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Prognostic Values of Serum Chloride and Sodium Levels in Patients with Three-vessel Disease

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Biomedical and Environmental Sciences 2019年第4期32卷 250-259页

作者： ZHANG Ce WANG Dong HOU Bing Jie JIANG Lin XU Lian Jun TIAN Jian zhao yan yan zhao xue yan FENG Xin Xing ZHANG Yin SUN Kai XU Bo zhao Wei HUI Ru Tai GAO Run Lin LOU Hui Ling YUAN Jin Qing SONG Lei Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Department of Internal Medicine The People's Hospital of Tang County Medical Research & Biometrics Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Department of Endocrinology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Information Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Department of Geriatrics Guangzhou First People's HospitalSchool of MedicineSouth China University of Technology

Objective Identification of new risk factors is needed to improve prediction of adverse outcomes in patients with three-vessel disease(TVD). The present study aimed to evaluate the prognostic values of serum chloride and sodium levels in patients with TVD. Methods We used data from a prospective cohort of consecutive patients with angiographically confirmed TVD. The primary endpoint was all-cause death. Cox proportional hazard regression was used to analyze the relationship of serum chloride and sodium levels with long-term outcomes of TVD patients. Results A total of 8,318 participants with available serum chloride and sodium data were included in this analysis. At baseline, patients in the low tertiles group of serum chloride level(≤ 102.0 mmol/L) or serum sodium level(≤ 139.0 mmol/L) had more severe disease conditions. During a median follow-up of 7.5-year, both low serum chloride level and low serum sodium level were found to be associated with an increased risk for mortality in univariate analysis. However, when both parameters were incorporated into a multivariate model, only low serum sodium level remained to be an independent predictor of all-cause death(hazard ratio: 1.16, 95% confidence interval: 1.01-1.34, P = 0.041). Modest but significant improvement of discrimination was observed after incorporating serum sodium level into the Synergy between percutaneous coronary intervention(PCI) with Taxus and Cardiac Surgery score. Conclusion Serum sodium level is more strongly associated with long-term outcomes of TVD patients compared with serum chloride level. Low serum sodium level is an independent risk factor for mortality, but only provides modest prognostic information beyond an established risk model.

关键词： Coronary disease Prognosis Biomarkers

Risk or Beneficial Factors Associated with Unplanned Revascularization Risk Following Percutaneous Coronary Intervention: A Large Single-Center Data

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Biomedical and Environmental Sciences 2020年第6期33卷 431-443页

作者： LIU Ru GAO Zhan GAO Li Jian zhao xue yan CHEN Jue QIAO Shu Bin yanG Yue Jin GAO Run Lin XU Bo YUAN Jin Qing Department of Cardiology Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China

Objective To analyze factors associated with unplanned revascularization(UR) risk in patients with coronary artery disease(CAD) who underwent percutaneous coronary intervention(PCI).Methods A total of 10,640 cases with CAD who underwent PCI were analyzed. Multivariate COX regressions and competing risk regressions were *** The patients who underwent UR following PCI in 30 days, 1, and 2 years accounted for 0.3%,6.5%, and 8.7%, respectively. After multivariate adjustment, the number of target lesions [hazard ratio(HR) = 2.320;95% confidence interval(CI): 1.643–3.277;P < 0.001], time of procedure(HR = 1.006;95%CI: 1.001–1.010;P = 0.014), body mass index(HR = 1.104;95% CI: 1.006–1.210;P = 0.036), incomplete revascularization(ICR)(HR = 2.476;95% CI: 1.030–5.952;P = 0.043), and age(HR = 1.037;95% CI:1.000–1.075;P = 0.048) were determined as independent risk factors of 30-day UR. Factors, including low-molecular-weight heparin or fondaparinux(HR = 0.618;95% CI: 0.531–0.719;P < 0.001), secondgeneration durable polymer drug-eluting stent(HR = 0.713;95% CI: 0.624–0.814;P < 0.001), left anterior descending artery involvement(HR = 0.654;95% CI: 0.530–0.807;P < 0.001), and age(HR = 0.992;95%CI: 0.985–0.998;P = 0.014), were independently associated with decreased two-year UR risk. While,Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery score(HR =1.024;95% CI: 1.014–1.033;P < 0.001) and ICR(HR = 1.549;95% CI: 1.290–1.860;P < 0.001) were negatively associated with two-year UR *** Specific factors were positively or negatively associated with short-and medium-long-term UR following PCI.

