检索结果-南通市图书馆

Advantages and limitations of the parthenogenetic embryonic stem cells in cell therapy

在线全文

学校读者我要写书评

暂无评论

Journal of Reproduction and Contraception 2016年第2期27卷 118-124页

作者： zhao-yang yu Bao-sheng HAN North China University of Science and Technology Department of Reproduction and Genetics Maternity and Child Health Care HospitalTangshan

Parthenogenetic embryonic stem cells（pE SCs）, as ＂seed cells＂ for regenerative medicine, are an effective way to build patient-specific pluripotent stem cells, due to the fact that characteristics of self-renewal and pluripotent are similar to embryonic stem cells（ESCs）. Parthenogenetic activation can be performed at meiosis I or meiosis II describing the embryos with distinct patterns of homozygosity and *** pE SCs are expected to be used for autologous transplantation, while homozygous pE SCs enable to be used for allogeneic gene therapy in theory but is hampered by immunological barriers defined by the recognition of natural killer（NK）cells. In this review, we describe the mechanism of deriving heterozygous and homozygous pE SCs, and summarize the advantages and limitations of pE SCs in the area of cell therapy.

关键词： parthenogenetic embryonic stem cells(pESCs) heterozygous homozygous advantages and limitations cell therapy

Synthesis and Photovoltaic Properties of Non-fullerene Solution Processable Small Molecule Acceptors

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2013年第3期29卷 596-599页

作者： LI Hui LIU zhao-yang ZHANG Xiao-yu YAO Shi-yu WEN Shan-peng TIAN Wen-jing State Key Laboratory of Supramolecular Structure and Materials Jilin University Changchun 130012 P. R. China

Two non-fullerene small molecules, BT-C6 and BT-C12, based on the vinylene-linked benzothiadiazole-thiophene（BT） moiety flanked with 2-（3,5,5-trimethylcyclohex-2-en-l-ylidene）malononitrile have been synthesized and characterized by solution/thin film UV-Vis absorption, photoluminescence（PL）, and cyclic voltammetry（CV） measurements. The two molecules show intense absorption bands in a wide range from 300 nm to 700 nm and low optical band- gaps for BT-C6（1.60 eV） and for BT-C12（1.67 eV）. The lowest unoccupied molecular orbital（LUMO） levels of both the molecules are relatively higher than that of [6,6]-phenyl C61 butyric acid methyl ester（PCBM）, promising high open circuit voltage（Voc） for photovoltaic application. Bulk heterojunction（BHJ） solar cells with poly（3-hexylthiophene）（P3HT） as the electron donor and the two molecules as the acceptors were fabricated. Under 100 mW/cm2 AM 1.5 G illumination, the devices based on P3HT：BT-C6（1：1, mass ratio） show a power conversion efficiency（PCE） of 0.67%, a short-circuit current（Jsc） of 1.63 mA/cm2, an open circuit voltage（Vow） of 0.74 V, and a fill factor（FF） of 0.56.

关键词： Non-fullerene small molecule Electron acceptor Bulk heterojunction

Posterior Selective Thoracic Fusion in Adolescent Idiopathic Scoliosis Patients:a Comparison of All Pedicle Screws versus Hybrid Instrumentation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Sciences Journal 2009年第1期24卷 30-35页

作者： Bin yu Jian-guo Zhang Gui-xing Qiu Yi-peng Wang yu zhao Jian-xiong Shen Hong zhao Xin-yu yang Department of Orthopedic Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences ＆ Peking Union Medical CollegeBeijing 100730 China

