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金属间化合物的标准生成焓估算模型

中南大学学报（自然科学版） 2011年第6期42卷 1578-1583页

作者：赵定国郭培民赵沛钢铁研究总院先进钢铁流程及材料国家重点实验室北京100081

在分析已有的热力学数据基础上,建立估算二元金属间化合物标准生成焓的双参数模型,通过模型求解,得到34种金属的双参数模型的参数值。用此模型可估算由简单金属形成的二元金属间化合物的标准生成焓,包括Fe,Si,Nb,Ti,Cu,Co和Mg等多个体系... 详细信息

在分析已有的热力学数据基础上,建立估算二元金属间化合物标准生成焓的双参数模型,通过模型求解,得到34种金属的双参数模型的参数值。用此模型可估算由简单金属形成的二元金属间化合物的标准生成焓,包括Fe,Si,Nb,Ti,Cu,Co和Mg等多个体系,估算109个已知金属间化合物AlCa,AlCo,CrNi,FeTi,FeSi,FeNb和MoSi等的标准生成焓。研究结果表明:双参数模型计算的平均误差为12.47 kJ/mol,标准差为17.40 kJ/mol;用双参数模型估算金属间化合物的标准生成焓精度高,其估算结果的正态分布比较集中,并且误差小于离子束缚模型和米德玛模型的误差。

关键词：标准生成焓金属间化合物双参数模型估算

Direct interaction between Rab5a and Rab4a enhanced epidermal growth factor-stimulated proliferation of gastric cancer cells

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World Journal of Gastrointestinal Oncology 2021年第10期13卷 1492-1505页

作者： Guo-Jun Cao Di Wang zhao-pei Zeng Guo-Xiang Wang Chun-Jiu Hu Zhi-Fang Xing Department of Laboratory Medicine Huashan Hospital NorthShanghai Medical CollegeFudan UniversityShanghai 201907China School of Life Sciences Fudan UniversityShanghai 200433China Department of Laboratory Medicine Diniu(Shanghai)Health Technology Co.Shanghai 201703China Department of Neurology Institutes of Brain ScienceState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceInstitute of Biological ScienceZhongshan HospitalFudan UniversityShanghai 200032China Department of Gastroenterology Ningbo First HospitalNingbo 315000Zhejiang ProvinceChina Department of Laboratory Medicine Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China

BACKGROUND Gastric cancer(GC)is one of the leading causes of cancer-related death *** targeted therapies such as antibodies against human epidermal growth factor receptor 2 or vascular endothelial growth factor receptor 2 have been widely used in the treatment of metastatic cancer,the overall outcomes are ***,elucidation of the mechanism underlying cancer progression is important to improve *** of the Rab5a gene has been confirmed to correlate with tumorigenesis of many cancers,but the mechanism underling,especially of GC,is still *** To investigate the effects of Rab5a overexpression on the tumorigenesis of *** First,the expression levels of Rab5a and Rab4a in primary tumorous tissues of GC patients diagnosed between 2015 and 2018 were *** we constructed HGC-27 cell lines overexpressing green fluorescent protein-Rab5a or red fluorescent protein-Rab4a and investigated the interaction between Rab5a or Rab4a using Western blotting,co-immunoprecipitation,confocal microscopy,and colocalization ***,epidermal growth factor-stimulated proliferation of these cell lines was analyzed using cell counting kit-8 cell viability *** Compared with normal gastric tissues,the expression levels of Rab5a and Rab4a increased progressively both in paracancerous tissues and in advanced cancerous *** growth factor could promote the proliferation of HGC-27 cells,especially Rab5a-overexpressing HGC-27 ***,Rab5a and Rab4a cooverexpression promoted the proliferation of HGC-27 cells to the greatest *** analysis identified a direct interaction between Rab5a and Rab4a in HGC-27 *** Co-overexpression of Rab5a and Rab4a in GC may promote the endosomal recycling of epidermal growth factor receptor,which in turn contributes to poor prognosis and tumor progression in GC *** of Rab5a or Rab4a expression might be a promising therapy for refractory

