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HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies

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Genes & Diseases 2024年第1期11卷 234-251页

作者： yan zhao Cheng Xing Yating Deng Can Ye Hongling Peng Department of Hematology The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Hunan Key Laboratory of Tumor Models and Individualized Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Hunan Engineering Research Center of Cell Immunotherapy for Hematopoietic Malignancies The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China

The hypoxic microenvironment is an essential characteristic of most malignant ***,hypoxia-inducible factor-1 alpha(HIF-1a)is a key regulatory factor of cellular adaptation to hypoxia,and many critical pathways are correlated with the biological activity of organisms via *** the intra-tumoral hypoxic environment,HIF-1αis highly expressed and contributes to the malignant progression of tumors,which in turn results in a poor prog-nosis in ***,it has been indicated that HiF-1αinvolves in various critical pro-cesses of life events and tumor development via regulating the expression of HiF-1a target genes,such as cell proliferation and apoptosis,angiogenesis,glucose metabolism,immune response,therapeutic resistance,*** from solid tumors,accumulating evidence has re-vealed that HiF-1αis also closely associated with the development and progression of hemato-logical malignancies,such as leukemia,lymphoma,and multiple *** inhibition of HiF-1a can facilitate an increased sensitivity of patients with malignancies to relevant ther-apeutic *** the review,we elaborated on the basic structure and biological functions of HIF-1a and summarized their current role in various *** is expected that they will have future potential fortargeted therapy.

关键词： Angiogenesis Hematological malignancies Hypoxia-inducible factor-1 alpha(HIF-1α) Immune escape Targeted therapy

Flexible and Stretchable Electrodes for In Vivo Electrophysiological and Electrochemical Monitoring

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Chinese Journal of Chemistry 2024年第13期42卷 1523-1545页

作者： Kai-Kai sheng Yi-Fei Lu Wen-Ting Fan yan-Ling Liu College of Chemistry and Molecular Sciences Wuhan University WuhanHubei 430072China Core Facilty of Wuhan University WuhanHubei 430072China

In vivo monitoring of bioelectrical and biochemical signals with implanted electrodes has received great interest over the past ***,this faces huge challenges because of the severe mechanical mismatch between conventional rigid electrodes and soft biological *** recent years,the emergence of flexible and stretchable electrodes offers seamless and conformable biological-electronic interfaces and has demonstrated significant advantages for in vivo electrochemical and electrophysiological *** review first summarizes the strategies for electrode fabrication from the point of substrate and conductive ***,recent progress in electrode functionalization for improved performance is ***,the advances of flexible and stretchable electrodes in exploring bioelectrical and biochemical signals are ***,we present some challenges and perspectives ranging from electrode fabrication to application.

关键词： Flexible electrodes Conductive materials Stretchable structures Electrode functionalization In vivo monitoring Biochemical signals Bioelectrical signals

Electrochromism-induced adaptive fresh air pre-handling system for building energy saving

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Energy and Built Environment 2024年第2期5卷 300-308页

作者： Dikai Xu Mingfeng sheng Xinpeng zhao Hua Qian Wenqing Liang Xiaohong Zheng Dongliang zhao School of Energy and Environment Southeast UniversityNanjingJiangsu 210096China Lyles School of Civil Engineering Purdue UniversityWest LafayetteIN 47907USA Department of Mechanical Engineering University of Colorado BoulderBoulderCO 80309USA

Building fresh air supply needs to meet certain regulations and fit people’s ever-growing indoor air quality ***,fresh air handling requires huge energy consumption that goes against the goal of net-zero energy ***,in this work,an adaptive fresh air pre-handling system is designed to reduce the cool-ing and heating loads of HVAC *** sky-facing surface of the system uses electrochromic mechanism to manipulate the optical properties and thus make full use of solar energy(solar heating)and deep space cold source(radiative cooling)by switching between heating and cooling *** the cooling mode,the sky-facing surface shows a transmittance of down to zero,while the reflectance is high at 0.89 on *** the heating mode,the electrochromic glass is highly transparent,allowing the sunlight to reach the solar heat *** obtain the energy-saving potential under different climates,six cities were selected from various climate regions in *** show that the adaptive fresh air pre-handling system can be effective in up to 55.4%time of a *** maximum energy-saving ratios for medium office,warehouse,and single-family house can reach up to 11.52%,26.62%,and 18.29%,*** addition,the system shows multi-climate adaptability and broad application scenarios,making it a potential solution to building energy saving.