Objective To analyze the influence of segmental pedicle screws versus hybrid instrumentation on the correction results in adolescent idiopathic scoliosis patients undergoing posterior selective thoracic fusion. Methods By reviewing the medical records and roentgenograms of adolescent idiopathic scoliosis patients who underwent selective thoracic fusion from February 2000 to January 2007 in our hospital, the patients were divided into 2 groups according to different instrumentation fashions： Group A was hook-screw-rod （hybrid） internal fixation type, Group B was screw-rod （all pedicle screws） internal fixation type, and the screws were used in every segment on the concave side of the thoracic curve. The parameters of the scoliosis were measured and the correction results were analyzed. Results Totally, 48 patients （7 males, 41 females） were included, with an average age of 14.4 years old and a mean follow-up time of 12.3 months. Thirty and 18 patients were assigned to group A and group B, respectively. The mean preoperative coronal Cobb angles of the thoracic curve were 48.8° and 47.4°, respectively. After surgery, they were corrected to 13.7° and 6.8°, respectively. At final follow-up, they were 17.0° and 9.5°, with an average correction rate of 64.6% and 79.0%, respectively, and the correction rate of group B was significantly higher than that of group A （P=0.003）. The mean preoperative coronal Cobb angles of the lumbar curve were 32.6° and 35.2°, respectively. After surgery, they were corrected to 8.6° and 8.3°, respectively. At final follow-up, they were 10.3° and 11.1°, with an average correction rate of 66.8% and 69.9%, respectively, and the correction rate of group B was significantly higher than that of group A （P=0.003）. The correction loss of the thoracic curve and lumbar curve in the 2 groups were 3.1° and 1.8°, 2.4° and 2.4°, respectively. No significant difference was noted （both P〉0.05）. The decompensation rate at final follow-up in these 2 groups wer

关键词： adolescent idiopathic scoliosis selective thoracic fusion internal fixator pedicle screw decompensation

Obstetric outcome of women with uterine anomalies in China

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2010年第4期123卷 418-422页

作者： ZHANG Yan zhao yang-yu QIAO Jie Department of Obstetrics and Gynaecology Peking University Third Hospital Beijing 100083 China

Background Congenital uterine anomalies are associated with the highest incidence of reproductive failure and obstetric complications. This study aimed to summarize the clinical characteristics and prenatal outcome of pregnancy in women with congenital uterine malformations. Methods This retrospective study evaluated the fertility and obstetric outcome of 116 inpatients with uterine malformations with pregnancy in Peking University Third Hospital from June 1998 to June 2009. A total of 270 randomly selected pregnant women with a previously confirmed normally shaped uterus as a control group. Student＇s t test and analysis of variance （ANOVA） were used to compare means for normally distributed variables. The analysis was carried out using the SPSS. Results Among 21 961 deliveries in Peking University Third Hospital, 116 （0.45%） were in women with uterine anomalies. A septate uterus was present in 43 （37.1%） and the uterus didelphys in 28 （24.2%） of the 116 women identified. Bicornuate uterus, arcuate and unicomate uterus were observed in 12 （10.3%）, 18 （15.5%） and 15 （12.9%） patients, respectively. Patients with uterine anomalies had significantly higher rates of malpresentation （38.8%）, preterm delivery （19.8%）, and cesarean section （78.5%） compared with the group of women with a normal uterus. Patients with uterine anomalies had significantly lower mean birth-weight neonates and a significantly higher incidence of small for gestationalage （SGA） neonates; women with uterus didelphys more frequently required infertility treatment than patients with other uterine anomalies （P 〈0.001）. The rate of malpresentation was significantly higher in patients with septated uterus in comparison with patients with uterus unicorns （P 〈0.05）. Conclusions Women with congenital uterinemal formation usually have higher incidence of complications during pregnancy and delivery. A septate uterus appears to be associated with poorer obstetric outcomes.

