检索结果-南通市图书馆

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： Lifang zhao Mingkai Zhang Qimeng Li Xuemin Wang jie Lu Ying Han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

Effect of strain,strain rate and temperature on workability of AZ80 wrought magnesium alloy

在线全文

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 2012年第S3期22卷 650-655页

作者： Lü wen-quan quan Guo-zheng YU Chun-tang zhao lei ZHOU jie College of Materials Science and Engineering Chongqing University

The hot deformation behavior of AZ80 wrought magnesium alloy was studied in the temperature range of 523-673 K and the strain rate range of 0.01-10 s-1 using hot compression *** the flow stresses behavior,the processing maps were calculated and analyzed according to the dynamic materials *** stable,metastable and unstable regimes were *** optimum processing conditions were suggested as following:the DRX regions in Domain #1-0.25,Domain #2-0.25,Domain #1-0.45,Domain #2-0.45,Domain #3-0.45,Domain #1-0.65 and Domain #1-0.85,and the DRV regions in Domain #3-0.25 and Domain #*** each "safe" DRX domain,it is preferable to conduct hot working in the small region around efficiency peak *** strain has a great influence on the processing *** whole area of the "safe" domains increases with the increase of true strain from 0.25 to 0.65,while it decreases with the increase of true strain from 0.65 to *** results of kinetic analysis reveal that the values of apparent activation energy in all the domains are higher than that for self-diffusion in pure magnesium (135kJ/mol),and the deformation mechanism in all the domains is likely to be cross-slip.

关键词： AZ80 magnesium alloy strain rate kinetic analysis processing map flow behavior

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： jie Jin Huajing Zhang Qianying Lu linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei zhao wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

quantum to classical transition induced by a classically small influence

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2020年第8期29卷 151-156页

作者： wen-lei zhao quanlin jie School of Science Jiangxi University of Science and TechnologyGanzhou 341000China Department of Physics Wuhan UniversityWuhan 430072China

We investigate the quantum to classical transition induced by two-particle interaction via a system of periodically kicked *** classical dynamics of particle 1 is almost unaffected in condition that its mass is much larger than that of particle ***,such classically weak influence leads to the quantum to classical transition of the dynamical behavior of particle ***,the quantum diffusion of this particle undergoes the transition from dynamical localization to the classically chaotic diffusion with the decrease of the effective Planck constantħ*** behind physics is due to the growth of entanglement in the *** classically very weak interaction leads to the exponential decay of purity in condition that the classical dynamics of external degrees freedom is strongly chaotic.

关键词： quantum to classical transition quantum decoherence quantum chaos

Leader-follower: Human-centered intention-guided controller for novel SuperLimb with application to load-carrying scenarios

在线全文

学校读者我要写书评

暂无评论

Science China Technological Sciences 2025年第1期 325-338页

作者： Qinghua ZHANG Xianglong LI Hongwei JING Kerui SUN Yuancheng LI Sikai zhao Lele LI Haotian JU Ziqi WANG Rui WU Tianjiao ZHENG jie zhao Yanhe ZHU The State Key Laboratory of Robotics and System Harbin Institute of Technology The Learning Algorithms and Systems Laboratory School of Engineeringécole Polytechnique Fédérale de Lausanne

Supernumerary robotic arms(SuperLimb) are a new type of wearable robot that works closely with humans as a third hand to augment human operation capability. Accurate conveyance of wearers' intentions, allocation of roles, and humancentered interaction considerations are the key points in the process of human–SuperLimb collaboration. This paper proposes a human-centered intention-guided leader–follower controller that relies on the dynamic modeling of SuperLimb with application to load-carrying scenarios. The proposed leader–follower controller takes the human as the leader and the SuperLimb as the follower, achieving effective information communication, autonomous coordination, and good force compliance between SuperLimb, humans, and the environment under human safety assurance. First, the human–SuperLimb dynamic system is modeled to achieve force interaction with the environment and wearer. Second, to achieve the precise intention extraction of humans, pose data from five visual odometry sensors are fused to capture the human state, the generalized position, the velocity of hands, and the surface electromyography signals from two myoelectric bracelets sensors are processed to recognize the natural hand gestures during load-carrying scenarios by a designed Swin transformer network. Then, based on the real-time distance detection between human and mechanical limbs, the security assurance and force-compliant interaction of the human–SuperLimb system are realized. Finally, the human hand muscle intention recognition, human–robot safety strategy verification,and comparative load-carrying experiments with and without the proposed method are conducted on the SuperLimb *** showed that the task parameters are well estimated to produce more reasonable planning trajectories, and SuperLimb could well understand the wearer's intentions to switch different SuperLimb actions. The proposed sensor-based human–robot communication framework motivates future studies of o

关键词：

Efficient and Stable Photoassisted Lithium‑Ion Battery Enabled by Photocathode with Synergistically Boosted Carriers Dynamics

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第3期17卷 440-454页

作者： Zelin Ma Shiyao Wang Zhuangzhuang Ma Juan Li Luomeng zhao Zhihuan Li Shiyuan Wang Yazhou Shuang Jiulong Wang Fang Wang Weiwei Xia jie Jian Yibo He Junjie Wang Pengfei Guo Hongqiang Wang State Key Laboratory of Solidification Processing Center for Nano Energy MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene(NPU)Xi’an 710072People’s Republic of China State Key Laboratory of Solidification Processing School of Materials Science and Engineering DepartmentNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518063People’s Republic of China Key Laboratory of Applied Surface and Colloid Chemistry Shaanxi Key Laboratory for Advanced Energy DevicesShaanxi Engineering Lab for Advanced Energy TechnologySchool of Materials Science and EngineeringNational Ministry of EducationShaanxi Normal UniversityXi’an 710119People’s Republic of China

