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Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： yi zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li zhang Zheng Gang zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

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花瑶挑花纹样在女士皮包中的创新设计与应用

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皮革科学与工程 2025年第1期35卷 89-97页

作者：刘辉超张毅江南大学数字科技与创意设计学院江苏无锡214400

花瑶挑花纹样造型多样、设计精巧,具有较高的美学价值与应用价值,但将其创新应用至箱包设计领域的相关研究却相对较少。从设计学角度出发,分析花瑶挑花的典型图案和文化内涵,归纳其核心元素特征;调查研析消费人群及其风格偏好,确立产品... 详细信息

花瑶挑花纹样造型多样、设计精巧,具有较高的美学价值与应用价值,但将其创新应用至箱包设计领域的相关研究却相对较少。从设计学角度出发,分析花瑶挑花的典型图案和文化内涵,归纳其核心元素特征;调查研析消费人群及其风格偏好,确立产品的设计定位;选取典型挑花纹样,运用形状文法和风格迁移算法分别进行创新再造设计,并结合3D数字化软件将创新方案应用于时尚女包设计中,开发出兼具民族特色和现代形式美感的革制品。通过将数字化技术手段与花瑶挑花纹样皮具的有机结合,既保证了挑花纹样的迭代与创新,又提高了革制品图案设计的创作效率。

关键词：挑花纹样女包形状文法风格迁移算法创新设计花瑶

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Numerical Study of Flow and Heat Transfer Characteristics of Shell-and-Tube Molten Salt Electric Heater with Circularly Perforated Baffles

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Journal of Thermal Science 2025年第1期 24-33页

作者： LIN Yongjie zhang Cancan WU Yuting zhang yi LU Yuanwei Key Laboratory of Heat Transfer and Energy Conversion National User-Side Energy Storage Innovation Research and Development CenterBeijing University of Technology

Numerical simulations of the flow and heat transfer characteristics of four shell-and-tube molten salt electric heaters with different perforation rates was ***-and-tube electric heaters have the same geometry and tube arrangement,and all of them use single segmental baffles,but there exist four different baffle openings（φ）,i.e.,0%,2.52%,4.06%,and 6.31%.The results indicated that the reasonable baffle opening could significantly reduce the shell-side pressure drop,effectively decreasing the shell-side flow dead zone *** can eliminate the local high-temperature phenomenon on the surface of electric heating tubes,but the heat transfer coefficient is slightly *** perforated schemes significantly reduce shell-side pressure drop compared to the baseline solution without open *** particular,the φ=6.31% scheme exhibits the optimal performance among all the schemes,with a maximum reduction of up to 50.50% in shell-side pressure drop relative to the unopened holes *** heat transfer coefficient is the highest for φ=0%,exhibiting a range of5.26% to 5.73%,5.14% to 5.99%,and 7.31% to 8.54% higher than φ=2.52%,4.06%,and 6.31%,respectively,within the calculated *** composite index h/（Δp）1/3was higher for all open-hole solutions than that for the unopened-hole *** best overall performance was for φ=6.31%,which improved the composite index by15.29% to 17.18% over the unopened-hole solution.

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The method of variation on parameters for integration of a generalized Birkhoffian system

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Acta Mechanica Sinica 2011年第6期27卷 1059-1064页

作者： yi zhang College of Civil Engineering Suzhou University of Science and Technology 215011 Suzhou China

This paper focuses on studying the integration method of a generalized Birkhoffian *** method of variation on parameters for the dynamical equations of a generalized Birkhoffian system is *** procedure for solving the problem can be divided into two steps：the first step,a system of auxiliary equations is constructed and its general solution is given;the second step,the parameters are varied,and the solution of the problem is obtained by using the properties of generalized canonical *** method of variation on parameters for the generalized Birkhoffian system is of universal significance,and we take a nonholonomic system and a nonconservative system as examples to illustrate the application of the results of this paper.

关键词： Birkhoffian system Method of integration Variation on parameter. Nonholonomic constraint. Nonconservative system

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Informational uncertainties of risk assessment about accidents of chemicals

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Journal of Environmental Sciences 2001年第1期13卷 69-74页

作者： zhang yi-xian Suzhou Institute of Urban Construction and Environmental Protection Suzhou 215011China

An analysis system of informational uncertainties for accidental risk assessment of chemicals is introduced. Statistical test methods and fuzzy sets method can do the quantitative analysis of the input parameters. The uncerainties of the model can be used by quantitative compared method for the leakage accidents of chemicals. The estimation of the leaking time is important for discussing accidental source term. The uncertain analyses of the release accident for pipeline gas (CO) liquid chlorine and liquid propane gas (LPG) have been discussed.

