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Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang Zhang Xia sheng Quanju Ding Yujun Wang Jiwei zhao Jingfa Zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

多光子纳米加工中激光扫描条件对金属微纳结构的影响

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材料工程 2011年第12期39卷 58-62页

作者：靳伟董贤子赵震声段宣明中国科学院功能晶体与激光技术重点实验室北京100190 中国科学院研究生院北京100190

研究了飞秒激光多光子还原制备银微纳结构技术中激光扫描条件对金属微纳结构与形貌的影响。结果表明:增加激光扫描点间距d可获得较小线宽,延长曝光时间t使线条变宽,增加扫描次数N可使金属微纳结构表面银纳米粒子熔融凝固成较大尺寸颗粒... 详细信息

研究了飞秒激光多光子还原制备银微纳结构技术中激光扫描条件对金属微纳结构与形貌的影响。结果表明:增加激光扫描点间距d可获得较小线宽,延长曝光时间t使线条变宽,增加扫描次数N可使金属微纳结构表面银纳米粒子熔融凝固成较大尺寸颗粒及块状物。

关键词：多光子纳米加工多光子光化学还原金属微纳结构

MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self‑Powered Motion Sensing

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Nano-Micro Letters 2025年第3期17卷 265-279页

作者： Yu‑Ze Wang Yu‑Chang Wang Ting‑Ting Liu Quan‑Liang zhao Chen‑Sha Li Mao‑sheng Cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Materials Science and Engineering Peking UniversityBeijing 100871People’s Republic of China School of Mechanical and Material Engineering North China University of TechnologyBeijing 100144People’s Republic of China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080People’s Republic of China

Polymeric microwave actuators combining tissue-like softness with programmablemicrowave-responsive deformation hold great promise for mobile intelligentdevices and bionic soft robots. However, their application is challenged by restricted electromagneticsensitivity and intricate sensing coupling. In this study, a sensitized polymericmicrowave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx(MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique spacechargepolarization and interfacial polarization, resulting in significant improvements of230% in the dielectric loss factor and 830% in the apparent efficiency of electromagneticenergy harvest. The sensitized microwave actuation demonstrates as the shortenedresponse time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (upto 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combinesdriving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of ~ 3 mV) duringactuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approachfor developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

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检察机关在刑事和解中角色冲突的原因探析

湖南人文科技学院学报 2008年第5期25卷 77-79页

作者：赵胜珍湘潭大学法学院湖南湘潭411105

由于刑事和解与传统的解决刑事纠纷的方式在目的、价值等不同,检察机关的检察权在刑事和解中有了新的诠释,而检察机关又必须在现有的法律框架下进行实践操作,难免会出现各种不同的角色身份之间的冲突,检察机关在刑事和解中存在角色的冲... 详细信息

由于刑事和解与传统的解决刑事纠纷的方式在目的、价值等不同,检察机关的检察权在刑事和解中有了新的诠释,而检察机关又必须在现有的法律框架下进行实践操作,难免会出现各种不同的角色身份之间的冲突,检察机关在刑事和解中存在角色的冲突,主要是由于检察系统考评机制的影响、立法原因、缺乏有效的控权机制、法制宣传不够等原因。

关键词：检察机关刑事和解角色冲突原因

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论检察机关在刑事和解中的作用

铜仁学院学报 2010年第5期4卷 21-23页

作者：赵胜珍湖南人文科技学院湖南娄底417000

当前我国各地检察机关对刑事和解展开了积极的实践和探索。由于我国对于刑事和解制度没有统一的立法,各地的检察机关分别以不同的模式参与刑事和解。检察机关的性质决定了检察机关在刑事和解中的作用。检察机关应采取指导监督的模式参... 详细信息

当前我国各地检察机关对刑事和解展开了积极的实践和探索。由于我国对于刑事和解制度没有统一的立法,各地的检察机关分别以不同的模式参与刑事和解。检察机关的性质决定了检察机关在刑事和解中的作用。检察机关应采取指导监督的模式参与到刑事和解中去,其在刑事和解中起的应是监督、保障以及平衡协调作用。

关键词：刑事和解检察机关监督

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua zhao Lei Xi zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang Liu Tingting Li Chengcheng Gai Danqing Xin Yijing zhao Yan Song Yahong Cheng Tong Li zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

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双室双层浮动床在电厂水处理中的应用

节能 2004年第4期23卷 49-51页

作者：赵振声中石化长岭分公司动力厂湖南岳阳414012

通过采用以双室双层浮动床为制水设备 ,不仅能够提高除盐水系统的供给能力 ,而且能够优化生产工艺 ,提高再生液的利用率 ,达到节能降耗增效益的目的。

关键词：电厂水处理双室双层浮动床固定床除盐水

Ultrastructure Observation of Cysticercus Pisiformis and Its Function Analysis

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Animal Husbandry and Feed Science 2012年第4期4卷 145-149,160页

作者： PAN Yao-qian zhao zhen-sheng CHEN Jin-shan YIN Mei TANG Hai-rong LI Rui-zheng LI Hui-zheng LIU Zhi-ke ZHANG Li-jie LIU Xing-you College of Animal Science Henan Institute of Science and Technology College of Animal Science and Technology Henan University of Science and Technology

[ Objective] The aim of the study was to observe the ultrastructure of Cysticercus pisiformis under different state. [ Method] The Cysti- cercus pisiformis were obtained in the procedure of slaughter inspection form meat-packing plant. The Cysticercus pisiformis was taken out by cut- ting cyst directly, or cultured with physiologic saline containing 10% bile until evagination. Then it was observed and recorded by scanning electron microscopy. [ Result] Observed from top of scolex of Cysticercus pisiformis locate in cyst, the rostellum looked like an umbrella. The cutaneous muscular columns with hamula covered the front end of scolex. Viewed from the side, a row of antlers-liking hamula adhered to the scolex. Four suckers were looked like more width and body segments less time, in which there were lots of wrinkles in their surface respectively. The Cysticercus pisiformis cultured was divided obviously into scolex, neck, body segment and zone of cyst. When cutaneous muscular column of rostellum con- tracted, the antler-liking hamula extended to periphery that the ring-liking contraction appeared in neck and the lengthways contraction in body seg- ments. [ Conclusion] The Cysticercus pisiformis under different state has distinctly dissimilar ultrastructure.

关键词： Cysticercus pisiformis Ultrastructure Rostellum Sucker Scanning electron microscope