关键词： abnotmatities uterus pregnancy

Correlation of An Ultrasonic Scoring System and Intraoperative Blood Loss in Placenta Accreta Spectrum Disorders: A Retrospective Cohort Study

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2021年第2期34卷 163-169页

作者： CHEN Lian SHI Hui Feng JIANG Hai SHI Xiao Ming WANG yuan yuan ZHANG Ai Qing CHONG Yi Wen zhao yang yu Department of Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China

Objective This study aims to investigate the correlation of an ultrasonic scoring system with intraoperative blood loss(IBL) in placenta accreta spectrum(PAS) *** A retrospective cohort study was conducted between January 2015 and November *** data for patients with PAS have been obtained from medical records. Generalized additive models were used to explore the nonlinear relationships between ultrasonic scores and IBL. Logistic regressions were used to determine the differences in the risk of IBL ≥ 1,500 m L among groups with different ultrasonic *** A total of 332 patients participated in the analysis. Generalized additive models showed a significant positive correlation between score and blood loss. The amount of IBL was increased due to the rise in the ultrasonic score. All cases were divided into three groups according to the scores(low score group: ≤ 6 points, n = 147;median score group: 7-9 points, n = 126;and high score group: ≥ 10 points, n = 59). Compared with the low score group, the high score group showed a higher risk of IBL≥ 1,500 m L [odds ratio, 15.09;95% confidence interval(3.85, 59.19);P ≤ 0.001] after a multivariable *** The risk of blood loss equal to or greater than 1,500 m L increases further when ultrasonic score greater than or equal to 10 points, the preparation for transfusion and referral mechanism should be considered.

关键词： Ultrasonic scoring system Intraoperative blood loss Placenta accreta spectrum disorders

High-temperature-tolerant flexible supercapacitors: Gel polymer electrolytes and electrode materials

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 426-457页

作者： Chong Peng Xinyi Huang Mingwei zhao Shuling Liao Quanhong yang Nianjun yang Siyu yu School of Chemistry & Chemical Engineering Southwest University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy Storage School of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Department of Chemistry & IMO-IMOMEC Hasselt University

The development of flexible supercapacitors(FSCs) capable of operating at high temperatures is crucial for expanding the application areas and operating conditions of supercapacitors. Gel polymer electrolytes and electrode materials stand as two key components that significantly impact the efficacy of hightemperature-tolerant FSCs(HT-FSCs). They should not only exhibit high electrochemical performance and excellent flexibility, but also withstand intense thermal stress. Considerable efforts have been devoted to enhancing their thermal stability while maintaining high electrochemical and mechanical performance. In this review, the fundamentals of HT-FSCs are outlined. A comprehensive overview of state-of-the-art progress and achievements in HT-FSCs, with a focus on thermally stable gel polymer electrolytes and electrode materials is provided. Finally, challenges and future perspectives regarding HT-FSCs are discussed, alongside strategies for elevating operational temperatures and *** review offers both theoretical foundations and practical guidelines for designing and manufacturing HT-FSCs, further promoting their widespread adoption across diverse fields.

关键词： Flexible supercapacitors High-temperature tolerance Gel polymer electrolytes Electrode materials

Inhibitory Effects of Mistletoe Alkali on Salivary Adenoid Cystic Carcinoma Cells

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2013年第2期29卷 275-279页

作者： LI Mei-hua WANG Yi-shu ZHOU Hong-lan LI Ya-juan QIU xin-ru WANG Xue-yao zhao yu-yang The Second Hospital of Jilin University Changchun 130041 P. R. China Key Laboratory of Pathobiology Ministry of Education School of Basic Medical Sciences The First Hospital 4. College of Pharmacy Jilin University Changchun 130021 P. R. China College of Pharmacy Jilin University Changchun 130021 P. R. China

Mistletoe alkali plays an important role in salivary adenoid cystic carcinoma（SACC） cell proliferation, apoptosis and invasion. Mistletoe alkali shows potent anticaner property. In this paper, immunocytochemical and immunofluorescence staining were employed to evaluate the expression levels of proliferating cell nuclear anti- gen（PCNA）, Caspase 3, Caspase 8 and Caspase 9. Apoptosis was detected by acridine orange/ethidium bromide （AO/EB） staining, cell invasion ability was assessed by Boyden Chamber assay. Pretreatment with mistletoe alkali markedly decreased PCNA expression in SACC cells in a dose-dependent manner（P〈0.001） and also led to increase the expression of Caspase 3, Caspase 8 and Caspase 9 in SACC cells compared with control group（P〈0.001）. Number of apoptotic cells increased dramatically in mistletoe alkali group（P〈0.001）. In Boyden Chamber assay, mistletoe al- kali treatment could inhibit SACC ceils to penetrate the artificial basement membrane compared with control group（P〈0.01）. Mistletoe alkali remarkably inhibited the proliferation and invasion of SACC cells and induced the apoptosis of SACC cells. These results provide an insight into the mechanisms of anticancer effects of mistletoe alka- li, and highlight the potential clinical application of it.

