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乡村青年媒介化圈层社交的转型与“情感团结”再造——基于晋东南J村的民族志研究

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中国青年研究 2024年第09期 39-48+56页

作者：张倩山西大学新闻学院

本文以乡村现代化、媒介化进程为背景，以期从历史经验中寻求现实启发，考察一个晋东南乡村青年媒介化圈层社交的历史转型，发掘不同阶段和媒介化时期青年运用媒介建构圈层关系和人际情感的特征和变化规律。研究发现，前互联网时代，青... 详细信息

本文以乡村现代化、媒介化进程为背景，以期从历史经验中寻求现实启发，考察一个晋东南乡村青年媒介化圈层社交的历史转型，发掘不同阶段和媒介化时期青年运用媒介建构圈层关系和人际情感的特征和变化规律。研究发现，前互联网时代，青年的媒介化圈层社交历经了遵循信任伦理的“流动式”圈层社交、情感边界紧缩的“核心-边缘”式圈层社交，在互联网个体化媒体的渗透下，青年的圈层社交发生结构消解和情感失序后，青年重新建构在地圈层的行动力又重新显现出来，并实现了“新乡愁”的情感生产。媒介化为乡村青年圈层社交的转型提供了强大动力，同时也是每个阶段乡村青年主体性发展和更新的引擎，由“参与”到“改造”再到“重建”乡土圈层，青年的媒介实践体现着自下而上建构乡村情感团结的强大韧性。未来的乡村组织化应以媒介功能的深度挖掘为突破点，充分调动青年“数字内生性”和主体性，激发青年运用媒介整合乡土圈层关系和建构情感共同体的潜质，带动其他主体共同参与乡土情感团结的重建。

关键词：乡村青年媒介化圈层情感团结

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决定论对道德责任的挑战

浙江学刊 2024年第2期 172-180页

作者：张茜东北师范大学马克思主义学部长春130022

在当代道德哲学中,决定论是一个关系重大的问题。作为一种道德理论,决定论主张人没有自由意志,也无法为自己的行为承担道德责任。它不仅在经验、形而上学和行为解释三个层面对人的自由构成了威胁,还在间接和直接两个层面对道德责任发起... 详细信息

在当代道德哲学中,决定论是一个关系重大的问题。作为一种道德理论,决定论主张人没有自由意志,也无法为自己的行为承担道德责任。它不仅在经验、形而上学和行为解释三个层面对人的自由构成了威胁,还在间接和直接两个层面对道德责任发起了挑战。从道德哲学的观点看,决定论对道德责任的否定引发了严重的道德后果:它不仅损害了人们的自我认知,还破坏了人们的人际交往,更全面摧毁了人们的道德生活。决定论在本质上是一种关于自由意志和道德责任的怀疑论,在理论上违反人们的道德直觉,在实践上动摇人的生存根基,因而是不合理的道德理论。我们应明确地反对决定论。

关键词：自由意志决定论道德责任

农业资本化的“横向集中”与“纵向集中”:重新理解马克思和恰亚诺夫

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中国农业大学学报（社会科学版） 2024年第3期41卷 34-55页

作者：张谦新加坡管理大学社会科学学院

资本化农业如何改造小农,是农政研究中最核心的问题。但在这个问题上最重要的两个理论——马克思主义和恰亚诺夫理论——都有不足:前者忽视了商业资本通过纵向一体化及各种商品关系对小农生产的资本化改造,以及在商品关系中发生的剩余... 详细信息

资本化农业如何改造小农,是农政研究中最核心的问题。但在这个问题上最重要的两个理论——马克思主义和恰亚诺夫理论——都有不足:前者忽视了商业资本通过纵向一体化及各种商品关系对小农生产的资本化改造,以及在商品关系中发生的剩余价值的剥削,而后者则在微观层面忽视了劳动力商品化对小农家庭经济行为的改造。这两个理论恰好在这两点上分别对对方做了有益的补充。本文在重新批判地理解马克思主义和恰亚诺夫理论的基础上,将两条理论路线结合起来形成统一的理论框架,提出农业资本化的“横向集中”和“纵向集中”两条道路,并以当代中国农政变迁的实践来辅以阐述这两条道路所形成的多种资本改造小农农业生产及从小农家庭获取剩余的方式。

