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Concentrations of Polybrominated Diphenyl Ethers in Maternal Blood,Placental Size,and Risk for Fetal Growth Restriction:A Nested Case-control Study

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Biomedical and Environmental Sciences 2020年第11期33卷 821-828页

作者： JIN Yu Ting DENG Xiao Kai zhao ying ya LI Jia Lin SONG Qi ZHANG Yun Hui yaNG Qing CHEN Shang Qin Department of Neonatology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027ZhejiangChina Department of Pediatrics Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310052ZhejiangChina Key Laboratory of Public Health Safety Ministry of EducationSchool of Public HealthFudan UniversityShanghai 200032China The Maternal and Child Healthcare Institute of Songjiang District Shanghai 201600China

Objective To explore the effects of prenatal exposure to polybrominated diphenyl ethers(PBDEs)on placental size and birth *** Based on the perspective Wenzhou Birth Cohort,this nested case-control study included 101 fetal growth restriction(FGR)and 101 healthy *** serum samples were collected during the third trimester and measured for PBDEs by gas chromatography tandem mass *** basic information of mother-newborn pairs was collected from questionnaires,whereas the placental size and birth outcomes of newborns were obtained from hospital *** A total of 19 brominated diphenyle ether(BDE)congeners were detected in maternal serum *** concentrations of BDE-207,-208,-209,and∑19PBDEs were detected in FGR cases than in *** BDE-207,-208,-209,and∑19PBDEs levels in maternal serum were related to decreased placental length,breadth,surface area,birth weight,birth length,gestational age,and Quetelet index of *** adjusting for confounders,BDE-207 and∑19PBDE concentrations in maternal serum were significantly associated with an increased risk of *** A negative association was found between PBDE levels in maternal serum and placental size and birth *** PBDE exposure may be associated with elevated risk of the incidence of FGR birth.

关键词： Polybrominated diphenyl ethers Fetal growth restriction Maternal serum Birth outcome

Pt(Ⅱ), Pd(Ⅱ) and Ni(Ⅱ) Complexes Binding to the N(7) Position of Guanine: Influence on the Guanine and Watson-crick GC Base Pair

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Chinese Journal of Structural Chemistry 2005年第1期24卷 114-120页

作者：章志强周立新和芹赵亚英 Department of Chemistry Fuzhou University Fuzhou 350002 China Department of Chemistry Jinan University Guangzhou 510632 China

Comprehensive ab initio calculations were performed on the coordination of Pt(II), Pd(II) and Ni(II) adducts to the N(7) of guanine and guanine-cytosine (GC) base pair at the DFT level. The fully optimized geometries of the metal complexes were obtained and the stabilization energies of the interaction between metal adducts and nucleobase were calculated with B3LYP method by using 6-31* basis set for the light atom. While the effective core potential (ECP) is used for metal cation. The results show that both cispalladium and cisnickel cause similar geometric changes of the base pair as cisplatin. For the coordination of metal adducts to guanine, platinum adduct possesses the highest stabilization energy; but the interaction between metal-guanine and cytosine for nickel is larger than that for platinum and palladium. It is worthy to note that hydrolysis effect can also cause significant changes in H-bonds.

关键词： cis-platin (palladium nickel) GC base pair hydrogen bond ab initio nature bond orbital (NBO)

Inhibition of HBV targeted ribonuclease enhanced by introduction of linker

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World Journal of Gastroenterology 2003年第7期9卷 1504-1507页

作者： Wei-Dong Gong Jun Liu Jin Ding ya zhao ying-Hui Li Cai-Fang Xue Department of Pathogenic Organisms,Fourth Military Medical University,Xi’an 710033,Shaanxi Province,China Department of Pathogenic Organisms Fourth Military Medical University Xi'an 710033 Shaanxi Province China.

