检索结果-南通市图书馆

Unraveling brain aging through the lens of oral microbiota

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si Wang Weiqi Zhang Jing Qu guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu Jing Wu guang Yin Fan‑Zhen Jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

Protein-based functional hydrogel improves cutaneous nerve repair and diabetic wound healing

在线全文

学校读者我要写书评

暂无评论

Nano Research 2025年第1期18卷 586-596页

作者： Hanzhi Lu Mingrui Cui Yi Wang Xinran Du Xinyi Zhou Yuhan Fang Xiaoyan Gao Ying Peng Jianyong Zhu guang Yang Fulun Li Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine College of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Cutaneous nerve regeneration in diabetic wounds remains a challenge for current clinical ***,a natural protein-based functional hydrogel is developed using keratin as the sole matrix,and protocatechuic aldehyde(PA)and zinc ions as the building blocks through dual-dynamic crosslinking reactions of thiol-aldehyde addition and catecholzinc ions *** unique structural design endows the hydrogel with excellent injectability,skin adhesion,self-healing and antibacterial ability,and *** addition,this hydrogel acts as a drug carrier for the loading and sustained release of phellopterin(PP),a natural compound extracted from traditional Chinese medicine Angelica *** findings demonstrate that the PP-loaded hydrogel promotes cutaneous nerve regeneration,angiogenesis and tissue remodeling in the full-thickness wounds in both db/db and streptozotocin-induced C57BL/6 diabetic mice,notably by the synergistic effect of zinc ions and PP,showing a great potential in diabetic wound therapy.

关键词： functional hydrogel cutaneous nerve regeneration dynamic crosslinking diabetic wounds

3D Surface velocity retrieval of mountain glacier using an offset tracking technique applied to ascending and descending SAR constellation data:a case study of the Yiga Glacier

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Digital Earth 2019年第6期12卷 614-624页

作者： Qun Wang Jinghui Fan Wei Zhou Liqiang Tong zhaocheng Guo guang Liu Weilin Yuan Joaquim Joao Sousa Zbigniew Perski School of Land Science and Technology China University of GeosciencesBeijingPeople’s Republic of China Division of Remote Sensing for Environment China Aero Geophysical Survey and Remote Sensing Center for Land and ResourcesBeijingPeople’s Republic of China Key Laboratory of Digital Earth Science Institute of Remote Sensing and Digital EarthChinese Academy of SciencesBeijingPeople’s Republic of China School of Sciences and Technology University of Trás-os-Montes e Alto DouroVila RealPortugal Centre for Robotics in Industry and Intelligent Systems INESC TECPortoPortugal Polish Geological Institute—National Research Institute CracowPoland

COSMO-SkyMed is a constellation of four X-band high-resolution radar satellites with a minimum revisit period of 12 *** satellites can obtain ascending and descending synthetic aperture radar(SAR)images with very similar periods for use in the three-dimensional(3D)inversion of glacier *** this paper,based on ascending and descending COSMO-SkyMed data acquired at nearly the same time,the surface velocity of the Yiga Glacier,located in the Jiali County,Tibet,China,is estimated in four directions using an offset tracking technique during the periods of 16 January to 3 February 2017 and 1 February to 19 February *** the geometrical relationships between the measurements and the SAR images,the least square method is used to retrieve the 3D components of the glacier surface velocity in the eastward,northward and upward *** results show that applying the offset tracking technique to COSMO-SkyMed images can be used to derive the true 3D velocity of a glacier’s *** the two periods,the Yiga Glacier had a stable velocity,and the maximum surface velocity,2.4 m/d,was observed in the middle portion of the glacier,which corresponds to the location of the steepest slope.

关键词： Mountain glacier inversion of 3D movement offset tracking SAR constellation data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

新质生产力、科技金融发展与投融资体制变革

新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 30-38,F0002页

作者：王曙光梁爽北京大学经济学院北京100871 北京大学产业与文化研究所北京100871

培育新质生产力需要形成与之相适应的新型生产关系,深化金融体制改革,形成与科技创新相适应的科技金融体系尤为关键。当前,中国科技金融发展面临诸多挑战,存在金融资源分配不均、耐心资本短缺、金融服务创新不足等问题。要充分发挥我国... 详细信息

培育新质生产力需要形成与之相适应的新型生产关系,深化金融体制改革,形成与科技创新相适应的科技金融体系尤为关键。当前,中国科技金融发展面临诸多挑战,存在金融资源分配不均、耐心资本短缺、金融服务创新不足等问题。要充分发挥我国社会主义制度优势,寻找政府引导、市场运作与科技型企业创新之间的最佳契合点,以壮大耐心资本为核心,服务初创期及中小规模科技型企业为重点,依托新型举国体制和社会主义市场经济体制,深化科技型企业的投融资体制变革。未来,要着力构建“股贷债保”联动、覆盖全生命周期、全链条、接力式的科技金融体系,为发展新质生产力提供坚实的金融支撑。

关键词：新质生产力科技金融投融资体制耐心资本新型举国体制

智慧医疗情境下四方主体隐私行为的交互机理及演化趋势研究

在线全文

学校读者我要写书评

暂无评论

现代情报 2025年第1期45卷 135-149页

作者：朱光吴晗逸刘雯南京信息工程大学风险治理与应急决策研究院江苏南京210044 南京信息工程大学管理工程学院江苏南京210044

[目的/意义]本文针对智慧医疗情境下隐私行为研究在博弈主体、模型参数等方面的不足,探寻患者、医疗机构、智慧医疗平台和政府四方主体之间的隐私行为交互机理与演化趋势。[方法/过程]基于演化博弈理论,构建患者、医疗机构、智慧医疗平... 详细信息

