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Evidence for the Late Pliocene Aridification in the Eastern Tarim Basin,Northwest China

Journal of Earth Science 2023年第5期34卷 1632-1634页

作者： Hua Zhang Feng-Lin Lü Cheng-Lin Liu Peng-Cheng Jiao Hui-Jing Yin Hui yan Bao-Cheng Ma Liang-Liang zhao Hong-Chao Liu Ministry of Natural Resources Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China National Centre for Archaeology Beijing 100013China School of Earth Resources China University of GeoscienceWuhan 430074China School of Earth Sciences and Resources China University of GeoscienceBeijing 100083China State Development and Investment Corp. Xin Jiang Luobupo Potash Co.LTDHami 839000China

INTRODUCTION The vast arid regions in mid-latitude Asia(MLA)are among the most prominent landscapes on Earth’s surface and have been thought to provide a key source of global atmospheric dust(Hovan et al.,1989).Over the past decades,research on aridification of MLA have made tremendous progress and pointed large-scale aridity has prevailed in this region since the Late Pliocene despite long-term stepwise drying(Fang et al.,2020;Liu et al.,2014).However,direct sedimentary records for the late Pliocene aridification is still lack,hindering our understanding of regional comparison and the behind drive *** Tarim Basin in northwest China is one of the driest and largest inland basins and is considered as an ideal candidate for aridity records of MLA(Sun et al.,2013).Although considerable studies of environmental variations have been conducted(Liu et al.,2020;Zheng et al.,2015),a comprehensive picture of climatic change of the basin during the Late Pliocene is still unavailable,due to fragmentary sedimentary records,especially in the eastern Tarim *** this contribution,we report the Late Pliocene lacustrine sediments found in Lop Nur of the east of Tarim *** occurrence of abundant magnesite,their related crystal morphology and C-O isotopic signature suggested a typical brackish or even saline lake environment and arid climatic condition in eastern Tarim Basin during this interval.

关键词： Tarim sedimentary climatic

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Identification of immunoreactive proteins of Brucella melitensis by immunoproteomics

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Science China(Life Sciences) 2011年第9期54卷 880-887页

作者： zhao ZhongPeng yan Fang JI WenHui LUO Deyan LIU Xin XING Li DUAN YueQiang yanG PengHui SHI XiuMin LI Zhong WANG XiLiang State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing 100071 China College of Animal Science and Veterinary Medicine Shanxi Agricultural University Taigu 030801 China

Infection with Brucella causes brucellosis, a chronic disease in humans, which induces abortion and sterility in livestock. Among the different Brucella species, Brucella melitensis is considered the most virulent and is the predominant species associated with outbreaks in China. To date, no safe human vaccine is available against Brucella infection. The currently used live vaccines against Brucella in livestock induce antibodies that interfere with the diagnosis of field infection in vaccinated ani- mals, which is harmful to eradication programs. However, there is as yet no complete profile of immunogenic proteins of B. melitensis. Towards the development of a safer, equally efficacious, and field infection-distinguishable vaccine, we used immunoproteomics to identify novel candidate immunogenic proteins from B. melitensis M5. Eighty-eight immunoreactive protein spots from B. melitensis M5 were identified by Western blotting and were assigned to sixty-one proteins by mass spectrometry, including many new immunoreactive proteins such as elongation factor G, FOFI ATP synthase subunit beta, and OMPI. These provide many candidate immunoreactive proteins for vaccine development.

关键词： Brucella immunoproteomics immunoreactive protein

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Identifying miRNA biomarkers of polycystic ovary syndrome through text mining

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Reproductive and Developmental Medicine 2023年第2期7卷 96-101页

作者： yan Wang Xiao-Jing Yuan Bin zhao Medical Reproductive Center People’s Hospital of Jiuquan CityJiuquan 735099GansuChina Xiamen health and Medical Big Data Center Xiamen 361008FujianChina

