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World Journal of Clinical Cases 2020年第20期8卷 4816-4825页

作者： meng-di Qu meng-Yuan zhang Gong-Ming Wang Zhun Wang Xu Wang Department of Anesthesiology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina

BACKGROUND The incidence of postoperative nausea and vomiting(PONV)in patients undergoing laparoscopic hysterectomy is very high compared with other surgeries,even when many prophylactic measures have been ***,the pathogenesis of PONV is *** sex,a history of motion sickness or PONV,nonsmokers,and perioperative opioid use are the most closely related *** the multiple risk factors,suboptimal gastrointestinal(GI)perfusion may be attributed to some cases of PONV,and increased systemic vascular resistance(SVR)may lead to GI *** hypothesis of this research was that SVR is related to *** To investigate the relationship between SVR and PONV in patients undergoing laparoscopic *** A total of 228 patients who underwent elective laparoscopic hysterectomy were included in this prospective observational *** was monitored using a noninvasive hemodynamic monitoring *** indices of SVR,the baseline,mean,area under the curve(AUC),and weighted AUC,were used for *** incidence and severity of nausea and vomiting were evaluated while patients were awake and throughout the intervals from 0 to 2 h,2 to 6 h,and 6 to 24 h starting upon arrival at the post-anesthesia care *** associations between various SVR indices and PONV were investigated by logistic regression.Pdiet and demonstrated poorer sleep quality on the first night

关键词： Postoperative nausea and vomiting Systemic vascular resistance Gastrointestinal perfusion Laparoscopic hysterectomy Prospective observational study Pneumoperitoneum

Electrospun naringin-loaded microsphere/sucrose acetate isobutyrate system promotes macrophage polarization toward M2 and facilitates osteoporotic bone defect repair

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Regenerative Biomaterials 2023年第1期10卷 470-485页

作者： Jihong Li Jinlin Song di meng Yin Yi Ting zhang Yu Shu Xiaohong Wu Stomatological Hospital of Chongqing Medical University No.426 Songshibei RoadYubei DistrictChongqing 401147China Chongqing Key Laboratory of Oral diseases and Biomedical Sciences Chongqing 401147China Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Chongqing 401147China

Repairing osteoporotic bone defects is still a major clinical *** studies have revealed that immune response is also essential in *** intrinsic inflammatory response of the host,especially the M1/M2 polarization status and inflammatory secretory function of macrophages,can directly affect osteogenic ***,in this study,an electrospun naringin-loaded microspheres/sucrose acetate isobutyrate(Ng-m-SAIB)system was constructed to investigate its effect on the polarization of macrophage and osteoporotic bone *** results of both in vitro and in vivo experiments showed that Ng-m-SAIB had good biocompatibility and could promote the polarization of macrophage toward M2,thereby forming a favorable microenvironment for *** animal experiments also showed that Ng-m-SAIB could promote the osteogenesis of critical size defects in the skull of the osteoporotic model mouse(the senescence-accelerated mouse-strain P6).Together,these results collectively suggested that Ng-m-SAIB might be a promising biomaterial to treat osteoporotic bone defects with favorable osteo-immunomodulatory effects.

关键词： electrospun microspheres macrophage polarization Ng-m-SAIB osteoporotic bone defects

Interaction Between Memory Load and Experimental Design on Brain Connectivity and Network Topology

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Neuroscience Bulletin 2023年第4期39卷 631-644页

作者： Heming zhang Xin di Bart Rypma Hang Yang Chun meng Bharat Biswal The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for NeuroinformationCenter for Information in MedicineSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu611731China Department of Biomedical Engineering New Jersey Institute of TechnologyNewark07102USA Department of Psychology University of Texas at DallasDallas75390USA

