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基于网络药理学和分子对接技术探讨药对赤芍-牡丹皮治疗银屑病的作用机制

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世界中医药 2021年第14期16卷 2061-2066页

作者：刘琪琪王春柳支文冰刘洋李纯周洁张红宗时宇赵一丁李晔陕西中医药大学药学院咸阳712046 陕西省中医药研究院西安710003

目的:基于网络药理学和分子对接技术研究赤芍-牡丹皮药对治疗银屑病的作用机制。方法:利用中药系统药理学数据库与分析平台(TCMSP)数据库检索赤芍-牡丹皮的化学成分及其相关靶点,利用DisGeNET数据库检索银屑病相关靶点,通过Venny 2.1.0... 详细信息

目的:基于网络药理学和分子对接技术研究赤芍-牡丹皮药对治疗银屑病的作用机制。方法:利用中药系统药理学数据库与分析平台(TCMSP)数据库检索赤芍-牡丹皮的化学成分及其相关靶点,利用DisGeNET数据库检索银屑病相关靶点,通过Venny 2.1.0映射得到赤芍-牡丹皮治疗银屑病的交集靶点,利用STRING数据库及Cytoscape3.7.1构建交集靶点蛋白质-蛋白质相互作用(PPI),利用R语言进行基因本体(GO)富集分析和京都基因和基因组百科全书(KEGG)富集分析;利用Cytoscape3.7.1软件构建网络互作图。采用AutoDock4.2.1软件评价主要药效成分与核心靶点的结合作用力。结果:筛选得到赤芍-牡丹皮药对通过11个活性成分作用于70个交集靶点,通过调控细胞的氧化刺激反应和生物刺激反应等生物过程以及丝裂原活化蛋白激酶(MAPK)通路、辅助性T细胞17(TH17)细胞分化等相关途径共同发挥治疗银屑病作用。分子对接结果表明,赤芍-牡丹皮中槲皮素(Quercetin)、芍药苷(Paeoniflorin)、山柰酚(Kaempferol)、芍药醇(Baicalein)与AKT1、VEGFA、MAPK1、MAPK8、AKT1、JUN、TNF具有较好的结合能力。结论:通过网络药理学和分子对接技术系统地探讨赤芍-牡丹皮药对治疗银屑病的作用机制,为后期的实验提供了理论依据。

关键词：银屑病网络药理学分子对接赤芍-牡丹皮

Nanomeshed Si nanomembranes

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npj Flexible Electronics 2019年第1期3卷 78-85页

作者： Xun Han Kyung Jin Seo Yi Qiang Zeping Li Sandra Vinnikova yiding Zhong Xuanyi zhao Peijie Hao Shuodao Wang Hui Fang Department of Electrical and Computer Engineering Northeastern UniversityBostonMA 02115USA School of Mechanical and Aerospace Engineering Oklahoma State UniversityStillwaterOK 74074USA

One of the main challenges in stretchable electronics is to achieve high-performance stretchable semiconductors. Here, weintroduce an innovative concept of nanomeshed semiconductor nanomembrane which can be regarded almost as intrinsicallystretchable to conventional microelectronic layouts. By making a silicon film into homogeneous nanomeshes with spring-like nanotraces, we demonstrated a high electron mobility of 50 cm^(2)/V·s, and moderate stretchability with a one-time strain of 25% andcyclic strain of 14% after stretching for 1000 cycles, further improvable with optimized nanomesh designs. A simple analytic modelcovering both fractional material and trace sidewall surfaces well predicted the transport properties of the normally on siliconnanomesh transistors, enabling future design and optimizations. Besides potential applications in stretchable electronics, thissemiconductor nanomesh concept provides a new platform for materials engineering and is expected to yield a new family ofstretchable inorganic materials having tunable electronic and optoelectronic properties with customized nanostructures.

关键词： stretching inorganic fractional

Diminished functional segregation and resilience are associated with symptomatic severity and cognitive impairments in schizophrenia: a large-scale study

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General Psychiatry 2024年第5期37卷 532-542页

作者： Haohao Yan yiding Han Xijjia Xu Hongxing Zhang Yiqun He Guojun Xie Huabing Li Feng Liu Ping Li Jingping zhao Wenbin Guo Department of Psychiatry National Clinical Research Center for Mental Disordersand National Center for Mental DisordersThe Second Xiangya Hospital of Central South Universitv Chanagsha Hunan China Department of Psychiatry the Affiliated Brain Hospital of Nanjing Medical UniversityNanjing Brain HospitalNanjingJiangsuChina Department of Psychiatry The Second Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenanChina Department of Clinical Psychology Psychology School of Xinxiang Medical UniversityXinxiangHenanChina Department of Psychosomatic Medicine The Second Affliated Hospital of Xinxiang Medical UniversityXinxiangHenanChina Department of Psychiatry The Third People's Hospital of FoshanFoshanGuangdongChina Department of Radiology The Second Xiangya Hospital of Central South UniversityChangshaHunanChina Department of Radiology Tianjin Medical University General HospitalTianjinChina Department of Psychiatry Qiqihar Medical UniversityQiqiharHeilongjangChina