关键词：商业资本商品化小农经济资本化农业纵向一体化

Gallic acid ameliorates colitis by modulating the Treg/Th17 balance via microbiota-derived secondary bile acids

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Food Science and Human Wellness 2024年

作者： Xiao zhang Yun Leng qian zhang Hansheng Yu Ziqiong Liao Jiaxuan Xia Chong Ma Kun Liu Yuefeng zhang Yanjun Hong Hao Li Zhiyong Xie School of Pharmaceutical Sciences (Shenzhen)， Sun Yat-sen University The Seventh Affiliated Hospital， Sun Yat-sen University Shenzhen Key Laboratory of Chinese Medicine Active Substance Screening and Translational Research， Sun Yat-sen University

Gallic acid (GA)， a plant phenol ubiquitously present in fruits and vegetables， has demonstrated efficacy in ameliorating ulcerative colitis (UC). Despite previous reports， the precise mechanism of GA's therapeutic action remains elusive. Herein， the present work aims to delineate the mechanism underlying the anti-UC effects of GA by focusing on the interplay of gut microbiota， microbial and host cometabolites， and gut immune regulation. The findings revealed that GA treatment improved the colitis symptoms and systematic inflammatory response， reliant on gut microbiota， as evidenced by microbiota depletion and fecal microbiota transplantation. According to the 16s rDNA sequencing results， GA altered the gut microbiota community structure and upregulated the biosynthesis of secondary bile acids (SBAs). Metabolomics and flow cytometry analysis (FCS) revealed a substantial increase in SBAs production， including UDCA， LCA， 3-oxo-LCA and IsoalloLCA， which further upregulated the proportion of regulatory T (Treg) cells and downregulated the proportion of T helper type 17 (Th17) cells in the colon， ultimately resulting in an improved Treg/Th17 balance. Further FCS and real-time quantitative PCR assays provided mechanistic insights， demonstrating that UDCA and IsoalloLCA facilitate Treg cell differentiation through the upregulation of nuclear hormone receptor 4A1 (NR4A1). This research elucidated that GA effectively mitigates colitis by modulating the Treg/Th17 balance， facilitated by the enhanced synthesis of microbiota-derived SBAs. These insights unveil innovative pathways through which GA exerts its anti-UC effects， emphasizing the potential therapeutic benefits of incorporating a GA-enriched diet into UC management.

关键词：

Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer

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GENOMICS PROTEOMICS & BIOINFORMATICS 2024年第2期22卷 qzae033页

作者： Huo, Zitian Duan, Yaqi Zhan, Dongdong Xu, Xizhen Zheng, Nairen Cai, Jing Sun, Ruifang Wang, Jianping Cheng, Fang Gao, Zhan Xu, Caixia Liu, Wanlin Dong, Yuting Ma, Sailong zhang, qian Zheng, Yiyun Lou, Liping Kuang, Dong Chu, qian Qin, Jun Wang, Guoping Wang, Yi Huazhong Univ Sci & Technol Tongji Hosp Inst Pathol Tongji Med Coll Wuhan 430030 Peoples R China Huazhong Univ Sci & Technol Tongji Med Coll Sch Basic Med Dept Pathol Wuhan 430030 Peoples R China Huazhong Univ Sci & Technol Tongji Med Coll Tongji Hosp Natl Hlth CommissKey Lab Resp Dis Wuhan 430030 Peoples R China Beijing Pineal Diagnost Co Ltd Beijing 102206 Peoples R China Beijing Inst Life Beijing Proteome Res Ctr Natl Ctr Prot Sci Beijing State Key Lab Prote Beijing 102206 Peoples R China Huazhong Univ Sci & Technol Tongji Hosp Tongji Med Coll Dept Oncol Wuhan 430030 Peoples R China Chongqing Univ Posts & Telecommun Sch Bioinformat Chongqing Key Lab Big Data Bio Intelligence Chongqing 400065 Peoples R China Henan Univ Affiliated Hosp 1 Inst Pathol Kaifeng 475001 Peoples R China Shanxi Canc Hosp Dept Tumor Biobank Taiyuan 030013 Peoples R China

