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Vitamin A regulates mitochondrial biogenesis and function through p38 MAPK‑PGC‑1α signaling pathway and alters the muscle fiber composition of sheep

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Journal of Animal Science and Biotechnology 2024年第2期15卷 898-910页

作者： Pengkang Song Jiamin zhao Fanqinyu Li Xiaoyi zhao Jinxin Feng Yuan Su Bo Wang Junxing zhao College of Animal Science Shanxi Agricultural UniversityTaiguShanxi 030801People’s Republic of China State Key Laboratory of Animal Nutrition and Feeding Department of Animal Nutrition and Feed ScienceCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193People’s Republic of China

Background Vitamin A(VA)and its metabolite,retinoic acid(RA),are of great interest for their wide range of physiological ***,the regulatory contribution of VA to mitochondrial and muscle fiber composition in sheep has not been *** Lambs were injected with 0(control)or 7,500 IU VA palmitate into the biceps femoris muscle on d 2 after *** the age of 3 and 32 weeks,longissimus dorsi(LD)muscle samples were obtained to explore the effect of VA on myofiber type *** vitro,we investigated the effects of RA on myofiber type composition and intrinsic *** The proportion of type I myofiber was greatly increased in VA-treated sheep in LD muscle at *** greatly promoted mitochondrial biogenesis and function in LD muscle of *** exploration revealed that VA elevated PGC-1αmRNA and protein contents,and enhanced the level of p38 MAPK phosphorylation in LD muscle of *** addition,the number of type I myofibers with RA treatment was significantly increased,and type IIx myofibers was significantly decreased in primary *** with in vivo experiment,RA significantly improved mitochondrial biogenesis and function in primary myoblasts of *** then used si-PGC-1αto inhibit PGC-1αexpression and found that si-PGC-1αsignificantly abrogated RA-induced the formation of type I myofibers,mitochondrial biogenesis,MitoTracker staining intensity,UQCRC1 and ATP5A1 expression,SDH activity,and enhanced the level of type IIx muscle *** data suggested that RA improved mitochondrial biogenesis and function by promoting PGC-1αexpression,and increased type I *** order to prove that the effect of RA on the level of PGC-1αis caused by p38 MAPK signaling,we inhibited the p38 MAPK signaling using a p38 MAPK inhibitor,which significantly reduced RA-induced PGC-1αand MyHC I *** VA promoted PGC-1αexpression through the p38 MAPK signaling pathway,improved mitochondrial biogenesis,and altered

关键词： Mitochondria Muscle fiber type PGC-1α p38 MAPK Retinoic acid Vitamin A

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Porous block copolymer films with self-adjustable optical transmittance and passive radiative cooling

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Nano Research 2024年第9期17卷 8472-8478页

作者： Xue Meng Weiming Tang Shuyun Zhuo Jince zhao Zixuan Ren Zhonghe Sun Hao Yan Tianyi zhao Ziguang zhao Mingjie Liu School of Future Technology University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of EducationSchool of ChemistryBeihang UniversityBeijing 100191China

As an energy-free cooling technique,radiative cooling has garnered significant attention in the field of energy ***,traditional radiative cooling films often possess static optical properties and their inherent opacity limits their applications in building such as ***,there exists a requirement for passive radiative cooling films endowed with adjustable *** we report the porous block copolymer films with self-adjustable optical transmittance and passive radiative *** a result,the film exhibited a high solar reflectance(0.3-2.5μm)of 96.9%and a high infrared emittance(8-13μm)of 97.9%.Outdoor experiments demonstrated that the film surface temperature was 6.6℃lower than ambient temperature,with a cooling power of 104.8 W·m^(-2).In addition,the film’s transmittance can be regulated by altering the polarity of the post-processing solvent,providing an effective approach for regulating indoor light intensity and thermal balance,thereby enhancing the applicability of radiative cooling.

