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Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu zeng Yige Song Chao Xu Kai zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

Role of Bloch oscillation in high-order harmonic generation from periodic structure

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Chinese Physics B 2019年第11期28卷 60-66页

作者： Lu Liu jing zhao Jian-Min Yuan zeng-xiu zhao Graduate School of China Academy of Engineering Physics Beijing 100193China Department of Physics College of Liberal Arts and ScienceNational University of Defense TechnologyChangsha 410073China

The high-order harmonic generation from a model solid structure driven by an intense laser pulse is investigated using the semiconductor Bloch equations(SBEs). The main features of harmonic spectrum from SBEs agree well with the result of the time-dependent Schro¨dinger equation(TDSE), and the cut-off energy can be precisely estimated by the recollision model. With increasing the field strength, the harmonic spectrum shows an extra plateau. Based on the temporal population of electron and the time–frequency analysis, the harmonics in the extra plateau are generated by the Bloch oscillation. Due to the ultrafast time response of the Bloch electron, the generated harmonics provide a potential source of shorter isolated attosecond pulse.

关键词： high-order harmonic generation attosecond pulse semiconductor Bloch equations time-dependent Schrodinger equation

Multi-Electron Effects in Attosecond Transient Absorption of CO Molecules

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Chinese Physics Letters 2018年第4期35卷 20-24页

作者： Bin Zhang Jian zhao zeng-xiu zhao Northwest Institute of Nuclear Technology Xi'an 710024 Department of Physics College of Science National University of Defense Technology Changsha 410073

Using the fully propagated time-dependent Hartree–Fock method, we identify that both the dynamic core polarization and multiorbital contributions are important in the attosecond transient absorption of CO *** dynamics of core electrons effectively modifies the behaviors of electrons in the highest occupied molecular orbital, resulting in the modulation of intensity and position of the absorption peaks. Depending on the alignment angles, different inner orbitals are identified to contribute, and even dominate the total absorption spectra. As a result, multi-electron fingerprints are encoded in the absorption spectra, which shed light on future applications of attosecond transient absorption in complex systems.

关键词： Multi-Electron Effects in Attosecond Transient Absorption of CO Molecules SAO As CO

Elliptical High-Order Harmonic Generation from H_(2)^(+) in Linearly Polarized Laser Fields

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Chinese Physics Letters 2013年第2期30卷 74-77页

作者： ZHANG Bin zhao zeng-xiu Department of Physics National University of Defense TechnologyChangsha 410073

We investigate the elliptical high-order harmonic generation(HHG)from the ground state of H_(2)^(+)subjected to linearly polarized laser fields,by numerically solving the three-dimensional(3D)time-dependent Schrödinger equation(TDSE)and using the strong-field approximation(SFA)*** elliptical HHG is yielded at intermedial alignment angles from the TDSE,while the standard SFA model fails to predict *** including the coulomb potential and the stark shift corrections,we yield qualitative agreement results with the *** comparisons show that in the description of elliptical HHG,both the coulomb potential and the stark-shift are necessary.

关键词： elliptical qualitative correction

Phylogenetic analysis of bacterial community in deep-sea sediment from the western Pacific “warm pool”

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Acta Oceanologica Sinica 2005年第5期24卷 127-138页

作者： zhao jing zeng Runying School of Life Sciences Xiamen University Xiamen 361005 China Key Laboratory of Marine Biogenetic Resources Third Institute of Oceanography State Oceanic Administration Xiamen 361005 China

A depth profile of bacterial community structure in one deep-sea sediment core of the western Pacific ＂warm pool＂（WP） was investigated and compared with that in a sediment sample from the eastern Pacific （EP） by phylogenetic analysis of 16S rDNA fragments. Five bacterial 16S rDNA clone libraries were constructed, and 133 clones with different restriction fragment length polymorphism （RFLP） patterns were sequenced. A phylogenetic analysis of these sequences revealed that the bacterial diversity in a sample from the WP was more abundant than that in the EP sample. The bacterial population in the sediment core of WP was composed of eight major lineages of the domain bacteria. Among them the γ-Proteobacteria was the predominant and most diverse group in each section of WP sediment core, followed by the α-Proteobacteria. The genus Colwellia belonging to γ-Proteobacteria was predominant in this sample. The shift of bacterial communities among different sections of the WP sediment core was δ-, ε-Proteobacteria, and Cytopahga-Flexibacteria-Bacteroides （CFB） group. The ratios between them in the bacterial communities all showed inversely proportional to the depth of sediment. The sequences related to sulphate reducing bacteria （SRB） were detected in every section. The bacterial community structure in this sediment core might be related to the environmental characteristics of the surface seawater of the western Pacific WP.

