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建筑与装饰 2024年第8期 145-147页

作者：赵玉霞平度市南村镇人民政府山东青岛 266736

农村自建房的建设面积较大,保温需求难以满足,长期采用家用电器来进行隔热保温,不仅增加了生活成本,也极大影响着人们的居住舒适性.以农村自建房保温技术为研究对象,通过对农村自建房保温优势进行剖析,寻找到农村自建房的保温需求,以此... 详细信息

农村自建房的建设面积较大,保温需求难以满足,长期采用家用电器来进行隔热保温,不仅增加了生活成本,也极大影响着人们的居住舒适性.以农村自建房保温技术为研究对象,通过对农村自建房保温优势进行剖析,寻找到农村自建房的保温需求,以此为切入点来分析农村自建房的保温技术的进展现状,包括屋顶架空隔热保温、悬挑屋檐隔热保温以及窗户隔热保温,根据当前的进展现状,提出了农村自建房保温技术的优化举措,即在保温层材料、保温层设计厚度、保温层的完整性以及保温层施工时间和方式等几方面,以此来达到农村自建房降低生活成本、提升居住舒适度以及延长房屋使用寿命的目的.

关键词：农村自建房保温技术保温效果优化举措

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生态批评视域下葛水平文学作品中的乡村书写

山西大同大学学报（社会科学版） 2024年第3期38卷 106-110页

作者：赵宇霞长治学院外语系山西长治046011

在作家葛水平的文学世界里,山西晋东南太行山区的乡村书写始终是作家致力的书写焦点。不管是地理空间映射的恋地情结还是民俗风物蕴含的家园意识,作家的审美情感始终贯穿于其乡村书写之中;从“人与自然共生”“敬畏生命”角度审视作家... 详细信息

在作家葛水平的文学世界里,山西晋东南太行山区的乡村书写始终是作家致力的书写焦点。不管是地理空间映射的恋地情结还是民俗风物蕴含的家园意识,作家的审美情感始终贯穿于其乡村书写之中;从“人与自然共生”“敬畏生命”角度审视作家的生态伦理,不仅是对作家乡村书写实质的探讨,同时也是对当下日渐式微的乡村文化及乡民普遍经历的精神生态危机的关照。

关键词：葛水平乡村书写审美情感生态伦理

Modification of Nano-alumina Surface by Michael Addition Reaction

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Chinese Chemical Letters 2006年第2期17卷 251-252页

作者： Jie ZHANG Jian yu zhao xia GUO Institute of Polymer Science and Engineering Department of Chemical EngineeringSchool of Materials Science and Engineering Tsinghua University Beijing 100084

A general method for modification of nano-alumina surface is investigated using Michael addition reaction with α,β-unsaturated carbonyl compounds.

关键词： Alumina surface modification Michael addition reaction carbonyl compounds ester.

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一种可变直径软体机器人的设计

科学技术与工程 2024年第2期24卷 631-638页

作者：赵玉侠万学锋多会晓钮乾坤北方工业大学机械与材料工程学院北京100144 南通大学药学院南通226001

为了解决刚性机械手安全性低、适应性差的问题,设计了一款具有抓取功能的软体机器人。该软体机器人由三个呈圆周120°分布的软体驱动器和一个夹具组成,夹具可以实现自动化改变直径以适应不同大小物体的抓取,经测算软体机器人可以抓取直... 详细信息

为了解决刚性机械手安全性低、适应性差的问题,设计了一款具有抓取功能的软体机器人。该软体机器人由三个呈圆周120°分布的软体驱动器和一个夹具组成,夹具可以实现自动化改变直径以适应不同大小物体的抓取,经测算软体机器人可以抓取直径范围为45~97 mm的物体。夹具和软体驱动器都采用3D打印制造,具有成本低、制造简单、易于大规模生产的优点。软体机器人采用气压驱动,当给驱动器充气时,三手指同时弯曲抓取物体,具有很好的稳定性。对于软体驱动器建立了相应的力学模型,得到了弯曲角度与输入气压的关系,并利用ABAQUS有限元仿真软件对驱动器弯曲特性进行仿真。对比发现,理论建模和仿真分析在驱动器弯曲角度具有很高的吻合性。

关键词：变直径软体机器人软体驱动器弯曲角度

Tong-xin-luo capsule inhibits left ventricular remodeling in spontaneously hypertensive rats by enhancing PPAR-γ expression and suppressing NF-κB activity

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Chinese Medical Journal 2008年第2期121卷 147-154页

作者： BU Pei-li zhao Xue-qiang WANG Li-ling zhao yu-xia LI Chuan-bao ZHANG yun Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Public Health Department of Cardiology Qilu Hospital of Shandong University Ji'nan Shandong 250012 China Department of Traditional Chinese Medicine Qilu Hospital of Shandong University Ji'nan Shandong 250012 China Department of Pediatrics Shandong Provincial Hospital Ji'nan Shandong 250021 China