Small cell lung cancer (SCLC) is a highly malignant and heterogeneous cancer with limited therapeutic options and prognosis prediction models. Here, we analyzed formalin-fixed, paraffin-embedded (FFPE) samples of surgical resections by proteomic profiling, and stratified SCLC into three proteomic subtypes (S-I, S-II, and S-III) with distinct clinical outcomes and chemotherapy responses. The proteomic subtyping was an independent prognostic factor and performed better than current tumor-node-metastasis or Veterans Administration Lung Study Group staging methods. The subtyping results could be further validated using FFPE biopsy samples from an independent cohort, extending the analysis to both surgical and biopsy samples. The signatures of the S-II subtype in particular suggested potential benefits from immunotherapy. Differentially overexpressed proteins in S-III, the worst prognostic subtype, allowed us to nominate potential therapeutic targets, indicating that patient selection may bring new hope for previously failed clinical trials. Finally, analysis of an independent cohort of SCLC patients who had received immunotherapy validated the prediction that the S-II patients had better progression-free survival and overall survival after first-line immunotherapy. Collectively, our study provides the rationale for future clinical investigations to validate the current findings for more accurate prognosis prediction and precise treatments.

关键词： Small cell lung cancer Proteomics Prognosis Chemotherapy response Immunotherapy DOMAIN-LIKE PROTEIN PROTEOGENOMIC CHARACTERIZATION PRIMARY TUMOR EXPRESSION NECROPTOSIS LINES IDENTIFICATION ESTABLISHMENT CHEMOTHERAPY BIOMARKER

Anisotropic coherence induced nonuniform amplification in N

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Hongqiang Xie qian zhang Hongbin Lei Na Wang Yuhan Zheng Zhiming Chen Guihua Li Zengxiu Zhao School of Science East China University of Technology Department of Physics National University of Defense Technology School of Science East China Jiaotong University

The continuous progress in N2+lasing recently stimulates a great deal of interest in nonlinear and quantum optics of molecular ions, while a complete description of the ionic polarization is still lacking to date. In this work, we are dedicated to constructing the fundamental ionic polarization theory where several ubiquitous strong-field processes including ionization, electronic couplings and molecular alignment jointly determine the spatial arrangement of ions. With the model, the elusive polarization of N2+lasing can be well interpreted. Our results show that the different electronic transition rules for strong-field ionization and resonant couplings result in peculiar population distributions of various electronic states of N2+in space. Meanwhile, the spatial nonuniformity of population distribution can be aggravated or mitigated during field-free evolutions of coherent molecular rotational wave packets. Furthermore, when a follow-up resonant seed pulse interacts with the prepared ionic system, the anisotropic quantum coherence determining the polarization of subsequent N2+lasing can be established. The qualitative agreement between experiments and simulations confirms the validity of the proposed model. The findings provide critical insights into the polarization and radiation mechanisms of molecular ions constructed via ultrafast laser pulses.

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火灾下活性粉末混凝土梁斜截面承载性能研究

材料导报 2024年第9期38卷 110-117页

作者：闫凯张倩黄彬超张鑫山东建筑大学土木工程学院济南250101 建筑结构加固改造与地下空间工程教育部重点实验室济南250101

为探明火灾下活性粉末混凝土(Receative power concrete,RPC)梁斜截面承载性能退化规律,设计制作了六根RPC简支梁试件,开展了恒载下ISO834标准火灾试验,获得了时间-位移曲线、荷载-位移曲线、内部温度变化、裂缝开展、破坏形态、高温爆... 详细信息

为探明火灾下活性粉末混凝土(Receative power concrete,RPC)梁斜截面承载性能退化规律,设计制作了六根RPC简支梁试件,开展了恒载下ISO834标准火灾试验,获得了时间-位移曲线、荷载-位移曲线、内部温度变化、裂缝开展、破坏形态、高温爆裂等数据,分析了剪跨比、荷载水平、配箍率、纵筋配筋率对火灾下RPC梁斜截面承载性能的影响规律。结果表明:剪跨比、荷载水平是影响RPC梁斜截面耐火极限的关键因素,剪跨比由2.5增至3.5,荷载水平由0.25增至0.45,RPC梁耐火极限可降低30 min以上;配箍率对RPC梁的斜截面承载力和耐火极限影响显著;纵筋配筋率对RPC梁耐火极限影响甚微。火灾高温、爆裂削弱了RPC梁的斜截面承载性能,爆裂导致内部材料直接受火,加速其力学性能劣化,使梁斜截面承载力降低33.5%以上。该研究可为火灾下RPC梁斜截面承载安全及火灾后加固修复提供参考。

