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Dynamic analysis of beta oscillations in Parkinsonian neural networks with the pedunculopontine nucleus under optogenetic control

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Acta Mechanica Sinica 2024年第6期40卷 125-140页

作者： Yuzhi zhao Honghui Zhang Ying Yu Lin Du zichen Deng School of Mathematics and Statistics Northwestern Polytechnical UniversityXi’an710072China School of Aeronautic Science and Engineering Beihang UniversityBeijing100191China School of Aeronautics Northwestern Polytechnical UniversityXi’an710072China

Clinical experiments have proven that the pedunculopontine nucleus(PPN)plays a crucial role in the modulation of beta oscillations in Parkinson’s disease(PD).Here,we propose a new computational framework by introducing the PPN and related synaptic connections to the classic basal ganglia-thalamo-cortical ***,the improved model can not only simulate the basic saturated and beta activities mentioned in previous studies but also produce the normal alpha rhythm that is much closer to physiological ***,the results show that Parkinsonian oscillation activities can be controlled and modulated by the connection strength between the PPN and the globus pallidus internal nucleus(GPi)and the subthalamic nucleus(STN),supporting the fact that PPN is overinhibited in ***,the internal mechanism underlying these state transitions is further explained from the perspective of ***,both deep brain stimulation(DBS)and optogenetic technology are considered effective in terms of abnormal *** when a low-frequency DBS is added to the PPN,beta oscillations can be suppressed,but it is excited again as the DBS’s frequency gradually increases to a larger *** results coincide with the experimental results that low-frequency stimulation of the PPN is effective,and verify the rationality of the ***,we show that optogenetic stimulation of the globus pallidus external(GPe)expressing excitatory channelrhodopsin(ChR2)can effectively inhibit beta oscillations,whereas exciting the STN and PPN has a limited *** results are consistent with experimental reports suggesting that the symptoms of PD’s movement disorder can be alleviated under the GPe-ChR2,but not STN-ChR2,*** the functional role of the PPN and the feasibility of optogenetic stimulation remain to be clinically explored,the results obtained help us understand the mechanisms of beta oscillations in PD.

关键词： Pedunculopontine nucleus Beta oscillations Optogenetic Deep brain stimulation Parkinson’s disease

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Julolidinyl aza-BODIPYs as NIR-Ⅱ fluorophores for the bioimaging of nanocarriers

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3155-3168页

作者： Chang Liu Yifan Cai zichen Zhang Yi Lu Quangang Zhu Haisheng He Zhongjian Chen Weili zhao Wei Wu Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China Department of MediChinal Chemistry School of PharmacyFudan UniversityShanghai 201203China

The aggregation-caused quenching(ACQ)rationale has been employed to improve the fluorescence imaging accuracy of nanocarriers by precluding free probe-derived ***,its usefulness is undermined by limited penetration and low spatiotemporal resolution of NIR-Ⅰ(700-900 nm)bioimaging owing to absorption and diffraction by biological tissues and tissue-derived *** study aimed to develop ACQ-based NIR-Ⅱ(1000-1700 nm)probes to further improve the imaging resolution and *** strategy employed is to install highly planar and electron-rich julolidine into the 3,5-position of aza-BODIPY based on the larger substituent *** newly developed probes displayed remarkable photophysical properties,with intense absorption centered at approximately 850 nm and bright emission in the 950-1300 nm *** with the NIR-Ⅰ counterpart P2,the NIR-Ⅱ probes demonstrated superior water sensitivity and quenching ***1 and ACQ6 exhibited more promising ACQ effects with absolute fluorescence quenching at water fractions above 40% and higher quenching stability with less than 2.0% fluorescence reillumination in plasma after 24 h of *** calculations verified that molecular planarity is more important than hydrophobicity for ACQ ***,in vivo and ex vivo reillumination studies revealed less than 2.5% signal interference from prequenched ACQ1,in contrast to 15% for P2.

