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Arctigenin attenuates paraquat-induced human lung epithelial A549 cell injury by suppressing ROS/p38 mitogen-activated protein kinases-mediated apoptosis

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World Journal of Emergency Medicine 2022年第5期13卷 373-378页

作者： Chao Liu zhao-rui Sun Meng-meng wang Zhi-zhou yang Wei zhang Yi Ren xiao-qin Han rui Liu quan Li Shi-nan Nie Department of Emergency Medicine Jinling HospitalMedical School of Nanjing UniversityNanjing 210002China

BACKGROUND:Paraquat(PQ)-induced acute lung injury(ALI)and pulmonary fi brosis are common diseases with high mortality but without eff ective antidotes in emergency *** previous study has proved that arctigenin suppressed pulmonary fibrosis induced by *** wondered whether arctigenin could also have a protective eff ect on PQ-induced ***:A PQ-induced A549 cell injury model was used,and the effect of arctigenin was determined by a cell counting kit-8(CCK-8)cell viability *** addition,terminal deoxynucleotidyl transferase(TdT)-mediated dUTP nick-end labelling(TUNEL)staining assays and mitochondrial membrane potential assays were performed to evaluate the level of cell *** generation of reactive oxygen species(ROS)was refl ected by dihydroethidium(Dhe)staining and a 2’,7’-dichlorodihy drofluorescein diacetate(DCFH-DA)***,immunoblotting studies were used to assess the expression of mitogen-activated protein kinases(MAPKs)and p38 ***:Arctigenin attenuated PQ-induced inhibition of A549 cell viability in a dose-dependent *** also significantly reduced PQ-induced A549 cell apoptosis,as refl ected by the TUNEL assay and mitochondrial membrane potential assay,which may result from suppressed ROS/p38 MAPK signaling because we found that arctigenin dramatically suppressed ROS generation and p38 MAPK ***:Arctigenin could attenuate PQ-induced lung epithelial A549 cell injury in vitro by suppressing ROS/p38 MAPK-mediated cell apoptosis,and arctigenin might be considered a potential candidate drug for PQ-induced ALI.

关键词： Paraquat A549 cells Arctigenin Reactive oxygen species Mitogen-activated protein kinases Apoptosis

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Dramatic Impact of Auxiliary Ligands on the Dynamic Magnetic Relaxation in Tetranuclear Dy^(III)_(2)Zn^(II)_(2) Single Molecule Magnets

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Chinese Journal of Chemistry 2022年第20期40卷 2415-2420页

作者： Gao-Peng Li Hong-Fang Xie Shi-rui yang yun-Long Fu Yi-quan zhang Yao-Yu wang Key Laboratory of Magnetic Molecules&Magnetic Information Materials of the Ministry of Education School of Chemistry&Material ScienceShanxi Normal UniversityTaiyuanShanxi030031 China Weinan Bureau of Natural Resources and Planning WeinanShaanxi714000 China Jiangsu Key Laboratory for NSLSCS School of Physical Science and TechnologyNanjing Normal UniversityNanjingJiangsu210023 China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education Shaanxi Key Laboratory of Physico-Inorganic ChemistryCollege of Chemistry and Materials ScienceNorthwest UniversityXi'anShaanxi710127 China

Better understanding the determining factors of dynamic magnetic relaxation in polynuclear lanthanide based single-molecule magnets(SMMs)remains a challenge due to the complexity of such architectures involving interactions between the magnetic *** address this issue,two structurally related heterometal Dy^(III)_(2)Zn^(II)_(2) SMMs,[Zn_(2)Dy_(2)(L)_(4)(Ac)_(2)(DMF)(CH_(3)OH)]·CH_(3)OH·2H_(2)O(1)and[Zn_(2)Dy_(2)(L)_(4)(Ac)_(2)(DMF)_(2)]·4CH_(3)CN(2)(H_(2)L=(E)-2-((2-hydroxy-3-methoxybenzylidene)amino)-4-methyphenol,DMF=N,N-dimethylformamide),are introduced and *** modifying the auxiliary ligands on one Dy^(III) site while retaining that on the other Dy^(III),the intramolecular magnetic interactions and relaxation dynamics in these two heterometallic-Dy^(III)_(2)Zn^(II)_(2) SMMs can be tuned,demonstrating a dramatic change in the magnet relaxation behavior with energy barrier changing from a negligible value for 1 to 305 K for *** initio calculations reveal that changing the coordination geometries on the Dy^(III) sites can significantly affect the magnetic interactions as well as single-ion anisotropy.

