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Identification and Interaction Analysis of Key Genes and MicroRNAs in Systemic Sclerosis by Bioinformatics Approaches

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Current Medical Science 2019年第4期39卷 645-652页

作者： Yan-hong SUN meng XIE Shi-di WU Jing zhang Chang-zheng HUANG Department of Dermatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Dermatology Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Dermatology General Hospital of the Central Theater Command of the People's Liberation ArmyWuhan 430070China

Systemic sclerosis (SSc) is a highly heterogeneous autoimmune disease with a high mortality ***,the cellular and molecular mechanisms of SSc remain ***,we identified the key hub genes and microRNAs (miRNAs) that modulate the occurrence and development of *** downloaded the microarray dataset GSE95065 from the Gene Expression Omnibus (GEO) database and then analyzed the data by using *** Database for Annotation,Visualization and Integrated discovery (DAVID) was used for functional pathway enrichment analyses of differentially expressed genes (DEGs),and Cytoscape software was used to generate the protein-protein interaction (PPI) *** addition,OmicsNet was used to predict the miRNAs for the hub genes of *** a result,783 DEGs were identified,of which 770 genes (142 up-regulated genes and 628 down-regulated genes) were matched to the genes in SSc skin *** Ontology (GO) analyses by DAVID indicated that the up-regulated genes were mainly involved in immune response,and the down-regulated genes were greatly enriched in glycinergic synaptic *** the PPI network,22 nodes were selected as key genes,including several members of the chemokine ***,after uploading these key genes to the OmicsNet tool,we found that hsa-miR-26b-5p might target CXCL9 and ***,we demonstrated that the hsa-miR-26b-5p inhibitor might inhibit fibrosis in TGF-β-activated fibroblasts,which would be a promising target for SSc therapy.

关键词： systemic sclerosis bioinformatics analysis CXCL9 CXCL13 hsa-miR-26b-5p

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Tail Bounds for the Supremums of Empirical Processes over Unbounded Classes of Functions

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Acta Mathematica Sinica,English Series 2006年第2期22卷 339-346页

作者： di Xin zhang Department of Finance Business SchoolNanjing University

So far the study of exponential bounds of an empirical process has been restricted to a bounded index class of functions. The case of an unbounded index class of functions is now studied on the basis of a new symmetrization idea and a new method of truncating the original probability space; the exponential bounds of the tail probabilities for the supremum of the empirical process over an unbounded class of functions are obtained. The exponential bounds can be used to establish laws of the logarithm for the empirical processes over unbounded classes of functions.

关键词： empirical process tail bound unbounded class of functions

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A review on analytical methods for pharmaceutical and personal care products and their transformation products

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Journal of Environmental Sciences 2021年第3期33卷 260-281页

作者： Yuan meng Weiyi Liu Xiaohui Liu Jinlan zhang meng Peng Tingting zhang Department of Environmental Science and Engineering Beijing Environmental Pollution Control and Resource Engineering Research CenterBeijing University of Chemical TechnologyBeijing 100029China National Engineering Laboratory for Lake Pollution Control and Ecological Restoration State Key Laboratory of Environmental Criteria and Risk AssessmentChinese Research Academy of Environmental SciencesBeijing 100012China School of Environment Tsinghua UniversityBeijing 100084China

Pharmaceutical and personal care products(PPCPs)and corresponding transformation products have caused widespread concern due to their persistent emissions and potential *** have wide octanol-water partition coefficients(K_(ow))and different ionization constants(pK_(a))resulting in a poor analysis accuracy and efficiency.A suitable analytical method is the first prerequisite for further research on their environmental behavior to prioritize the *** study reviewed a full-scale analytical protocol for environmental samples in the recent ten years:from sampling to instrumental *** sampling techniques were compared and recommended for long-term continuous and scientific observation.A quick and effective sample extraction and clean-up method are highly *** methods coupled to mass spectrometry for determining PPCPs with a wide range of logK_(ow)(-7.53 to 10.80)were summed ***-resolution mass spectrometry was confirmed to be a promising strategy for screening unknown transformation products,which would provide a nanogram level of detection limits and more accurate mass *** strategies and mass change principles were summarized in *** recovery rate was important in multiple contaminants analysis identification and factors affecting the recovery rate of PPCPs were also discussed in this review,including sample matrix,target compounds characteristics,extraction method and solid-phase *** review provides useful information for the selection of appropriate analytical methods and future development directions.

