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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing xue Yuejia Ma Ke Ye xue zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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Solid-gas interface thermal conductance for the thermal barrier coating with surface roughness:The confinement effect

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Chinese Physics B 2022年第12期31卷 418-423页

作者： xue zhao Jin-Wu Jiang Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200072China Zhejiang Laboratory Hangzhou 311100China

The yttria-stabilized zirconia(YSZ)is a famous thermal barrier coating material to protect hot-end components of an *** a characteristic feature of the YSZ,the surface roughness shall play an important role in the interface thermal conductance between the YSZ and gas,considering that the gas is typically at an extremely high *** investigate the effect of the surface roughness on the thermal conductance of the YSZ-gas interface with surface roughness described by nanoscale pores on the surface of the *** reveal two competitive mechanisms related to the microstructure of the pore,i.e.,the actual contact area effect and the confinement *** increase of the pore depth will enlarge the actual contact area between the YSZ and gas,leading to enhancement of the solid-gas interface thermal *** contrast to the positive actual contact area effect,the geometry-induced confinement effect greatly reduces the interface thermal *** findings shall offer some fundamental understandings for the microscopic mechanisms of the YSZ-gas interface thermal conductance.

关键词： interface thermal conductance thermal barrier coating solid-gas interface confinement effect

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Some properties of the psi function and evaluations of γ

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Applied Mathematics(A Journal of Chinese Universities) 2016年第1期31卷 103-111页

作者： QIU Song-liang zhao xue School of Science Zhejiang Sci-Tech University

In this paper, the authors show some monotonicity and concavity of the classical psi function, by which several known results are improved and some new asymptotically sharp estimates are obtained for this function. In addition, applying the new results to the psi function, the authors improve the well-known lower and upper bounds for the approximate evaluation of Euler＇s constant γ.

关键词： Psi function gamma function monotonicity concavity inequality Euler's constant.

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Effects of Halogen Substitution on Naphthazarin Tautomerism in the Ground and Excited States

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Chinese Journal of Structural Chemistry 2007年第8期26卷 980-987页

作者： zhao xue CHEN De-Zhan WANG Zhen HAO zhao-Ling Department of Chemistry Taishan University Taian 271000 China College of Chemistry Shandong Normal University Jinan 250014 China

5,8-Hihydroxyl-1,4-naphthazarin was taken as a model compound to explore the effect of halogen substitution on intramolecular proton transfer process. Calculations indicate that the substitution in the R2- and R4-positions far away from the active region has much weaker influence on the IPT process than that in the R1- and R3-positions. IPT barriers for substitution in the R1-position are higher than that of parent molecule. However, it is quite reverse for substitution in the R3-position. The IPT process is a proton transfer process coupled with charge separation and coulombic interaction would be dominant during this process. As for naphthazarin, halogen substitution would decrease the quantum yields of O2 but increase those of ^1O2.

关键词： naphthazarin intramolecular proton transfer halogen substitution

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Generalized dominance-based rough set approach to security evaluation with imprecise information

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High Technology Letters 2010年第3期16卷 254-262页

作者： zhao Liang xue Zhi School of Electronic and Electric Engineering Shanghai Jiaotong University Shanghai 200240 P.R. China

The model of grey multi-attribute group decision-making （MAGDM） is studied, in which the attribute values are grey numbers. Based on the generalized dominance-based rough set approach （G-DR- SA）, a synthetic security evaluation method is presented. With-the grey MAGDM security evaluation model as its foundation, the extension of technique for order performance by similarity to ideal solution （TOPSIS） integrates the evaluation of each decision-maker （DM） into a group＇s consensus and obtains the expected evaluation results of information system. Via the quality of sorting （QoS） of G-DRSA, the inherent information hidden in data is uncovered, and the security attribute weight and DMs＇ weight are rationally obtained. Taking the computer networks in a certain university as objects, the example illustrates that this method can effectively remove the bottleneck of the grey MAGDM model and has practical significance in the synthetic security evaluation.

关键词： security evaluation grey number multi-attribute group decision-making (MAGDM) generalized dominance-based rough set approach (G-DRSA)

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High-Performance Hardware Implementation of the 3GPP Algorithm KASUMI

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The Journal of China Universities of Posts and Telecommunications 2006年第1期13卷 60-62页

作者： zhao xue GUO Shu-xu College of Electronic Science and Engineering Jilin University Changehun 130012 P.R. Chins

KASUMI is a block cipher that forms the heart of the 3GPP confidentiality algorithm fS, and the 3GPP integrity algorithm fg. This paper presents a hardware-based high-performance field programmable gate array implementation of the KASUMI algorithm. Our KASUMI implementation uses pipeline techniques and a field programmable gate array device, and outperforms previous published KASUMI implementations in terms both of clock frequency and of throughput.

