 were mixtype inhibitors on PTP1B with Ki values of 15.6 and 132.5μ*** investigation manifests the antidiabetic potency of *** with triterpenoids as the active constituents.

关键词： Uncaria rhynchophylla triterpenoids antidiabetic effects PTP1B inhibitors

造血干细胞生成免疫细胞的潜力及其应用研究进展

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细胞与分子免疫学杂志 2024年第3期40卷 279-286页

作者：张雅琳李娟娟闫鹏辉周瑾庄玉洁张雪梅王小龙张君涛张志平邓立新河南农业大学动物医学院临床兽医系河南郑州450046 河南省银丰生物工程技术有限公司河南郑州450000

造血干细胞(HSC)具有高度自我更新、增殖和多向分化等潜能。长期以来,HSC移植一直是治疗血液性疾病和自身免疫性疾病的主要方法,而移植后免疫系统的重建能力是评价移植是否成功的关键。为了提高移植后免疫系统的重建能力,目前研究多集... 详细信息

造血干细胞(HSC)具有高度自我更新、增殖和多向分化等潜能。长期以来,HSC移植一直是治疗血液性疾病和自身免疫性疾病的主要方法,而移植后免疫系统的重建能力是评价移植是否成功的关键。为了提高移植后免疫系统的重建能力,目前研究多集中于基因工程,以及利用规律间隔成簇短回文重复序列(CRISPR)基因编辑技术改造HSC作为移植细胞的来源。本文主要对HSC的生物学特性、调控机制、分化为免疫细胞的能力以及在治疗血液、免疫缺陷、癌症等相关疾病的应用及其研究进展进行总结,以期为相关疾病的研究提供参考。

关键词：造血干细胞免疫细胞基因工程调控机制综述

基于碳足迹的黑龙江省典型旅游区生态效率研究——以伊春市为例

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环境科学与管理 2024年第7期49卷 50-55页

作者：邢洁孙赫奕张雪梅李婉婷黑龙江省环境科学研究院黑龙江哈尔滨150056 黑龙江省哈尔滨生态环境监测中心黑龙江哈尔滨150076

此研究基于碳足迹方法,以伊春市为研究对象,从旅游全环节对生态效率进行分析。研究表明,随着旅游经济的增长旅游二氧化碳排放量也随之增加,旅游人数和季节性的变化对于旅游碳排放具有较大影响。旅游生态效率相对较好。优先实施碳排放约... 详细信息

此研究基于碳足迹方法,以伊春市为研究对象,从旅游全环节对生态效率进行分析。研究表明,随着旅游经济的增长旅游二氧化碳排放量也随之增加,旅游人数和季节性的变化对于旅游碳排放具有较大影响。旅游生态效率相对较好。优先实施碳排放约束措施,对于提升旅游生态效率有更好的效果,同时持续发展旅游经济和利用新技术、新发明等方式增大碳减排空间对于旅游业可持续发展具有良好的促进作用。此外,应以旅游业绿色低碳转型为切入点,激发旅游经济增长绿色动能,从而实现更高质量、更有效率、更可持续的发展。

关键词：碳足迹旅游生态效率低碳旅游

承气汤在重症胰腺炎合并肺损伤患者中的应用效果

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检验医学与临床 2024年第20期21卷 3026-3032页

作者：徐超刘君李仲琪张雪梅刘伟山东省日照市人民医院重症医学科山东日照276800 山东省日照市中医医院医保科山东日照276800

目的分析承气汤在重症胰腺炎(SAP)合并肺损伤患者中的应用效果。方法选取2022年9月至2023年9月山东省日照市人民医院、山东省日照市中医医院收治的120例SAP合并肺损伤患者作为研究对象,采用随机数字表法分为观察组与对照组,每组60例。... 详细信息