关键词： Rab4a Rab5a Epidermal growth factor Cell proliferation Gastric cancer HGC-27 cell lines

Combined detection of serum tumor markers for differential diagnosis of solid lesions located at the pancreatic head

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Hepatobiliary & Pancreatic Diseases International 2007年第6期6卷 641-645页

作者： Liao, Quan zhao, Yu-pei Yang, Ying-Chi Li, Li-Jun Long, Xiao Han, Shao-Mei Beijing Union Med Coll Hosp Dept Gen Surg Beijing 100730 Peoples R China

BACKGROUND: The differential diagnosis of solid lesions located at the pancreatic head is very important for choosing therapies and setting up surgical tactics. This study was designed to evaluate the clinical significance of combined measurement of multiple serum tumor markers and the application of the receiver-operating characteristic (ROC) curves in the differential diagnosis of solid lesions located at the pancreatic head. METHODS: The serum levels of CA19-9, CA242, CA50 and carcinoembryonic antigen (CEA) in 112 patients with carcinoma of the pancreatic head and 38 patients with focal chronic pancreatitis in the pancreatic head were measured with ELISA. The sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR) of the four serum tumor markers were calculated. The ROC curves for the four serum tumor markers were constructed and the area under the curve (AUC) was calculated. RESULTS: The AUCs of CA19-9, CA242, CA50 and CEA were 0.805, 0.749, 0.738 and 0.705; the PLRs were 1.91, 3.43, 5.09 and 5.46; and the NLRs were 0.41, 0.56, 0.59 and 0.71, respectively. Combined measurements increased the diagnostic specificity, and parallel combined testing increased the diagnostic sensitivity. CONCLUSIONS: Combined measurement of serum tumor markers CA19-9, CA242, CA50 and CEA is valuable in differential diagnosis of solid lesions located at the pancreatic head, and CA19-9 has the best diagnostic ability. Combined measurements can increase the specificity of diagnosis. Evaluation with the ROC curve is better than the sensitivity or specificity alone and the results are more integrated and objective.

关键词： pancreatic neoplasm tumor markers ROC curve differential diagnosis

On multiple testing,validation of gene expression profiling,and translational research

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中华医学杂志(英文版) 2008年第13期121卷 1247-1248页

作者： zhao Yu-pei CHEN Ge Departmem of General Surgery Peking Union Medical College Hospital Beijing 100730 China）

To the editor:With great interest,we read the recent article by zhao et al,in which the authors performed a genome-wide screen for genes that are associated with multi-drug resistance *** authors concluded that construction of a chemoresistance prediction rule,based on gene expression patterns, is practical and that their results may be useful for the detection and treatment of MDR in pancreatic cancer patients.

关键词： gene expression cancer patients

Prognostic Impact of Cell Division Cycle Associated 2 Expression on Pancreatic Ductal Adenocarcinoma

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Chinese Medical Sciences Journal 2016年第3期31卷 149-154页

作者： Meng-yi Wang Zhe-yu Niu Xiang-Gao Li Zhou Quan Liao Yu-pei zhao Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College

Objective To examine the expression of cell division cycle associated 2(CDCA 2) in pancreatic ductal adenocarcinoma(PDAC) and investigate its role in prognosis of PDAC *** This retrospective study included 155 PDAC patients who underwent surgical treatment and complete post-operative *** data were collected through clinical *** microarray was constructed and immunohistochemistry was performed to detect CDCA2 expression in the PDAC tumor tissues and adjacent non-tumor *** characteristics between high and low CDCA2 expression were *** of CDCA2 expressions with patients' survival was analyzed using Kaplan-Meier method and Cox regression *** Expression of CDCA2 in PDAC cells was significantly higher than that in adjacent non-tumor tissues(U=4056.5,P<0.001).Univariate analysis showed that CDCA2 expression [hazard ratio(HR)=1.574,95% confidence interval(CI)=1.014-2.443,P=0.043] and node metastasis(HR=1.704,95%CI=1.183-2.454,P=0.004) were significantly associated with *** regression analysis showed CDCA2 expression was not an independent prognostic risk factor(HR=1.418,95%CI=0.897-2.242,P=0.135) for PDCA *** survival analysis demonstrated CDCA2 expression as an independent prognostic risk factor in male patients(HR=2.554,95%CI=1.446-4.511,P=0.003) or in non-perineural invasion patients(HR=2.290,95%CI=1.146-4.577,P=0.012).Conclusions CDCA2 is highly expressed in PDAC tumor *** CDCA2 is not an independent prognostic risk factor for PDAC patients,it might be used to help predict prognosis of male or non-perineural invasion patients of PDAC.