Objective:Polycystic ovary syndrome(PCOS)is an endocrine disorder with diverse clinical manifestations that often occurs in women of childbearing ***,its molecular pathogenesis remains unclear,and this study aimed to identify miRNA targets in PCOS through text mining and database ***:First,three different sets of text mining genes(TMGs)associated with"polycystic ovary syndrome","obesity/adiposis",and"anovulation"keywords were retrieved from the GenCLiP3 database,and overlapping genes were ***,Gene ontology annotation and biological pathway enrichment analyses of these overlapping TMGs were performed,followed by protein-protein interaction(PPI)network ***,genes in the gene module clustered in the PPI were selected to predict potential miRNAs for PCOS via miRNA-mRNA ***:A total of 4291 TMGs related to three different keywords were obtained through text mining;72 intersect TMGs were retained among the three gene sets,and 62 TMGs participated in the establishment of the PPI network,of which 18 were aggregated in the gene ***,11 miRNAs that simultaneously bound to two TMGs(IGF1,ESR1,MAPK1,NAMPT,PIK3CA,and SERPINE1)could be prioritized as targets to study ***(s):The discovery of 11 miRNAs(miR-301a-3p,miR-301b-3p,miR-3666,miR-454-3p,miR-130a-3p,miR-130b-3p,miR-4295,miR-190a-3p,miR-5011-5p,miR-548c-3p,and miR-4799-5p)and 6 TMGs,which are associated with the HIF-1 signaling pathway(P=4.799E-08),could be used as potential targets for PCOS.

关键词： Text mining Polycystic ovary syndrome Obesity Anovulation microRNA

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304LN表面沉积异质合金过程多组元传输行为数值模拟

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表面技术 2024年第19期53卷 141-152页

作者：赵天碕赵吉宾何振丰王志国赵宇辉陈燕中国科学院沈阳自动化研究所沈阳 110016 辽宁科技大学机械工程与自动化学院辽宁鞍山 114051 中国科学院沈阳自动化研究所沈阳 110016 中国科学院机器人与智能制造创新研究院沈阳 110169 辽宁科技大学机械工程与自动化学院辽宁鞍山 114051

目的探究在304LN不锈钢表面上激光沉积Stellite 6合金过程中的多元素传输机制.方法采用流体体积法VOF(Volume of Fluid),建立气-液两相传热传质激光沉积模型.模型中使用改进VOF法对熔池表面进行追踪,结合多组分传输模型与熔凝杠杆原则... 详细信息

目的探究在304LN不锈钢表面上激光沉积Stellite 6合金过程中的多元素传输机制.方法采用流体体积法VOF(Volume of Fluid),建立气-液两相传热传质激光沉积模型.模型中使用改进VOF法对熔池表面进行追踪,结合多组分传输模型与熔凝杠杆原则(Lever Rule),对异质材料熔覆界面的多元素传输进行模拟,采用扫描电子显微镜(SEM)与能谱仪(EDS)观察组织结构和元素分布,对比模拟结果分析多组沉积层宏观形貌和元素分布特征.结果沉积过程中,熔池的流动与材料导热对温度的传输起着重要作用,前端对流不断地将已熔化的基材金属运输至熔池中部,后端对流则将卷积的Fe元素和Co元素进一步混合.最终沉积层的宏观形貌平均误差为2.67％,主要元素Fe、Co、Cr的质量分数误差分别为0.64％、1.27％、0.31％.结论 Fe元素浓度整体区域分布相对均匀,但在沉积层底部,Fe元素浓度迅速升高,Co元素浓度随沉积深度加深逐渐降低,Cr元素在沉积层中部富集的分布特性.该优化后的模型可以准确模拟异质合金沉积过程中的温度场、流场与质量传输过程.

关键词：表面沉积多组分传输元素分布热量传输钴基合金

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Optical analysis method for fast plasma characterization of high-speed miniaturized synthetic jet

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Chinese Optics Letters 2022年第7期20卷 41-46页

作者： Ye Yuan yan Zhang Cheng Guo Xiaolu Kang Zhong yan Xiaoping Huang Qing zhao School of Resources and Environment University of Electronic Science and Technology of ChinaChengdu 610054China Shanghai Institute of Space Propulsion Shanghai Engineering Research Center of Space EngineShanghai 201112China

In this paper,a new optical analysis method for plasma characterization is *** characteristics are obtained directly by measuring the plasma luminous color,rather than the complex spectral diagnosis method,which is difficult to obtain at high *** using the light transmittance curve of the human cornea,the RGB coordinates are calculated from the measured plasma spectrum *** characteristics are diagnosed using the Boltzmann plot method and the Stark broadening *** corresponding relationship of the electron temperature,electron density data points,and luminous color is established and *** research results indicate that this optical analysis method is feasible and promising for fast plasma characterization.

