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Highly efficient and stable electrocatalyst for hydrogen evolution by molybdenum doped Ni-Co phosphide nanoneedles at high current density

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Nano Research 2024年第3期17卷 1066-1074页

作者： Chengyu Huang Zhonghong Xia Jing Wang Jing Zhang Chenfei zhao Xingli Zou Shichun Mu Jiujun Zhang Xionggang Lu Hong Jin Fan Shengjuan Huo yufeng zhao College of Sciences&Institute for Sustainable Energy Shanghai UniversityShanghai 200444China State Key Laboratory of Metastable Materials Science and Technology Hebei Key Laboratory of Heavy Metal Deep-Remediation in Water and Resource ReuseYanshan UniversityQinhuangdao 066004China State Key Laboratory of Advanced Special Steel and Shanghai Key Laboratory of Advanced Ferrometallurgy School of Materials Science and EngineeringShanghai UniversityShanghai 200444China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore639798

There is an increasingly urgent need to develop cost-effective electrocatalysts with high catalytic activity and stability as alternatives to the traditional Pt/C in catalysts in water *** this study,microspheres composed of Mo-doped NiCoP nanoneedles supported on nickel foam were prepared to address this *** results show that the nanoneedles provide sufficient active sites for efficient electron transfer;the small-sized effect and the micro-scale roughness enhance the entry of reactants and the release of hydrogen bubbles;the Mo doping effectively improves the electrocatalytic performance of NiCoP in alkaline *** catalyst exhibits low hydrogen evolution overpotentials of 38.5 and 217.5 mV at a current density of 10 mA·cm^(-2) and high current density of 500 mA·cm^(-2),respectively,and only 1.978 V is required to achieve a current density of 1000 mA·cm^(-2) for overall water *** functional theory(DFT)calculations show that the improved hydrogen evolution performance can be explained as a result of the Mo doping,which serves to reduce the interaction between NiCoP and intermediates,optimize the Gibbs free energy of hydrogen adsorption(△G_(*H)),and accelerate the desorption rate of **** study provides a promising solution to the ongoing challenge of designing efficient electrocatalysts for high-current-density hydrogen production.

关键词： transition metal phosphides Mo-doped NiCoP hydrogen evolution reaction gradient hydrothermal water splitting

Short-term solar eruptive activity prediction models based on machine learning approaches: A review

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Science china.Earth Sciences 2024年

作者： Xin HUANG Zhongrui zhao yufeng ZHONG Long XU Marianna B.KORSóS R.ERDéLYI Faculty of Electrical Engineering and Computer Science Ningbo University State Key Laboratory of Space Weather National Space Science Center Chinese Academy of Sciences School of Astronomy and Space Science University of Chinese Academy of Sciences Beijing Cellular Exploration Science and Technology Center Dipartimento di Fisica e Astronomia “Ettore Majorana” Università di Catania department of Astronomy E?tv?s Loránd University Hungarian Solar Physics Foundation Solar Physics & Space Plasma Research Center (SP2RC) School of Mathematics and Statistics University of Sheffield

Solar eruptive activities, mainly including solar flares, coronal mass ejections (CME), and solar proton events (SPE),have an important impact on space weather and our technosphere. The short-term solar eruptive activity prediction is an active field of research in the space weather prediction. Numerical, statistical, and machine learning methods are proposed to build prediction models of the solar eruptive activities. With the development of space-based and ground-based facilities, a large amount of observational data of the Sun is accumulated, and data-driven prediction models of solar eruptive activities have made a significant progress. In this review, we briefly introduce the machine learning algorithms applied in solar eruptive activity prediction, summarize the prediction modeling process, overview the progress made in the field of solar eruptive activity prediction model, and look forward to the possible directions in the future.

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Efficient expression of codon-adapted human acetaldehyde dehydrogenase 2 cDNA with 6×His tag in Pichia pastoris

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Science china.Life Sciences) 2009年第10期52卷 935-941页

作者： zhao yufeng1,2, LEI MingKe2, WU YuanXin2, ZHANG ZiSheng3 & WANG CunWen2 1 State key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agriculture university, Wuhan 430070, china.2 Key Laboratory for Green Chemical Processes of the Ministry of Education, Hubei Key Lab of Novel Reactor & Green Chemical Technology, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430074, china.3 department of Chemical Engineering, university of Ottawa, Ottawa, Canada K1N 6N5 State key Laboratory of Agricultural Microbiology College of Life Science and Technology Huazhong Agriculture University Wuhan China Key Laboratory for Green Chemical Processes of the Ministry of Education Hubei Key Lab of Novel Reactor & Green Chemical Technology School of Chemical Engineering and Pharmacy Wuhan Institute of Technology Wuhan China department of Chemical Engineering University of Ottawa Ottawa Canada