[目的/意义]本文针对智慧医疗情境下隐私行为研究在博弈主体、模型参数等方面的不足,探寻患者、医疗机构、智慧医疗平台和政府四方主体之间的隐私行为交互机理与演化趋势。[方法/过程]基于演化博弈理论,构建患者、医疗机构、智慧医疗平台和政府四方博弈模型。根据不同参数调节下各方行为策略的收益、成本、损失等计算收益矩阵,求解主体的演化稳定策略,并考虑不同因素对主体行为策略及系统稳定状态的影响。[结果/结论]患者的隐私披露行为与披露隐私后获得的服务收益密切相关,医疗机构的隐私保护投入成本和隐私泄露概率对其隐私保护行为有显著影响,智慧医疗平台的政府奖惩、罚款收益和投入成本是影响其严格管理行为的关键因素,政府的监管行为与奖惩机制等因素密切相关。通过应用本文模型和方法,可以动态调整隐私保护机制,明确各方职责,推动智慧医疗可持续健康发展。

关键词：智慧医疗演化博弈隐私行为患者医疗机构智慧医疗平台政府

Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang Zhi-Lai Zhan guang-Lu Chang Yan Gao Xia Li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

改进暗通道原理下视觉图像光晕消除算法

现代电子技术 2025年第1期48卷 60-64页

作者：任晓楠李广中北大学山西太原030051

在光晕区域附近进行光晕消除操作可能会降低图像的对比度、清晰度和细节。因此,需要开发有效的方法来恢复和增强光晕消除后的图像细节,以确保整体图像质量的提高,为此设计一种改进暗通道原理下视觉图像光晕消除算法。建立大气散射模型... 详细信息

在光晕区域附近进行光晕消除操作可能会降低图像的对比度、清晰度和细节。因此,需要开发有效的方法来恢复和增强光晕消除后的图像细节,以确保整体图像质量的提高,为此设计一种改进暗通道原理下视觉图像光晕消除算法。建立大气散射模型深度分析光晕产生条件,根据图像中的像素强度值计算成像环境中的透射率,按照大气光照的散射系数建立光照条件研究模型。在较高的像素颜色通道条件下,根据图像中高亮度和强反射部分搭建无光晕图像亮通道定义,聚类图像亮通道特征,利用快速双边滤波器细化透射率,建立光晕图像的成像模型。在改进暗通道原理的过程中通过调整多个计算参数,包括改变权重函数,设置光晕消除的恢复指令,完成对视觉图像的光晕消除处理。经过实验分析可以证明,所提方法具备良好的光晕消除性能,光晕消除效果较好。

关键词：改进暗通道视觉图像光晕消除透射率多尺度算法大气散射模型

维普期刊数据库博看期刊

3D打印技术辅助前交叉韧带重建治疗前交叉韧带断裂的研究

在线全文

学校读者我要写书评

暂无评论

中国疗养医学 2025年第1期34卷 109-112页

作者：王社光洛阳市孟津区中医院骨伤科河南洛阳471100

目的探讨关节镜下前交叉韧带(ACL)重建术治疗ACL断裂使用3D打印技术的辅助效果。方法选择2021年1月至2023年12月洛阳市孟津区中医院收治的102例ACL断裂患者,按照随机数字表分为3D打印组(n=51)和对照组(n=51)。对照组患者实施常规关节镜... 详细信息

目的探讨关节镜下前交叉韧带(ACL)重建术治疗ACL断裂使用3D打印技术的辅助效果。方法选择2021年1月至2023年12月洛阳市孟津区中医院收治的102例ACL断裂患者,按照随机数字表分为3D打印组(n=51)和对照组(n=51)。对照组患者实施常规关节镜下ACL重建术治疗,3D打印组行关节镜下3D打印技术辅助ACL重建术治疗。对比围术期指标、膝关节功能[国际膝关节主观功能评分(IKDC)、膝关节Lysholms评分]、膝关节活动范围、并发症。结果比较两组股骨骨隧道长度、住院时间,差异无统计学意义(P>0.05);相比于对照组,3D打印组手术时间短,差异有统计学意义(P<0.05);两组术后Lysholms评分、IKDC评分均高于术前,而3D打印组IKDC评分为(96.32±7.26)分、Lysholms评分为(94.25±3.85)分,高于对照组的(82.66±6.54)分、(88.20±8.25)分,差异有统计学意义(P<0.05);术后两组膝关节活动度均高于术前,而3D打印组膝关节活动度为(119.25±7.66)°,高于对照组的(98.66±8.22)°,差异有统计学意义(P<0.05);两组术后均无移植物断裂、移植物撞击、感染、深静脉血栓等并发症发生。结论关节镜下3D打印技术辅助ACL重建术治疗ACL断裂可缩短手术用时,改善患者膝关节活动度、膝关节功能,缩短住院时间,安全性较高。

关键词：前交叉韧带断裂关节镜前交叉韧带重建术 3D打印技术膝关节功能