Background Tong-xin-luo capsule （TXL）, used as a traditional Chinese herb, offeres a therapeutic potential for treatment of cardiovascular diseases. It has been shown to exert a variety of pharmacological effects, including antihypertensive effects, and is able to improve ventricular remodeling. However, the mechanisms of its action are not completely understood. The aim of this study was to evaluate the molecular mechanisms of Tong-xin-luo capsule on left ventricular remodeling in spontaneously hypertensive rats （SHR）. Methods Sixteen eight-week-old SHRs were randomized into an SHR group （n=8） and a TXL group （n=8） that were given Tong-xin-luo capsule （1.5 mg·kg^-1·d^-1）. Eight Wistar Kyoto （WKY） rats fed with 0.9% NaCl served as the control group （WKY group）. Systolic blood pressure （BP）, body weight and heart rate were monitored once every two weeks. Ventricular remodeling was detected by histopathological examination. Nuclear factor kappa B P65 （NF-κB P65） and peroxisome proliferators activated receptor y （PPAR-γ） protein and phosphorylated inhibitor kappa a （IκBα） protein were detected by immunohistochemistry and western blot respectively. The physical interaction of the P65-P50 heterodimer with IκBα and NF-κB were measured by co-immunoprecipitation. PPAR-γ mRNA, collagen Ⅰ mRNA and collagen Ⅲ mHNA were measured by real-time PCR.Results TXL inhibited NF-κB P65 expression and ventricular remodeling and suppressed the activation of NF-κB compared with the SHR group （P〈0.01, P〈0.05）. TXL reduced IκBα phosphorylation, increased expression of PPAR-γ protein and enhanced the physical interaction of the P65-P50 heterodimer with IκBα. The mRNA expression of PPAR-γ was enhanced but the mRNA expression of collagen Ⅰ mRNA and collagen Ⅲ mRNA were suppressed by TXL. Conclusions In spontaneously hypertensive rats, TXL could inhibit ventricular remodeling induced by hypertension, and the inhibitory effect might be associated with the process of TXL increasing the express

关键词： peroxisome proliferator-activated receptors ventricular remodeling Chinese herbal nuclear factor-kappa B inbred spontaneously hypertensive rat

Evolution of inner wall wrinkle defects in the sinking zone of a thick-walled steel tube during radial forging

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Advances in Manufacturing 2024年第2期12卷 396-408页

作者： yu-zhao Yang Cheng Xu Li-xia Fan School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094People’s Republic of China

An axial wrinkle defect was observed in the inner wall of the sinking zone of a thick-wall steel tube processed by cold radial *** can evolve into *** present study focuses on the evolution of wrinkles and the effects of process parameters on them using a three-dimensional radial forging process finite element model,radial forging experiments,and surface morphology *** results indicated that the vertical section angle of the hammer die and the size of the tube blank significantly affect the evolution of *** height-to-width ratioλwas introduced to describe the morphology of *** had an approximately linear relationship with the radius reduction in the sinking *** was a linear correlation between the growth slope ofλand the axial to circumferential strain ratio|εr/εθ|,which can predict theλunder few process *** the 30SiMn2MoVA steel,at the junction of the forging and sinking zones,the threshold ofλof the wrinkle that can evolve into a fissure is approximately 1.123.

关键词： Radial forging Inner wall Wrinkle defects Evolution Sinking zone

Ginsenoside Rd Induces Differentiation of Myeloid Leukemia Cells via Regulating ERK/GSK-3βSignaling Pathway

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Chinese Journal of Integrative Medicine 2024年第7期30卷 588-599页

作者： JIANG yu-xia zhao Yan-na yu xiao-ling YIN Li-ming Department of Hematology Tongde Hospital of Zhejiang ProvinceHangzhou310012China Institute of Hematology Research the First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou310006China

Objective To investigate the role of ginsenoside Rd(GRd)in acute myeloid leukemia(AML)cell *** AML cells were treated with GRd(25,50,100 and 200µg/mL),retinoic acid(RA,0.1g/L)and PD98059(20 mg/mL)for 72 h,cell survival was detected by methylthiazolyldiphenyl-tetrazolium bromide and colony formation assays,and cell cycle was detected by flow *** morphology and differentiation were observed by Wright-Giemsa staining,peroxidase chemical staining and cellular immunochemistry assay,*** protein expression levels of GATA binding protein 1(GATA-1),purine rich Box-1(PU.1),phosphorylated-extracellular signal-related kinase(p-ERK),ERK,phosphorylated-glycogen synthase kinase-3β(p-GSK3β),GSK3βand signal transducer and activator of transcription 1(STAT1)were detected by Western ***-six mice were randomly divided into 3 groups using a random number table:model control group(non-treated),GRd group[treated with 200 mg/(kg·d)GRd]and homoharringtonine(HTT)group[treated with 1 mg/(kg·d)HTT].A tumor-bearing nude mouse model was established,and tumor weight and volume were *** of subcutaneous tumor tissue were observed after hematoxylin and eosin ***1 and GATA-1 expressions were detected by immunohistochemical *** The cell survival was inhibited by GRd in a dose-dependent manner and GRd caused G0/G1 cell arrest(p<0.05).GRd treatment induced leukemia cell differentiation,showing increased expressions of peroxidase and specific proteins concerning erythrogenic or granulocytic differentiation(p<0.05).GRd treatment elicited upregulation of p-ERK,p-GSK-3βand STAT1 expressions in cells,and reversed the effects of PD98059 on inhibiting the expressions of peroxidase,GATA-1 and PU.1(P<0.05).After GRd treatment,tumor weight and volume of mice were decreased,and tumor cells underwent massive apoptosis and necrosis(P<0.05).WT1 level was decreased,and GATA-1 level was significantly increased in subcutaneous tumor ti