关键词： uncertainty risk assessment accident chemicals pipeline gas liquid chlorine LPG

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基于LSTM的变电站电气设备运行状态自动化预测方法

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科学技术创新 2025年第2期 39-42页

作者：张懿吴艳国网浙江省电力公司杭州供电公司浙江杭州中国联合工程有限公司浙江杭州

针对变电站电气设备运行状态传统监测方法的不足,本文提出了一种基于长短期记忆(LSTM)网络的变电站电气设备运行状态自动化预测方法,利用LSTM网络处理时间序列数据的优势,实现了对设备运行状态的高精度预测。研究中,首先通过高斯滤波器... 详细信息

针对变电站电气设备运行状态传统监测方法的不足,本文提出了一种基于长短期记忆(LSTM)网络的变电站电气设备运行状态自动化预测方法,利用LSTM网络处理时间序列数据的优势,实现了对设备运行状态的高精度预测。研究中,首先通过高斯滤波器对采集的声波信号进行去噪处理,随后采用小波包分解技术提取信号特征,构建特征向量,进一步结合卷积神经网络(CNN)和LSTM构建混合模型,优化特征提取和时间序列预测过程。实验结果表明,所提方法在平均误差幅度和预测时间上均优于数字孪生技术(DTSE)和自适应概率神经网络(APNN)方法,验证了该方法在提高电力系统预测准确性和运维效率方面的潜力。

关键词：长短期记忆网络变电站电气设备信号去噪小波包分解状态预测

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The Method of Variation of Parameters for Solving a Dynamical System of Relative Motion

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Chinese Physics Letters 2011年第10期28卷 146-149页

作者： zhang yi College of Civil Engineering Suzhou University of Science and TechnologySuzhou 215011

The integration method of a dynamical system of relative motion is studied,and the method of variation of parameters for the dynamical equations of relative motion is ***,the dynamic equations of relative motion are brought into the frame of generalized Birkhoffian systems and are expressed in the contravariant algebraic ***,an auxiliary system is constructed and its complete solution is ***,the variation of parameters is given,and a complete solution of the problem is obtained by taking advantage of the properties of generalized canonical *** example is given to illustrate the application of the results.

关键词： form dynamical system

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Numerical Study of the High-Frequency Wave Loads and Ringing Response of A Bottom-Hinged Vertical Cylinder in Focused Waves

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China Ocean Engineering 2020年第4期34卷 513-525页

作者： zhang yi TENG Bin State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

This paper presents a numerical study on the high-frequency wave loads and ringing response of offshore wind turbine foundations exposed to moderately steep transient water *** wave groups are generated by the technique of frequency-focusing,and the numerical simulation of focused waves is based on the NewWave model and a Fourier time-stepping *** proposed model is validated by comparison with the published laboratory *** respect of both the wave elevations and the underlying water particle kinematics,the numerical results are in excellent agreement with the experimental ***,the local evolution of power spectra and the transfer of energy into higher frequencies can be clearly *** the generalized FNV theory and Rainey’s model are applied respectively to calculate the nonlinear wave loads on a bottom-hinged vertical cylinder in focused *** ringing response excited by the nonlinear high-frequency wave loads is found in the numerical simulation when frequency ratios(natural frequency of the structure to peak frequency of wave spectra)are equal to 3–*** amplification factor of ringing response is also investigated for different dynamic properties(natural frequency and damping ratio)of the structure.

关键词： high-frequency wave loads ringing response focused wave vertical cylinder

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Effect of Aspect on Climate Variation in Mountain Ranges of Shennongjia Massif, Central China

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Chinese Geographical Science 2018年第1期28卷 74-85页

作者： zhang yi School of Earth Sciences China University of Geosciences The College of Urban & Environmental Sciences Central China Normal University

The aim of this study was to better understand the mechanisms of regional climate variation in mountain ranges with contrasting aspects as mediated by changes in global climate. It may help predict trends of vegetation variations in native ecosystems in natural reserves. As measures of climate response, temperature and precipitation data from the north, east, and south-facing mountain ranges of Shennongjia Massif in the coldest and hottest months(January and July), different seasons(spring, summer, autumn, and winter) and each year were analyzed from a long-term dataset(1960 to 2003) to tested variations characteristics, temporal and spatial quantitative relationships of climates. The results showed that the average seasonal temperatures and precipitation in the north, east, and south aspects of the mountain ranges changed at different rates. The average seasonal temperatures change rate ranges in the north, east, and south-facing mountain ranges were from –0.0210℃/yr to 0.0143℃/yr, –0.0166℃/yr to 0.0311℃/yr, and –0.0290 ℃/yr to 0.0084℃/yr, respectively, and seasonal precipitation variation magnitude were from –1.4940 mm/yr to 0.6217 mm/yr, –1.6833 mm/yr to 2.6182 mm/yr, and –0.8567 mm/yr to 1.4077 mm/yr, respectively. The climates variation trend among the three mountain ranges were different in magnitude and direction, showing a complicated change of the climates in mountain ranges and some inconsistency with general trends in global climate change. The climate variations were significantly different and positively correlated cross mountain ranges, revealing that aspects significantly affected on climate variations and these variations resulted from a larger air circulation system, which were sensitive to global climate change. We conclude that location and terrain of aspect are the main factors affecting differences in climate variation among the mountain ranges with contrasting aspects.

关键词： regional climate variation slope aspect Shennongjia Massif One-way ANOVA global climate change

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Symmetries and Two Types of Non-Noether Conservation Laws of Birkhoffian System with Unilateral Constraints

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Communications in Theoretical Physics 2006年第2期45卷 239-244页

作者： zhang yi Department of Civil Engineering University of Science and Technology of Suzhou Suzhou 215011 China

The symmetries and non-Noether conservation laws of Birkhoffian system with unilateral constraints are studied. The differential equations of motion of the system are established, and the criterions of Noether symmetry, Lie symmetry and Mei symmetry of the system are given. Two types of new conservation laws, called the Hojman conservation law and the Mei conservation law respectively, are obtained, and the intrinsic relations among the symmetries and the new conservation laws are researched. At the end of the paper, an example is given to illustrate the application of the results.

关键词： analytical mechanics unilateral constraint Birkhoffian system symmetry conservation law

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