Human mitochondrial acetaldehyde dehydrogenase 2 (ALDH2) catalyzes the oxidation of acetaldehyde to acetic acid. Therefore, ALDH2 has therapeutic potential in detoxification of acetaldehyde. Further-more, ALDH2 catalyzes nitroglycerin to nitrate and 1, 2-glyceryldinitrate during therapy for angina pectoris, myocardial infarction, and heart failure. Large quantities of ALDH2 will be needed for potential clinical practice. In this study, Pichia pastoris was used as a platform for expression of human ALDH2. Based on the ALDH2*1 cDNA sequence, we designed ALDH2 cDNA by choosing the P. pastoris preferred codons and by decreasing the G + C content level. The sequence was synthesized using the overlap extension PCR method. The cDNA and 6×His tags were subcloned into the plasmid pPIC9K. The recombinant protein was expressed in P. pastoris GS115 and purified using Ni2+-Sepharose affinity chromatography. The amount of secreted protein in the culture was 80 mg/L in shake-flask cultivation and 260 mg/L in high-density bioreactor fermentation. Secreted ALDH2 was easily purified from the culture supernatant by using Ni2+-Sepharose affinity chromatography. After purification of the fermentation supernatant, the enzyme had a specific activity of 1.2 U/mg protein. The yield was about 16 mg/L in a shake flask culture of P. pastoris GS115 which contained the original human ALDH2*1 cDNA.

关键词： acetaldehyde dehydrogenase codon optimization overlap extension PCR Pichia pastoris.

艾司氯胺酮泵注对依托咪酯靶控输注所致苏醒期躁动的影响

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临床麻醉学杂志 2024年第2期40卷 165-169页

作者：杨玉峰赵冰清曾毅空军军医大学西京医院麻醉与围术期医学科西安市710032

目的探讨艾司氯胺酮恒速泵注对依托咪酯靶控输注患者苏醒期躁动的影响。方法选择拟在依托咪酯靶控输注全麻下行中耳鼓室成形手术的患者120例,男61例,女59例,年龄18~64岁,BMI 18~30 kg/m^(2),ASAⅠ或Ⅱ级。将患者随机分为两组:艾司氯胺酮... 详细信息

目的探讨艾司氯胺酮恒速泵注对依托咪酯靶控输注患者苏醒期躁动的影响。方法选择拟在依托咪酯靶控输注全麻下行中耳鼓室成形手术的患者120例,男61例,女59例,年龄18~64岁,BMI 18~30 kg/m^(2),ASAⅠ或Ⅱ级。将患者随机分为两组:艾司氯胺酮组(E组)和对照组(C组),每组60例。麻醉诱导开始至手术结束前30 min,E组泵注艾司氯胺酮0.2 ml·kg^(-1)·h^(-1),C组泵注生理盐水0.2 ml·kg^(-1)·h^(-1)。记录手术时间、麻醉时间、苏醒时间、拔管时间、PACU停留时间。记录苏醒期躁动例数、出PACU时和术后1 d VAS疼痛评分、术后1 d恶心呕吐例数以及术后1 d恶心呕吐VAS评分。评估术前、术后1、2 d的焦虑和抑郁评分。结果E组苏醒期躁动发生率、出PACU时和术后1 d VAS疼痛评分明显低于C组(P<0.05)。两组手术时间、麻醉时间、苏醒时间、拔管时间、PACU停留时间、术后1 d恶心呕吐发生率、术后1 d恶心呕吐VAS评分以及不同时点焦虑、抑郁评分差异无统计学意义。结论艾司氯胺酮泵注辅助依托咪酯靶控输注可以减少苏醒期躁动,促进患者术后恢复。

关键词：艾司氯胺酮依托咪酯苏醒期躁动靶控输注

Perioperative toripalimab plus neoadjuvant chemotherapy might improve outcomes in resectable esophageal cancer:an interim analysis of a phase Ⅲ randomized clinical trial

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Cancer Communications 2024年第10期44卷 1214-1227页