Background The research findings on the topological properties of functional connectomes(TP-FCs)in patients with schizophrenia(SZPs)exhibit inconsistencies and contradictions,which can be attributed to limitations such as small sample sizes and heterogeneous data processing *** To address these limitations,we conducted a large-scale *** processing flows were employed to investigate the aberrant TP-FCs and the associations between TP-FCs and symptoms or cognitions(A-TP-SCs)in *** The large-scale study included six datasets from four sites,involving 497 SZPs and 374 healthy controls(HCs).A uniform process for imaging data preprocessing and functional connectivity matrix configuration was *** was employed for data harmonisation,and various TPs were *** explored between-group differences in brain functional integration(Fl)and functional segregation(FS)measured with TP-FCs,and conducted partial correlation analyses,with adjustments for age,gender and educational level,to identify *** Comparedwith randomnetworks and HCs,SZPs maintained small-worldness and global FI capacity despite their compromised global FS capacity and resilience.A decline in nodal Fl and FS capacity was observed in sensory areas,whereas an increase in nodal FI capacity was found in regions associated with cognition and information *** addition,associations between TP-FCs and positive symptoms,negative symptoms or cognitive functions including speed of processing,visual learning and the ability to inhibit cognitive interference were identified in *** The identified A-TP-SCs verified that reductions in FS and resilience indicated pathological impairments in *** A-TP-SCs or TP-FCs,which measured the same attributes of the functional connectomes,exhibited high internal consistency,robustly reinforcing these findings.

关键词： finding limitations contradiction

镇心安神法治疗特应性皮炎多中心随机对照研究

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中国药业 2021年第20期30卷 87-90页

作者：迟慧彦黄尧洲李贻奎陈少君佘远遥姚春海赵一丁文海泉王萍马琳顾超颖郎娜中国中医科学院西苑医院北京100091 中南大学附属湘雅二医院湖南长沙410008 首都医科大学附属北京中医医院北京100010 首都医科大学附属北京儿童医院北京100045 复旦大学附属华山医院上海200040

目的探讨镇心安神法治疗特应性皮炎(AD)的临床疗效。方法选取作者所在5家医院收治的AD患者210例,随机分为试验组和对照组,各105例。试验组患者按辨证分型予中药镇心安神法治疗;对照组患者予氯雷他定片口服及丁酸氢化可的松乳膏外用。两... 详细信息

目的探讨镇心安神法治疗特应性皮炎(AD)的临床疗效。方法选取作者所在5家医院收治的AD患者210例,随机分为试验组和对照组,各105例。试验组患者按辨证分型予中药镇心安神法治疗;对照组患者予氯雷他定片口服及丁酸氢化可的松乳膏外用。两组均持续治疗8周。结果试验组脱落9例,对照组脱落8例、剔除1例。试验组总有效率为88.54%,与对照组的83.33%无显著差异(P>0.05);两组患者病变范围、皮疹严重程度、瘙痒指数与影响睡眠程度、特应性皮炎指数(SCORAD)评分、生活质量评分均无显著差异(P>0.05);试验组复发率为22.22%,显著低于对照组的54.17%(P0.05)。结论镇心安神法治疗AD,具有较好的近期和远期疗效,且能降低复发率。

关键词：特应性皮炎多中心随机对照试验镇心安神法近期疗效远期疗效

Development of a widely targeted volatilomics method for profiling volatilomes in plants

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Molecular Plant 2022年第1期15卷 189-202页

作者： Honglun Yuan Guangping Cao Xiaodong Hou Menglan Huang Pengmeng Du Tingting Tan Youjin Zhang Haihong Zhou Xianqing Liu Ling Liu yiding Jiangfang Yufei Li Zhenhuan Liu Chuanying Fang Liqing zhao Alisdair R.Fernie Jie Luo College of Tropical Crops Hainan UniversityHaikou 570288China Sanya Nanfan Research Institute of Hainan University Hainan Yazhou Bay Seed LaboratorySanya572025China College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research(Wuhan) Huazhong Agricultural UniversityWuhan 430070China Department of Molecular Physiology Max-Planck-lnstitute of Molecular Plant PhysiologyAm Muhlenberg 114476 Potsdam-GolmGermany