关键词： Single-molecule magnets Dynamic magnetic relaxation Dysprosium Auxiliary ligands Ab initio calculations

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直肠癌患者新辅助治疗后临床完全缓解或近临床完全缓解行等待观察策略的远期预后:一项来自中国等待观察数据协作组的多中心登记研究

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中华胃肠外科杂志 2024年第4期27卷 372-382页

作者：赵一鸣王维虎张卫王林李帅王靖雯廖乐恩于冠宇孙振屈艳丽巩阳卢云武涛李云峰王权赵国华肖毅丁培荣章真武爱文北京大学肿瘤医院暨北京市肿瘤防治研究所胃肠肿瘤中心三病区恶性肿瘤发病机制及转化研究教育部重点实验室北京100142 北京大学肿瘤医院暨北京市肿瘤防治研究所放射治疗科恶性肿瘤发病机制及转化研究教育部重点实验室北京100142 海军军医大学附属长海医院肛肠外科上海200433 复旦大学上海医学院附属肿瘤医院放射肿瘤科复旦大学上海医学院肿瘤学系上海市放射肿瘤学重点实验室上海200032 中山大学肿瘤防治中心结直肠外科广州510060 中国医学科学院北京协和医学院北京协和医院基本外科北京100730 辽宁省肿瘤医院普通外科沈阳110042 吉林大学第一医院胃结直肠外科长春130021 青岛大学附属医院普外科青岛266555 云南省肿瘤医院结直肠外科昆明650118 消化系肿瘤整合防治全国重点实验室恶性肿瘤转化研究北京市重点实验室北京100142

目的报告中国直肠癌患者新辅助治疗后等待观察后的远期结局。方法基于真实世界的多中心横断面研究。纳入新辅助治疗后评价为临床完全缓解(cCR)或近cCR(near-cCR)进行等待观察的直肠癌患者以及少数新辅助治疗后疗效较好、以活检为目的行... 详细信息

目的报告中国直肠癌患者新辅助治疗后等待观察后的远期结局。方法基于真实世界的多中心横断面研究。纳入新辅助治疗后评价为临床完全缓解(cCR)或近cCR(near-cCR)进行等待观察的直肠癌患者以及少数新辅助治疗后疗效较好、以活检为目的行局部切除确认ypCR的患者,随访时间需≥2年;剔除基线时伴有远处转移或带瘤生存自行等待观察的患者。根据以上标准,回顾性收集中国等待观察数据协作组(CWWD)中的数据信息,包括基本信息、新辅助治疗类型、治疗前影像学检查结果、新辅助治疗后疗效评价、补救措施及治疗结局等,分析本组患者新辅助治疗后等待观察后的远期结局,并比较cCR及near-cCR两组间的差异。结果来自8家医疗中心(北京大学肿瘤医院、复旦大学附属肿瘤医院、中山大学附属肿瘤医院、上海长海医院、北京协和医院、辽宁省肿瘤医院、吉林大学附属第一医院以及云南省肿瘤医院)共计318例接受等待观察且随访超过两年的直肠癌患者的临床资料。全组患者中男性221例(69.4%),女性107例(30.6%);中位年龄60(26~86)岁。肿瘤距离肛缘中位距离为3.4(0~10.4)cm。291例接受新辅助治疗后评效为cCR,27例评效为near-cCR。中位随访48.4(10.2~110.3)个月,5年累计总体生存率(OS)为92.4%(95%CI:86.8%~95.7%),5年累计疾病特异生存率(CSS)为96.6%(95%CI:92.2%~98.5%),5年累计器官保留研究校正无病生存率(OP-DFS)为86.6%(95%CI:81.0%~90.7%),5年累计器官保留率(OPR)为85.3%(95%CI:80.3%~89.1%),5年局部再生率为18.5%(95%CI:14.9%~20.8%),5年远处转移率为8.2%(95%CI:5.4%~12.5%)。全组共56例发生局部再生,82.1%(46/56)的局部再生发生于2年内,91.1%(51/56)的局部再生发生于3年内,中位再生时间为11.7(2.5~66.6)个月。91.1%(51/56)的局部再生发生于肠腔内。共23例患者发生远处转移,60.9%(14/23)远处转移发生于2年内,73.9%(17/23)发生于3年内,中位远处转移时间为21.9(2.6~90.3)个月。17例发生于单个脏器,6例为多脏器转移;累及脏器包括肺转移(15例,65.2%)、肝转移(6例,26.1%)和骨转移(7例,30.4%)。cCR和near-cCR患者的OS、CSS、OP-DFS及远处转移率差异均无统计学意义(均P>0.05);但相比cCR患者,near-cCR患者5年局部再生率较高(41.6%比16.4%,P<0.01),5年OPR率较低(69.2%比88.0%,P<0.001)。局部再生和远处转移拯救成功率(行拯救性手术后转为无疾病证据状态)分别为82.1%(46/56)和13.0%(3/23)。结论新辅助治疗后达到cCR或near-cCR接受等待观察的直肠癌患者具有良好的肿瘤学结局和较高的器官保留率。等待观察过程中的局部再生和远处转移具有一定规律,局部再生拯救率较高,开展过程中需要强调密切的随访和及时的补救。