关键词： Adaptive fresh air pre-handling Electrochromism Radiative sky cooling Solar air heating Building energy saving

Hexagonal boron nitride based slippery liquid infused porous surface with anti-corrosion, anti-contaminant and anti-icing properties for protecting magnesium alloy

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Chinese Chemical Letters 2024年第4期35卷 532-538页

作者： Wenhao yan Shuaiya Xue Xuerui zhao Wei Zhang Jian Li Key Laboratory of Eco-Functional Polymer Materials of the Ministry of Education College of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China

In an era where the concept of green development is deeply rooted, magnesium(Mg) alloy as a light metal has a long-term development prospect in the process of energy saving, emission reduction and environmental improvement. However, anti-corrosion performance of Mg alloy is poor due to the high chemical activity and low equilibrium potential, which limits the development of Mg alloy ***, three-dimensional mesopore hollow polypyrrole spheres(MHPS) were prepared, and the MHPS was inserted into the middle of the stacked hexagon boron nitride(h-BN) lamellae, which allowed the hBN to be separated forming a further composite with abundant pore structure. Subsequently, the MHPS/hBN-OH composite was uniformly sprayed on the Mg alloy surface via simple spraying method to form the superhydrophobic surface(SHS). Finally, the slippery liquid infused porous surface(SLIPS) was successfully fabricated by applying drops of silicone lubricant on the superhydrophobic coating surface. After a series of characterization and testing, the results showed that the stacking of h-BN lamellae was significantly reduced after h-BN was successfully embedded by MHPS. In addition, the fabricated SLIPS have excellent self-cleaning, mechanical stability, anti-icing and anti-corrosion properties. Therefore, the method of embedding polymer microspheres not only offers a new strategy for h-BN exfoliation, but also the successful prepared SLIPS largely retards the corrosion of Mg alloy while providing new ideas for the development of SLIPS.

关键词： Anti-corrosion Mg alloy Hexagon boron nitride Polypyrrole SLIPS

Intelligent UAV Based Energy Supply for 6G Wireless Powered IoT Networks

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China Communications 2024年第9期21卷 321-337页

作者： Miao Jiansong Chen Haoqiang Wang Pengjie Li Hairui zhao yan Mu Junsheng yan Shi School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China Beijing Key Laboratory of Network System Architecture and Convergence Beijing University of Posts and TelecommunicationsBeijing 100876China

In this paper,we develop a 6G wireless powered Internet of Things(IoT)system assisted by unmanned aerial vehicles(UAVs)to intelligently supply energy and collect data at the same *** our dual-UAV scheme,UAV-E,with a constant power supply,transmits energy to charge the IoT devices on the ground,whereas UAV-B serves the IoT devices by data collection as a base *** this framework,the system's energy efficiency is maximized,which we define as a ratio of the sum rate of IoT devices to the energy consumption of two UAVs during a fixed working *** the constraints of duration,transmit power,energy,and mobility,a difficult non-convex issue is presented by optimizing the trajectory,time duration allocation,and uplink transmit power of *** tackle the non-convex fractional optimization issue,we deconstruct it into three subproblems and we solve each of them iteratively using the descent method in conjunction with sequential convex approximation(SCA)approaches and the Dinkelbach *** simulation findings indicate that the suggested cooperative design has the potential to greatly increase the energy efficiency of the 6G intelligent UAV-assisted wireless powered IoT system when compared to previous benchmark systems.

关键词： 6G wireless powered network energy efficiency IoT intelligent network UAV communication

Multiphase Interfacial Regulation Based on Hierarchical Porous Molybdenum Selenide to Build Anticorrosive and Multiband Tailorable Absorbers

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Nano-Micro Letters 2024年第1期16卷 85-105页

作者： Tianbao zhao Zirui Jia Jinkun Liu yan Zhang Guanglei Wu Pengfei Yin College of Science Sichuan Agricultural UniversityYa’an 625014People’s Republic of China Institute of Materials for Energy and Environment State Key Laboratory of Bio‑Fibers and Eco‑TextilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071People’s Republic of China College of Chemistry and Chemical Engineering Qingdao UniversityQingdao 266071People’s Republic of China

Electromagnetic wave(EMW)absorbing materials have an irreplaceable position in the field of military stealth as well as in the field of electromagnetic pollution *** in order to cope with the complex electromagnetic environment,the design of multifunctional and multiband high efficiency EMW absorbers remains a tremendous *** this work,we designed a three-dimensional porous structure via the salt melt synthesis strategy to optimize the impedance matching of the ***,through interfacial engineering,a molybdenum carbide transition layer was introduced between the molybdenum selenide nanoparticles and the three-dimensional porous carbon matrix to improve the absorption behavior of the *** analysis indicates that the number and components of the heterogeneous interfaces have a significant impact on the EMW absorption performance of the absorber due to mechanisms such as interfacial polarization and conduction loss introduced by interfacial ***,the prepared MoSe_(2)/MoC/PNC composites showed excellent EMW absorption performance in C,X,and Ku bands,especially exhibiting a reflection loss of−59.09 dB and an effective absorption bandwidth of 6.96 GHz at 1.9 *** coordination between structure and components endows the absorber with strong absorption,broad bandwidth,thin thickness,and multi-frequency absorption ***,it can effectively reinforce the marine anticorrosion property of the epoxy resin coating on Q235 steel *** study contributes to a deeper understanding of the relationship between interfacial engineering and the performance of EMW absorbers,and provides a reference for the design of multifunctional,multiband EMW absorption materials.