关键词： cell division cycle associated 2 immunohistochemistry prognosis pancreatic ductal adenocarcinoma

Rainfall and Tillage Impacts on Soil Erosion of Sloping Cropland with Subtropical Monsoon Climate- A Case Study in Hilly Purple Soil area, China

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Journal of Mountain Science 2015年第1期12卷 134-144页

作者： TANG Jia-liang CHENG Xun-qiang ZHU Bo GAO Mei-rong WANG Tao ZHANG Xi-feng zhao pei YOU Xiang Key Laboratory of Mountain Environment Evolution and Regulation Institute of Mountain Hazards and EnvironmentChinese Academy of Sciences Provincial Monitoring Station of Soil and Water Conservation

Under global warming, storm events tend to intensify, particularly in monsoon-affected regions. As an important agricultural area in China, the purple soil region in the Sichuan Basin, where it has a prevailing monsoon climate, is threatened by serious soil erosion. Tillage operations alter runoff and soil erosion processes on croplands by changing the physical properties of the soil surface. To clarify the relationship between tillage and soil erosion in the purple soil region, three different tillage practices in this region were investigated at the plot scale over 4 years： bare land with minimum tillage （BL）, conventional tillage （CT） and seasonal no-tillage ridges （SNTR） which was initially designed to prevent soil erosion by contoured ridges and no-tillage techniques. The results showed that although there were no significant differences in the surface runoff and soil erosion among the three oractices, BL caused relatively high surface runoff and soil erosion, followed by CT and SNTR. Classification and comparison of the rainfall events based on cluster analysis （CA） verified that the surface runoff was not significantly different between most intensive event and long intensive events but was significantly different between most intensive and short and medium-duration events. Only the rainfall events with the highest rainfall intensity could trigger serious soil erosion, up to 1000 kg ha^-1 in the region. Further detailed investigations on the effects of tillage operations on the soil erosion in a subtropical region with a monsoon climate are needed to provide a basis for modeling catchments and designing better management practices.

关键词： Soil erosion Purple soil Tillage types Rainfall intensity Cluster analysis.

Synthesis of Thin Film of a Three-Dimensional Covalent Organic Framework as Anti-counterfeiting Label

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Chinese Journal of Chemistry 2022年第10期40卷 1171-1176页

作者： Xin Dong Jing Yang Honglei Wang pei zhao Fanglin Tan Zhipeng Zhou zhaowei Ou Li Gong Wei Liu Xudong Chen Zhikun Zheng Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education School of Chemistryand State Key Laboratory of Optoelectronic Materials and TechnologiesSun Yat-sen UniversityGuangzhouGuangdong 510275China Key Laboratory of Low-Carbon Chemistry&Energy Conservation of Guangdong Province Key Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationState Key Laboratory of Optoelectronic Materials and TechnologiesSchool of Materials Science and EngineeringSun Yat-sen UniversityGuangzhouGuangdong 510275China Instrumental Analysis and Research Center Sun Yat-sen UniversityGuangzhouGuangdong 510275China

Film plays a key role in the sustainable development of our *** thin films of two-dimensional covalent organic frameworks(coFs)have been produced by interface,spin coating,microwave-assisted synthesis,and screen printing methods and are applied in nanofitration,molecular separation,photochemical sensing,anion transport,heat conduction,and proton *** the other hand,the synthesis of their three-dimensional(3D)analogues and subsequent integration in devices remains ***,self-supporting thin films of a three-dimensionai COF with tunable thickness was created by a stearic acid mediated synthesis methodology on water surface at room temperature in *** film could be transferred onto arbitrary substrate,and when supported on indium tin oxide glass,it exhibited irreversible *** optical feature made it act as a one-time anti-counterfeiting label in an electrochemical *** work will inspire the synthesis of thin films of 3D COFs as well as other 3D materials,and boost their property and application exploration.