关键词： optical analysis method plasma characteristics spectral diagnosis high-speed miniaturized actuator

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Effect of corneal graft diameter on therapeutic penetrating keratoplasty for fungal keratitis

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International Journal of Ophthalmology(English edition) 2012年第6期5卷 698-703页

作者： Cui Li Gui-Qiu zhao Cheng-Ye Che Jing Lin Na Li Wen-yan Jia Qiu-QiuZhang Nan Jiang Li-Ting Hu Department of Ophthalmology the Affiliated Hospital of Medical College Qingdao University Tengzhou Central People's Hospital

AIM: To evaluate the effect of corneal graft diameter on therapeutic penetrating keratoplasty(PKP) for fungal keratitis. METHODS: A total of 116 patients (116 eyes) suffered from fungal keratitis underwent PKP at the Affiliated Hospital of Medical College Qingdao University from May 2006 to May 2010. They were divided into two groups according to the corneal graft diameter. 64 eyes' corneal graft diameter was 8.00mm or larger and 52 eyes' graft diameter was smaller than 8.00mm. The follow-up time was 2 years. The postoperative visual acuity and complications were documented and compared. RESULTS: Sixty-two (96.88%) eyes and fifty (96.15%) eyes preserved eyeballs respectively in two groups. There was no statistical difference in postoperative visual acuity (P = 0.961), corneal graft dear rate (P=0.132) or the incidence of recurred fungal infection (P=0.770) between two groups. But there was a higher incidence of graft rejection (P=0.020) and secondary glaucoma (P=0.039) in group with corneal graft diameter 8.00mm or larger. CONCLUSION: PKP is an effective treatment approach for fungal keratitis. There is a higher incidence of complications in large-diameter PKP for fungal ***, preventive and therapeutic measures can improve the prognosis.

关键词： keratoplasty penetrating eye infection fungal corneal graft

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Relationship between intestinal microbiota and ulcerative colitis:Mechanisms and clinical application of probiotics and fecal microbiota transplantation

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World Journal of Gastroenterology 2018年第1期24卷 5-14页

作者： zhao-hua Shen Chang-xin Zhu Yong-sheng Quan Zhen-yu yang Shuai Wu Wei-wei Luo Bei Tan Xiao-yan Wang Department of Gastroenterology Third Xiangya HospitalCentral South UniversityChangsha 410013Hunan ProvinceChina Hunan Key Laboratory of Nonresolving Inflammation and Cancer Changsha 410008Hunan ProvinceChina

Ulcerative colitis(UC) is an inflammatory disease that mainly affects the colon and rectum. It is believed that genetic factors, host immune system disorders, intestinal microbiota dysbiosis, and environmental factors contribute to the pathogenesis of UC. however, studies on the role of intestinal microbiota in the pathogenesis of UC have been inconclusive. Studies have shown that probiotics improve intestinal mucosa barrier function and immune system function and promote secretion of anti-inflammatory factors, thereby inhibiting the growth of harmful bacteria in the intestine. Fecal microbiota transplantation(FMT) can reduce bowel permeability and thus the severity of disease by increasing the production of short-chain fatty acids, especially butyrate, which help maintain the integrity of the epithelial barrier. FMT can also restore immune dysbiosis by inhibiting Th1 differentiation, activity of T cells, leukocyte adhesion, and production of inflammatory factors. Probiotics and FMT are being increasingly used to treat UC, but their use is controversial because of uncertain efficacy. here, we briefly review the role of intestinal microbiota in thepathogenesis and treatment of UC.

关键词： fecal microbiota transplantation Intestinal microbiota ulcerative colitis probiotics mechanism clinical application

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Acupoint Injection Decreases Anesthetic Cosumption during Combined Spinal-Epidural and Patient-Controlled Epidural Labor Analgesia

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Chinese Journal of Integrative Medicine 2022年第3期28卷 257-262页

作者： HUANG Min-li FANG Chang-ping zhao Hai-yan ZHANG Zi-jing WU Shu-zhen YI Wei LI Shang-rong WU Ling-ling Department of Obstetrics and Gyn ecology The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou(510630)China Medical College of Acupuncture-Moxibustion and Rehabilitation Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Anesthesiology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou(510630)China