The conventional approach to investigating functional connectivity in the block-designed study usually concatenates task blocks or employs residuals of task *** providing many insights into brain functions,the block design adds more manipulation in functional network analysis that may reduce the purity of the blood oxygenation level-dependent *** studies utilized one single long run for task trials of the same condition,the so-called continuous design,to investigate functional connectivity based on task functional magnetic resonance *** brain activities associated with the single-task condition can be directly utilized for task-related functional connectivity assessment,which has been examined for working memory,sensory,motor,and semantic task experiments in previous *** it remains unclear how the block and continuous design influence the assessment of task-related functional connectivity *** study aimed to disentangle the separable effects of block/continuous design and working memory load on task-related functional connectivity networks,by using repeated-measures analysis of *** 50 young healthy adults,behavioral results of accuracy and reaction time showed a significant main effect of design as well as interaction between design and *** results revealed that the cingulo-opercular,fronto-parietal,and default model networks were associated with not only task activation,but significant main effects of design and load as well as their interaction on intra-and inter-network functional connectivity and global network ***,a significant behavior-brain association was identified for the continuous *** work has extended the evidence that continuous design can be used to study task-related functional connectivity and subtle brain-behavioral relationships.

关键词： Working memory Functional connectivity Network topology Block design Continuous design Memory load

Range-wide genetic diversity in natural populations of Larix principis-rupprechtii Mayr.

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Journal of Forestry Research 2021年第1期32卷 319-327页

作者： Xiaoyan di Xiangxiang meng mengben Wang Institute of Loess Plateau Shanxi UniversityTaiyuan 030006People’s Republic of China

Prince Rupprecht’s larch(Larix principis-rupprechtii Mayr.),a deciduous conifer,widely grows in middle and high elevations of Northern *** natural distribution has sharply decreased and has become fragmented,which may have resulted in the loss of genetic *** this study,ten natural populations across the entire range of this species were analyzed using amplifi ed fragment length polymorphism markers.A total of 309 loci were detected from 225 individuals of these populations,of which 261(84.5%)were *** the species level,the genetic diversity was high(average of the Nei’s genetic diversity H e=0.2602,and Shannon’s information index I=0.3967).The results of molecular variance analysis showed that 90.71%of the genetic diversity occurred within *** genetic diff erentiation among populations was moderate as a whole(F ST=0.0929,G ST=0.1510),which is consistent with the moderate level of gene fl ow among populations(N m=2.8116).Based on the unweighted pair group method with arithmetic mean and STRU CTU RE analysis,these populations were grouped into three genetically distinct *** degree of inter-population diff erentiation(G ST=0.1338)for the south group was larger than that for the north group(G ST=0.0915).There was a signifi cant correlation between genetic distance and geographic distance across the species range(r=0.316,Pdiversity was signifi-cantly associated with longitude but not elevation or climatic *** populations with high genetic diversity from each cluster are therefore recommended for future conservation and management of this species.

关键词： Larix principis-rupprechtii Amplifi ed fragment length polymorphism markers(AFLP) Genetic diversity Environmental factors

Flex Ethernet Technology and Application in 5G Mobile Transport Network

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China Communications 2021年第2期18卷 250-258页

作者： meng zhang Research Institute of Telecommunications Transmission(RITT) China Academy of Information Communications Technology(CAICT)MIITBeijing 100191China

With the advent of 5G era,the rise of cloud services,virtual reality/virtual reality(AR/VR),vehicle networking and other technologies has put forward new requirements for the bandwidth and delay of the bearer *** Ethernet technology cannot meet the new requirements very *** Ethernet(FlexE)technology has emerged as the times *** paper introduces the background,standardization process,functional principle,application mode and technical advantages of FlexE technology,and finally analyses its application prospects and shortcomings in 5G mobile transport network.

关键词： Flex Ethernet(FlexE) 5G mobile transport network network slicing

Oral colon-targeted mucoadhesive micelles with enzyme-responsive controlled release of curcumin for ulcerative colitis therapy

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Chinese Chemical Letters 2022年第11期33卷 4924-4929页

作者： Chen zhang Jiaxin Li meng Xiao di Wang Yan Qu Liang Zou Chuan Zheng Jinming zhang State Key Laboratory of Southwestern Chinese Medicine Resources School of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611130China Key Laboratory of Coarse Cereal Processing Ministry of Agriculture and Rural AffairsChengdu UniversityChengdu 610106China Oncology Teaching and Research Department Hospital of Chengdu University of Traditional of Chinese MedicineChengdu 610072China