作者： Yan Zheng Guanghui Liang Dongfeng Yuan Xianben Liu yufeng Ba Zimin Qin Sining Shen Zhenxuan Li Haibo Sun Baoxing Liu Quanli Gao Peng Li Zongfei Wang Shilei Liu Jianping Zhu Haoran Wang Haibo Ma Zhenzhen Liu Fei zhao Jun Zhang He Zhang Daoyuan Wu Jinrong Qu Jie Ma Peng Zhang Wenjie Ma Ming Yan Yongkui Yu Qing Li Jiangong Zhang Wenqun Xing department of Thoracic Surgery The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China department of Immunotherapy The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China department of Endoscopy The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China department of Pathology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China department of Radiology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China department of Biobank The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China department of Strategic Development The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China department of Statistics LinkDoc Technology Co.LtdBeijingP.R.China department of Cancer Epidemiology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouP.R.China

Background:In the era of immunotherapy,neoadjuvant immunochemotherapy(NAIC)for the treatment of locally advanced esophageal squamous cell carcinoma(ESCC)is used clinically but lacks of high-level clinical *** study aimed to compare the safety and long-term efficacy of NAIC followed byminimally invasive esophagectomy(MIE)with those of neoadjuvant chemotherapy(NAC)followed by ***:A prospective,single-center,open-label,randomized phase Ⅲ clinical trial was conducted at Henan Cancer Hospital,Zhengzhou,*** were randomly assigned to receive either neoadjuvant toripalimab(240mg)plus paclitaxel(175 mg/m^(2))+cisplatin(75 mg/m^(2))(toripalimab group)or paclitaxel+cisplatin alone(chemotherapy group)every 3 weeks for 2 *** surgery,the toripalimab group received toripalimab(240 mg every 3 weeks for up to 6 months).The primary endpoint was event-free survival(EFS).The pathological complete response(pCR)and overall survival(OS)were key secondary *** events(AEs)and quality of life were also ***:Between May 15,2020 and August 13,2021,252 ESCC patients ranging fromT1N1-3M0 to T2-3N0-3M0were enrolled for interim analysis,with 127 in the toripalimab group and 125 in the chemotherapy *** 1-year EFS rate was 77.9%in the toripalimab group compared to 64.3%in the chemotherapy group(hazard ratio[HR]=0.62;95%confidence interval[CI]=0.39 to 1.00;P=0.05).The 1-year OS rates were 94.1%and 83.0%in the toripalimab and chemotherapy groups,respectively(HR=0.48;95%CI=0.24 to 0.97;P=0.037).The patients in the toripalimab group had a higher pCR rate(18.6%vs.4.6%;P=0.001).The rates of postoperative Clavien-Dindo grade Ⅲb or higher morbidity were 9.8%in the toripalimab group and 6.8%in the chemotherapy group,with no significant difference observed(P=0.460).The rates of grade 3 or 4 treatment-related AEs did not differ between the two groups(12.5%versus 12.4%).Conclusions:The interim results of this ongoing trial showed that in resec

关键词： esophageal squamous cell carcinoma minimally invasive esophagectomy neoadjuvant chemotherapy neoadjuvant immunochemotherapy survival

EFFECTS OF DIFFERENT WAVELENGTHS OF INTRAVASCULAR LOW LEVEL LASER IRRADIATION ON MURINE IMMUNOLOGICAL ACTIVITY

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南京大学学报(自然科学) 1999年第5期35卷 598-600页

作者： Tong Miao 1) Liu yufeng 1) zhao Xiaoning 1) Yan Chenzhong 1) Hu Zhengrong 2) Zhang Zuxuan 1) (1)School of Medicine, Nanjing university, 210093,Nanjing PRC 2)department of Electrical Engineering, Southeast Universit 南京大学医学院江苏东南大学电子工程系江苏

补肺活血胶囊干预慢性阻塞性肺疾病大鼠模型气道炎症及黏液高分泌的作用及机制研究

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北京中医药 2024年第4期43卷 352-358页

作者：孟玉凤王成祥史良恬赵敬军冯淬灵北京中医药大学第三附属医院北京100029 北京大学人民医院北京100044

目的研究补肺活血胶囊对慢性阻塞性肺疾病(简称“慢阻肺”)大鼠模型气道炎症及黏液高分泌的干预作用和机制。方法采用烟熏并气道内滴注脂多糖的方法制备慢阻肺大鼠模型。40只Wistar大鼠随机分为空白对照组、模型组、补肺活血组和茶碱组... 详细信息