关键词： western Pacific "warm pool" deep-sea sediment bacterial community

Preparation of Monoclonal Antibody and Development of Enzyme-linked Immunosorbent Assay Specific for Escherichia coli O157 in Foods

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Biomedical and Environmental Sciences 2005年第4期18卷 254-259页

作者： ZHI-jing zhao xiu-MEI LIU National Institute of Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100050 China

To prepare monoclonal antibodies （MAb） and antisera specific for Escherichia coli （***） O157, and to develop a sandwich enzyme-linked immunosorbent assay （ELISA） to detect Eocoli O157 in foods. Methods Spleen cells from BALB/c mice immunized with the somatic antigen of *** O157：H7 were fused with routine Sp2/0 myeloma cells. The hybridoma cell line specific for *** O157 was established after having been subcloned. Antisera specific for *** O157 was prepared by intravenous injection into New Zealand rabbits with a stain of *** O157：H7. The sandwich ELISA was developed with the polyclonal antibody as the capture antibody and the MAb 3A5 as the detection antibody. The inoculated ground poultry meat and pasteurized miLk were tested to confirm efficiency of the method. Results MAb 3A5 specific for *** O157 and O 113：H21 belonged to subtype IgM. The ascetic titers of the antibody was 1：1× 10^6. No cross-reactivity of the MAb was observed with strains of Salmonella spp, Yersinia enterocolitica, Shigella dysenteriae, etc. The purified polyclonal antibody had a titer of 1： 1× 10^5 with *** O 157. The detection limit of this sandwich ELISA was 10^3- 10^4 cfu *** O157/mL in pure culture with a high specificity, which was characterized by every non-O157 strain with negative response. With 10h enrichment procedure, *** O157：H7 recovered well from inoculated ground poultry meat and pasteurized milk at levels of 0.1 cfu/g and 0.1 cfu/mL. Conclusion MAb 3A5 specific for *** O 157 and O 113：H21 can be produced by immunizing BALB/c mice with a strain of *** O157：H7. Then a sandwich ELISA can be developed with the polyclonal antibody as the capture antibody and the MAb 3A5 as the detection antibody. The method is proved to be a sensitive and specific technique to detect low number of *** O157 in food.

关键词： Escherichia coli O 157 Monoclonal antibody Polyclonal antibody ELISA

Theoretical analysis and experimental study of an air inflated membrane structure

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第1期11卷 25-33页

作者： jing-hai GONG xiu-ying YANG Zi-zhao ZHANG Jin-cheng zhao Department of Civil Engineering Shanghai Jiao Tong University Sharighai 200240 China

In this paper,an experimental study of an air inflated membrane was carried out based on the China National Stadium (the Bird's Nest). After the 2008 Olympic Games,it was apparent that the future use of the Bird's Nest would be enhanced if rainfall could be prevented from entering the stadium. The installation of an air inflated membrane across the opening of the steel structure was proposed as a solution to this problem. To verify the scheme,a theoretical analysis and experimental study of an air inflated membrane was carried out. Experimental and computational models were developed,form-finding was carried out using both experimental and theoretical methods,and the results from the two approaches,including the deflection of the air inflated membrane and deformation of the support structure,were analyzed and compared. The force-transfer path and deformation of the air inflated membrane under loads was studied. Conclusions and suggestions are presented.

关键词： China National Stadium Air inflated membrane Form-finding

Coextraction of microbial metagenomic DNA and RNA from deep-sea sediment

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Acta Oceanologica Sinica 2007年第6期26卷 150-157页

作者： zhao jing YANG Xiangsheng zeng Runying College of Oceanography and Environmental Science Xiamen University Xiamen 361005 China School of Life Sciences Xiamen University Xiamen 361005 China Key Laboratory of Marine Biogenetic Resources Third Institute of Oceanography State Oceanic Administration Xiamen 361005 China

A protocol to coextract the microbial metagenomic DNA and RNA from deep-sea sediment was developed for the microbiological study of environmental samples. The obtained pure metagenomic DNA with the size larger than 23 kb and stable RNA could be used directly for PCR and reverse transcription - PCR （ RT - PCR） respectively. The direct lysis including the treatments of SDS, proteinase and lysozyme was applied to acquiring the metagenomic DNA and RNA furthest. Prior to the lysis treatment, the glass bead and denaturing solution were added to enhance the lysis efficiency and keep the integrity of RNA respectively. Denaturing gradient gel electrophoresis （DGGE） was applied in accessing the microbial 16S rRNA diversity by PCR and RT -PCR amplification from a single extraction. The pattern obtained by this analysis revealed some differences between them, indicating the efficiency of the protocol in extracting the metagenomic DNA and total RNA from deep-sea sediment.

关键词： deep-sea sediment metagenomic DNA total RNA coextraction

Green synthesis of 1,2,4-thiadizoles from thioamides in water using molecular oxygen as an oxidant

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Chinese Chemical Letters 2014年第11期25卷 1499-1502页

作者： Jin-Wu zhao jing-xiu Xu xiu-Zhen Guo School of Pharmacy Guangdong Medical College

We present here an efficient green process for the synthesis of 1,2,4-thiadiazoles via iodine-catalyzed,oxidative dimerization of thioamides in water using molecular oxygen as a terminal oxidant. Under the optimized reaction conditions, aryl thioamides produced 3,5-diaryl-1,2,4-thiadiazoles in good to excellent yields. Alkyl thioamides and substituted thioureas could also provide corresponding 1,2,4-thiadiazole products.

关键词： 1 2 4-Thiadizole Thioamide Water Oxygen