Although multitudinous nanoscale drug-delivery systems(DDSs)have been recommended to improve anti-ulcerative colitis(UC)outcomes,to enhance the mucoadhesion of nanosystems on the colon and specifically release the loaded drugs in response to the colon micro-environment would be critical *** application of curcumin(Cur),an acknowledged anti-UC phytochemical compound,for UC therapy requires more efficient nano-carriers to improve its therapeutic ***,we developed the colon-targeted nano-micelles with mucoadhesive effect and Azo reductase-triggered drug release profiles for Cur delivery in UC ***,the amphiphilic block polymer containing the Azo-reductase sensitive linkage(PEG-Azo-PLGA),and catechol-modified TPGS(Cat-TPGS)were synthesized *** on the self-assembly of the mixed polymers,Cur-micelles(142.7±1.7 nm of average size,72.36%±1.54%of DEE)were ***,the Cur-micelles exhibited the Azo-reductase sensitive particle dissociation and drug release,the enhanced cellular uptake and the prolonged retention on colonic mucosa,mediated by the strong mucoadhesion of catechol ***,Cur-micelles significantly mitigated colitis symptoms and accelerated colitis repair in DSS-treated mice by regulating the intestinal flora and the levels of pro-inflammatory factors(MPO,IL-6,IL-1β,and TNF-α)related to TLR4/MyD88/NF-κB signaling *** work provides an effective drug delivery strategy for anti-UC drugs by oral administration.

关键词： Curcumin Enzyme-responsive Micelles Mucoadhesion Ulcerative colitis

Properties of a general quaternion-valued gradient operator and its applications to signal processing

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Frontiers of Information Technology & Electronic Engineering 2016年第2期17卷 83-95页

作者： meng-di JIANG Yi LI Wei LIU Department of Electronic and Electrical Engineering University of Sheffield School of Mathematics and Statistics University of Sheffield

The gradients of a quaternion-valued function are often required for quaternionic signal processing *** HR gradient operator provides a viable framework and has found a number of ***,the applications so far have been limited to mainly real-valued quaternion functions and linear quaternionvalued *** generalize the operator to nonlinear quaternion functions,we define a restricted version of the HR operator,which comes in two versions,the left and the right *** then present a detailed analysis of the properties of the operators,including several different product rules and chain *** the new rules,we derive explicit expressions for the derivatives of a class of regular nonlinear quaternion-valued functions,and prove that the restricted HR gradients are consistent with the gradients in the real *** an application,the derivation of the least mean square algorithm and a nonlinear adaptive algorithm is *** results based on vector sensor arrays are presented as an example to demonstrate the effectiveness of the quaternion-valued signal model and the derived signal processing algorithm.

关键词： Quaternion Gradient operator Signal processing Least mean square(LMS) algorithm Nonlinear adaptive filtering Adaptive beamforming

中西医结合治疗乳腺癌术后上肢水肿的Meta分析

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海南医学院学报 2021年第10期27卷 768-774页

作者：梁鸿艺张梦棣许继升王博杨丽爽李静蔚山东中医药大学中医学院山东济南250014 山东中医药大学第一临床医学院山东济南250014 北京中医药大学枣庄医院普外科山东枣庄277101 山东中医药大学附属医院乳腺甲状腺外科山东济南250014

目的:系统评价中医与西医结合治疗乳腺癌术后出现上肢水肿的疗效,临床效果用有效率和患肢周径的变化来描述。方法:借助计算机网络检索中国知网(CNKI)、万方(Wan Fang)、维普(VIP)网、中国生物医学文献服务系统(CBM)、PubMed、Embase,检... 详细信息