关键词：活性粉末混凝土梁抗火试验耐火极限斜截面承载力

A secure visualization platform for pathogenic genome analysis with an accurate reference database

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生物安全与健康(英文) 2024年第04期06卷 235-243页

作者： Fan Guomei Guo Chongye zhang qian Liu Dongmei Sun Qinglan Cui Zhigang Zhou Haijian Zhou Yuanchun Guo Zhibin Ma Juncai Wu Linhuan Microbial Resource and Big Data Center Institute of Microbiology Chinese Academy of Sciences Beijing China Chinese National Microbiology Data Center (NMDC) Beijing China National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China Computer Network Information Center Chinese Academy of Sciences Beijing China State Key Laboratory of Microbial Resources Institute of Microbiology Chinese Academy of Sciences Beijing China

Investigating the genetic and developmental characteristics, infection transmission attributes, and epidemiological trends of pathogens using genomic data represents the foundation for pathogen surveillance and is a crucial prerequisite for guaranteeing global health security. To meet the analytical demands of research relating to pathogen prevention and control, we designed a secure visualization system capable of pathogen genome assembly, annotation, species identification, sequence typing, antibiotic resistance and virulence analysis, genomic mobile element and transferable resistance gene annotation, and phylogenetic tree reconstruction. For highly pathogenic organisms requiring complete data protection, we have developed a secure computing tool that utilizes a trusted execution environment, is combined with blockchain and privacy computing technologies, and is specifically designed for nucleotide basic local alignment search tool (BLASTn) comparison analysis. This technological advancement offers scientific support for in-depth investigations into pathogen transmission and epidemiological mechanisms, environmental adaptability, evolutionary trends, and immune evasion mechanisms, as well as the identification of new or emerging pathogen strains. This, in turn, aids efforts in infectious disease prevention, treatment, and research.

关键词： Pathogen surveillance One-stop analysis tools Sequence typing Horizontal transfer Secure computing

Impact of gonadotropin-releasing hormone agonist and hormone replacement therapy on pregnancy outcomes in single euploid frozen-thawed embryo transfer for patients with endometrial polyps

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生殖与发育医学(英文) 2024年第1期08卷 1-7页

作者： Zhao Qing Li Jie Wang Wei-Lin Liu Ying-Bo Li Jing Ni Tian-Xiang Zhou Wei zhang qian Yan Jun-Hao Center for Reproductive Medicine Shandong University 3. Jinan 250012 4. China

Objective: Although consensus on the optimal endometrial preparation protocol for frozen-thawed embryo transfer (FET) is lacking, this is particularly true for patients with infertility and a history of endometrial polyps (EPs). In this study, we aimed to investigate whether a gonadotropin-releasing hormone agonist combined with hormone replacement therapy (GnRHa-HRT) could improve pregnancy outcomes in single euploid FET for patients with a history of ***: In this retrospective cohort study, 395 women who underwent their first single euploid FET cycle were divided into groups according to endometrial preparation protocols as follows: natural cycle (NC) (n = 220), hormone replacement therapy (HRT) (n = 122), and GnRHa-HRT groups (n = 53). Subsequently, the FET cycles in the three groups were subdivided according to maternal age. All patients underwent hysteroscopic polypectomy before FET, and their EPs were confirmed by ***: No statistically significant differences were observed in live birth rates among the three groups (58.64%vs. 58.20%vs. 56.60%,P = 0.964). Furthermore, the rates of miscarriage, ectopic pregnancy, premature live birth, and pregnancy complications were comparable among the three groups (P >0.05). After adjusting for potential confounding factors, no significant differences in pregnancy outcomes were reported between the groups (adjusted odds ratios [OR] and 95% credible intervals [CI] for live birth rate, HRTvs. NC: 1.119, 0.660–1.896,P = 0.677; GnRHa-HRTvs. NC: 1.165, 0.610–2.226,P = 0.643). Additionally, the pregnancy outcomes of the FET cycle were not influenced by the endometrial preparation protocols in the subgroups when stratified by maternal age (P >0.05).Conclusion: GnRHa-HRT did not improve the pregnancy outcomes of the single euploid FET in patients with a history of EPs.

关键词： Endometrial polyps Frozen-thawed embryo transfer GnRHa Hormone replacement therapy Preimplantation genetic testing