目的分析承气汤在重症胰腺炎(SAP)合并肺损伤患者中的应用效果。方法选取2022年9月至2023年9月山东省日照市人民医院、山东省日照市中医医院收治的120例SAP合并肺损伤患者作为研究对象,采用随机数字表法分为观察组与对照组,每组60例。对照组给予常规治疗,观察组在对照组基础上给予承气汤治疗。比较两组预后指标、血气指标[动脉血氧分压(PaO_(2))、SpO_(2)、氧合指数(PaO_(2)/FiO_(2))]、炎症反应指标[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平、肺水肿程度[血管外肺水指数(EVLWI)及肺通透性指数(PVPI)]。结果观察组治疗总有效率明显高于对照组,差异有统计学意义(χ^(2)=4.910,P=0.027)。观察组机械通气、入住ICU及AMS恢复时间明显短于对照组,28 d病死率明显低于对照组,差异均有统计学意义(P治疗后5 d>治疗后1 d>治疗前,且任意两时间点比较,差异均有统计学意义(P治疗后5 d>治疗后1 d>治疗前,且任意两时间点比较,差异均有统计学意义(P治疗后5 d>治疗后1 d>治疗前,且任意两时间点比较,差异均有统计学意义(P治疗后5 d>治疗后1 d>治疗前,且任意两时间点比较,差异均有统计学意义(P<0.05)。多变量方差分析结果显示,观察组治疗后1、5、7 d PaO_(2)、PaO_(2)/FiO_(2)均高于对照组,差异均有统计学意义(P<0.05)。重复测量方差分析结果显示,两组治疗期间CRP、TNF-α、IL-6均存在时间、组间、交互效应(P<0.05)。单因素重复测量方差分析结果显示,观察组CRP水平为治疗后7 d<治疗后5 d<治疗后1 d<治疗前,且任意两时间点比较,差异均有统计学意义(P<0.05);对照组CRP水平为治疗后7 d<治疗后5 d<治疗后1 d<治疗前,且任意两时间点比较,差异均有统计学意义(P<0.05)。观察组TNF-α水平为治疗后7 d<治疗后5 d<治疗后1 d<治疗前,且任意两时间点比较,差异均有统计学意义(P<0.05);对照组TNF-α水平为治疗后7 d<治疗后5 d<治疗后1 d<治疗前,且任意两时间点比较,差异均有统计学意义(P<0.05)。观察组IL-6水平为治疗后7 d<治疗后5 d<治疗后1 d<治疗前,且任意两时间点比较,差异均有统计学意义(P<0.05);对照组IL-6水平为治疗后7 d<治疗后5 d<治疗后1 d<治疗前,且任意两时间点比较,差异均有统计学意义(P<0.05)。多变量方差分析结果显示,观察组治疗后1、5、7 d CRP、TNF-α、IL-6水平均低于对照组,差异均有统计学意义(P<0.05)。重复测量方差分析结果显示,两组治疗期间EVLWI存在时间、组间、交互效应(P<0.05)。单因素重复测量方差分析结果显示,观察组EVLWI为治疗后7 d<治疗后5 d<治疗后1 d<治疗前,且任意两时间点比较,差异均有统计学意义(P<0.05);对照组EVLWI为治疗后7 d<治疗后5 d<治疗后1 d<治疗前,且任意两时间点比较,差异均有统计学意义(P<0.05)。多变量方差分析结果显示,观察组治疗后1、5、7 d EVLWI均低于对照组,差异均有统计学意义(P<0.05)。结论承气汤治疗SAP合并肺损伤的效果较好,可改善患者血气指标,降低炎症反应及肺水肿程度,促进患者病情好转。

关键词：重症胰腺炎肺损伤承气汤血气指标炎症反应

Rupture process and aftershock focal mechanisms of the 2022 M6.8 Luding earthquake in Sichuan

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Earthquake Science 2022年第6期35卷 474-484页

作者： Zhigao Yang Danqing Dai Yong zhang xuemei zhang Jie Liu China Earthquake Networks Center Beijing 100045China School of Earth and Space Sciences Peking UniversityBeijing 100871China

According to the China Earthquake Networks Center,a strong earthquake of M6.8 occurred in Luding County,Ganzi Tibetan Autonomous Prefecture,Sichuan Province,China(102.08°E,29.59°N),on September 5,2022,with a focal depth of 16 *** determination of the source parameters of the earthquake sequence is vital for post-earthquake rescue,disaster assessment,and scientific ***-field seismic observations play a key role in the fast and reliable determination of earthquake source *** numerous broadband seismic stations and strong-motion stations recently deployed by the National Earthquake Intensity Rapid Report and Early Warning project have provided valuable real-time near-field observation *** these near-field observations and conventional mid-and far-field seismic waveform records,we obtained the focal mechanism solutions of the mainshock and M≥3.0 aftershocks through the waveform fitting *** were further able to rapidly invert the rupture process of the *** on the evaluation of the focal mechanism solution of the mainshock and the regional tectonic setting,we speculate that the Xianshuihe fault formed the seismogenic structure of the M6.8 strong *** aftershocks formed three spatially separated clusters with distinctly different focal mechanisms,reflecting the segmented nature of the Xianshuihe *** more high-frequency information has been applied in this study,the absolute location of the fault rupture is better constrained by the near-field strong-motion *** rupture process of the mainshock correlates well with the spatial distribution of aftershocks,i.e.,aftershock activities were relatively weak in the maximum slip area,and strong aftershock activities were distributed in the peripheral regions.