AIM: To construct human eosinophil-derived neurotoxin (hEDN) and HBV core protein (HBVc) eukaryotic fusion expression vector with a linker (Gly4 Ser)3 between them to optimize the molecule folding, which will be used to inhibit HBV replication in ***: Previously constructed pcDNA3. 1(-)/TR was used as a template. Linker sequence was synthesized and annealed to form dslinker, and cloned into pcDNA3.1(-)/TR to produce plasmid pcDNA3.1(-)/HBc-linker. Then the hEDN fragment was PCR amplified and inserted into pcDNA3.1(-)/HBc-linker to form pcDNA3.1(-)/TNL in which the effector molecule and the target molecule were separated by a linker sequence. pcDNA3.1(-)/TNL expression was identified by indirect immunofluorescence staining. Radioimmunoassay was used to analyse anti-HBV activity of pcDNA3.1(-)/***, metabolism of cells was evaluated by NTT ***: hEDN and HBVc eukaryotic fusion expression vector with a linker (Gly4Ser)3 between them was successfully constructed. pcDNA3.1(-)/TNL was expressed in HepG2.2.15 cells efficiently. A significant decrease of HBsAg concentration from pcDNA3.1(-)/TNL transfectant was observed compared to pcDNA3. 1(-)/TR (P=0.036, P＜0.05).MTT assay suggested that there were no significant differences between groups (P=0.08, P＞0.05).CONCLUSION: Linker introduction enhances the inhibitory effect of HBV targeted ribonuclease significantly.

关键词：乙型肝炎病毒核糖核酸酶噬酸性细胞神经毒素

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高水分褐煤燃烧对锅炉的影响研究

东北电力大学学报 2012年第6期32卷 55-58页

作者：赵亚莹东北电力大学能源与动力工程学院吉林吉林132012

褐煤在我国煤炭能源中占有很大比重,因其含水量高、灰分大、容易风化、发热量低的缺点使褐煤的利用率较低。研究了褐煤中的高水分对燃料热值、烟气量、耗煤量等的影响规律并分析了电厂的经济行。研究表明,水分增加时,燃料热值降低,锅炉... 详细信息

褐煤在我国煤炭能源中占有很大比重,因其含水量高、灰分大、容易风化、发热量低的缺点使褐煤的利用率较低。研究了褐煤中的高水分对燃料热值、烟气量、耗煤量等的影响规律并分析了电厂的经济行。研究表明,水分增加时,燃料热值降低,锅炉效率增加;燃料燃烧产生的烟气量(Nm3/kg)随水分的增加而降低,但由于煤耗量随水分的增加而增加,产生的结果是总烟气量(Nm3/s)随水分的增加而增加。

关键词：褐煤水分热力性能

Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

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Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui Sun Sanlong Wang Pengyang Wang yali Liu Shanshan Qi Biao Shi ying zhao Xiaodan Zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage Center State Key Laboratory of Photovoltaic Materials and CellsNankai University Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Haihe Laboratory of Sustainable Chemical Transformations Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells （IPSCs）,which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid （5-MVA） was introduced as a strain buffer to release the residual strain of *** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb2+through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI2.85Br0.15perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI2.85Br0.15,resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency （PCE） of NiOxbased inverted IPSCs increased from 19.25% to 20.82% with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI2.85Br0.15perovskite films and devices.

关键词： Inverted inorganic perovskite solar cells Flexible molecules Strain release Crystallization Energy barrier High PCE

基于样本扩充和改进2DPCA的单样本人脸识别

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计算机应用 2011年第10期31卷 2728-2730,2756页

作者：赵雅英谭延琪马小虎苏州大学计算机科学与技术学院江苏苏州215006

针对大多数人脸识别方法在单个训练样本条件下识别性能下降的问题,提出了结合多种样本扩充方法和改进二维主成分分析(2DPCA)的人脸识别算法。通过分析各种样本扩充方法的优缺点,用多种样本扩充方法来生成虚拟样本,以充分利用单一样本所... 详细信息

针对大多数人脸识别方法在单个训练样本条件下识别性能下降的问题,提出了结合多种样本扩充方法和改进二维主成分分析(2DPCA)的人脸识别算法。通过分析各种样本扩充方法的优缺点,用多种样本扩充方法来生成虚拟样本,以充分利用单一样本所提供的信息。采用改进的2DPCA方法对生成的虚拟样本进行特征提取,对训练样本进行分块,并用类内平均值规范后的分块来构造总体散布矩阵。在ORL和yale人脸库上的实验表明,所提出的方法在识别性能方面优于普通的2DPCA方法,优于单一的样本扩充方法。

关键词：单样本人脸识别样本扩充类内平均值二维主成分分析(2DPCA)

肠瘘合并腹腔感染患者血清IL-6与sCD22和sTREM-1及IL-18的表达水平

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中华医院感染学杂志 2020年第12期30卷 1880-1884页

作者：宋笑飞宋玉成赵亚莹河南省人民医院(郑州大学人民医院河南大学医学院)胃肠外科河南郑州450003 河南省人民医院(郑州大学人民医院河南大学医学院)消毒供应中心河南郑州450003