目的研究补肺活血胶囊对慢性阻塞性肺疾病(简称“慢阻肺”)大鼠模型气道炎症及黏液高分泌的干预作用和机制。方法采用烟熏并气道内滴注脂多糖的方法制备慢阻肺大鼠模型。40只Wistar大鼠随机分为空白对照组、模型组、补肺活血组和茶碱组,空白对照组及模型组予以生理盐水灌胃,补肺活血组和茶碱组分别予补肺活血胶囊和茶碱缓释片溶液灌胃。使用小动物肺功能仪检测大鼠肺功能,苏木精-伊红染色和阿利新蓝-过碘雪芙染色进行形态学分析,酶联免疫吸附实验检测肺泡灌洗液中IL-1β、IL-6、NE、TGF-β、EGF、IL-13和TNF-α的表达,免疫组化法检测大鼠肺组织中黏蛋白5AC(Muc5ac)的表达,免疫印迹法检测Toll样受体4(TLR4)、髓样分化初级应答基因88(MyD88)、NF-κB、Muc5ac、EGFR/p-EGFR、PI3K/p-PI3K、AKT/p-AKT的蛋白表达。结果补肺活血胶囊能够改善慢阻肺模型大鼠FVC、FEV_(0.3)、FEV_(0.3)/FVC和FEF25-75(P<0.05,P<0.01),显著降低肺泡灌洗液中IL-1β、IL-6、NE、TGF-β、EGF、IL-13和TNF-α的含量(P<0.05,P<0.01),减少TLR4、MyD88、ERK1/2、P38MAPK、NF-κB、Muc5ac、p-EGFR、p-PI3K和p-AKT蛋白的表达(P<0.05,P<0.01)。结论补肺活血胶囊可能通过抑制慢阻肺大鼠模型气道炎症及黏液高分泌改善肺功能。

关键词：补肺活血胶囊慢性阻塞性肺疾病慢性炎症气道黏液高分泌

面向DSP平台的CiSSA-CSP特征提取算法的移植与优化

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计算机测量与控制 2024年第1期32卷 260-267页

作者：刘哲贤赵金库赵玉峰王鹏清华大学精密仪器系北京100084 黑龙江北方工具有限公司黑龙江牡丹江157000

为实现便携式信号二分类解析系统的在线实时处理,采用DSP平台完成CiSSA-DSP特征提取算法的嵌入式移植;CiSSA-CSP特征提取算法具有出色的时-频-空域特征提取性能,适合于提取实时二分类系统中非平稳信号的特征;相比于PC机,嵌入式系统具有... 详细信息

为实现便携式信号二分类解析系统的在线实时处理,采用DSP平台完成CiSSA-DSP特征提取算法的嵌入式移植;CiSSA-CSP特征提取算法具有出色的时-频-空域特征提取性能,适合于提取实时二分类系统中非平稳信号的特征;相比于PC机,嵌入式系统具有小型化、便携性、低功耗和低延时的特点,而嵌入式平台处理器的计算资源和内存受到限制,必须优化移植特征提取算法,才能保证二分类解析系统的分类精度和低延时;通过优化CiSSA-CSP算法流程,使用编译器优化、关键字和库函数等手段提高编译效率,将CiSSA-CSP特征提取算法移植到TMS320C6678DSP嵌入式平台,并利用公共数据库数据验证了其用于实时分类系统的有效性;相比于PC机的Matlab实现,DSP平台实现的二分类系统分类准确度下降小于0.5%,且单次实验信号解析耗时少于0.15 s。

关键词：二分类特征提取 CiSSA-CSP DSP 优化移植

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Development of a monochromatic crystal backlight imager for the recent double-cone ignition experiments

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Chinese Physics B 2024年第2期33卷 40-45页

作者：张成龙张翌航远晓辉张喆徐妙华戴羽董玉峰谷昊琛刘正东赵旭李玉同李英骏朱健强张杰 State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyBeijing 100083China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Key Laboratory for Laser Plasmas(MoE)and School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of IFSA(CICIFSA) Shanghai Jiao Tong UniversityShanghai 200240China Songshan Lake Materials Laboratory Dongguan 523808China School of Science China University of Mining and Technology(Beijing)Beijing 100089China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China department of Astronomy Beijing Normal UniversityBeijing 100875China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Key Laboratory of High Power Laser and Physics Chinese Academy of SciencesShanghai 201800China

We developed a monochromatic crystal backlight imaging system for the double-cone ignition(DCI) scheme, employing a spherically bent quartz crystal. This system was used to measure the spatial distribution and temporal evolution of the head-on colliding plasma from the two compressing cones in the DCI experiments. The influence of laser parameters on the x-ray backlighter intensity and spatial resolution of the imaging system was investigated. The imaging system had a spatial resolution of 10 μm when employing a CCD detector. Experiments demonstrated that the system can obtain time-resolved radiographic images with high quality, enabling the precise measurement of the shape, size, and density distribution of the plasma.

关键词： double-cone ignition(DCI) spatial resolution x-ray radiography