关键词： Pharmaceutical and personal care products Transformation products Passive sampling Extraction High-resolution mass spectrometry

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Plasmon-mediated photodecomposition of NH3 via intramolecular charge transfer

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Nano Research 2022年第5期15卷 3894-3900页

作者： Yimin zhang Weite meng Daqiang Chen Lili zhang Shunfang Li Sheng meng Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China Key Laboratory of Material Physics Ministry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450001China School of Chemical Engineering Anhui University of Science and TechnologyHuainan 232000China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China

As an excellent clean medium for hydrogen storage and fuel cell applications,the photolysis of ammonia via localized surface plasmon could be invoked as a promising route towards significantly reducing the temperature for conventional ***,we explore the underlying microscopic mechanism of ultrafast carrier dynamics in plasmon-mediated NH3 photodecomposition at the single-molecular level using real-time time-dependent density functional *** NH_(3)molecule adsorbed on the tip of archetypal magic metal clusters represented by tetrahedral Ag_(2)0 and icosahedral Ag147,splits within a hundred femtoseconds upon laser pulse *** found that the splitting of the first N-H bond is dominated by the intramolecular charge transfer driven by localized surface ***,the phase of laser pulse could modulate the dynamics of charge transfer and thus affect the plasmon-induced bond *** findings offer a new avenue for NH3 decomposition and provide in-depth insights in designing highly efficient plasmon-mediated photocatalysts.

关键词： ammonia photodecomposition localized surface plasmon intramolecular charge transfer time-dependent density functional theory

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A modified generalized scaling law for the similitude of dynamic strain in centrifuge modeling

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Earthquake Engineering and Engineering Vibration 2023年第3期22卷 589-600页

作者： Ma Qiang Ling Daosheng meng di Kyohei Ueda Zhou Yanguo MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Institute of Geotechnical EngineeringCenter for Hypergravity Experiment and Interdisciplinary ResearchZhejiang UniversityHangzhou 310058China disaster Prevention Research Institute Kyoto UniversityGokashoUjiKyoto 611-0011Japan

Soil strain is the key parameter to control the elasto-plastic deformation and even the failure *** overcome the defect that the strain of the model soil is always smaller than that of the prototype in Iai′s generalized scaling law(GSL),a modified scaling law was proposed based on Iai′s GSL to secure the same dynamic shear strain between the centrifuge model and the prototype by modulating the amplitude and frequency of the input motion at the base.A suite of dynamic centrifuge model tests of dry sand level ground was conducted with the same overall scaling factor(λ=200)under different centrifugal accelerations by using the technique of“modeling of models”to validate the modified *** test results show that the modified GSL could achieve the same dynamic strain in model as that of the prototype,leading to better modeling for geotechnical problems where dynamic strain dominates the response or failure of ***,the applicability of the proposed scaling law and possible constraints on geometry scaling due to the capability limits of existing centrifuge shaking tables are discussed.

关键词： deep deposit seismic response generalized scaling law centrifuge model test

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Fault self-repair strategy based on evolvable hardware and reparation balance technology

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Chinese Journal of Aeronautics 2014年第5期27卷 1211-1222页

作者： zhang Junbin Cai Jinyan meng Yafeng meng Tianzhen Department of Electronic and Optical Engineering Mechanical Engineering College

In the face of harsh natural environment applications such as earth-orbiting and deep space satellites, underwater sea vehicles, strong electromagnetic interference and temperature stress,the circuits faults appear easily. Circuit faults will inevitably lead to serious losses of availability or impeded mission success without self-repair over the mission duration. Traditional fault-repair methods based on redundant fault-tolerant technique are straightforward to implement, yet their area, power and weight cost can be excessive. Moreover they utilize all plug-in or component level circuits to realize redundant backup, such that their applicability is limited. Hence, a novel selfrepair technology based on evolvable hardware（EHW） and reparation balance technology（RBT） is proposed. Its cost is low, and fault self-repair of various circuits and devices can be realized through dynamic configuration. Making full use of the fault signals, correcting circuit can be found through EHW technique to realize the balance and compensation of the fault output-signals. In this paper, the self-repair model was analyzed which based on EHW and RBT technique, the specific self-repair strategy was studied, the corresponding self-repair circuit fault system was designed, and the typical faults were simulated and analyzed which combined with the actual electronic devices. Simulation results demonstrated that the proposed fault self-repair strategy was feasible. Compared to traditional techniques, fault self-repair based on EHW consumes fewer hardware resources, and the scope of fault self-repair was expanded significantly.