关键词： 3,5-Julolidinyl Aza-BODIPY Nanocarriers Near-infraredⅡ Fluorescence imaging Aggregation-caused quenching Polymeric micelles Polymeric nanoparticles

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Adenosine triphosphate mediates the pain tolerance effect of manual acupuncture at Zusanli(ST36) in mice

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Journal of Traditional Chinese Medicine 2024年第4期44卷 660-669页

作者： LI Zhongzheng zhao Yadan Ma Weigang Zhang Yonglong XU Zhifang XI Qiang LI Yanqi QIN Siru ZHANG zichen WANG Songtao zhao Xue LIU Yangyang GUO Yi GUO Yongming Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjin 301617China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 301617China Department of Acupuncture and Moxibustion Qingdao Hiser Hospital Affiliated of Qingdao University(Qingdao Traditional Chinese Medicine Hospital)Qingdao 266033China School of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China School of Acupuncture and Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin 301617China

OBJECTIVE:To investigate the mechanisms behind the effects of acupuncture in Traditional Chinese Medicine,we delved into the adenosine triphosphate/peripheral purinergic P2X receptor 3(ATP/P2X3)receptor signaling system as an indicator of the body's energy state,commonly referred to as"Qi".METHODS:The tail-flick test was utilized to explore the impact of acupuncture on pain tolerance threshold(PTT)in mice,while also assessing adenosine(ADO)levels and adenylate energy charge(EC)at Zusanli(ST36).The study further investigated the dose-dependent effects of acupuncture on PTT and ADO levels at Zusanli(ST36).To shed light on the underlying mechanisms of acupuncture's effects,the study examined the impact of ATP,a P2X3 receptor antagonist,and adenosine disodium on PTT following acupuncture ***:Acupuncture at Zusanli(ST36)led to significant improvements in PTT in mice,with the most effective interventions being twirling for 2 min and needle retention for 28 *** interventions also resulted in significant increases in ATP *** effects of acupuncture were further augmented by administration of different doses of ATP at Zusanli(ST36),and pretreatment with a P2X3 receptor antagonist decreased *** EC peaked at 30 min after intraperitoneal injection of ATP,and pretreatment with various doses of *** 30 min prior to acupuncture increased PTT in a dose-dependent ***,pretreatment with an *** intramuscular injection of adenosine disodium enhanced the effects of ***:This research provides compelling evidence that ATP is involved in the regulation of PTT through acupuncture,revealing new avenues for achieving enhanced clinical outcomes.

关键词： acupuncture point ST36(Zusanli) adenosine triphosphate receptors,purinergic P2X3 energy state

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纵隔子宫诊断标准新观点

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中华妇产科杂志 2022年第9期57卷 668-670页

作者：朱兰赵子辰中国医学科学院北京协和医学院北京协和医院妇产科国家妇产疾病临床医学研究中心北京100730

纵隔子宫是最常见的子宫畸形。近年来,国际上应用较多且公认的两种诊断标准[即美国生殖医学学会(ASRM)标准、欧洲人类生殖与胚胎学会(ESHRE)和欧洲妇科内镜学会(ESGE)]分别由美国和欧洲的相关学术组织于2016年制定和发布,但存在诊断不... 详细信息

纵隔子宫是最常见的子宫畸形。近年来,国际上应用较多且公认的两种诊断标准[即美国生殖医学学会(ASRM)标准、欧洲人类生殖与胚胎学会(ESHRE)和欧洲妇科内镜学会(ESGE)]分别由美国和欧洲的相关学术组织于2016年制定和发布,但存在诊断不足或过度诊断、甚至过度医疗的风险。2018年,欧洲研究者提出另一关于纵隔子宫的专家共识新分类标准(即CUME标准);2021年,ASRM再次更新纵隔子宫的诊断标准,即:纵隔长度>1 cm、夹角<90°且宫底外轮廓凹陷<1 cm。这些诊断标准已在临床应用,但亟需临床评估研究和临床实践的检验。