关键词：直肠肿瘤新辅助治疗等待观察器官保留

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Comparison of the efficacy of anti-VEGF monotherapy versus PDT and intravitreal anti-VEGF combination treatment in AMD： a Meta-analysis and systematic review

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International Journal of Ophthalmology(English edition) 2016年第7期9卷 1028-1037页

作者： Yao Tong Ke-ke zhao Dong Feng Manas Biswal Pei-quan zhao zhao-yang wang yun zhang Eye Hospital of Wenzhou Medical University Wenzhou 325027 Zhejiang Province China Department of Ophthalmology Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai 200092China Department of Ophthalmology Shanghai Children's Medical Center Shanghai Jiaotong University School of MedicineShanghai 200127 China Department of Ophthalmology The First Affiliated Hospital of College of Medicine Zhejiang University Hangzhou 310006 Zhejiang Province China Department of Molecular Genetics University of FloridaGainesville 32610 Florida USA

AIM：To compare the effect of anti-vascular endothelial growth factor（VEGF） monotherapy versus photodynamic therapy（PDT） and anti-VEGF combination treatment in age-related macular degeneration（AMD）.METHODS：A computerized online search was performed using PubMed,Web of Science and the Cochrane *** that compared anti-VEGF monotherapy with PDT and anti-VEGF combination treatment of AMD and were designed as randomized controlled trials were *** means and standard deviations of the best-corrected visual acuity（BCVA）,central retinal thickness（CRT）,number of treatments and proportions of patients who gained BCVA ≥15,10,5,or 0 letters at 12^（th） month were extracted.A systematic review and Meta-analysis of the comparison of the two approaches was conducted using Review Manager ***.A sensitivity analysis was also ***：Eight studies were *** the subgroup and sensitivity analysis was conducted,the results indicated that in the findings that included the monotherapy group and PDT（standard fluence,SF）group of Kaiser＇s study,the patients in the monotherapy group had a better BCVA compared with the combination group at 12^（th） month in the PDT（SF） subgroup[weighted mean difference（WMD）：3.54;95% Cl：0.36 to 6.73;P=0.03],and there were more patients who gained ≥15 letters of BCVA in the monotherapy group compared with the combination group in the total result[odds ratio（OR）：1.41;95% Cl：1.02 to 1.95;P=0.04].The same conclusion was obtained in the total result that included the monotherapy group and PDT（reduced fluence,RF）group of Kaiser＇s study（OR：1.56;95% CI：1.13 to 2.15;P=0.007）.However,there were no significant differences in the other indexes between the two ***：We found that anti-VEGF monotherapy is more effective on the recovery of visual acuity than combination therapy and more researches with lager sample size should be performed to study on the effect of the two therapy approaches on CRT and number of inject

关键词： age-related macular degeneration antivascular endothelial growth factor photodynamic therapy Meta-analysis

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A novel hybrid thermodynamic model for pore size distribution characterisation for shale

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Petroleum Science 2022年第3期19卷 963-978页

作者： Ze-zhang Song Abide Abula Jun-Yi zhao Guang-Di Liu Ming-rui Li Dai-Lin yang yun-Long wang State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China College of Geosciences China University of PetroleumBeijing102249China The Exploration Department of the Changqing Oilfield Company PetroChinaXi'anShaanxi710021China Research Institute of Petroleum Exploration and Development Southwest Oil and Gas Field CompanyPetroChinaChengduSichuan 610041China