Objective:To explore if acupoint injection can improve analgesic effects or delivery outcomes in parturients who received combined spinal-epidural analgesia(CSEA)and patient-controlled epidural analgesia(PCEA)for labor ***:A total of 307 participants were prospectively collected from July 2017 to December *** participants were randomized into the combined acupoint injection with CSEA plus PCEA group(AICP group,n=168)and CSEA plus PCEA group(CP group,n=139)for labor analgesia using a random number *** groups received CSEA plus PCEA at cervical dilation 3 cm during labor process,and parturients of the AICP group were implemented acupoint injection for which bilateral acupoint of Zusanli(ST 36)and Sanyinjiao(SP 6)were selected in *** primary outcome was Visual Analogue Scale(VAS)score,and the secondary outcomes were obstetric outcomes and requirement of anesthetics *** evaluations were performed after ***:The VAS scores were significantly lower in the AICP group than in the CP group at 10,30,60,and 120 min after labor analgesia(all Phe latent phase of the AICP group was shorter than that of the CP group(Phere were less additional anesthetics consumption,lower incidences of uterine atony,fever,pruritus and urinary retention in the AICP group than those in the CP group(all Phe anesthetic consumption,improve analgesic quality,and reduce adverse reactions in the parturients.(Registration ***-2000003120)

关键词： acupoint injection combined spinal-epidural analgesia labor analgesia anesthetic consumption multimodal analgesia

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Predictive model for acute abdominal pain after transarterial chemoembolization for liver cancer

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World Journal of Gastroenterology 2020年第30期26卷 4442-4452页

作者： Li-Fang Bian Xue-Hong zhao Bei-Lei Gao Sheng Zhang Guo-Mei Ge Dong-Di Zhan Ting-Ting Ye yan Zheng Department of hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Nursing The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Hospital Infection Control The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Transarterial chemoembolization(TACE)is the first-line treatment for patients with unresectable liver cancer;however,TACE is associated with postembolization *** To analyze the risk factors for acute abdominal pain after TACE and establish a predictive model for postembolization *** From January 2018 to September 2018,all patients with liver cancer who underwent TACE at our hospital were *** characteristics;clinical,imaging,and procedural data;and postembolization pain were *** pain was defined as acute moderate-to-severe abdominal pain within 24 h after *** regression and a classification and regression tree were used to develop a predictive *** operating characteristic curve analysis was used to examine the efficacy of the predictive *** We analyzed 522 patients who underwent a total of 582 TACE ***-seven(16.70%)episodes of severe pain occurred.A predictive model built based on the dataset from classification and regression tree analysis identified known invasion of blood vessels as the strongest predictor of subsequent performance,followed by history of TACE,method of TACE,and history of abdominal pain after *** area under the receiver operating characteristic curve was 0.736[95%confidence interval(CI):0.682-0.789],the sensitivity was 73.2%,the specificity was 65.6%,and the negative predictive value was 92.4%.Logistic regression produced similar results by identifying age[odds ratio(OR)=0.971;95%CI:0.951-0.992;P=0.007),history of TACE(OR=0.378;95%CI:0.189-0.757;P=0.007),history of abdominal pain after TACE(OR=6.288;95%CI:2.963-13.342;P<0.001),tumor size(OR=1.978;95%CI:1.175-3.330;P=0.01),multiple tumors(OR=2.164;95%CI:1.243-3.769;P=0.006),invasion of blood vessels(OR=1.756;95%CI:1.045-2.950;P=0.034),and TACE with drug-eluting beads(DEBTACE)(OR=2.05;95%CI:1.260-3.334;P=0.004)as independent predictive factors for postembolization *** Blood vesse

关键词： Liver cancer Predictive model Pain Transarterial chemoembolization Postembolization syndrome

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一种用于非制冷红外焦平面阵列的低噪声高均匀性读出电路（英文）

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红外与毫米波学报 2018年第3期37卷 261-268页

作者：周同何勇赵健姜波苏岩南京理工大学机械工程学院江苏南京210094 清华大学电子工程系北京100084

提出了一种高均匀性低噪声的读出电路,该电路通过抑制非制冷红外焦平面阵列固定模式噪声,从而可实现高质量的红外图像.该电路前端采用了行共享的增益可控NMOS管抑制像元固定模式噪声,同时采用了新型的相关双采样电路抑制列固定模式噪声... 详细信息

提出了一种高均匀性低噪声的读出电路,该电路通过抑制非制冷红外焦平面阵列固定模式噪声,从而可实现高质量的红外图像.该电路前端采用了行共享的增益可控NMOS管抑制像元固定模式噪声,同时采用了新型的相关双采样电路抑制列固定模式噪声.在仿真基础上,采用了AMS 0.35μm CMOS工艺完成了16×16像元芯片的制备.对芯片的大量测试结果表明提出的读出电路可以有效地降低非制冷红外焦平面阵列的固定模式噪声,同时具有高均匀性的特点,适用于高性能非制冷红外探测器.

关键词：读出电路固定模式噪声抑制相关双采样高均匀性

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