关键词： ginsenoside Rd myeloid leukemia survival differentiation extracellular signal-related kinase signaling pathway

Molecular engineering binuclear copper catalysts for selective CO_(2) reduction to C_(2) products

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Journal of Energy Chemistry 2024年第6期93卷 166-173,I0005页

作者： Qi zhao Kai Lei Bao yu xia Rachel Crespo-Otero Devis Di Tommaso Department of Chemistry School of Physical and Chemical SciencesQueen Mary University of LondonLondonE14NSUK Key Laboratory of Material Chemistry for Energy Conversion and Storage(Ministry of Education) Hubei Key Laboratory of Material Chemistry and Service FailureState Key Laboratory of Materials Processing and Die&Mould TechnologySchool of Chemistry and Chemical EngineeringHuazhong University of Science and Technology(HUST)Wuhan 430074HubeiChina Department of Chemistry University College LondonLondonWC1H 0AJUK Digital Environment Research Institute Queen Mary University of LondonEmpire HouseLondon E11HHUK

Molecular copper catalysts serve as exemplary models for correlating the structure-reaction-mechanism relationship in the electrochemical CO_(2) reduction(eCO_(2)R),owing to their adaptable environments surrounding the copper metal *** investigation,employing density functional theory calculations,focuses on a novel family of binuclear Cu molecular *** modulation of their coordination configuration through the introduction of organic groups aims to assess their efficacy in converting CO_(2) to C_(2)*** findings highlight the crucial role of chemical valence state in shaping the characteristics of binuclear Cu catalysts,consequently influencing the eCO_(2)R behaviour,Notably,the Cu(Ⅱ)Cu(Ⅱ)macrocycle catalyst exhibits enhanced suppression of the hydrogen evolution reaction(HER),facilitating proton trans fer and the eCO_(2)R *** rthermore,we explo re the impact of diverse electro n-withdrawing and electron-donating groups coordinated to the macrocycle(R=-F,-H,and-OCH_3)on the electron distribution in the molecular *** placement of-OCH_3 groups in the macrocycles leads to a favourable oxidation state of the Cu centres and subsequent C-C coupling to form C_(2) *** research provides fundamental insights into the design and optimization of binuclear Cu molecular catalysts for the electrochemical conversion of CO_(2) to value-added C_(2) products.

关键词： Molecular catalyst design Selective CO_(2)reduction C_(2)products Density functional theory calculations

Toward a rapid and convenient nanoplastic quantification method in laboratory-scale study based on fluorescence intensity

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Frontiers of Environmental Science & Engineering 2024年第5期18卷 117-126页

作者： Ruiqi Yan Sen Lin Qian Ding Lei Zhang xia yu Wentao zhao Qian Sui State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process School of Resources and Environmental EngineeringEast China University of Science and TechnologyShanghai200237China State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai200092China

The thorough investigation of nanoplastics(NPs)in aqueous environments requires efficient and expeditious quantitative analytical methods that are sensitive to environmentally relevant NP concentrations and convenient to *** analysis-based quantitative methods have been acknowledged as effective and rapid approaches for quantifying NP concentrations in laboratory-scale ***,we compared three commonly used optical response indicators,namely fluorescence intensity(FI),ultraviolet absorbance,and turbidity,to assess their performance in quantifying ***,orthogonal experiments were conducted to evaluate the influence of various water quality parameters on the preferred indicator-based quantification *** results revealed that FI exhibits the highest correlation coefficient(>0.99)with NP ***,the limit of quantification(LOQ)for various types of NPs is exceptionally low,ranging from 0.0089 to 0.0584 mg/L in ultrapure water,well below environmentally relevant *** variations in water quality parameters such as pH,salinity,suspended solids(SS),and humic acid,a robust relationship between detectable FI and NP concentration was ***,an increased matrix,especially SS in water samples,results in an enhanced LOQ for ***,the quantitative method remains applicable in real water bodies,especially in drinking water,with NP LOQ as low as 0.0157–0.0711 mg/*** exceeds the previously reported detectable concentration for 100 nm NPs at 40µg/mL using surface-enhanced Raman *** study confirms the potential of FI as a reliable indicator for the rapid quantification of NPs in aqueous environments,offering substantial advantages in terms of both convenience and cost-effectiveness.

关键词： Nanoplastic quantification Fluorescence intensity Drinking water Limit of quantification(LOQ) Matrix effects