关键词： Coronary artery disease Unplanned revascularization Percutaneous coronary intervention

MOCVD Preparation of YBCO Coated Conductors on CeO_2/YSZ/Y_2O_3 Buffered RABiTS Substrate

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稀有金属材料与工程 2011年第S3期40卷 334-337页

作者： Gao Lei, Yu Miao, Jing Tongguo, Zhang zhao, xue yan, zhao Xiaohui, Xiong Jie, Tao Bowan State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu 610054, China Univ Elect Sci & Technol China State Key Lab Elect Thin Films & Integrated Devic Chengdu 610054 Peoples R China

Superconducting YBa2Cu3O7-x films were grown on the CeO2/YSZ/Y2O3 buffered rolling assisted biaxial textured Ni-5at%W substrate by MOCVD method. Self-made Y(DPM)3, Ba(DPM)2, and Cu(DPM)2 were used as the precursors. Different ratios of the precursors were applied to optimize the hetero-epitaxial structure and property of YBCO films. X-ray diffraction revealed that YBCO films had excellent in plane texture with full width at half maximum (FWHM) value of (103)=5.6°-6.5° and out-of-plane texture with FWHM of (005)=3.1°-3.7°. The superconductivity of YBCO films was measured. The relationship between the ratios of the precursors and the property of the films were discussed in detail.

关键词： MOCVD YBCO DPM RABiTS coated conductors

高寒生态脆弱区农户对气候变化的感知与适应意向——以甘南高原为例

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应用生态学报 2016年第7期27卷 2329-2339页

作者：赵雪雁薛冰西北师范大学地理与环境科学学院兰州730070 中国科学院沈阳应用生态研究所沈阳110016

以地处青藏高原东缘的甘南高原为研究区,基于农户调查数据,分析了农户的气候变化感知对其适应意向的影响,为制定有效的气候变化适应政策提供依据.结果表明:纯农户、兼业户、非农户对气候变化的严重性的感知依次降低,但适应功效感知依次... 详细信息

以地处青藏高原东缘的甘南高原为研究区,基于农户调查数据,分析了农户的气候变化感知对其适应意向的影响,为制定有效的气候变化适应政策提供依据.结果表明:纯农户、兼业户、非农户对气候变化的严重性的感知依次降低,但适应功效感知依次增强,且与非农户、纯农户相比,兼业户的可能性感知、自我效能感知与适应成本感知均较高;纯农户、兼业户、非农户对气候变化的积极适应意向趋于增强;气候变化风险感知、适应功效感知促使农户产生积极适应意向,而适应成本感知促使其产生消极适应意向.同时,农户拥有的耕地面积、牲畜数量、收入水平以及性格乐观程度与积极适应意向发生概率呈显著正相关,而固定资产拥有量、无偿现金援助机会、亲戚网及帮助网规模与其呈显著负相关.最后,提出了促使农户产生积极适应意向的对策建议及未来研究中需关注的问题.