关键词： Interfacial engineering Anticorrosion Multiband Electromagnetic wave absorber

Effects of iron oxide on crystallization behavior and spatial distribution of spinel in stainless steel slag

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 292-300页

作者： Zihang yan Qing zhao Chengzhi Han Xiaohui Mei Chengjun Liu Maofa Jiang Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

Chromium plays a vital role in stainless steel due to its ability to improve the corrosion resistance of the ***,the re-lease of chromium from stainless steel slag(SSS)during SSS stockpiling causes detrimental environmental *** prevent chromium pollution,the effects of iron oxide on crystallization behavior and spatial distribution of spinel were investigated in this *** results revealed that FeO was more conducive to the growth of spinels compared with Fe2O3 and *** were found to be mainly distrib-uted at the top and bottom of *** amount of spinel phase at the bottom decreased with the increasing FeO content,while that at the top *** average particle size of spinel in the slag with 18wt%FeO content was 12.8μ***,no notable structural changes were observed with a further increase in FeO *** other words,the spatial distribution of spinel changed when the content of iron oxide varied in the range of 8wt%to 18wt%.Finally,less spinel was found at the bottom of slag with a FeO content of 23wt%.

关键词： stainless steel slag spinel chromium waste remediation ferrous oxide

Qualitative analysis of aromatic compounds via 1D TOCSY techniques

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Magnetic Resonance Letters 2024年第1期4卷 21-27页

作者： Wenbo Dong Qi zhao Jiancheng zhao Jiarong Zhang Yingxiong Wang yan Qiao State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of Sciences27 South Taoyuan RoadTaiyuan030001China Graduate University of Chinese Academy of Sciences Beijing100049China Marine Biomedical Research Institution Guangdong Medical UniversityZhanjiang524023China College of Chemistry Taiyuan University of Technology79 Yingze West StreetWanbailin DistrictTaiyuan030024China

The aromatic compounds,including o-xylene,m-xylene,p-xylene,and ethylbenzene,primarily originate from the catalytic reforming of crude oil,and have a wide variety of ap***,because of similar physical and chemical properties,these compounds are difficult to be identified by gas chromatography(GC)without standard *** the development of modern nuclear magnetic resonance(NMR)techniques,NMR has emerged as a powerful and efficient tool for the rapid analysis of complex and crude mixtures without *** this study,the parameters of one-dimensional(1D)total correlation spectroscopy(TOCSY)NMR techniques,including 1D selective gradient TOCSY and 1D chemicalshift-selective filtration(CSSF)with TOCSY,were optimized to obtain comprehensive molecular structure *** results indicate that the overlapped signals in NMR spectra of nonpolar aromatic compounds(including o-xylene,m-xylene,p-xylene and ethylbenzene),polar aromatic compounds(benzyl alcohol,benzaldehyde,benzoic acid),and aromatic compounds with additional conjugated bonds(styrene)can be resolved in 1D *** importantly,full molecular structures can be clearly distinguished by setting appropriate mixing time in 1D *** approach simplifies the NMR spectra,provides structural information of entire molecules,and can be applied for the analysis of other structural isomers.

关键词： 1D TOCSY NMR technologies Xylenes Aromatic compounds Structure information of entire molecular Qualitative analysis

Influence and optimization of swirler parameters on elbow wear of deep coal fluidization pipeline transportation system

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Friction 2024年第7期12卷 1408-1433页

作者： Shaodi zhao Jiusheng BAO Shirong GE Zhongbin WANG yan YIN Congguang HUANG School of Mechanical and Electrical Engineering China University of Mining and TechnologyXuzhou 221116China School of Mechanical Electronic and Information Engineering China University of Mining and Technology-BeijingBeijing 100083China Frontier Scientific Research Center for Fluided Mining of Deep Underground Resources China University of Mining and TechnologyXuzhou 221008China

Elbow wear is a major threat to the multiphase pipeline transportation industry,which has a negative impact on the stable operation of the transportation *** order to find the wear reduction methods of elbows in the fluidization pipeline transportation system for 2000-meter-deep coal resources,the swirler was installed upstream of the elbows,and wear simulations and tests of three kinds of elbows were carried *** results showed that the maximum wear rate(MWR)of elbows increased and then decreased along the elbow *** to the different directions of gravity,the heavy wear position(HWP)of the horizontal-vertical(H-V)elbow was in front of the vertical-horizontal(V-H)*** the downstream portion of the horizontal-horizontal(H-H)elbow was still a horizontal pipe,the HWP of the H-H elbow almost covered the whole *** swirler placed upstream of the elbows could make the particles at the elbow move to the intrados of the elbows,resulting in less collision between the particles and the extrados of the elbows,thus reducing the wear of the *** wear reduction effects of swirlers on three different elbows were favorably connected with the guide vane angle(GVA)and negatively correlated with the guide vane length(GVL),decreased first and then increased as the guide vane height(GVH)increased,and were little affected by the guide vane number(GVN)and the guide vane thickness(GVT).The mathematical models between the MWR of the elbows and guide vane parameters were *** bench tests,the wear reduction effect of three kinds of elbows under the optimal guide vane parameters was 58.4%,76.9%,and 78.6%,*** errors between the bench test results and the simulation results were around 10%.

关键词： pipe elbow erosion wear spiral flow swirler guide vane parameters particle collision