关键词： passive radiative cooling block copolymer porous structure self-adjustable optical transmittance

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A Multi-Stage Differential-Multifactorial Evolutionary Algorithm for Ingredient Optimization in the Copper Industry

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IEEE/CAA Journal of Automatica Sinica 2024年第10期11卷 2135-2153页

作者： Xuerui Zhang Zhongyang Han Jun zhao School of Control Science and Engineering Dalian University of TechnologyDalian 116024China IEEE

Ingredient optimization plays a pivotal role in the copper industry,for which it is closely related to the concentrate utilization rate,stability of furnace conditions,and the quality of copper *** acquire a practical ingredient plan,which should exhibit long duration time with sufficient utilization and feeding stability for real applications,an ingredient plan optimization model is proposed in this study to effectively guarantee continuous production and stable furnace *** address the complex challenges posed by this integer programming model,including multiple coupling feeding stages,intricate constraints,and significant non-linearity,a multi-stage differential-multifactorial evolution algorithm is *** the proposed algorithm,the differential evolutionary(DE)algorithm is improved in three aspects to efficiently tackle challenges when optimizing the proposed ***,unlike traditional time-consuming serial approaches,the multifactorial evolutionary algorithm is utilized to optimize multiple complex models contained in the population of evolutionary algorithm caused by the feeding stability in a parallel ***,a repair algorithm is employed to adjust infeasible ingredient lists in a timely *** addition,a local search strategy taking feedback from the current optima and considering the different positions of global optimum is developed to avoiding premature convergence of the differential evolutionary ***,the simulation experiments considering different planning horizons using real data from the copper industry in China are conducted,which demonstrates the superiority of the proposed method on feeding duration and stability compared with other commonly deployed *** is practically helpful for reducing material cost as well as increasing production profit for the copper industry.

关键词： Copper industry differential-multifactorial evolution ingredient optimization multi-stage optimization

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Digital Twin Technology of Human-Machine Integration in Cross-Belt Sorting System

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 195-212页

作者： Yanbo Qu Ning zhao Haojue Zhang School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China Institute of Microelectronics of the Chinese Academy of Sciences Beijing 100029China Wayzim Technology Co. LtdWuxi 214108China Business School Beijing Technology and Business UniversityBeijing 100048China

The Chinese express delivery industry processes nearly 110 billion items in 2022,averaging an annual growth rate of 200%.Among the various types of sorting systems used for handling express items,cross-belt sorting systems stand out as the most ***,despite their high degree of automation,the workload for operators has intensified owing to the surging volume of express *** the era of Industry 5.0,it is imperative to adopt new technologies that not only enhance worker welfare but also improve the efficiency of cross-belt *** a balance between efficiency in handling express items and operator well-being is *** twin technology offers a promising solution in this respect.A realization method of a human-machine integrated digital twin is proposed in this study,enabling the interaction of biological human bodies,virtual human bodies,virtual equipment,and logistics equipment in a closed loop,thus setting an operating *** technologies in the proposed framework include a collection of heterogeneous data from multiple sources,construction of the relationship between operator fatigue and operation efficiency based on physiological measurements,virtual model construction,and an online optimization module based on real-time *** feasibility of the proposed method was verified in an express distribution center.

关键词： Industry 5.0 Cross-belt sorting system Human-machine integrated Digital twin Online optimization

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A risk assessment method considering risk attributes and work safety informational needs and its application

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Chinese Journal of Chemical Engineering 2024年第4期68卷 253-262页

作者： Cong Luo Yunsheng zhao Ke Xu School of Political Science and Public Administration Shandong UniversityQingdao 266200China Faculty of Engineering China University of GeosciencesWuhan 430074China Department of Emergency Management of Hubei Province Wuhan 430064China