关键词： Evolutionary algorithm Evolvable hardware Fault Self-repair Fault-tolerant Genetic algorithm particle swarm optimization Reparation balance technology

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In Vitro Protein Expression Profile of Campylobacter jejuni Strain NCTC11168 by Two-dimensional Gel Electrophoresis and Mass Spectrometry

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Biomedical and Environmental Sciences 2013年第1期26卷 48-53页

作者： zhang Mao Jun GU Yi Xin di Xiao ZHAO Fei YOU Yuan Hai meng Fan Liang zhang Jian Zhong Key Laboratory for Infectious disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention

Objective To investigate the protein expression profiles of the major food‐borne pathogen Campylobacter jejuni *** Membrane and soluble cellular proteins were extracted from the genome‐sequenced *** strain *** expression profiles were determined using two‐dimensional gel electrophoresis（2‐DE）.All the detected spots on the 2‐DE map were subjected to matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry（MALdi‐TOF/TOF） *** A total of 537 and 333 spots were detected from the whole cell and membrane‐associated proteins of *** NCTC11168 cultured on Columbia agar medium at 42 ℃ by 2‐DE and Coomassie Brilliant Blue staining,*** of whole cell and membrane‐associated proteins included 399 and 133 spots,respectively,which included 182 and 53 functional proteins identified by MALdi‐TOF/TOF *** The comprehensive expression protein profiles of *** NCTC11168 obtained in this study will be useful for elucidating the roles of these proteins in further pathogenesis investigation.

关键词： Campylobacter jejuni Two‐dimensional gel electrophoresis MALdi‐TOF Soluble cellular protein Membrane protein

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An Explicit Example of a Reich Sequence for a Uniquely Extremal Quasiconformal Mapping

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Chinese Annals of Mathematics,Series B 2021年第3期42卷 327-332页

作者： Xue meng Sihui zhang College of Science University of Shanghai for Science and TechnologyShanghai 200093China Corresponding author.College of Science University of Shanghai for Science and TechnologyShanghai 200093China

An explicit example of a Reich sequence for a uniquely extremal quasiconformal mapping in a borderline case between uniqueness and non-uniqueness is given.

关键词： Quasiconformal mapping Uniquely extremal quasiconformal mapping Reich sequence

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Compressive surface strained atomic-layer Cu2O on Cu@Ag nanoparticles

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Nano Research 2019年第5期12卷 1187-1192页

作者： Xiyue Zhu Hongpan Rong Xiaobin zhang Qiumei di Huishan Shang Bing Bai Jiajia Liu Jia Liu meng Xu Wenxing Chen Jiatao zhang Beijing Key Laboratory of Construction-Tailorable Advanced Functional Materials and Green Applications Experimental Center of Advanced MaterialsSchool of Materials Science & EngineeringBeijing Institute of TechnologyBeijing 100081China Center for Nano Materials and Technology Japan Advanced Institute of Science and Technology1-1 AsahidaiNomiIshikawa 923-1292Japan

Control of surface structure at the atomic level can effectively tune catalytic properties of *** surface strain is an effective strategy for enhancing catalytic activity;however,the correlation studies between the surface strain with catalytic performance are scant because such mechanistic studies require the precise control of surface strain on *** this work,a simple strategy of precisely tuning compressive surface strain of atomic-layer Cu2O on Cu@Ag (AL-Cu2O/Cu@Ag) nanoparticles (NPs) is *** AL-Cu2O is synthesized by structure evolution of Cu@Ag core-shell nanoparticles,and the precise thickness-control of AL-Cu2O is achieved by tuning the molar ratio of Cu/Ag of the starting ***-corrected high-resolution transmission electron microscopy (AC-HRTEM) and EELS elemental mapping characterization showed that the compressive surface strain of AL-Cu2O along the [111] and [200] directions can be precisely tuned from 6.5% to 1.6% and 6.6% to 4.7%,respectively,by changing the number of AL-Cu2O layer from 3 to *** as-prepared AL-Cu2O/Cu@Ag NPs exhibited excellent catalytic property in the synthesis of azobenzene from aniline,in which the strained 4-layers Cu2O (4.5% along the [111] direction,6.1% along the [200] direction) exhibits the best catalytic *** work may be beneficial for the design and surface engineering of catalysts toward specific applications.

关键词： compressive surface strain atomic-layer Cu2O precise thickness-control catalytic activity

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An Angle Structure Descriptor for Image Retrieval

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China Communications 2016年第8期13卷 222-230页

作者： meng Zhao Huaxiang zhang Lili meng School of Information Science and Engineering Shandong Normal University Institute of Data Science and Technology Shandong Normal University

This paper presents an efficient image feature representation method, namely angle structure descriptor(ASD), which is built based on the angle structures of images. According to the diversity in directions, angle structures are defined in local blocks. Combining color information in HSV color space, we use angle structures to detect images. The internal correlations between neighboring pixels in angle structures are explored to form a feature vector. With angle structures as bridges, ASD extracts image features by integrating multiple information as a whole, such as color, texture, shape and spatial layout information. In addition, the proposed algorithm is efficient for image retrieval without any clustering implementation or model training. Experimental results demonstrate that ASD outperforms the other related algorithms.

关键词： image retrieval angle structure descriptor HSV color space local descriptor

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