关键词： Thin films Interfaces Electrochromism Anti-counterfeiting Covalent organic frameworks

Pancreatic duct stones in patients with chronic pancreatitis:surgical outcomes

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Hepatobiliary & Pancreatic Diseases International 2010年第4期9卷 423-427页

作者： Liu, Bo-Nan Zhang, Tai-Ping zhao, Yu-pei Liao, Quan Dai, Meng-Hua Zhan, Han-Xiang Peking Union Med Coll Peking Union Med Coll Hosp Dept Gen Surg Beijing 100730 Peoples R China Chinese Acad Med Sci Beijing 100730 Peoples R China

BACKGROUND: Pancreatic duct stone (PDS) is a common complication of chronic pancreatitis. Surgery is a common therapeutic option for PDS. In this study we assessed the surgical procedures for PDS in patients with chronic pancreatitis at our hospital. METHOD: Between January 2004 and September 2009, medical records from 35 patients diagnosed with PDS associated with chronic pancreatitis were retrospectively reviewed and the patients were followed up for up to 67 months. RESULTS: The 35 patients underwent ultrasonography, computed tomography, or both, with an overall accuracy rate of 85.7%. Of these patients, 31 underwent the modified Puestow procedure, 2 underwent the Whipple procedure, 1 underwent simple stone removal by duct incision, and 1 underwent pancreatic abscess drainage. Of the 35 patients, 28 were followed up for 4-67 months. There was no postoperative death before discharge or during follow-up. After the modified Puestow procedure, abdominal pain was reduced in patients with complete or incomplete stone clearance (P>0.05). Steatorrhea and diabetes mellitus developed in several patients during a long-term follow-up. CONCLUSIONS: Surgery, especially the modified Puestow procedure, is effective and safe for patients with PDS associated with chronic pancreatitis. Decompression of intraductal pressure rather than complete clearance of all stones predicts postoperative outcome.

关键词： pancreatic duct stone chronic pancreatitis surgical management modified Puestow procedure

Anti-tumor effects of combined doxorubicin and siRNA for pulmonary delivery

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Chinese Chemical Letters 2017年第4期28卷 807-812页

作者： Cai-Na Xu Hua-Yu Tian Yan-Bing Wang Yang Du Jie Chen Lin Lin zhao-pei Guo Xue-Si Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sdences Changchun 130022 China

Direct administration of drugs and genes to the lungs by pulmonary delivery offers a potential effective therapy for lung *** this study,combined doxorubicin（DOX） and Bcl2 siRNA was employed for cancer therapy using polyethylenimine（pei） as the carrier of Bcl2 *** of the DOX and siRNA possessed high cellular uptake efficiency in B16F10 cells,which was proved by FCM and CLSM ***-time PCR showed that pei/Bcl2 siRNA exhibited high gene silencing efficiency with 70%Bcl2 mRNA being knocked *** combination of DOX and siRNA could enhance the cell proliferation inhibition and the cell apoptosis against B16F10 cells compared to free DOX or pei/Bcl2 ***,the biodistribution of DOX and siRNA via pulmonary administration was studied in mice with B16F10 metastatic lung *** results showed that most of the DOX and siRNA were accumulated in lungs and lasted at least for 3 days,which suggested that combined DOX and siRNA by pulmonary administration may have high anti-tumor effects for metastatic lung cancer treatment in vivo.

关键词： Pulmonary delivery Anti-tumor effects Metastatic lung cancer Combined DOX and siRNA therapy Synergistic anti-tumor