Scholars often see the gas adsorption technique as a straight-to-interpret technique and adopt the pore size distribution(PSD)given by the gas adsorption technique directly to interpret pore-structure-related *** oversimplification of interpreting shale PSD based on monogeometric thermodynamic models leads to apparent bias to the realistic pore *** work aims at establishing a novel thermodynamic model for shale PSD *** simplified the pore space into two geometric types—cylinder-shaped and ***,Low-temperature Nitrogen Adsorption data were analyzed utilizing two monogeometric models(cylindrical and slit)to generate PSD_(cyl).and PSD_(slit);Secondly,pore geometric segmentation was carried out using Watershed by flooding on typical SEM images to obtain the ratio of slit-shaped(∅_(s))and cylinder-shaped pores(∅_(c)).Combining the results of the two,we proposed a novel hybrid *** performed pyrolysis,XRD,FE-SEM observation,quantitative comparison with the results obtained by the DFT model,and fractal analysis to discuss the validity of the obtained PSD_(Hybrid).The results showed that:the hybrid model proposed in this work could better reflect the real geometry of pore space and provide a more realistic PSD;compared with thermodynamic monogeometric models,PSD obtained from the hybrid model are closer to that from the DFT model,with an improvement in the deviation from the DFT model from 5.06%to 68.88%.The proposed hybrid model has essential application prospects for better interpretation of shale pore *** is also worth noting that we suggest applying the proposed hybrid model for PSD analysis in the range of 5-100 nm.

关键词： Pore size distribution Monogeometric thermodynamic model The hybrid model Pore structure Shale

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色瓦绵羊GPIHBP1基因克隆及其组织表达特征分析

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南方农业学报 2024年第1期55卷 235-242页

作者：潘君茹李蕊张馨仁青措姆孙宇杨井泉张贞贞陈华丽赵旺生宋天增西南科技大学生命科学与工程学院四川绵阳621010 西藏农牧科学院畜牧兽医研究所西藏拉萨850009 河南农业大学动物科技学院河南郑州450002 新疆农垦科学院畜牧兽医研究所新疆石河子832000

【目的】克隆色瓦绵羊乳腺组织糖基化磷脂酰肌醇锚定高密度脂蛋白结合蛋白1基因(GPIHBP1),明确其生物信息学特性及组织表达分布特征,为揭示GPIHBP1基因影响绵羊产奶性状的作用机制提供参考依据。【方法】克隆色瓦绵羊GPIHBP1基因编码区(... 详细信息

【目的】克隆色瓦绵羊乳腺组织糖基化磷脂酰肌醇锚定高密度脂蛋白结合蛋白1基因(GPIHBP1),明确其生物信息学特性及组织表达分布特征,为揭示GPIHBP1基因影响绵羊产奶性状的作用机制提供参考依据。【方法】克隆色瓦绵羊GPIHBP1基因编码区(CDS)序列,通过Prot Para、Prot Scale、SOPMA、SWISS-MODEL、TMHMM-2.0等在线软件进行生物信息学分析,并以实时荧光定量PCR检测该基因在色瓦绵羊乳腺、肌肉、心脏、肾脏、肝脏、小肠、瘤胃和卵巢等8个组织中的表达情况。【结果】色瓦绵羊GPIHBP1基因CDS序列长519 bp,共编码172个氨基酸残基,与山羊GPIHBP1氨基酸序列(XM_018058666.1)比对,有4处氨基酸发生突变(^(32)A→P、^(52)V→A、^(130)S→N和^(170)M→V);色瓦绵羊GPIHBP1蛋白分子量为18063.87 Da,理论等电点(p I)为4.29,不存在跨膜螺旋结构,但存在信号肽(位于第20~21位氨基酸处),是一种细胞外的酸性亲水性蛋白。色瓦绵羊GPIHBP1蛋白存在12个磷酸化位点(6个丝氨酸磷酸化位点,5个苏氨酸磷酸化位点,1个酪氨酸磷酸化位点),其二级结构以无规则卷曲状态(占55.07%)为主,其次是α-螺旋(占35.47%),延伸链、β-转角分别占5.81%和4.65%。GPIHBP1基因在色瓦绵羊乳腺、肌肉、心脏、肾脏、肝脏、小肠、瘤胃和卵巢等8个组织中均有表达,以乳腺中的相对表达量最高,其次是心脏和肝脏,均极显著高于肌肉中的相对表达量(P<0.01)。【结论】GPIHBP1基因在色瓦绵羊不同组织中均有表达,且以乳腺中的相对表达量最高,可能与乳脂相关基因表达的增减有关,其中,GPIHBP1基因与LPL基因共同作用而参与绵羊泌乳调控。