关键词： Luding earthquake rupture process focal mechanism strong motion

聚乙烯微塑料与镉联合暴露对赤子爱胜蚓的毒性效应及交互作用评估

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环境科学学报 2024年第7期44卷 482-496页

作者：杨晓霞张雪梅舒晓谢蔓莉龚久平杨俊英李必全柴勇刘剑飞重庆市农业科学院农业质量标准与检测技术研究所重庆401329

将蚯蚓(赤子爱胜)分别暴露于不同浓度(0.5、2.5、10、20 g·kg^(-1))的聚乙烯(PE)微塑料(30~50μm)与镉(Cd,1、10 mg·kg^(-1))单独或复合污染土壤中28 d.以个体生长及繁殖、细胞色素P450亚酶(CYP1A2、CYP2B6、CYP2C9与CYP3A4)和小分子... 详细信息

将蚯蚓(赤子爱胜)分别暴露于不同浓度(0.5、2.5、10、20 g·kg^(-1))的聚乙烯(PE)微塑料(30~50μm)与镉(Cd,1、10 mg·kg^(-1))单独或复合污染土壤中28 d.以个体生长及繁殖、细胞色素P450亚酶(CYP1A2、CYP2B6、CYP2C9与CYP3A4)和小分子代谢标记物(代谢组学)多指标为受试终点,并采用生物标记物响应指数法(Biomarker response index,BRI)和联合效应加成指数法(Effect addition index,EAI),评估PE微塑料与Cd复合污染毒性效应及交互作用.暴露试验结果显示,联合胁迫能显著影响Cd的生物累积.联合暴露下,蚯蚓体内Cd的积累受微塑料浓度的影响显著.PE与Cd的交互作用随效应水平的增加由拮抗作用转变为协同作用.20 g·kg^(-1) PE与1 mg·kg(-1) Cd联合暴露,以及10~20 g·kg(-1) PE与10mg·kg^(-1) Cd联合暴露下,CYP2B6及CYP3A4活力显著低于对照水平,提示蚯蚓氧化损伤的产生.基于代谢组识别出的前10位重要的小分子代谢物分别为:十二羟基十二烷酸、3'-磷酸腺苷、肌苷、喹啉酸、亚麻酸衍生物(9Z,11E,13S,15Z)-13-羟基十八碳-9,11,15-三烯酸(13(S)-HOT)、硬脂酸、尿苷、L-胱硫醚、胸苷酸与亮氨酸.PE与Cd联合暴露下,上述小分子代谢物水平均发生显著平变化.PE与Cd联合暴露的毒性作用模式与蚯蚓自身解毒能力受损、脂质代谢、嘌呤、嘧啶代谢及氨基酸代谢紊乱有关.本研究结果有助于精准评估土壤PE微塑料与Cd的复合生态风险,为提升PE微塑料与Cd复合污染生态风险的认知提供科学依据.

关键词：赤子爱胜蚓聚乙烯(PE)微塑料镉细胞色素P450亚酶代谢组学变化水平生物标记物响应指数法效应加成指数法

Artemdubinoids A-N:novel sesquiterpenoids with antihepatoma cytotoxicity from Artemisia dubia

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Chinese Journal of Natural Medicines 2023年第12期21卷 902-915页

作者： GAO Zhen LI Tianze MA Yunbao HUANG Xiaoyan GENG Changan zhang xuemei CHEN Jijun State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China

In pursuit of effective agents for hepatocellular carcinoma derived from the Artemisia species,this study built upon initial findings that an ethanol(EtOH)extract and ethyl acetate(EtOAc)fraction of the aerial parts of Artemisia dubia *** *** cytotoxicity against HepG2 cells with inhibitory rates of 57.1%and 84.2%(100μg·mL−1),*** by bioactivity,fourteen previously unidentified sesquiterpenes,artemdubinoids A–N(1–14),were isolated from the EtOAc *** structural elucidation was achieved through comprehensive spectroscopic analyses and corroborated by the comparison between the experimental and calculated ECD *** crystal X-ray diffraction provided definitive structure confirmation for artemdubinoids A,D,F,and *** A and B(1–2)represented unique sesquiterpenes featuring a 6/5-fused bicyclic carbon scaffold,and their putative biosynthetic pathways were discussed;artemdubinoid C(3)was a novel guaianolide derivative that might be formed by the[4+2]Diels–Alder reaction;artemdubinoids D and E(4–5)were rare 1,10-seco-guaianolides;artemdubinoids F–K(6–11)were chlorinecontaining *** compounds exhibited cytotoxicity against three human hepatoma cell lines(HepG2,Huh7,and SKHep-1)with half-maximal inhibitory concentration(IC50)values spanning 7.5−82.5μmol·L^(−1).Artemdubinoid M(13)exhibited the most active cytotoxicity with IC50 values of 14.5,7.5 and 8.9μmol·L^(−1)against the HepG2,Huh7,and SK-Hep-1 cell lines,respectively,which were equivalent to the positive control,sorafenib.

关键词： Artemdubinoids A-N Artemisia dubia Sesquiterpenoids Antihepatoma activity