The technological revolution has spawned a new generation of industrial systems,but it has also put forward higher requirements for safety management accuracy,timeliness,and *** assessment needs to evolve to address the existing and future challenges by considering the new demands and advancements in safety *** study aims to propose a systematic and comprehensive risk assessment method to meet the needs of process system safety *** methodology first incorporates possibility,severity,and dynamicity(PSD)to structure the“51X”evaluation indicator system,including the inherent,management,and disturbance risk ***,the four-tier(risk point-unit-enterprise-region)risk assessment(RA)mathematical model has been established to consider supervision *** in conclusion,the application of the PSD-RA method in ammonia refrigeration workshop cases and safety risk monitoring systems is presented to illustrate the feasibility and effectiveness of the proposed PSD-RA method in safety *** findings show that the PSD-RA method can be well integrated with the needs of safety work informatization,which is also helpful for implementing the enterprise's safety work responsibility and the government's safety supervision responsibility.

关键词： Risk assessment Safey “51X”evaluation indicator system Four-tier risk assessment model Risk attributes Process system

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Understanding Human and Machine Interaction from Decision Perspective: An Empirical Study Based on the Game of Go

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Journal of Systems Science & Complexity 2024年第2期37卷 647-667页

作者： zhao Ping LI Xuerong WANG Shouyang Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100190China

The authors aim to interpret human and AI interactions from the decision *** authors decompose the interaction analysis into the following main components in the context of interactions:Individual behavior patterns,interaction relationships,and comprehensive *** authors interpret intertemporal decisions from a physical perspective and employ cross-discipline concepts and methodologies to extract the behavior characteristics of players in the empirical case *** the individual behavior patterns,the authors find that human players prefer short-term periods to AI in *** interaction relationship analysis reveals a dynamic relationship between possible short-term co-movement and nearly counter-movement in the long *** authors apply principal component analysis to descriptive indicators and discover a regular decision *** main behavior pattern of players in the game of Go is switching between careful and daring *** differences in the decision hierarchies imply a discrepancy of patience between humans and AI.

关键词： Coherence analysis decision hierarchy machine behaviour multitaper spectral analysis

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The Strategic Analysis of Demand Forecast-Sharing in a Hybrid-Format Online Platform Supply Chain

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Journal of Systems Science and Systems Engineering 2024年第3期33卷 281-310页

作者： Jing zhao Zijun Yin Guobiao Zhou School of Mathematical Sciences Tiangong UniversityTianjin300387China

This paper examines the optimal forecast-sharing strategy in a hybrid-format online platform supply chain where a supplier sells a product through agency format and reselling format provided by a platform retailer who possesses demand forecasts from two *** asymmetry and co-opetitive relationship arise between the platform retailer and the supplier,which affect their operational decisions and the supply chain’s *** improve supply chain efficiency,we compare different forecast-sharing strategies(i.e.,no forecast sharing,sharing a single forecast,and sharing two forecasts),and analyze the effects of co-opetitive parameters on the optimal forecast-sharing *** analysis shows that forecast sharing is always beneficial to the supplier,and sharing two forecasts is more beneficial than sharing a single *** for the platform retailer and the whole supply chain,forecast sharing is beneficial only under certain conditions,depending on the co-opetitive *** optimal forecast-sharing strategy is the result of a combination of the negative effect of double marginalization in reselling channel and the positive effect of responding pricing to demand uncertainty in agency *** illustrate the parameter regions of the platform retailer’s voluntary sharing,contract sharing,and no sharing,and also find that higher channel competition intensity,higher market share of agency channel,and higher commission rate can promote the platform retailer’s voluntary *** study extends the research scope of demand forecast-sharing and sheds light on the decision-making processes for managing a hybrid-format online platform supply chain.