目的对肠瘘合并腹腔感染患者血清标志物白细胞介素-6(Interleukin-6,IL-6)、可溶性CD22(soluble CD22,sCD22)、可溶性髓样细胞触发受体-1(soluble triggering receptor expressed on myeloid cells-1,sTREM-1)和白细胞介素-18(Interleukin-18,IL-18)的表达水平进行分析,为肠瘘合并腹腔感染的患者在临床中的早期诊治提供参考。方法选取2016年3月-2018年3月河南省人民医院收治的肠瘘患者260例,根据诊断结果,将合并腹腔感染的肠瘘患者139例设为感染组,未合并感染的患者121例设为未感染组,同时选取医院同期体检健康成年志愿者130名作为健康对照组。对引起患者腹腔感染的致病菌进行比较,观察患者单一菌种感染和多个菌种感染的发生情况,并对两组患者的病死率和治愈率进行比较;比较三组研究对象血清IL-6、sCD22、sTREM-1和IL-18。结果感染组患者共培养分离病原菌224株,其中革兰阴性菌121株占54.02%,革兰阳性菌103株占45.98%,以革兰阴性菌为主。在革兰阳性菌中,以金黄色葡萄球菌和屎肠球菌为主;在革兰阴性菌中,以大肠埃希菌和铜绿假单胞菌为主。多个菌种感染率为73.38%高于单个菌种感染率26.62%(P=0.012)。感染组的病死率为20.86%高于未感染组,感染组治愈率为60.43%低于未感染组,差异有统计学意义(P<0.05)。在治疗前和治疗后24 h,感染组患者IL-18的表达水平高于未感染组患者和对照组的表达水平(P<0.05)。在治疗后48 h,三组间的sCD22、sTREM-1表达水平比较,差异有统计学意义(P<0.05)。在治疗后96 h,感染组和未感染组患者的sCD22、sTREM-1分别为107.59(52.22,162.96)pg/ml、191.27(142.24,240.30)pg/ml和107.96(87.23,138.69)pg/ml、146.64(113.77,179.51)pg/ml高于对照组(P<0.05),但感染组和未感染组sCD22,差异无统计学意义,而sTREM-1差异有统计学意义(P<0.05);三组IL-6、IL-18差异无统计学意义。结论肠瘘患者容易发生感染,其中大肠埃希菌造成感染的发生率最高,且存在单一菌种或多个菌种感染的情况,病死率高,治愈率低,因此需要早发现早治疗,降低患者的病死率。可通过患者血清中的IL-6、sCD22、sTREM-1、IL-18水平的变化判断患者是否发生感染。

关键词：肠瘘腹腔感染疾病谱白细胞介素-6 可溶性CD22 可溶性髓系细胞触发受体-1 白细胞介素-18

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： Lifang zhao Mingkai Zhang Qimeng Li Xuemin Wang Jie Lu ying Han yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

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不同萃取方式对胜利褐煤结构的影响

实验室研究与探索 2016年第4期35卷 5-8页

作者：赵迎亚冯莉张曼于晓慧中国矿业大学化工学院江苏徐州221116

选取丙酮、甲醇、四氢呋喃3种溶剂,采用索氏萃取、超声波辅助萃取和微波辅助萃取3种方式萃取胜利褐煤。通过比较萃余煤孔隙结构的改变,探索了不同能量场对小分子相溶出过程的影响。利用FT-IR、比表面积及孔径分布对萃余煤进行表征。结... 详细信息

选取丙酮、甲醇、四氢呋喃3种溶剂,采用索氏萃取、超声波辅助萃取和微波辅助萃取3种方式萃取胜利褐煤。通过比较萃余煤孔隙结构的改变,探索了不同能量场对小分子相溶出过程的影响。利用FT-IR、比表面积及孔径分布对萃余煤进行表征。结果表明,萃取过程对煤样官能团影响不明显,但对孔结构影响较大。说明萃取过程只是破坏了小分子相与煤大分子网络结构之间的各种弱相互作用力,并没有破坏煤的大分子结构。超声波辅助萃取和微波辅助萃取不仅增加了微孔的数量而且改变了微孔的孔径分布,主要增加了0.92 nm左右的微孔数量,说明在微波和超声波作用下,微孔中的小分子物质易溶出。煤样经3种方式萃取后,比表面积均增加,增幅为:超声波辅助萃取>微波辅助萃取>索氏萃取。

关键词：褐煤萃余煤超声波辅助萃取微波辅助萃取