目的:系统评价中医与西医结合治疗乳腺癌术后出现上肢水肿的疗效,临床效果用有效率和患肢周径的变化来描述。方法:借助计算机网络检索中国知网(CNKI)、万方(Wan Fang)、维普(VIP)网、中国生物医学文献服务系统(CBM)、PubMed、Embase,检索筛选中西医结合治疗乳腺癌术后上肢水肿的临床随机对照试验(RCT),查阅时间范围是2011年1月~2020年5月,检索关键词是乳腺癌术后上肢水肿、中西医治疗,管理软件Note Express用来进行文献筛选和数据提取,Meta分析借助于软件RevMan5.3操作,研究中所有需要的文献指标均被采纳。结果:10篇临床随机对照试验,644例患者符合纳入标准,9篇为治疗有效率观察,5项是患肢周径的变化研究,观察组322例,对照组322例,纳入的文献全部为中文文献。研究结果表明,对照组(单纯西医治疗)对于乳腺癌术后上肢水肿治疗的有效率为68.9%,明显低于观察组(中西医结合治疗)有效率91.1%[95%CI(1.22,1.44),Z=6.55,P<0.000 01];观察组(中西医结合治疗)患肢周径减小程度明显高于对照组(单纯西医治疗)[95%CI(-0.98,-0.64),Z=9.40,P<0.000 01]。结论:中西医结合方法治疗乳腺癌术后上肢水肿的临床效果显著,可以明显提高水肿缓解率,有效减小患肢周径,在临床上值得推广和使用。但是,由于纳入文献的质量较低,因此仍需要进一步的研究与学习。

关键词：乳腺癌术后上肢水肿中西医结合治疗 Meta分析

通心降脂滴丸对犬冠脉结扎致心肌缺血的保护作用

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中国生化药物杂志 2016年第3期36卷 27-29页

作者：张秀慧常福厚白图雅吕晓丽高峰张梦迪内蒙古医科大学药学院内蒙古呼和浩特010110 内蒙古医科大学新药安全评价研究中心内蒙古呼和浩特010110 内蒙古自治区新药筛选工程研究中心内蒙古呼和浩特010110

目的观察通心降脂滴丸对犬冠脉结扎致心肌缺血的保护作用。方法取25只健康Beagle犬,雌雄兼用,按体重随机分为假手术组、缺血模型组、复方丹参滴丸组(阳性对照组),通心降脂滴丸低、高剂量组,每组5只。采用冠脉结扎方法造成Beagle犬急性... 详细信息

目的观察通心降脂滴丸对犬冠脉结扎致心肌缺血的保护作用。方法取25只健康Beagle犬,雌雄兼用,按体重随机分为假手术组、缺血模型组、复方丹参滴丸组(阳性对照组),通心降脂滴丸低、高剂量组,每组5只。采用冠脉结扎方法造成Beagle犬急性心肌缺血,研究通心降脂滴丸对心肌缺血后心肌缺血范围(N-ST)、心肌缺血程度(Σ-ST)和血清中乳酸脱氢酶(LDH)、肌酸激酶(CK)、超氧化物歧化酶(SOD)活力以及心肌组织中丙二醛(MDA)含量的影响。结果与缺血模型组比较,通心降脂滴丸组显著降低N-ST、Σ-ST,抑制LDH、CK释放,减少MDA含量而提高SOD活力(P<0.05)。结论通心降脂滴丸对缺血心肌具有一定的保护作用。

关键词：通心降脂滴丸心肌缺血比格犬

Myeloid zinc finger 1(MZF1) is the most important transcriptional factor for porcine follistatin promoter

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Journal of Integrative Agriculture 2015年第7期14卷 1383-1389页

作者： SUN Ya-meng WANG Liang YANG Xiu-qin zhang Dong-jie LIU di College of Animal Sciences and Technology Northeast Agricultural University Heilongjiang Academy of Agricultural Sciences

Follistatin （FS） is a secreted protein, which was originally isolated from porcine follicular fluid. Expression of follistatin is tightly regulated during porcine growth and development. To study the essential transcriptional regions of the porcine FS promoter, ten primer pairs were designed to amplify segments with different lengths of the FS promoter from -1 800 to ＋16 bp. The products were then inserted into the pGL3-basic vector to analyze the relative luciferase activity. The results showed that the most remarkable changes of promoter activity were observed between constructs （-302/＋16 bp）-FS and （-180/＋16 bp）-FS （P〈0.01）. Further research showed that the reconstructed reporter plasmid lacking myeloid zinc finger 1 （MZF1） binding sequence had significantly decreased luciferase activity （P〈0.05）. Furthermore, the FS protein expression was significantly increased in PK15 cells while the MZF1 was overexpressed, suggesting that the short sequence ＂TCCCCACC＂（the recognition site of transcription factor MZF1） was the most important for FS transcription activation in the porcine.

关键词： promoter follistatin porcine firefly luciferase myeloid zinc finger 1