关键词：诊断标准纵隔子宫子宫畸形过度医疗临床评估临床实践人类生殖生殖医学

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Application of Modern Intelligent Optimization Method in Parameter Setting of PI Regulator of Accelerator Power Suppies Components

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IMP & HIRFL Annual Report 2022年第1期 299-300页

作者： Lu Yanhong Yang Feng Chen Youxin Wang Jing zhao zichen Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

In the accelerator control system,many components use PI regulators for feedback control of the closed-loop *** the process of parameter setting of PI regulators,empirical methods are often required and a lot of time is spent on parameter *** paper proposes a serial algorithm for generating multiple dimensional variables,which covld greatly improve the speed of parameter setting,reduce the time of manual parameter setting,and provide a fast and feasible method for parameter setting of equipment in accelerators that requires manual intervention solution.

关键词： generating feasible Components

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Identification of S-RNase genotype and analysis of its origin and evolutionary patterns in Malus plants

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Journal of Integrative Agriculture 2024年第4期23卷 1205-1221页

作者： zhao Liu Yuan Gao Kun Wang Jianrong Feng Simiao Sun Xiang Lu Lin Wang Wen Tian Guangyi Wang zichen Li Qingshan Li Lianwen Li Dajiang Wang Research Institute of Pomology Chinese Academy of Agricultural Sciences/Key Laboratory of Horticultural Crops Germplasm Resources UtilizationMinistry of Agriculture and Rural AffairsXingcheng 125100China College of Agriculture Shihezi University/Key Laboratory of Special Fruits and Vegetables Cultivation Physiology and Germplasm Resources Utilization of Xinjiang Production and Construction CorpsShihezi 832000China

Identification of the S genotype of Malus plants will greatly promote the discovery of new genes,the cultivation and production of apple,the breeding of new varieties,and the origin and evolution of self-incompatibility in Malus *** this experiment,88 Malus germplasm resources,such as Aihuahong,Xishuhaitang,and Reguanzi,were used as *** gene-specific primer combinations were used in the genotype *** amplification using leaf DNA produced a single S-RNase gene fragment in all *** results revealed that 70 of the identified materials obtained a complete S-RNase genotype,while only one S-RNase gene was found in 18 of *** homology comparison and analysis,13 S-RNase genotypes were obtained:S_(1)S_(2)(Aihuahong,etc.),S_(1)S_(28)(Xixian Haitang,etc.),S_(1)S_(51)(Hebei Pingdinghaitang),S_(1)S_(3)(Xiangyangcun Daguo,etc.),S_(2)S_(3)(Zhaiyehaitang,etc.),S_(3)S_(51)(Xishan 1),S_(3)S_(28)(Huangselihaerde,etc.),S_(2)S_(28)(Honghaitang,etc.),S_(4)S_(28)(Bo 11),S_(7)S_(28)(Jiuquan Shaguo),S_(10)S_e(Dongchengguan 13),S_(10)S_(21)(Dongxiangjiao)and S_(3)S_(51)(Xiongyue Haitang).Simultaneously,the frequency of the S gene in the tested materials was *** findings revealed that different S genes had varying frequencies in Malus resources,as well as varying frequencies between intraspecific and interspecific.S_(3) had the highest frequency of 68.18%,followed by S_(1)(42.04%).In addition,the phylogenetic tree and origin evolution analysis revealed that the S gene differentiation was completed prior to the formation of various apple species,that cultivated species also evolved new S genes,and that the S_(50) gene is the oldest S allele in Malus *** S_(1),S_(29),and S_(33) genes in apple-cultivated species,on the other hand,may have originated in ***,***,and ***,*** addition to ***,*** and *** may have also played a role in the origin and evolution of some Chine

关键词： Malus S-RNase genotype self-incompatibility origin and evolution

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当前部队政治工作中偏离战斗力标准的现象及成因

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南京政治学院学报 2009年第5期25卷 104-108页