Volatile organic compounds play essential roles in plant environment interactions as well as determining the fragrance of *** gas chromatography-mass spectrometry-based untargeted metabolo-mics is commonly used to assess plant volatiles,it suffers from high spectral convolution,low detection sensitivity,a limited number of annotated metabolites,and relatively poor ***,we report a widely targeted volatilomics(WTV)method that involves using a“targeted spectra extraction”algorithm to address spectral convolution,constructing a high-coverage MS2 spectral tag library to expand volatile annotation,adapting a multiple reaction monitoring mode to improve sensitivity,and using regression models to adjust for signal *** newly developed method was used to profile the volatilome of rice *** with the untargeted method,the newly developed WTV method shows higher sensitivity(for example,the signal-to-noise ratio of guaicol increased from 4.1 to 18.8),high annotation coverage(the number of annotated volatiles increased from 43 to 132),and better reproducibility(the number of volatiles in quality control samples with relative standard deviation value below 30.0%increased from 14 to 92 after normalization).Using the WTV method,we studied the metabolic responses of tomato to environmental stimuli and profiled the volatilomes of different rice *** results identified benzothiazole as a potential airborne signal priming tomato plants for enhanced defense and 2-nonanone and 2-heptanone as novel aromatic compounds contributing to rice *** case studies suggest that the widely targeted volatilomics method is more efficient than those currently used and may considerably promote plant volatilomics studies.

关键词： widely targeted volatilomics GC-MS MS2T library plant volatilome rice tomato

An Association Study on the Cognitive Function and the Cerebral Grey Matter Volume of Patients with First-Episode Schizophrenia

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上海精神医学 2018年第3期30卷 154-167页

作者： Xinyue ZHANG Jingjing YAO yiding LV Xiaoxin zhao Yuan LI Yuxiu SUI Zhiping DAI Nanjing Medical University Nanjing China Ningbo Kangning Hospital Ningbo China Nanjing Brain Hospital Nanjing China

UNASSIGNED:The impairment of cognitive function is one of the core symptoms in schizophrenia, and the degree of recovery is closely related to whether patients are able to rejoin society successfully.;UNASSIGNED:This study was to clarify the correlation between cognitive function and cerebral grey matter volume in schizophrenia.;UNASSIGNED:The neuro-cognitive functions of thirty-seven patients with first-episode schizophrenia (the patient group) and thirty healthy controls (the control group) was evaluated with the Clock Drawing Test, Trail Marking Test, Digit Span Test, Auditory Verbal Learning Test, Wisconsin Card Sorting Test, Verbal Fluency Test, Semantic Similarity Test and Stroop Color-Word Test. The facial emotion cognitive task was employed to assess the facial emotion cognitive functions of thirty-two patients with first-episode schizophrenia (the patient group) and 29 healthy controls (the control group). The psychotic symptoms of patients with first-episode schizophrenia were evaluated using the Positive and Negative Syndrome Scale (PANSS). The brain imaging data of the patient group and control group were collected using the magnetic resonance imagine (MRI).;UNASSIGNED:The difference between the patient group and the control group in the results of Clock Drawing Test, Trail Marking Test, Digit Span Test, Auditory Verbal Learning Test, Wisconsin Card Sorting Test, Verbal Fluency Test, Semantic Similarity Test and Stroop Color-Word Test's reaction time were significant. These two groups' Slopes in the facial emotion cognitive task were also significantly different from each other. According to the comparison of cerebral grey matter volume between the patient group and the control group, it was found that the grey matter volume of the patient group increased in the left superior frontal gyrus, and decreased in the left occipital gyrus, lingual gyrus and upper cerebellum. Based on the analyses of neuro-cognitive data and brain imaging data of the patient gro

关键词：精神分裂症事件函数反应时间协会认知功能数据组织颜色词

Recent Progresses on Ionospheric Climatology Investigations

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Recent Progresses on Ionospheric Climatology Investigations

Empirical modeling of ionospheric F2 layer critical frequency over Wakkanai under geomagnetic quiet and disturbed conditions

中国科学院地质与地球物理研究所2012年度（第12届）学术年会

作者： LIU Libo WAN Weixing CHEN yiding LE Huijun zhao Biqiang Beijing National Observatory of Space Environment Institute of Geology and GeophysicsChinese Academy of Sciences

The ionosphere varies over multiple time scales,which are classified into two categories: the climatology and weather *** this national report,we give a brief summary of recent progresses in ionospheric climatology with focus on(1) the seasonal variations,(2) solar cycle effects, and(3) empirical modeling of the *** seasonal variations of the ionosphere have been explored in many works to give a more detailed picture with regional and global features at various altitudes by analyzing the observation data from various sources and ***,a series of studies reported the response of the ionosphere to solar cycle variations,which revealed some novel and detailed features of solar activity dependence of ionospheric parameters at different altitudes. These investigations have improved our understanding on the states of the ionosphere and underlying fundamental processes,provided clues to future studies on ionospheric weather,and guided ionospheric modeling,forecasting and related applications.