关键词： Mistletoe alkali Adenoid cystic carcinoma cell Proliferation Apoptosis

Gut microbiota dysbiosis in preeclampsia patients in the second and third trimesters

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2020年第9期133卷 1057-1065页

作者： Jing Wang Zhong-Hua Shi Jing yang yuan Wei Xiao-Ye Wang yang-yu zhao Department of Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China Department of Obstetrics and Gynecology Women’s Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210011China

Background:Preeclampsia(PE)is a serious complication that affects maternal and perinatal ***,the mechanisms have not been fully *** study was designed to analyze longitudinal gut microbiota alterations in pregnant women with and without PE in the second(T2)and third trimesters(T3).Methods:In this nested case-control study,which was conducted at Nanjing Maternity and Child Health Care Hospital,fecal samples from 25 PE patients(25 fecal samples obtained in T2 and 15 fecal samples obtained in T3)and 25 matched healthy controls(25 fecal samples obtained in T2 and 22 fecal samples obtained in T3)were collected,and the microbiota were analyzed using 16S rRNA gene *** diversity and composition of the microbiota of PE cases and controls were ***:No significant differences in diversity were found between the PE and control groups(P>0.05).In the control group,from T2 to T3,the relative abundances of Proteobacteria(median[Q1,Q3]:2.25%[1.24%,3.30%]vs.0.64%[0.20%,1.20%],Z=-3.880,P<0.05),and Tenericutes(median[Q1,Q3]:0.12%[0.03%,3.10%]vs.0.03%[0.02%,0.17%],Z=-2.369,P<0.05)decreased *** the PE group,the relative abundance of Bacteroidetes in T2 was lower than in T3(median[Q1,Q3]:18.16%[12.99%,30.46%]vs.31.09%[19.89%,46.06%],Z=-2.417,P<0.05).In T2,the relative abundances of mircrobiota showed no significant differences between the PE group and the control ***,in T3,the relative abundance of Firmicutes was significantly lower in the PE group than in the control group(mean±standard deviation:60.62%±15.17%vs.75.57%±11.53%,t=-3.405,P<0.05).The relative abundances of Bacteroidetes,Proteobacteria,and Enterobacteriaceae were significantly higher in the PE group than in the control group(median[Q1,Q3]:31.09%[19.89%,46.06%]vs.18.24%[12.90%,32.04%],Z=-2.537,P<0.05;1.52%[1.05%,2.61%]vs.0.64%[0.20%,1.20%],Z=-3.310,P<0.05;0.75%[0.20%,1.00%]vs.0.01%[0.004%,0.023%],Z=-4.152,P<0.05).Linear discriminant analysis combined effect

关键词： Gut microbiota Preeclampsia Inflammation Second trimester Third trimester

A case of pregnancy complicated by non-Hodgkin＇s lymphoma and idiopathic thrombocytopenic purpura

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第5期126卷 948-956页

作者： Wang Jia-lue zhao yang-yu Jiang yuan-hui Peking Univ Hosp 3 Dept Obstet & Gynaecol Beijing 100191 Peoples R China

To the editor： Pregnancy complicated by non-Hodgkin＇s lymphoma （NHL） has rarely been reported. It has been estimated that about 0.76% （0-1.8%） of NHL cases are accompanied by idiopathic thrombocytopenic purpura （ITP）. There are few reports in the medical literature of pregnancy complicated by both NHL and ITP. Here we reported a case.

关键词：