作者：赵子忱南京政治学院上海分院上海200433

当前部队政治工作中不同程度地存在着政治工作偏离战斗力标准的现象。这不仅表现于政治工作中存在着平战脱节、军政分离的问题,而且表现为以投入资源或中间成果的多少、上级领导印象的好坏以及事故案件等评价政治工作的绩效。究其原因,... 详细信息

当前部队政治工作中不同程度地存在着政治工作偏离战斗力标准的现象。这不仅表现于政治工作中存在着平战脱节、军政分离的问题,而且表现为以投入资源或中间成果的多少、上级领导印象的好坏以及事故案件等评价政治工作的绩效。究其原因,这些现象的背后有着深层的社会背景和制度根源。

关键词：战斗力标准政治工作偏离成因

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信息化对思想政治教育方式的影响与对策

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军队政工理论研究 2005年第6期6卷 46-48页

作者：赵子忱南京政治学院上海分院上海200433

传统思想政治教育方式的核心特征是教育双方由于信息不对称导致的不平等地位。随着现代信息网络技术的发展,思想政治教育者的信息优势丧失,但同时又出现了信息超载和逆向选择的新问题。探索信息化条件下的思想政治教育方式创新,主要是... 详细信息

传统思想政治教育方式的核心特征是教育双方由于信息不对称导致的不平等地位。随着现代信息网络技术的发展,思想政治教育者的信息优势丧失,但同时又出现了信息超载和逆向选择的新问题。探索信息化条件下的思想政治教育方式创新,主要是建设资源共享的思想政治教育信息网络,构筑平等互动的思想政治教育信息平台,开展灵活多样的个性化思想政治教育,培养教育对象选择和控制信息的能力。

关键词：信息化思想政治教育方式影响对策

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现阶段军队政治工作的根本任务和主要矛盾

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军队政工理论研究 2008年第4期9卷 4-7页

作者：赵子忱南京政治学院上海分院上海200433

履行军队新的历史使命、完成多样化军事任务给政治工作提出诸多新课题。现阶段军队政治工作的根本任务是:为全面履行新世纪新阶段军队历史使命、完成以打赢信息化条件下局部战争为核心的多样化军事任务提供精神力量和组织保证。政治工... 详细信息

履行军队新的历史使命、完成多样化军事任务给政治工作提出诸多新课题。现阶段军队政治工作的根本任务是:为全面履行新世纪新阶段军队历史使命、完成以打赢信息化条件下局部战争为核心的多样化军事任务提供精神力量和组织保证。政治工作能力与这一根本任务不相适应的矛盾是军队政治工作的主要矛盾。为此,必须加强军队政治工作的能力建设。

关键词：军队政治工作根本任务信息化

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制度环境、行业契约密集度对出口国内增加值的影响

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南京社会科学 2021年第10期 35-44页

作者：杨继军赵梓辰南京财经大学国际经贸学院南京210023 中国建设银行杭州分行杭州310000

在传统比较优势逐渐式微的背景下,制度环境等新型比较优势对出口增加值的作用逐步显现,文章从制度环境与行业特征的协同效应入手,利用2002—2014年间40个经济体双边——行业层面数据进行了实证检验。研究发现,制度环境的提升有助于约束... 详细信息

在传统比较优势逐渐式微的背景下,制度环境等新型比较优势对出口增加值的作用逐步显现,文章从制度环境与行业特征的协同效应入手,利用2002—2014年间40个经济体双边——行业层面数据进行了实证检验。研究发现,制度环境的提升有助于约束交易双方的机会主义行为,降低贸易成本,对契约密集度较高行业的出口增加值具有显著的促进作用;异质性分析发现,制度环境对技术密集型行业、资本密集型行业和劳动密集型行业出口国内增加值率的正向作用依次减弱;在选择历史时期人口死亡率的倒数作为制度环境的工具变量控制内生性问题后,研究结论依然稳健。因此,应加强制度建设,积极构建良好的营商环境,提高契约执行效率,提升出口国内增加值。

关键词：制度环境行业契约密集度出口国内增加值

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