关键词：色瓦绵羊 GPIHBP1基因乳腺产奶性状泌乳调控

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Use of Rich BHI Medium Instead of Synthetic TMH Medium for Gene Regulation Study in Yersinia pestis

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Biomedical and Environmental Sciences 2012年第6期25卷 639-644页

作者： zhang Yi quan MA Li Zhi wang Li GAO he TAN Ya Fang GUO zhao Biao QIU Jing Fu yang rui Fu ZHOU Dong Sheng State Key Laboratory of Pathogen and Biosecurity Beo'ing Institute of Microbiology and Epidemiology Beijing 100071 China Department of Emergency Medicine General Hospital of Chinese People's Armed Police Forces Beijing 100039 China Department of Medical Laboratory Chongqing Medical University Chongqing 400016 China State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and Prevention Chinese Centre for Disease Control and Prevention Beijing 102206 China

Objective This study is to verify the use of rich BHI medium to substitute synthetic media for gene regulation studies in Yersinia pestis. Methods The transcriptional regulation of rovA by PhoP or via temperature upshift, and that of pla by CRP were investigated when Y. pestis was cultured in BHI. After cultivation under 26 ~C, and with temperature shifting from 26 to 37 ~C, the wild-type （WT） strain or its phoP or crp null mutant （AphoP or Acrp, respectively） was subject to RNA isolation, and then the promoter activity of rovA or plo in the above strains was detected by the primer extension assay. The rovA promoter-proximal region was cloned into the pRW50 containing a promoterless lacZ gene. The recombinant LacZ reporter plasmid was transformed into WT and AphoP to measure the promoter activity of rovA in these two strains with the ^-Galactosidase enzyme assay system. Results When Y. pestis was cultured in BHI, the transcription of rovA was inhibited by PhoP and upon temperature upshift while that ofpla was stimulated by CRP. Conclusion The rich BHI medium without the need for modification to be introduced into the relevant stimulating conditions （which are essential to triggering relevant gene regulatory cascades）, can be used in lieu of synthetic TMH media to cultivate Y. pestis for gene regulation studies.

关键词： Yersinia pestis BHI TMH Gene regulation

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Azobenzene Based Photo-responsive Mechanical Actuator Fabricated by Intermolecular H-bond Interaction

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Chinese Journal of Polymer Science 2021年第4期39卷 417-424,I0005页

作者： Chun-Yan Yu Jia-Hui Mu yun-Lei Fu yun-Chao zhang Ji-Shu Han rui-yang zhao Jia zhao Zi-Hao wang Zhong-cheng zhao Wei-Jun Li Fu-Sheng Liu State Key Laboratory Base of Eco-chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao 266042China Taishan Scholar Advantage and Characteristic Discipline Team of Eco Chemical Process and Technology College of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China State Key Laboratory Breeding Base of Green Chemistry Synthesis Technology College of Chemical EngineeringZhejiang University of TechnologyHangzhou 310014China

Photo-responsive mechanical actuator is a class of stimuli-responsive materials transferring light to mechanical energy through macroscopic *** fabricate photo-responsive mechanical actuator,soft polymeric materials crosslinked with functional bridging structures are *** interaction is a relatively common way to fabricate crosslinked materials due to its excellent self-assembly *** azobenzene and derivatives are ideal candidates of photo-responsive materials because of the unique photo-induced trans-cis ***,a new kind of crosslinked materials based on supramolecular interaction between 4,4'-dihydroxyazobenzene and chitosan is *** 355 nm irradiation,the macroscopic bending of polymeric materials occurs rapidly due to the photo-isomerization of 4,***,the photo-responsive mechanical actuator can also lift weight which is up to 200 times that of the actuator itself,and convert energy from light to mechanical work *** report suggests a new kind of photo-responsive actuator based on supramolecular interaction and may be helpful to contribute a theoretical basis to the design and synthesis of photo-responsive mechanical actuator suitable for large-scale manufacturing industrialization in future.