Efficient and stable photocathodes with versatility are of significance in photoassisted lithium-ion batteries(PLIBs),while there is always a request on fast carrier transport in electrochemical active *** work proposes a general approach of creating bulk heterojunction to boost the carrier mobility of photocathodes by simply laser assisted embedding of plasmonic *** employed in PLIBs,it was found effective for synchronously enhanced photocharge separation and transport in light charging ***,experimental photon spectroscopy,finite difference time domain method simulation and theoretical analyses demonstrate that the improved carrier dynamics are driven by the plasmonic-induced hot electron injection from metal to TiO_(2),as well as the enhanced conductivity in TiO2 matrix due to the formation of oxygen vacancies after Schottky *** from these merits,several benchmark values in performance of TiO2-based photocathode applied in PLIBs are set,including the capacity of 276 mAh g^(−1)at 0.2 A g^(−1)under illumination,photoconversion efficiency of 1.276%at 3 A g^(−1),less capacity and Columbic efficiency loss even through 200 *** results exemplify the potential of the bulk heterojunction strategy in developing highly efficient and stable photoassisted energy storage systems.

关键词： Photoassisted lithium-ion batteries Bulk heterojunction Carrier dynamics TiO2 nanofiber Plasmonic metal nanocrystals

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

环糊精聚合物在食品分析样品前处理中的应用

分析测试学报 2025年第1期44卷 34-42页

作者：王楠王媛宗帅赵文杰河南工业大学化学化工学院河南郑州450001 宁夏计量质量检验检测研究院宁夏银川750411

环糊精聚合物(CDPs)是由环糊精(CD)分子以化学键合等手段构筑的含有多个环糊精单元的高分子衍生物,不仅很好地保留了环糊精的包络识别性能,还兼具聚合物优良的机械强度、稳定性和化学可调性等优点。CDPs在样品前处理中具有广泛的应用潜... 详细信息

环糊精聚合物(CDPs)是由环糊精(CD)分子以化学键合等手段构筑的含有多个环糊精单元的高分子衍生物,不仅很好地保留了环糊精的包络识别性能,还兼具聚合物优良的机械强度、稳定性和化学可调性等优点。CDPs在样品前处理中具有广泛的应用潜力,选择性吸附与分离、高效去除污染物、可再生性与环保性等特性为其在环境保护、食品安全等领域的应用提供了有力支持。该文概括了不同的CDPs的合成方法及其在食品分析样品前处理领域的重要作用,通过与固相微萃取、磁性固相萃取、搅拌棒萃取等技术结合,CDPs能够有效地分离和富集食品中的目标分析物(如农药残留、食品添加剂和天然香味成分等)。并总结与展望了CDPs的发展现状和未来发展趋势。

关键词：环糊精环糊精聚合物样品前处理食品分析选择性吸附

Kinetics of austenite grain growth in medium-carbon niobium-bearing steel

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第3期12卷 171-176页

作者： Ying-li zhao jie SHI wen-quan CAO Mao-qiu WANG Gang XIE School of Material and Metallurgy Engineering Kunming University of Science and Technology Kunming 650093 China Institute for Structural Materials Central Iron and Steel Research Institute Beijing 100081 China

In order to locate a reasonable heating system,the austenite grain growth behavior of Nb microalloyed medium carbon steel has been experimentally studied at various austenitizing temperatures and for different holding *** is indicated that austenite grain growth increases with increasing austenitizing temperatures and holding *** when the austenitizing temperature was above 1100 ℃,austenite grains grew rapidly,and an abnormal austenite grain growth was *** the austenitizing temperature was lower than 1100 ℃,austenite grain size and growth rate were *** activation energy of grain growth in the tested steel is 397 679.5 J/*** ensure an absence of coarse grains in microstructures,the heating technology of the tested steel should be controlled for 1 h at 1100 ℃.The relationships of austenite average grain size with soaking temperature and time of tested steel were obtained by mathematical calculation,and austenite average grain size was found to be in agreement with the measured size for different holding times.

关键词： Microalloyed steel Grain growth Modeling

Effect of direct quenching on microstructure and mechanical properties of medium-carbon Nb-bearing steel

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第10期11卷 776-781页

作者： Ying-li zhao jie SHI wen-quan CAO Mao-qiu WANG Gang XIE School of Material and Metallurgy Engineering Kunming U~iversity of Scienee and Technology Kunming 650093 China Institute for Structural Materials Central Iron and Steel Research Institute Beijing 100081 China

The influence of direct quenching (DQ) on microstructure and mechanical properties of 0.19C-1.7Si-1.0 Mn-0.05Nb steel was studied. The microstructure and mechanical properties of reheat quenched and tempered (RQ&T) steel plate were compared with those of direct quenched and tempered (DQ&T) steel plates which were hot rolled at different finish rolling tem-peratures (1173 K and 1123 K), i.e., recrystallization-controlled-rolled direct-quenched (RCR&DQ) and controlled-rolled direct-quenched (CR&DQ), respectively. The strengths generally increased in the following order: RQ&Tling direction, while complete equiaxed grains were visible in RQ&T and RCR&DQ&T steels. Transmission electron microscopy (TEM) and electron backscattering diffraction (EBSD) of the DQ steels showed smaller block width and higher density of dislocations. Inheritance of austenite deformation substructure by the martensite and differences in martensite block width were ruled out as major causes for the strength differences between DQ and RQ steels.

关键词： Direct quenching (DQ) Block Mechanical properties Electron backscattering diffraction (EBSD) Nb steel