关键词：农户气候变化风险感知适应感知适应意向甘南高原

牧民对高寒牧区生态环境的感知——以甘南牧区为例

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生态学报 2009年第5期29卷 2427-2436页

作者：赵雪雁西北师范大学地理与环境科学学院兰州730070 中国科学院寒区旱区工程研究所兰州730000

地处青藏高原的甘南牧区是典型的生态敏感区,牧民作为牧区最主要的经济活动主体与最基本的决策单位,其对生态环境的认识和响应影响着牧区的生态安全。采用参与性农户评估方法(PRA)对甘南牧区的97户牧民家庭进行了调查,并根据分布区域将... 详细信息

地处青藏高原的甘南牧区是典型的生态敏感区,牧民作为牧区最主要的经济活动主体与最基本的决策单位,其对生态环境的认识和响应影响着牧区的生态安全。采用参与性农户评估方法(PRA)对甘南牧区的97户牧民家庭进行了调查,并根据分布区域将其分成纯牧区牧户和半农半牧区牧户两组,就牧民的环境意识、对环境变化的感知、对环境变化原因的认识进行比较分析,基于分析结果,提出了相关的政策建议。研究结果表明:研究区牧民对生态环境重要性的认识非常明确,但在生产中却较少真正考虑对生态环境的影响;与20 a前相比,85%的牧户认为生态环境有所恶化,纯牧区牧户的感受更为深刻;对于生态环境恶化的原因,超过40%的牧户认为是超载过牧,其次是破坏植被(22.68%)和气候变化(18.56%)。两组牧户对于生态环境恶化原因的认识具有一定差别,纯牧区牧户认为主要原因是过度放牧及气候变化,半农半牧区牧户认为是过度放牧与破坏植被、滥垦土地。

关键词：牧民生态环境感知甘南牧区

Association of CDKN2B-AS1 Polymorphisms with Premature Triple-vessel Coronary Disease and Their Sex Specificity in the Chinese Population

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Biomedical and Environmental Sciences 2018年第11期31卷 787-796页

作者： XU Jing Jing JIANG Lin XU Lian Jun GAO Zhan zhao xue yan ZHANG Yin SONG Ying LIU Ru SUN Kai GAO Run Lin XU Bo SONG Lei YUAN Jin Qing Department of cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical College State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical College Department of Hypertension Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical College

Objective The aim of this study is to establish whether cyclin-dependent kinase inhibitor 2B antisense RNA 1(CDKN2 B-AS1) gene polymorphisms are associated with premature triple-vessel disease(PTVD). Methods Nine single-nucleotide polymorphisms(rs1063192, rs10757274, rs1333042, rs1333049, rs2285327, rs3217986, rs3217992, rs4977574, and rs9632884) were genotyped in 884 PTVD patients and 907 control subjects(males ≤ 50 years old and females ≤ 60 years old) using the improved multiplex ligase detection reaction method. Results The allele frequencies of rs10757274 G, rs1333049 C, rs4977574 G(all P < 0.001), and rs3217986 G(P = 0.040) were significantly higher in the PTVD group than in the control group, but those of rs1063192 A, rs1333042 G, and rs9632884 C(all P < 0.001) were significantly lower in the former than in the latter. Logistic regression analysis revealed that homozygote AA of rs1333042 is associated with decreased risk for PTVD(OR = 0.42, 95% CI: 0.22-0.82, P = 0.011). In addition, the allele frequencies observed differed between genders. The G allele of rs3217986 was associated with increased risk for PTVD in male patients only(OR = 2.94, 95% CI: 1.27-6.80, P = 0.012) in the dominant model, and no positively mutated allele was found in female patients. Conclusion Polymorphisms of the CDKN2 B-AS1 gene are associated with the incidence of PTVD in the Chinese population. Furthermore, the frequencies of mutated alleles differed between genders.