关键词： Photo-response Supramolecular interaction Mechanical actuator Azobenzene Energy conversion

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Different Strategies for Preparation of Non-tagged rV270 Protein and Its Efficacy against Yersinia Pestis Challenge

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Biomedical and Environmental Sciences 2010年第5期23卷 333-340页

作者： wang wang ZHI-ZheN QI QING-WEN zhang BEN-CHUAN WU ZI-WEN ZHU YONG-HAI yang BAI-ZHONG CUI rui-XIA DAI YE-FENG QIU ZU-yun wang zhao-BIAO GUO TAO-XING SHI HU wang rui-FU yang xiao-YI wang Laboratory of Analytical Microbiology State Key Laboratory of Pathogen and BiosecurityBeijing Institute of icrobiology and EpidemiologyBeijing 100071China Qinghai Institute for Endemic Disease Prevention and Control of Qinghai Province Xining811602China Beijing Institute of Bioengneering Beijing 100071China

Objective LcrV is an important component for the development of a subunit vaccine against *** reduce immunosuppressive activity of LcrV,a recombinant LcrV variant lacking amino acids 271 to 326 （rV270） was prepared by different methods in this *** A new strategy that produced non-tagged or authentic rV270 protein was designed by insertion of rV270-thrombin-hexahistidine fusion gene into the vector pET24a,or by insertion of hexahistidine-enterokinase-rV270 or hexahistitine-factor Xa-rV270 fusion gene into the vector *** Co2＋ affinity chromatography,a purification strategy was developed by cleavage of His tag on column,following Sephacryl S-200HR column filtration *** Removal of His tag by thrombin,enterokinase and factor Xa displayed a yield of 99.5%,32.4% and 15.3%,*** Sephacryl S-200HR column filtration chromatography,above 97% purity of rV270 protein was *** rV270 that was adsorbed to 25% （v/v） Al（OH）3 adjuvant in phosphate-buffered saline （PBS） induced very high titers of antibody to rV270 in BALB/c mice and protected them （100% survival） against subcutaneous challenge with 106 CFU of *** virulent strain *** The completely authentic rV270 protein can be prepared by using enterokinase or factor Xa,but they exhibited extremely low cleavage activity to the corresponding recognition *** cleavage is an efficient strategy to prepare non-tagged rV270 protein and can be easily operated in a large scale due to its relatively low cost and high cleavage *** recombinant rV270 can be used as a key component to develop a subunit vaccine of plague.

关键词： Yersinia pestis rV270 antigen Purification Protection Plague

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Associations between PRF1 Ala91 Val polymorphism and risk of hemophagocytic lymphohistiocytosis: a meta-analysis based on 1366 subjects

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World Journal of Pediatrics 2020年第6期16卷 598-606页

作者： Guang-Hua Zhu Li-Ping zhang Zhi-Gang Li Ang Wei Ying yang Yu Tian Hong-Hao Ma Dong wang xiao-Xi zhao yun-Ze zhao Na Li Wei Liu Tian-You wang rui zhang Beijing Children's Hospital.Nanlishi Road No.56 Xicheng DistrictBeijingChina

Background Perforin(PRF1)gene mutation can cause the onset of hemophagocytic lymphohistiocytosis(HLH).It has reported that PRFl Ala91 Val polymorphism was related with HLH *** the meta-analysis,we aim to evaluate the association between PRF1 Ala91 Val polymorphism and HLH *** We accomplished a meta-analysis of six published case-control studies including 391 patients with HLH and 975 *** evaluated the quality of each study through Newcastle-Ottawa Scale(NOS).Data analysis was performed with Stata *** In general,all studies were of high quality(NOS score higher than 7).There were statistically significant between the PRFl Ala91 Val polymorphism and HLH risk though the pooled analysis[for Ala/Val ***/Ala:pooled odds ratio(OR)=3.22,95%confidence interval(Cl)1.08-9.56,P=0.035,random model;for Ala/Val+Val/Val ***/Ala:pooled OR=2.96,95%Cl 1.14-7.69,P=0.025,random model].Furthermore,sensitivity analysis also revealed a relationship between PRFl Ala91Val polymorphism and HLH risk(for Ala/Val ***/Ala:pooled OR=5.236,95%Cl 2.72-10.08,Pheterogeneity=0-332;for Ala/Val+Val/Val ***/Ala,pooled OR=4.856,95%Cl 2.66-8.85,Pheterogeneity=0.373).Funnel plot and Egger’s test did not indicate obvious published bias(P=0.841 for Ala/Val ***/Ala;?=0.284 for Ala/Val+Val/Val ***/Ala).Conclusion This meta-analysis indicated that PRFl Ala91 Val polymorphism affects the factor for developing HLH and future studies of PRFl Ala91 Val on the onset of HLH will be guaranteed.

关键词： Ala91Val polymorphism hemophagocytic lymphohistiocytosis PRFl

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