关键词： Ionosphere Climatological variation Seasonal variations Solar cycle Ionospheric modeling

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Empirical modeling of ionospheric F2 layer critical frequenc...

酮肼交联及硅烷偶联水性聚氨酯的成膜机理及其性能研究

中国科学院地质与地球物理研究所2012年度（第12届）学术年会

作者： LIU Jing LIU LiBo zhao BiQiang WAN WeiXing CHEN yiding Beijing National Observatory of Space Environment Institute of Geology and GeophysicsChinese Academy of Sciences Graduate University of Chinese Academy of Sciences State Key Laboratory of Space Weather Center for Space Science and Applied ResearchChinese Academy of Sciences

The hourly values of the ionospheric F2 layer critical frequency,foF2,recorded at Wakkanai lonosonde station(45.4°N, 141.7°E) have been collected to construct a middle-latitude single-station model for forecasting foF2 under geomagnetic quiet and disturbed *** module for the geomagnetic quiet conditions incorporates local time,seasonal,and solar variability of climatological foF2 and its upper and lower *** is the first attempt to predict the upper and lower quartiles of foF2 to account for the notable day-to-day variability in ionospheric *** validation statistically verifies that the model captures the climatological variations of foF2 with higher accuracy than IRI *** storm-time module is built to capture the geomagnetic storm induced relative deviations of foF2 from the quiet time *** the geomagnetically disturbed module,the storm-mduced deviations are described by diurnal and semidiurnal waves,which are modulated by a modified magnetic activity index,the Kf index,reflecting the delayed responses of foF2 to geomagnetic activity *** coefficients of the model in each month are determined by fitting the model formula to the observation in a least-squares *** provide two options for the geomagnetic disturbed module,including or not including Kalman filter *** Kalman filler algorithm is introduced to optimize these coefficients in real *** results demonstrate that the introduction of the Kalman filter algorithm in the storm time module is promising for improving the accuracy of *** addition,comparisons indicate that the IRI model prediction of the F2 layer can be improved to provide better performances over this region.

关键词： Empirical modeling Kalman filter ionospheric storm

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高分子学报 2010年第9期20卷 1122-1128页

作者：赵静沈一丁赖小娟教育部轻化工助剂化学与技术重点实验室陕西科技大学西安710021

用二乙醇胺(DEA)和双丙酮丙烯酰胺(DAAM)按Michael加成反应机理合成了一种新的聚氨酯扩链剂DDP(N-[(1,1-二甲基-2-乙酰基)乙基]-β-二羟乙氨基丙酰胺).以异佛尔酮二异氰酸酯(IPDI)、聚四氢呋喃二醇(PTMG1000)、二羟甲基丙酸(DMPA)、三... 详细信息

用二乙醇胺(DEA)和双丙酮丙烯酰胺(DAAM)按Michael加成反应机理合成了一种新的聚氨酯扩链剂DDP(N-[(1,1-二甲基-2-乙酰基)乙基]-β-二羟乙氨基丙酰胺).以异佛尔酮二异氰酸酯(IPDI)、聚四氢呋喃二醇(PTMG1000)、二羟甲基丙酸(DMPA)、三羟甲基丙烷(TMP)等为主要原料,在用γ-氨基丙基三乙氧基硅烷(KH550)封端改性聚氨酯的基础上,采用自制含酮羰基二元醇N-[(1,1-二甲基-2-乙酰基)乙基]-β-二羟乙氨基丙酰胺(DDP)和1,4-丁二醇(BDO)作为扩链剂,制备了侧链含酮羰基的聚氨酯乳液.通过外加己二酸二酰肼(ADH),制得室温自交联乳液.利用衰减全反射红外光谱(ATR-FTIR)和核磁共振波谱(NMR)对扩链剂(DDP)和涂膜结构进行表征,ATR-FTIR和NMR测试证实了DDP的生成并参与反应合成了聚氨酯及乳液成膜时酮肼交联反应的发生.研究了n(—NHNH2)/n(—CO—)、n(NCO)/n(OH)、DDP含量对聚氨酯涂膜性能的影响.结果表明,在己二酸二酰肼(ADH)的用量为0时,涂膜的吸水率随DDP含量的增加而增大;n(NCO)/n(OH)>1.40时,聚氨酯难以乳化并且乳液稳定性变差;在最佳配比n(—NHNH2)/n(—CO—)=1,n(NCO)/n(OH)=1.40的条件下,DDP%从0增大到7.22%时,涂膜的吸水率从39.36%降低到18.92%同时表现出很好的耐溶剂性能,交联度从51.49%上升至90.23%,拉伸强度从20.09MPa增大到28.26MPa,硬度达2H.热失重分析(TGA)表明酮肼交联结构的引入提高了涂膜的热稳定性.

关键词：高交联水性聚氨酯酮肼交联力学性能吸水率热稳定性