关键词： KASUMI algorithm mobile communication information security

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A Review and Prospects on Collaborative Ontology Editing Tools

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Journal of Integrative Agriculture 2012年第5期11卷 731-740页

作者： XIAN Guo-jian zhao Rui-xue Agricultural Information Institution Chinese Academy of Agricultural SciencesBeijing 10008lPR.China

Building ontology is a fundamental but also hard work. Collaborative ontology editing tools can make ontology development more efficiently. In this paper, the important features of collaborative ontology development were analyzed, and several tools such as AGROVOC Concept Server Workbench （ACSW）, Collaborative Prot6g6 and WebProt6g6 were studied. Besides, some comparisons among them from several aspects were made and some prospects for the further improvement of these tools were given. Finally, we show it is a good way to build agricultural ontology with these tools collaboratively and simultaneously.

关键词： collaborative ontology editing agricultural ontology ACSW Collaborative Prot6g6 WebProt6g6

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An Improved F-Expansion Method and Its Application to Coupled Drinfel'd-SokolovWilson Equation

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Communications in Theoretical Physics 2008年第8期50卷 309-314页

作者： zhao xue-Qin ZHI Hong-Yan Department of Mathematics Qufu Normal University Shandong Rizhao 276826 China Department of Applied Mathematics Dalian University of Technology Dalian 116024 China

With the aid of computerized symbolic computation, an improved F-expansion method is presented to uniformly construct more new exact doubly periodic solutions in terms of rational formal Jscobi elliptic function of nonlinear partial differential equations （NPDFs）. The coupled Drinfel＇d-Sokolov-Wilson equation is chosen to illustrate the method. As a result, we can successfully obtain abundant new doubly periodic solutions without calculating various Jacobi elliptic functions. In the limit cases, the rational solitary wave solutions and trigonometric function solutions are obtained as well.

关键词： Jacobi elliptic function doubly periodic solution rational solitary wave solution

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A New General Algebraic Method and Its Application to Shallow Long Wave Approximate Equations

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Communications in Theoretical Physics 2007年第5X期48卷 781-786页

作者： zhao xue-Qin ZHI Hong-Yan Department of Mathematics Qufu Normal University Rizhao 276826 China Department of Applied Mathematics Dalian University of Technology Dalian 116024 China

A new general algebraic method is presented to uniformly construct a series of exact solutions for nonlinear evolution equations （NLEEs）. For illustration, we apply the new method to shallow long wave approximate equations and successfully obtain abundant new exact solutions, which include rational solitary wave solutions and rational triangular periodic wave solutions. The method is straightforward and concise, and it can also be applied to other nonlinear evolution equations in mathematical physics.

关键词： new general algebraic method nonlinear evolution equations solitary wave solutions

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Potential production and spatial distribution of hybrid poplar as a biofuel crop in Connecticut,USA

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International Journal of Agricultural and Biological Engineering 2014年第2期7卷 10-18页

作者： zhao xue Liqin Qu Xiusheng Yang Department of Natural Resources and the Environment University of ConnecticutStorrsCT 06269-4087USA

The objective of this study was to assess the biomass production potential from hybrid poplars using marginal lands in the state of Connecticut,USA.A land-use suitability model was developed to identify and classify marginal lands in the state that could be used for growing hybrid poplars as a biofuel woody energy *** model was built on a geographic information system(GIS)platform,consisting of an exclusion area section,an ecological suitability section,and an economic/land-use suitability *** model then was used to estimate the total biomass of the land-cover forests,annual biomass from forest and agricultural residues,and in particular the production potential of biomass from hybrid poplars over marginal lands in the state at county *** results indicated that about 50%of the land in this state is unavailable for hybrid poplar cultivation and that less than 5%is highly *** amount of usable area is highly variable on the county *** large-scale land use change,it appears that biofuel production in this state can only be a supplemental resource to the current energy supply.

关键词： biofuel plants hybrid poplar spatial distribution ethanol production Connecticut suitability model ecological suitability

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