关键词： Premature triple-vessel disease Single-nucleotide polymorphism Risk

黄河首曲地区草地退化的人文因素分析——以甘肃省玛曲县为例

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资源科学 2007年第5期29卷 50-56页

作者：赵雪雁西北师范大学地理与环境科学学院兰州730070

人文因子是引起草地退化的重要因素。本文从定性与定量角度全面系统地进行了甘肃省玛曲县草地退化的人文因素研究。得出以下结论:①影响玛曲县草地退化的人文因素可归纳为牧民家庭支出因子、载畜因子和牧业结构调整因子等3个因子;②牧... 详细信息

人文因子是引起草地退化的重要因素。本文从定性与定量角度全面系统地进行了甘肃省玛曲县草地退化的人文因素研究。得出以下结论:①影响玛曲县草地退化的人文因素可归纳为牧民家庭支出因子、载畜因子和牧业结构调整因子等3个因子;②牧民家庭支出因子、载畜因子与草地退化呈正相关,牧业结构调整因子与草地退化呈负相关;③牧业结构调整因子对草地退化的减弱作用远低于牧民家庭支出因子、载畜因子对其的加速作用。其中,牧民家庭支出因子每提高一个单位,草地沙化面积、固定沙丘面积、流动沙丘面积、沙化率分别增加0.869、0.765、0.809、0.883个单位;载畜因子每提高一个单位,上述指标分别增加0.362、0.574、0.301、0.304个单位;而牧业结构调整因子每提高一个单位,上述指标仅分别降低0.160、0.237、0.248、0.111个单位;④遏制草地退化的关键在于拓宽牧民收入渠道,提高牧民收入。

关键词：草地退化人文因素牧业结构玛曲县

水资源约束下的河西走廊农业结构优化与调整研究

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干旱区资源与环境 2005年第4期19卷 7-12页

作者：赵雪雁西北师范大学地理与环境科学学院甘肃兰州730070

河西走廊生态环境脆弱,干旱少雨,单位面积环境容量狭小,以农业为主的用水结构限制了区域可持续发展。本文指出河西走廊农业节水潜力巨大,应调整与优化农业结构,发展玉米、蔬菜、瓜果、花卉制种业;大田反季节蔬菜种植及其加工、销售业;... 详细信息

河西走廊生态环境脆弱,干旱少雨,单位面积环境容量狭小,以农业为主的用水结构限制了区域可持续发展。本文指出河西走廊农业节水潜力巨大,应调整与优化农业结构,发展玉米、蔬菜、瓜果、花卉制种业;大田反季节蔬菜种植及其加工、销售业;酿酒葡萄栽培及葡萄酒酿造业;草畜业及畜产品加工业,建立节水型农业体系,以促进水资源合理配置、高效利用,为加快城市化和工业化进程提供水资源保证。

关键词：河西走廊水资源约束结构优化调整区域可持续发展水资源合理配置畜产品加工业工业化进程环境脆弱环境容量单位面积用水结构节水潜力农业结构蔬菜种植葡萄栽培农业体系高效利用供水资源制种业反季节

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甘肃省产业空间结构及其生态效应分析

干旱区资源与环境 2007年第6期21卷 17-21页

作者：赵雪雁西北师范大学地理与环境科学学院兰州730070

区域产业空间结构与生态环境之间存在着强烈的交互胁迫关系。本文分析了甘肃省产业空间结构特征、不同产业发展对生态环境的影响及产业空间结构的生态环境效应。得出以下结论:(1)甘肃省第一产业分布分散且与农业资源的空间分布态势基本... 详细信息

区域产业空间结构与生态环境之间存在着强烈的交互胁迫关系。本文分析了甘肃省产业空间结构特征、不同产业发展对生态环境的影响及产业空间结构的生态环境效应。得出以下结论:(1)甘肃省第一产业分布分散且与农业资源的空间分布态势基本一致,第二产业发展空间高度集中且与矿产资源分布一致,第三产业集中在大中城市和旅游资源丰富的地区;(2)甘肃省产业空间结构的生态环境效应具有明显的空间差异;(3)甘肃省生态环境地域分异与产业空间结构分异交互胁迫,强化了生态环境的地域分异,加剧了生态环境的脆弱性。

关键词：甘肃省产业空间结构生态环境效应