关键词： Supply chain management hybrid-format online platform demand forecast-sharing co-opetitive relationship channel competition intensity

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Challenges and Opportunities in Preserving Key Structural Features of 3D-Printed Metal/Covalent Organic Framework

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Nano-Micro Letters 2024年第8期16卷 362-381页

作者： Ximeng Liu Dan zhao John Wang Department of Materials Science and Engineering National University of SingaporeSingapore 117574Singapore Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore National University of Singapore(Chongqing)Research Institute Chongqing 401123People’s Republic of China

Metal-organic framework(MOF)and covalent organic framework(COF)are a huge group of advanced porous materials exhibiting attractive and tunable microstructural features,such as large surface area,tunable pore size,and functional surfaces,which have significant values in various application *** emerging 3D printing technology further provides MOF and COFs(M/COFs)with higher designability of their macrostructure and demonstrates large achievements in their performance by shaping them into advanced 3D ***,the currently available 3D printing M/COFs strategy faces a major challenge of severe destruction of M/COFs’microstructural features,both during and after 3D *** is envisioned that preserving the microstructure of M/COFs in the 3D-printed monolith will bring a great improvement to the related *** this overview,the 3D-printed M/COFs are categorized into M/COF-mixed monoliths and M/COF-covered *** differences in the properties,applications,and current research states are *** up-to-date advancements in paste/scaffold composition and printing/covering methods to preserve the superior M/COF microstructure during 3D printing are further discussed for the two types of 3D-printed M/*** the analysis of the current states of 3D-printed M/COFs,the expected future research direction to achieve a highly preserved microstructure in the 3D monolith is proposed.

关键词： Metal-organic frameworks Covalent organic frameworks 3D printing Microstructure Monolith

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Modified constitutive models for Inconel 718 considering current density and temperature in electrically assisted forming process

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Chinese Journal of Aeronautics 2024年第2期37卷 524-540页

作者： Xuan CUI Rui zhao Min WAN School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Jiangxi Research Institute of Beihang University Jiangxi 330000China

Electrically Assisted Forming(EAF)technology has obvious advantages in material *** develop an effective constitutive model considering electrical effects,room temperature and electrically assisted quasi-static uniaxial tensile tests were conducted using ultrathin nickelbased superalloy plates with a thickness of 0.25 *** research focused on the two most widely recognized effects:the Joule thermal and the electric athermal *** mechanism of current action can be divided into two scenarios:one considering the Joule thermal effect only,and the other considering both effects *** basic constitutive models,namely the Modified-Hollomon model and the Johnson-Cook(J-C)model,were selected to be optimized through the classification of two different situations,and four optimized constitutive models were *** was found that the J-C model with simultaneous consideration of the Joule thermal effect and electric athermal effect had the best prediction effect by comparing the results of these four ***,the accuracy of the optimization model was verified by finite element simulation of the electrically assisted stretching optimization *** results show that the constitutive model can effectively predict the temperature effect caused by the Joule heat effect and the athermal effect of current on the material.

关键词： Joule heating Elastoplasticity Plastic deformation Superalloys Constitutive models

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Recent advances in small-scale hydrogel-based robots for adaptive biomedical applications

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Nano Research 2024年第2期17卷 649-662页

作者： Mingzhe Nie Qilong zhao Xuemin Du Institute of Biomedical&Health Engineering Shenzhen Institute of Advanced Technology(SIAT)Chinese Academy of Sciences(CAS)Shenzhen 518055China

Small-scale robots,ranging in size from micrometers to centimeters,have gained significant attention in the biomedical ***,conventional small-scale robots made of rigid materials encounter challenges in adapting themselves to the soft tissues and complicated environments of human *** to the rigid counterpart,small-scale hydrogel-based robots hold great promises due to their tissue-like low modulus,outstanding biocompatibility and accessible stimuli-responsive *** attributes offer small-scale hydrogel-based robots with multimodal locomotion and reinforced functions,further enhancing the adaptability in manipulation and tasks execution for various biomedical *** this review,we present recent advances in small-scale hydrogel-based *** first summarize the design principles of small-scale hydrogel-based robots including materials,fabrication techniques and manipulation strategies,then highlighting their upgraded functions and adaptive biomedical ***,we discuss existing challenges and future perspectives for small-scale hydrogel-based robots.

关键词： small-scale robot hydrogel locomotion multi-function adaptability

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